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1 | (14) |
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2 | (2) |
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Historical Context for Probabilistic Exposure Assessment |
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4 | (3) |
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When Is Probabilistic Analysis Useful and/or Justified? |
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7 | (1) |
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Assessing the Existing Information Base |
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8 | (2) |
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10 | (2) |
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Composition of Exposure Assessment Teams |
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12 | (1) |
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Conventions Used in This Text |
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12 | (1) |
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12 | (1) |
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13 | (1) |
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13 | (1) |
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Summary of Goals and Philosophy |
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13 | (2) |
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A Basic Framework for Probabilistic Analysis |
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15 | (22) |
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Philosophy of Probabilistic Analysis |
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15 | (6) |
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The Frequentist View of Probability |
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15 | (3) |
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Subjective or Bayesian Views of Probability |
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18 | (2) |
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20 | (1) |
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Taxonomy of Variability and Uncertainty |
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21 | (12) |
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21 | (9) |
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30 | (1) |
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31 | (2) |
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Comparison of Variability and Uncertainty |
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33 | (4) |
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Approaches to Model Uncertainty |
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37 | (22) |
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38 | (2) |
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40 | (7) |
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Uncertainty Propagation Characteristics of Models |
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41 | (3) |
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When Is a Complex Model Needed? |
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44 | (1) |
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Simplifying a Complex Model |
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45 | (2) |
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Setting Up the Right Problem |
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47 | (1) |
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48 | (2) |
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50 | (3) |
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Validating with Data: The Elusive Ideal |
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50 | (2) |
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Partial Validation: When You Have Some Data |
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52 | (1) |
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What If There Are No Data? |
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52 | (1) |
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Can You Validate by Comparing Models? |
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53 | (1) |
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Extrapolation and Uncertainty |
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53 | (1) |
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Can Input Uncertainties Reflect Model Uncertainty? |
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54 | (1) |
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What Do You Do When Models Disagree? |
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55 | (1) |
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Examples of Model Uncertainty Issues |
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56 | (3) |
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Characterizing Variability and Uncertainty in Model Inputs |
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59 | (22) |
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Data Availability and Characteristics |
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59 | (3) |
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60 | (1) |
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61 | (1) |
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Interindividual Variability |
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61 | (1) |
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62 | (1) |
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62 | (2) |
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Families and Models for Probability Distributions |
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64 | (17) |
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Theoretical Basis for Probability Distribution Models |
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64 | (14) |
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Characterizing Uncertainty in Distribution Parameters |
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78 | (3) |
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81 | (80) |
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82 | (7) |
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82 | (3) |
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85 | (2) |
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87 | (2) |
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Empirical Basis for Selecting a Parametric Probability Distribution Model |
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89 | (3) |
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Empirical Cumulative Distribution Functions |
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92 | (4) |
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93 | (1) |
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Examples of Empirical Cumulative Distributions |
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94 | (2) |
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Other Ways to Visualize Data |
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96 | (3) |
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Uncertainty in Summary Statistics |
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99 | (23) |
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99 | (8) |
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Uncertainty in the Variance and Standard Deviation |
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107 | (5) |
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112 | (1) |
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112 | (1) |
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Multivariate Distributions for Uncertainty in Statistics |
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113 | (3) |
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116 | (2) |
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Summary of Uncertainty in Statistics for the PCB Concentration Data Sets |
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118 | (4) |
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Probability Distribution Models |
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122 | (3) |
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Method of Matching Moments Estimates of Distribution Parameters |
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122 | (1) |
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Maximum Likelihood Estimates of Distribution Parameters |
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122 | (1) |
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Examples of the Use of Statistical Estimators |
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123 | (2) |
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125 | (18) |
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Empirical Basis for Selecting Probability Models |
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126 | (1) |
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Methods for Probability Plotting |
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127 | (2) |
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Identifying Distribution Types Based upon Probability Plotting |
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129 | (6) |
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Normal and Lognormal Probability Plots |
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135 | (1) |
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Estimating Distribution Parameters Using Probability Plots |
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135 | (2) |
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Probability Plots for the Weibull Distribution |
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137 | (1) |
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Probability Plots and Censored Data Sets |
