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E-grāmata: Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications

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  • Formāts: EPUB+DRM
  • Izdošanas datums: 18-Aug-2017
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781119406808
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Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical IndicationsPalielināt
  • Formāts: EPUB+DRM
  • Izdošanas datums: 18-Aug-2017
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781119406808
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The first book devoted exclusively to the subject, Platelet Rich Fibrin in Regenerative Dentistry offers comprehensive, evidence-based coverage of the biological basis and clinical applications of PRF in dentistry. Co-edited by a leading researcher in tissue regeneration and the inventor of the PRF technique, it brings together original contributions from expert international researchers and clinicians.

Chapters cover the biological foundation of PRF before addressing specific uses of the technology within clinical dentistry. Topics describe the use of PRF in many dental applications, including extraction socket management, sinus lifting procedures, root coverage, periodontal regeneration, soft tissue healing around implants, guided bone regeneration, and facial esthetics. The text is supplemented with color photographs and explanatory illustrations throughout.

Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications is an indispensable professional resource for periodontists, oral surgeons and oral and maxillofacial surgeons, as well as general dentists who use PRF or are interested in introducing it into their practices. It is also an excellent reference for undergraduate and postgraduate dental students.

About the Authors xiii
Foreword xv
Preface xvii
1 Platelet Rich Fibrin: A Second-Generation Platelet Concentrate 1(14)
Joseph Choukroun
Richard J. Miron
1.1 Introduction
1(3)
1.2 Brief history of platelet concentrates
4(1)
1.3 The development of PRF from PRP
5(3)
1.4 Effect of PRF on periosteum behavior
8(1)
1.5 The first case treated with PRF
8(3)
1.6 Conclusion
11(1)
References
11(4)
2 Biological Components of Platelet Rich Fibrin: Growth Factor Release and Cellular Activity 15(18)
Masako Fujioka-Kobayashi
Richard J. Miron
2.1 Introduction
16(1)
2.2 Cell components of PRF
16(2)
2.3 Advantages of a three-dimensional fibrin network
18(1)
2.4 Growth factors in blood
19(1)
2.5 PRP versus PRF for growth factor release
20(2)
2.6 L-PRF versus A-PRF vs A-PRF+-new findings with the low-speed centrifugation concept and low-time induces even higher growth factor release
22(2)
2.7 i-PRF versus PRP-growth factor release
24(1)
2.8 Cell behavior in response to L-PRF, A-PRF, and A-PRF+
25(1)
2.9 Cell behavior in response to PRP, i-PRF
26(1)
2.10 Future prospective
26(3)
References
29(4)
3 Introducing the Low-Speed Centrifugation Concept 33(14)
Joseph Choukroun
Shahram Ghanaati
3.1 Introduction
33(1)
3.2 Development of advanced solid PRF matrices following the low speed centrifugation concept (LSCC)
34(4)
3.3 Development of an injectable PRF (i-PRF) following the low speed centrifugation concept (LSCC)
38(1)
3.4 Platelets and leukocytes are key elements in the regeneration process
39(2)
3.5 Clinical insights
41(1)
3.6 Conclusion
42(1)
References
42(5)
4 Uses of Platelet Rich Fibrin in Regenerative Dentistry: An Overview 47(12)
Richard J. Miron
Giovanni Zucchelli
Joseph Choukroun
4.1 Introduction
47(1)
4.2 Extraction socket management with PRF
48(1)
4.3 Sinus elevations procedures with PRF
48(1)
4.4 Use of PRF for soft-tissue root coverage
49(1)
4.5 Use of PRF for periodontal regeneration
50(1)
4.6 Use of PRF for the regeneration of soft tissues around implants
50(1)
4.7 Use of PRF in guided bone regeneration
51(3)
4.8 Use of PRF in various other aspects of dentistry and medicine
54(1)
4.9 Conclusion
54(1)
References
54(5)
5 Use of Platelet Rich Fibrin for the Management of Extraction Sockets: Biological Basis and Clinical Relevance 59(22)
