Thanks to a resurgence of interest and a recent proliferation of research techniques, much new and illuminating data has emerged during the last decade relating to the prefrontal cortex, particularly in primates and rodents. In view of this progress, the 16th International Summer School of Brain Research was held in Amsterdam, The Netherlands from 28 August to 1 September 1989, devoted to the topic of `The Prefrontal Cortex: Its Structure, Function and Pathology'. The edited proceedings, embodied in this 85th volume of `Progress in Brain Research', fall into three sections - the first of which, following two introductory chapters, discusses the present knowledge of the organization of prefrontal cortical systems. In the second section, developmental and plasticity aspects in rodent and human cortex are considered, whilst the third section deals extensively with the functional aspects characteristic for the prefrontal cortex in primates, rats and rabbits. The last section reviews several topics on dysfunction of prefrontal cortex in rat and man, including a historical review on psychosurgery.
List of contributors. Preface. Acknowledgements. Section I: Organization
of Prefrontal Cortical Systems.
1. How sensory cortex is subdivided in
mammals: implications for studies in prefrontal cortex (J.H. Kaas).
2.
Neurotransmitters in the cerebral cortex (J.G. Parnavelas).
3. Qualitative
and quantitative comparison of the prefrontal cortices in rat and in
primates, including humans (H.B.M. Uylings and C.G. van Eden).
4. Prefrontal
cortex in relation to other cortical areas in rhesus monkey: architecture and
connections (D.N. Pandya and E.H. Yeterian).
5. The anatomical relationship
of the prefrontal cortex with the striatopallidal system, the thalamus and
the amygdala: evidence for a parallel organization (H.J. Groenewegen, H.W.
Berendse, J.G. Wolters and A.H.M. Lohman).
6. Basal ganglia-thalamocortical
circuits: parallel substrates for motor, oculomotor, `prefrontal' and
`limbic' functions (G.E. Alexander, M.D. Crutcher and M.R. DeLong).
7.
Prefrontal cortical control of the autonomic nervous system: anatomical and
physiological observations (E.J. Neafsey). Section II: Development and
Plasticity in Prefrontal Cortex.
8. The development of the rat prefrontal
cortex. Its size and development of connections with thalamus, spinal cord
and other cortical areas (C.G. van Eden, J.M. Kros and H.B.M. Uylings).
9.
Neuronal development in human prefrontal cortex in prenatal and postnatal
stages (L. Mrzljak, H.B.M. Uylings, C.G. van Eden and M. Judas).
10.
Structural and histochemical reorganization of the human prefrontal cortex
during perinatal and postnatal life (I. Kostovici).
11. Anatomical correlates
of behavioural change after neonatal prefrontal lesions in rats (B. Kolb and
R. Gibb).
12. Age-dependent effects of lesioning the mesocortical dopamine
system upon prefrontal cortex morphometry and PFC-related behaviours (A.
Kalsbeek, J.P.C. de Bruin, M.G.P. Feenstra and H.B.M. Uylings).
13. Is it
possible to repair the damaged prefrontal cortex by neural tissue
transplantation (S.B. Dunnett).
14. Enhanced cortical maturation:
gangliosides in CNS plasticity (S.E. Karpiak and S.P. Mahadik). Section III:
Functional Aspects of Prefrontal Cortex.
15. Behavioural electrophysiology of
the PFC of the primate (J.M. Fuster).
16. Cellular and circuit basis of
working memory in prefrontal cortex of nonhuman primates (P.S.
Goldman-Rakic).
17. Distributed neuroelectric patterns of human neocortex
during simple cognitive tasks (A. Gevins).
18. Influence of the ascending
monoaminergic systems on the activity of the rat prefrontal cortex (A.-M.
Thierry, R. Godbout, J. Mantz and J. Glowinski).
19. The determinants of
stress-induced activation of the prefrontal cortical dopamine system (A.Y.
Deutch and R.H. Roth).
20. Involvement of mesocorticolimbic dopaminergic
systems in emotional states (M. Bertolucci-D'Angio, A. Serrano, P. Driscoll
and B. Scatton).
21. The neurobiological basis of prefrontal cortex
self-stimulation: a review and an integrative hypothesis ( F.
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