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138 | (1) |
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Percentile-Percentile Plots |
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139 | (3) |
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142 | (1) |
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143 | (18) |
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144 | (5) |
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149 | (6) |
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155 | (6) |
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Special Topics Related to Distribution Development |
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161 | (20) |
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161 | (2) |
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Suggested Information to Accompany Initial Distributions |
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162 | (1) |
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Maximum Entropy Inference Approach |
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163 | (2) |
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The Basis of Maximum Entropy Inference |
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163 | (1) |
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164 | (1) |
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165 | (7) |
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167 | (1) |
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168 | (1) |
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When to Consider Preserving Separate Sources of Information? |
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169 | (1) |
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169 | (3) |
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172 | (3) |
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173 | (1) |
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174 | (1) |
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175 | (2) |
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177 | (4) |
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Sources of Bias in Judgments about Uncertainty |
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178 | (1) |
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178 | (3) |
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Probabilistic Modeling Techniques |
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181 | (62) |
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Implications of the Central Limit Theorem for Propagation of Distributions |
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181 | (2) |
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Properties of the Mean and Variance |
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183 | (1) |
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Analytical Methods: transformation of Variables |
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184 | (2) |
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Approximation Methods Based upon Taylor Series Expansions |
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186 | (8) |
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Numerical Simulation Methods |
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194 | (23) |
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196 | (11) |
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207 | (6) |
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Other Sampling Techniques |
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213 | (1) |
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Selecting a Sample Size for Numerical Simulations |
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213 | (2) |
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Verification of Monte Carlo Results |
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215 | (1) |
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216 | (1) |
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Two-Dimensional Simulations |
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217 | (20) |
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Background on Two-Dimensional Methods |
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217 | (2) |
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Distinctions between Variability and Uncertainty in Simulations |
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219 | (1) |
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Characterization of Uncertainty as an Aid to Model Validation |
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219 | (2) |
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Taxonomy of Variability and Uncertainty in Model Inputs |
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221 | (2) |
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General Approach for Simulation of Variability and Uncertainty |
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223 | (1) |
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Developing Input Assumptions for Two-Dimensional Analyses |
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224 | (12) |
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Simulating Correlations among Frequency Distributions for Variability in Two-Dimensional Analyses |
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236 | (1) |
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Discussion of Analytical, Approximation, and Numerical Methods |
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237 | (3) |
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Assessing Model Uncertainties |
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240 | (1) |
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Uncertainty Reduction Techniques |
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241 | (2) |
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Identifying Key Constributors to Variability and Uncertainty in Model Outputs |
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243 | (28) |
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Introduction to the Examples |
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244 | (3) |
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245 | (1) |
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245 | (2) |
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Methods to Use Prior to Simulation |
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247 | (2) |
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Apportioning Variance by the Gaussian Approximation |
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247 | (1) |
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248 | (1) |
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Methods to Use after Simulation |
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249 | (19) |
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249 | (4) |
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253 | (10) |
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263 | (1) |
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Multivariate Linear Regression |
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264 | (2) |
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Nominal Range Sensitivity |
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266 | (1) |
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Probabilistic Sensitivity Analysis |
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267 | (1) |
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268 | (1) |
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268 | (1) |
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269 | (2) |
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An Example of Probabilistic Exposure Assessment in the Community Surrounding New Bedford Harbor |
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271 | (38) |
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Defining the Exposure Scenario |
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271 | (6) |
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272 | (2) |
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274 | (1) |
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274 | (3) |
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Distribution Development for Exposure Model Inputs |
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277 | (26) |
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277 | (1) |
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Concentration of PCBs in Environmental Media |
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278 | (14) |
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Human Physical Characteristics |
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292 | (4) |
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Inputs Related to Intake and Consumption Rates |
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296 | (5) |
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301 | (2) |
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303 | (6) |
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One-Dimensional Analysis of Variability |
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303 | (1) |
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Two-Dimensional Analysis of Variability and Uncertainty |
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304 | (2) |
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Identification of Key Contributors to Variability in Output |
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306 | (3) |
Glossary |
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309 | (8) |
References |
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317 | (10) |
Index |
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327 | |