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Principles of Nucleic Acid Structure [Mīkstie vāki]

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(Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK)
  • Formāts: Paperback / softback, 302 pages, height x width: 260x184 mm, weight: 570 g, Approx. 150 illustrations; Illustrations, unspecified
  • Izdošanas datums: 22-Nov-2007
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0123695074
  • ISBN-13: 9780123695079
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Principles of Nucleic Acid StructurePalielināt
  • Formāts: Paperback / softback, 302 pages, height x width: 260x184 mm, weight: 570 g, Approx. 150 illustrations; Illustrations, unspecified
  • Izdošanas datums: 22-Nov-2007
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0123695074
  • ISBN-13: 9780123695079
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780123695079.html
Keywords:
This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.

* Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA)
* Includes a complete list of resources, including relevant online databases and software
* Defines technical lingo for novices

Recenzijas

Review of the previous edition: "Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances." --Crystallography News

Papildus informācija

Practical resource providing a complete and concise summary of underlying principles and approaches to studying nucleic acid structure.
Methods for Studying Nucleic Acid Structure
1(19)
Introduction
1(1)
X-ray Diffraction Methods for Structural Analysis
2(8)
Overview
2(3)
Fiber Diffraction Methods
5(2)
Single-Crystal Methods
7(3)
NMR Methods for Studying Nucleic Acid Structure and Dynamics
10(1)
Molecular Modelling and Simulation of Nucleic Acids
11(3)
Chemical, Enzymatic, and Biophysical Probes of Structure and Dynamics
14(1)
Sources of Structural Data
15(1)
Visualization of Nucleic Acid Molecular Structures
15(5)
The Structures in This Book
16(4)
The Building-Blocks of DNA and RNA
20(18)
Introduction
20(3)
Base Pairing
23(1)
Base and Base Pair Flexibility
24(4)
Sugar Puckers
28(4)
Conformations About the Glycosidic Bond
32(1)
The Backbone Torsion Angles and Correlated Flexibility
33(5)
DNA Structure as Observed in Fibers and Crystals
38(43)
Structural Fundamentals
38(1)
Helical Parameters
38(1)
Base-Pair Morphological Features
38(1)
Polynucleotide Structures from Fiber Diffraction Studies
39(8)
Classic DNA Structures
39(4)
DNA Polymorphism in Fibers
43(4)
B-DNA Oligonucleotide Structure as Seen in Crystallographic Analyses
47(13)
The Dickerson--Drew Dodecamer
47(2)
Other Studies of the Dickerson--Drew Dodecamer
49(2)
Other B-DNA Oligonucleotide Structures
51(5)
Sequence-Dependent Features of B-DNA: Their Occurrence and Their Prediction
56(4)
A-DNA Oligonucleotide Crystal Structures
60(4)
A-Form Octanucleotides
60(1)
Do A-Form Oligonucleotides Occur in Solution? Crystal-Packing Effects
61(2)
The A ←→ B Transition in Crystals
63(1)
Z-DNA -- Left-Handed DNA
64(5)
The Z-DNA Hexanucleotide Crystal Structure
64(1)
Overall Structural Features
65(1)
The Z-DNA Helix
66(1)
Other Z-DNA Structures
67(1)
Biological Aspects of Z-DNA
67(2)
Bent DNA
69(5)
DNA Periodicity in Solution
69(1)
A-Tracts and Bending
70(1)
Structures Showing Bending
71(2)
The Structure of Poly dA•dT
73(1)
Concluding Remarks
74(7)
Nonstandard and Higher-Order DNA Structures: DNA--DNA Recognition
81(51)
Mismatches in DNA
81(7)
General Features
81(1)
Purine: Purine Mismatches
82(3)
Alkylation Mismatches
85(3)
DNA Triple Helices
88(13)
Introduction
88(2)
Structural Studies
90(5)
Antiparallel Triplexes and Nonstandard Base-pairings
95(5)
Triplex Applications
100(1)
Guanine Quadruplexes
101(13)
Introduction
101(2)
Overall Structural Features of Quadruplex DNA
103(4)
Examples of Simple Quadruplex Structures
107(1)
Some Complex Quadruplex Structures
108(5)
The i-Motif
113(1)
DNA Junctions
114(6)
Holliday Junction Structures
114(4)
DNA Enzyme Structures
118(2)
Unnatural DNA Structures
120(12)
Principles of Small Molecule-DNA Recognition
132(72)
Introduction
132(4)
DNA-Water Interactions
136(7)
Hydration in the Grooves in Detail
140(3)
General Features of DNA-Drug and Small-Molecule Recognition
143(1)
Intercalative Binding
144(19)
Simple Intercalators
146(1)
Complex Intercalators
147(4)
Major-Groove Intercalation
151(7)
Bis-Intercalators
158(5)
Intercalative-Type Binding to Higher-Order DNAs
163(6)
Triplex DNA--Ligand Interactions
163(1)
Ligand Binding to Quadruplex DNAs
164(2)
Ligand Binding to Junction DNAs
166(3)
Groove-Binding Molecules
169(18)
Simple Groove Binding Molecules
169(9)
Netropsin and Distamycin
178(4)
Sequence-Specific Polyamides
182(5)
Small Molecule Covalent Bonding to DNA
187(17)
The Platinum Drugs
188(3)
Covalent-Binding Combined with Sequence-Specific Recognition
191(13)
RNA Structures and Their Diversity
204(45)
Introduction
204(2)
Fundamentals of RNA Structure
206(11)
Helical RNA Conformations
206(4)
Mismatched and Bulged RNA Structures
210(7)
Transfer RNA Structures
217(4)
Ribozymes
221(6)
The Hammerhead Ribozyme
223(1)
Complex Ribozymes
224(3)
Riboswitches
227(2)
The Ribosome, a Ribozyme Machine
229(6)
The Structure of the 30S Subunit
232(2)
The Structure of the 50S subunit
234(1)
Complete Ribosome Structures
234(1)
RNA-Drug Complexes
235(6)
RNA Motifs
241(8)
Principles of Protein-DNA Recognition
249(34)
Introduction
249(3)
Direct Protein-DNA Contacts
252(5)
Major-Groove Interactions -- the α-Helix as the Recognition Element
257(2)
Zinc-Finger Recognition Modes
259(4)
Other Major Groove Recognition Motifs
263(1)
Minor-Groove Recognition
264(8)
Recognition of B-DNA
264(3)
The Opening-up of the Minor Groove by TBP
267(1)
Other Proteins that Induce Bending of DNA
268(4)
DNA-Bending and Protein Recognition
272(3)
Protein-DNA-Small Molecule Recognition
275(8)
Index 283


Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.