Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Total Synthesis of Glycosylated Proteins.- Modern Extensions of Native Chemical Ligation for Chemical Protein Synthesis.- Chemical methods for protein ubiquitination.- Peptide Thioester Formation via an Intramolecular N to S Acyl Shift for Peptide Ligation.- Chemical Synthesis and Biological Function of Lipidated Proteins.- Protein Chemical Synthesis in Drug Discovery Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer.
