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E-grāmata: Phytochemistry of Plants of Genus Piper [Taylor & Francis e-book]

, , (Central Drug Research, India),
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Phytochemistry of Plants of Genus PiperPalielināt
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Piper is the representative genus of family Piperaceae. Piper species are pan-tropical in distribution and found in both the hemispheres. As the king of all spices, black pepper, Piper nigrum, led to the global expeditions culminating in the discovery of India and the new world. Piper species have been reported to possess various pharmacological activities such as insecticidal, antibacterial, anti-inflammatory, antiplatelet, anti-hypertensive, antithyroid, antitumor activities and hepatoprotective properties. Botanical authentication of the plants of Piper species is difficult because of the morphological similarity among the species. This book describes ultra-performance liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry in multiple reactions monitoring (MRM) mode to study the quantitative variation of thirteen bioactive markers in different plant parts of ten Piper species.

Features

:

  • Collection of Ayurvedic features and scientific evidence of the most important medicinal plants of Piper species.

  • Describes chemical signatures for identification of Piper species.

  • Provides easy-to-use analytical procedure for quality control of Piper species and its products.



This book describes ultra-performance liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry in multiple reactions monitoring (MRM) mode with continuous polarity switching in the species to study the quantitative variation of thirteen bioactive markers in different plant parts of ten Piper species.
Preface ix
Acknowledgments xi
Authors xiii
List of Abbreviations and Units
xv
1 Introduction
1(26)
1.1 Common Names of Piper Species
2(1)
1.2 Distribution of Piper Species
2(3)
1.3 Botanical Description of Piper Species
5(5)
1.3.1 Piper argyrophyllum Miq.
6(1)
1.3.2 Piper attenuatum Buch.-Ham. ex Miq.
6(1)
1.3.3 Piper divaricatum G. Mey. (Synonym: P. adenophyllum Miq., P. apiculatum CDC, P. colubrina (Link) Miq., P. colubrinum Link)
7(1)
1.3.4 Piper galeatum (Miq.) CDC. (Synonym: Muldera galeata Miq.)
7(1)
1.3.5 P/per hymenophyllum (Miq.) Wight
7(1)
1.3.6 Piper Longum I.
8(1)
1.3.7 P/per mullesua Buch.-Ham. ex D.Don (Synonym: P. guigual Buch.-Ham. ex D.Don)
8(1)
1.3.8 Piper nigrum L.
8(1)
1.3.9 Piper retrofractum Vahl (Synonym: P. chaba Hunter, P. officinarum CDC)
9(1)
1.3.10 Piper umbellatum L.
9(1)
1.4 Brief Review on Chemistry of Piper Species
10(2)
1.5 Brief Review on Pharmacology and Biological Activity of Piper Species
12(7)
1.5.1 Insecticidal and Acaricidal Activity
12(1)
1.5.2 Antifungal Activity
12(3)
1.5.3 Antiamoebic Activity
15(1)
1.5.4 Antimicrobial Activity
15(1)
1.5.5 Effect on Respiratory System
15(1)
1.5.6 Antiasthmatic Activity
16(1)
1.5.7 Antidiabetic Activity
16(1)
1.5.8 Hypocholesterolemic Activity
16(1)
1.5.9 Antioxidant Activity
16(1)
1.5.10 Analgesic Activity
17(1)
1.5.11 Antiinflammatory Activity
17(1)
1.5.12 Immunomodulatory Activity
17(1)
1.5.13 Anticancer Activity
17(1)
1.5.14 Antidepressant Activity
18(1)
1.5.15 Antiulcer Activity
18(1)
1.5.16 Effect on Reproductive System
18(1)
1.5.17 Bioavailability Enhancement
18(1)
1.5.18 Hepatoprotective Activity
19(1)
1.6 Traditional Medicinal Uses of Piper Species
19(3)
1.7 Commercially Available Products Obtained from Various Piper Species
22(1)
1.8 Phytochemical Analysis
22(5)
2 Metabolic Profiling of Piper Species by Direct Analysis Using Real Time Mass Spectrometry Combined with Principal Component Analysis
27(10)
2.1 Plant Material and Chemicals
28(1)
2.2 Optimization of DART-MS Analysis
28(1)
2.3 DART-MS Analysis of Piper Species
29(5)
2.4 Identification of Marker Using Principal Component Analysis
34(3)
3 Quantitative Determination of Chemical Constituents of Piper Species Using UPLC-ESI-MS/MS
37(16)
3.1 Plant Material and Chemicals
37(1)
3.2 Extraction and Sample Preparation
38(1)
3.3 UPLC-MS/MS Conditions
39(1)
3.3.1 Instrumental Parameters
39(1)
3.3.2 Compound-dependent Parameters
39(1)
3.4 Optimization of UPLC Conditions
40(1)
3.5 Optimization of MS/MS Conditions
41(1)
3.6 Quantitative Analysis
41(10)
3.6.1 MS/MS Spectra and MRM Transitions
41(2)
3.6.2 Analytical Method Validation
43(1)
3.6.3 Linearity, LOD and LOQ
43(2)
3.6.4 Precision, Stability and Recovery
45(1)
3.6.5 Quantitative Analysis of Samples
46(5)
3.7 Discrimination of Piper Species by Principal Component Analysis
51(2)
4 Conclusions
53(2)
References 55(12)
Index 67
Dr. Brijesh Kumar is a Professor (AcSIR) and Chief Scientist of sophisticated analytical instrument facility division, CSIR-Central Drug Research Institute, Lucknow, India. Currently he is facility in charge at Sophisticated Analytical Instrument Facility (SAIF) division of CSIR-CDRI. He has completed his PhD from CSIR-CDRI Lucknow (Dr. R.M.L Avadh University Faizabad UP, India). He has to his credit 7 book chapters, one book and 145 papers in International journal of repute. His current area of research is applications of Mass Spectrometry (DART MS/Q-TOF LC-MS/4000 Q Trap LC-MS/ Orbitrap MSn) for qualitative and quantitative analysis of molecules for quality control and authentication/standardization of Indian medicinal plants/parts and their herbal formulations. He is also involved in identification of marker compounds using statistical software to check adulteration/substitution.

Ms. Surabhi Tiwari completed her masters from the University of Allahabad India in Chemistry. She has worked in Pharmacognosy Division, NBRI, Lucknow, for analysis of herbals using instruments like- HPTLC and HPLC. Currently she is working as Senior Research Fellow in SAIF Division under supervision of Dr. Brijesh Kumar at CSIR-Central Drug research Institute Lucknow India. Her current research interest includes phytochemical analysis of medicinal plants.

Vikas Bajpai completed his PhD from the Academy of Scientific and Innovative Research (AcSIR), New Delhi, India and carried his research work under supervision of Dr. Brijesh Kumar at CSIR-Central Drug research Institute Lucknow. His research includes development and validation of LC-MS/MS methods for qualitative and quantitative analysis of small molecules of Indian medicinal plants.

Dr. Bikarma Singh is working as Scientist in CSIR-Indian Institute of Integrative Medicine Jammu and is a recognized Assistant Professor in AcSIR, New Delhi. He graduated as an Honours and Gold Medalist in Botany from North-Eastern Hill University, Shillong in 2005, and completed Doctorate Degree in Botany from Gauhati University, Assam and Botanical Survey of India (Shillong), Meghalaya in 2012. He authored/co-authored 8 books and published 82 scientific research papers/experimental findings in peer reviewed national and international journals.
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