Richard J. Miron
Jonathan Du Toit
5.1 Introduction
59(1)
5.2 Natural dimensional changes occurring post-extraction
60(3)
5.3 Conventional socket grafting and ridge preservation techniques
63(3)
5.4 Immediate implant placement into fresh extraction sockets
66(2)
5.5 Overview of utilizing PRF in extraction sockets
68(6)
5.5.1 Socket grafting and ridge preservation with PRF
68(3)
5.5.2 Preventing postoperative pain and infection
71(3)
5.6 Discussion and future research
74(3)
References
77(4)
6 Maxillary Sinus Floor Elevation in the Atrophic Posterior Maxillae: Anatomy, Principles, Techniques, Outcomes, and Complications 81(18)
Alberto Monje
Hom-Lay Wang
Richard J. Miron
6.1 Introduction
81(1)
6.2 Anatomical considerations
82(4)
6.2.1 Embryologic development
82(1)
6.2.2 Maxillary sinus dimension
83(1)
6.2.3 Vascularization
83(1)
6.2.4 Lining membrane
84(2)
6.2.5 Sinus septa
86(1)
6.3 Biological principles
86(1)
6.4 Surgical techniques
87(1)
6.5 Clinical outcomes
88(1)
6.6 Surgical and post-surgical complications
89(4)
6.6.1 Schneiderian membrane perforation
89(2)
6.6.2 Acute or chronic infections
91(1)
6.6.3 Hemorrhage
92(1)
6.6.4 Implant migration
92(1)
6.7 Conclusion
93(1)
References
93(6)
7 Maxillary Sinus Floor Elevation Procedures with Platelet Rich Fibrin: Indications and Clinical Recommendations 99(16)
Richard J. Miron
Michael A. Pikos
Hom-Lay Wang
7.1 Introduction
99(1)
7.2 PRF as a sole grafting material during sinus lifting procedures
100(3)
7.3 PRF for the repair of Schneiderian membranes
103(1)
7.4 PRF for the closure of the lateral maxillary access window
104(1)
7.5 Discussion and future outlook
105(6)
References
111(4)
8 Use of Platelet Rich Fibrin for the Treatment of Muco-Gingival Recessions: Novel Improvements in Plastic Aesthetic Surgery Utilizing The Fibrin Assisted Soft Tissue Promotion (FASTP) Technique 115(12)
Alexandre-Amir Aalam
Alina Krivitsky Aalam
8.1 Introduction
115(2)
8.2 Plastic periodontal procedures with PRF
117(1)
8.3 Fibro promotion: the basic mechanism of Fibrin-Assisted Soft Tissue Promotion (FASTP) technique
117(3)
8.3.1 Biotensegrity
118(2)
8.3.2 Volume
120(1)
8.4 FASTP: the surgical technique
120(3)
8.4.1 Incision
120(1)
8.4.2 Root preparation and decontamination
120(1)
8.4.3 Volume packing
121(1)
8.4.4 Suturing
121(2)
8.5 Conclusion
123(1)
References
123(4)
9 Use of Platelet Rich Fibrin for Periodontal Regeneration/Repair of Intrabony and Furcation Defects 127(18)
Richard J. Miron
Brian L. Mealey
Hom-Lay Wang
9.1 Introduction
127(2)
9.2 Role of barrier membranes in periodontal regeneration
129(1)
9.3 Role of bone-grafting materials in periodontal regeneration
129(1)
9.4 Biologic agents/growth factors for periodontal regeneration
130(1)
9.5 Platelet rich fibrin (PRF) as a potential autologous biological agent for periodontal regeneration
131(1)
9.6 Intrabony defect regeneration with PRF: results from controlled clinical trials
131(3)
9.7 Furcation defect regeneration with PRF
134(1)
9.8 Discussion and future research
135(2)
References
137(8)
10 Platelet Rich Fibrin as an Adjunct to Implant Dentistry 145(14)
Howard Gluckman
10.1 Introduction
146(1)
10.2 PRF treatment of peri-implant defects
146(1)
10.3 PRF and soft-tissue healing at implants
147(2)
10.4 Osseointegration
149(2)
10.5 Techniques to improve primary stability in poor bone quality
151(1)
10.6 The use of PRF at osteotomy preparation
152(2)
10.7 The future of PRF and implants
154(1)
References
154(5)
11 Guided Bone Regeneration with Platelet Rich Fibrin 159(26)
Richard J. Miron
Michael A. Pikos
Yufeng Zhang
Tobias Fretwurst
11.1 Introduction
159(1)
11.2 Overview of GBR
160(1)
11.3 Available options of GBR
161(1)
11.4 Non-resorbable PTFE membranes
161(5)
11.5 Titanium mesh
166(1)
11.6 Collagen-based resorbable membranes
166(1)
11.7 Synthetic resorbable membranes
167(1)
11.8 Plasma-rich proteins as growth factors for membranes
167(2)
11.9 Choice of bone-grafting materials during GBR procedures
169(1)
11.10 Alternative strategies to induce new bone formation during GBR procedures
170(1)
11.11 Recent surgical approaches using PRF in combination with GBR
