In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Part A: Molecular and Biochemical Aspects of Proteases.-
1. An Overview
of Endoplasmic Reticulum Calpain System.-
2. Mitochondrial Calpains: Who,
What, Where, When and Why?.-
3. Role of Calpains in Calmodulin Regulated
Systems.-
4. Exercise and Matrix Metalloproteases: A Brief Overview.-
5.
Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression.-
6.
Microbial Source of Fibrinolytic Protease and Its Biotechnological
Potential.-
7. Aspartic Proteolytic Inhibitors Induce Cellular and
Biochemical Alterations in Fungal Cells.-
8. Cysteine Proteases of Human
Malaria Parasites.-
9. Proteases as Virulence Factors in Leishmania: Focus on
Serine Proteases as Possible Therapeutic Targets.-
10. An Updated Inventory
on Properties, Pathophysiology and Therapeutic Potential of Snake Venom
Thrombin-like Proteases.-
11. Macrocyclic Protease Inhibitors Constrained
into a -Strand Geometry.- Part B: Involvement of Proteases in Disease
Processes.-
12. Regulation of MT1-MMP Activation and Its Relevance to Disease
Processes.-
13. Role of Proteases During Intra-erythrocytic Developmental
Cycle of Human Malaria Parasite Plasmodium falciparum.-
14. Proteases in
Vibrio cholerae and Their Role in Pathogenesis.-
15. ADAMTS13: The von
Willebrand Factor Cleaving Protease and Its Role in Thrombotic
Thrombocytopenic Purpura.-
16. Role of Proteases and Their Tissue Inhibitors
in Pregnancy Outcome.-
17. Matrix Metalloproteinases in Bone Health and
Disease.-
18. Escalated Expression of Matrix Metalloproteinases in
Osteoarthritis.-
19. Role of Proteases in Autism Spectrum Disorder.-
20. Role
of Proteases in the Management of Hepatitis C Virus.-
21. Role of Protease in
Inflammatory Lung Diseases.-
22. Involvement of Some Proteolytic Enzymes in
Cardiac Dysfunction Due to Ischemia-Reperfusion Injury.
Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.
Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 40 years.
