Acknowledgements |
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x | |
Preface |
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xi | |
Foreword |
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xiii | |
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Introduction |
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1 | |
Section 1 Mathematical principles |
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5 | |
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Mathematical relationships |
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5 | |
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Exponential relationships and logarithms |
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7 | |
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Physical measurement and calibration |
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14 | |
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18 | |
Section 2 Physical principles |
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21 | |
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21 | |
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24 | |
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26 | |
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27 | |
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Bernoulli, Venturi and Coanda |
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28 | |
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30 | |
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33 | |
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35 | |
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37 | |
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38 | |
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Osmosis and colligative properties |
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40 | |
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42 | |
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Capacitors and capacitance |
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43 | |
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46 | |
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48 | |
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50 | |
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54 | |
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57 | |
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Absorption of carbon dioxide |
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62 | |
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Cardiac output measurement |
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64 | |
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68 | |
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Neuromuscular blockade monitoring |
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69 | |
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74 | |
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Cleaning, disinfection and sterilization |
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76 | |
Section 3 Pharmacological principles |
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78 | |
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The MeyerOverton hypothesis |
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78 | |
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The concentration and second gas effects |
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80 | |
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82 | |
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85 | |
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88 | |
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89 | |
Section 4 Pharmacodynamics |
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91 | |
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Drugreceptor interaction |
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91 | |
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Affinity, efficacy and potency |
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93 | |
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97 | |
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103 | |
Section 5 Pharmacokinetics |
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104 | |
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104 | |
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105 | |
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107 | |
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109 | |
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Context-sensitive half time |
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113 | |
Section 6 Respiratory physiology |
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115 | |
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115 | |
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117 | |
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119 | |
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The alveolar gas equation |
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123 | |
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124 | |
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Pulmonary vascular resistance |
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126 | |
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Ventilation/perfusion mismatch |
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127 | |
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128 | |
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129 | |
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130 | |
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Oxygen delivery and transport |
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132 | |
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The oxyhaemoglobin dissociation curve |
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134 | |
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Carriage of carbon dioxide |
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136 | |
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138 | |
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Control and effects of ventilation |
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139 | |
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Compliance and resistance |
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142 | |
Section 7 Cardiovascular physiology |
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144 | |
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Cardiac action potentials |
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144 | |
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146 | |
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Pressure and flow calculations |
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149 | |
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151 | |
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Pulmonary arterial wedge pressure |
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153 | |
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The FrankStarling relationship |
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155 | |
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Venous return and capillary dynamics |
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157 | |
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Ventricular pressurevolume relationship |
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162 | |
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Systemic and pulmonary vascular resistance |
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167 | |
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169 | |
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171 | |
Section 8 Renal physiology |
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173 | |
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173 | |
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Glomerular filtration rate |
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176 | |
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Autoregulation and renal vascular resistance |
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177 | |
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179 | |
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181 | |
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182 | |
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183 | |
Section 9 Neurophysiology |
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184 | |
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184 | |
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Muscle structure and function |
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188 | |
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191 | |
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193 | |
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Intracranial pressure relationships |
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194 | |
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Formation and circulation of cerebrospinal fluid |
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197 | |
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198 | |
Section 10 Statistical principles |
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200 | |
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200 | |
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Indices of central tendency and variability |
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202 | |
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206 | |
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208 | |
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Error and outcome prediction |
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217 | |
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219 | |
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220 | |
Appendix |
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222 | |
Index |
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236 | |