170(1)
11.12 PRF as a barrier membrane in GBR procedures
171(1)
11.13 PRF in combination with bone-grafting materials
172(1)
11.14 Studies investigating PRF for GBR
173(4)
11.15 Discussion and future research
177(2)
References
179(6)
12 Modern Approach to Full Arch Immediate Loading: The Simonpieri Technique with PRF and i-PRF 185(30)
Alain Simonpieri
12.1 Introduction
186(1)
12.2 Immediate loading in implant dentistry-what is success?
187(1)
12.3 Biological requirements
188(1)
12.4 Anatomical and surgical requirements
189(6)
12.4.1 Implant placement
189(5)
12.4.2 Systematic apposition graft
194(1)
12.4.3 Flap management and suture technique
195(1)
12.5 Prosthetic requirements
195(5)
12.6 Final results
200(1)
12.7 Documented long-term stability
201(1)
12.8 Long-term statistical results: full arch immediate implant placement and loading
202(5)
12.8.1 The "Fast Guide" System for immediate implant placement
204(1)
12.8.2 An injectable-PRF (i-PRF) for adequate graft stability and compaction
205(1)
12.8.3 The collagen Twin Matrix
205(1)
12.8.4 Can we get more soft tissue?
205(1)
12.8.5 Potential wound healing: example of aesthetic failure without management of tension and regeneration with a Twin Matrix and PRF
205(2)
12.9 Conclusion
207(2)
References
209(6)
13 Use of Platelet Rich Fibrin in Facial Aesthetics and Rejuvenation 215(22)
Cleopatra Nacopoulos
13.1 Introduction
215(2)
13.2 Features of the skin
217(2)
13.3 Aging and the epidermal barrier function mechanisms in skin aesthetics
219(1)
13.4 Pre-evaluation and patient selection
219(1)
13.5 Conventional therapies in facial aesthetics
220(2)
13.6 Lasers and epidermal barrier function
222(1)
13.7 Overview of utilizing platelet derivatives in facial aesthetics
222(1)
13.8 Clinical procedures utilizing PRF in facial aesthetics
222(5)
13.9 i-PRF injections with a derma rollers
227(1)
13.10 i-PRF injections with a derma pen
228(1)
13.11 i-PRF and PRF for mesotherapy by syringe injections
228(1)
13.12 Platelet concentrate during the vampire technique
229(1)
13.13 Augmentation techniques with PRF matrix and i-PRF-combination Therapies
229(1)
13.14 Nasolabial fold rejuvenation with PRF and i-PRF
229(1)
13.15 Use of PRF and i-PRF for lip augmentation
230(1)
13.16 PDO threads using PRF and i-PRF
230(1)
13.17 Conclusion
231(3)
References
234(3)
14 Use of Platelet Rich Fibrin in Other Areas of Medicine 237(14)
Richard J. Miron
Joseph Choukroun
14.1 Introduction
237(1)
14.2 Effects of PRF on cell activity in vitro
238(1)
14.3 Evidence that PRF improves soft-tissue wound healing/regeneration in vivo
238(1)
14.4 Clinical studies evaluating the use of PRF in medicine
239(1)
14.5 PRF for regeneration of chronic leg ulcers
240(1)
14.6 PRF for cartilage (knee) regeneration
241(1)
14.7 PRF for the regeneration of ligaments and tendons
242(1)
14.8 PRF in orthopedic medicine
242(1)
14.9 PRF for skin regeneration
243(1)
14.10 Discussion and future perspectives
243(2)
References
245(6)
15 Future Research with Platelet Rich Fibrin 251(12)
Richard J. Miron
Joseph Choukroun
15.1 PRF and centrifugation speeds
251(1)
15.2 Effect of hematocrit count on PRF scaffolds
252(1)
15.3 The influence of PRF for the treatment of osteonecrosis of the jaw
252(1)
15.4 Injectable platelet rich fibrin as a potential therapy for temporomandibular joint disorders
253(1)
15.5 Potential use of platelet rich fibrin for pulp regeneration
253(3)
15.6 Platelet rich fibrin and periodontal regeneration
256(1)
15.7 Potential use of stem cells derived from blood
256(1)
15.8 PRF: regeneration by growth factors, leukocytes, or fibrin?
256(1)
15.9 PRF and its degradation properties
257(1)
15.10 PRF and osteoinduction
258(1)
References
258(5)
Index 263
Richard J. Miron, DDS, BMSC, MSc, PhD, dr. med. dent. is an Adjunct Faculty and Group Leader of the Miron Lab at the Department of Periodontology, Nova Southeastern University, Florida, USA.

Joseph Choukroun, MD is the inventor of the Platelet Rich Fibrin technique and Director of the Pain Clinic, Nice, France.
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