Biographies |
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ix | |
Preface |
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xi | |
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1 | (18) |
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1.1 Background of medical image analysis in cancer |
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2 | (2) |
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1.2 Multidimensional complexity of biomedical research |
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4 | (2) |
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6 | (1) |
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7 | (1) |
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1.5 Workflow of radiomics |
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7 | (9) |
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1.5.1 Image acquisition and reconstruction |
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8 | (1) |
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8 | (1) |
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1.5.3 Feature extraction and selection |
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8 | (1) |
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1.5.4 Database and data sharing |
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9 | (1) |
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1.5.5 Informatics analysis |
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9 | (1) |
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1.5.6 Medical image acquisition |
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9 | (2) |
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1.5.7 Segmentation of the tumor |
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11 | (1) |
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1.5.8 Tumor image phenotype |
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12 | (1) |
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1.5.9 Clinical prediction for tumor |
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13 | (2) |
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1.5.10 New technology of artificial intelligence |
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15 | (1) |
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1.6 Prospect of clinical application of radiomics |
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16 | (3) |
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16 | (3) |
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Chapter 2 Key technologies and software platforms for radiomics |
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19 | (80) |
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20 | (4) |
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20 | (2) |
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2.1.2 Detection of candidate nodules |
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22 | (2) |
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24 | (15) |
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2.2.1 Segmentation of pulmonary nodules based on the central-focused convolutional neural network |
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25 | (8) |
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2.2.2 Segmentation of brain tumor based on the convolutional neural network |
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33 | (1) |
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2.2.3 Fully convolutional networks |
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34 | (1) |
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2.2.4 Voxel segmentation algorithm based on MV-CNN |
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35 | (4) |
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39 | (4) |
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2.3.1 The features of artificial design |
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40 | (1) |
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2.3.2 Deep learning features |
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41 | (2) |
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2.4 Feature selection and dimension reduction |
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43 | (9) |
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2.4.1 Classical linear dimension reduction |
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43 | (1) |
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2.4.2 Dimension reduction method based on feature selection |
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43 | (3) |
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2.4.3 Feature selection based on the linear model and regularization |
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46 | (6) |
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52 | (31) |
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2.5.1 Linear regression model |
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52 | (5) |
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2.5.2 Linear classification model |
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57 | (4) |
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61 | (1) |
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62 | (2) |
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64 | (1) |
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2.5.6 Convolutional neural network |
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65 | (6) |
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71 | (5) |
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2.5.8 Semisupervised learning |
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76 | (7) |
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2.6 Radiomics quality assessment system |
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83 | (2) |
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2.7 Radiomics software platform |
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85 | (14) |
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85 | (1) |
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2.7.2 Pyradiomics---radiomics algorithm library |
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86 | (11) |
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97 | (2) |
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Chapter 3 Precision diagnosis based on radiomics |
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99 | (76) |
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3.1 Application of radiomics in cancer screening |
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101 | (11) |
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3.1.1 Lung cancer screening |
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101 | (6) |
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3.1.2 Gastrointestinal cancer screening |
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107 | (2) |
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3.1.3 Breast cancer screening |
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109 | (2) |
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3.1.4 Prostate cancer screening |
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111 | (1) |
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3.2 Application of radiomics in cancer staging |
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112 | (24) |
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3.2.1 Prediction of parametrial invasion in cervical cancer |
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113 | (2) |
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3.2.2 Correlation between PET and CT features in lymph node metastasis |
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115 | (3) |
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3.2.3 Prediction of lymph node metastasis in colorectal cancer |
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118 | (3) |
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3.2.4 Prediction of axillary lymph node status in breast cancer |
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121 | (4) |
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3.2.5 Prediction of lymph node metastases in gastric cancer |
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125 | (3) |
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3.2.6 Prediction of distant metastasis in lung adenocarcinoma |
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128 | (1) |
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3.2.7 Prediction of distant metastasis in oropharyngeal cancer |
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129 | (2) |
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3.2.8 Prediction of distant metastasis in nasopharyngeal carcinoma |
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131 | (2) |
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3.2.9 Prediction of occult peritoneal metastasis in gastric cancer |
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133 | (3) |
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3.3 Application of radiomics in histopathological diagnosis of cancer |
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136 | (8) |
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3.3.1 Prediction of Gleason score in prostate cancer |
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137 | (1) |
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3.3.2 Prediction of histopathological grade in bladder cancer |
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138 | (1) |
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3.3.3 Prediction of histopathological grade in cervical cancer |
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138 | (3) |
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3.3.4 Identification of pathological subtype of lung ground-glass nodules |
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141 | (2) |
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3.3.5 Identification of histologic subtype in non-small cell lung cancer |
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143 | (1) |
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3.4 Application of radiomics in prediction of cancer gene mutation and molecular subtype |
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144 | (11) |
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3.4.1 Prediction of somatic mutations in lung cancer |
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144 | (2) |
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3.4.2 Prediction of gene mutations in gliomas |
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146 | (4) |
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3.4.3 Prediction of KRAS/NRAS/BRAF mutations in colorectal cancer |
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150 | (4) |
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3.4.4 Prediction of molecular subtypes in breast cancer |
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154 | (1) |
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3.5 Application of radiomics in other diseases |
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155 | (20) |
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3.5.1 Diagnosis of COVID-19 |
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155 | (6) |
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3.5.2 Staging of liver fibrosis |
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161 | (1) |
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3.5.3 Diagnosis of portal hypertension |
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162 | (2) |
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3.5.4 Diagnosis of cardiovascular plaques |
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164 | (2) |
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3.5.5 Identification of coronary plaques with napkin-ring sign |
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166 | (1) |
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167 | (8) |
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Chapter 4 Treatment evaluation and prognosis prediction using radiomics in clinical practice |
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175 | (90) |
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4.1 Radiomics and its application in treatment evaluation |
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177 | (27) |
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4.1.1 Evaluation of radiotherapy |
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177 | (5) |
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4.1.2 Evaluation of response to targeted therapy |
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182 | (12) |
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4.1.3 Application of radiogenomics in efficacy evaluation |
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194 | (10) |
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4.2 Radiomics-based prognosis analysis |
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204 | (61) |
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205 | (27) |
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232 | (1) |
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233 | (1) |
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234 | (1) |
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4.2.5 Esophageal and gastric cancers |
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235 | (2) |
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237 | (2) |
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239 | (2) |
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241 | (2) |
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4.2.9 Central nervous system cancers |
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243 | (2) |
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4.2.10 Other solid cancers |
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245 | (4) |
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249 | (16) |
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Chapter 5 Summary and prospects |
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265 | (18) |
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265 | (1) |
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266 | (11) |
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5.2.1 Prospective clinical application of radiomics |
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267 | (1) |
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5.2.2 Formulate the research norms |
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268 | (1) |
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5.2.3 Fundamentals of medical big data |
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268 | (1) |
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5.2.4 Lesion segmentation algorithms |
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269 | (1) |
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5.2.5 Reproducibility of the experiment |
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269 | (1) |
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5.2.6 Influence of machine parameters |
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270 | (2) |
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5.2.7 Integration of radiomics and multi-omics |
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272 | (1) |
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273 | (1) |
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5.2.9 Distributed learning in medical research |
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274 | (1) |
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5.2.10 Interpretability of radiomics |
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275 | (1) |
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5.2.11 Advancement in clinical guidelines |
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276 | (1) |
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277 | (6) |
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278 | (5) |
Index |
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283 | |