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E-grāmata: Sample Sizes for Clinical, Laboratory and Epidemiology Studies

(National Cancer Centre, Singapore), (Medical Research Council Cancer Trials Office, Cambridge), (University of Southampton), (National Cancer Centre)
  • Formāts: EPUB+DRM
  • Izdošanas datums: 29-May-2018
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118874936
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  • Formāts: EPUB+DRM
  • Izdošanas datums: 29-May-2018
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118874936
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"Sample Size Tables for Clinical Studies provides the statistical tools - equations, formulae and numerical tables - statisticians and researchers need to design and plan valid clinical studies and to accurately analyse publishable results. It explains the sample size considerations that are important when designing and planning any type of clinical study. It clearly outlines the methodologies employed, within the context of clinical studies and trials, and provides relevant practical examples. Each chapter provides and explains sets of sample size tables. They also include Bibliography and References sections directed towards further guidance on the principles discussed and more detailed explanations"--Provided by publisher.

Now in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studies includes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research.

The authors explain step-by-step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.

This revised fourth edition:

Offers the only text available to include sample size software for use in designing and planning clinical studies

Presents new and extended chapters with many additional and refreshed examples

Includes clear explanations of the principles and methodologies involved with relevant practical examples

Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results

Contains guidance from an internationally recognised team of medical statistics experts

Written for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and Epidemiology Studies offers an updated fourth edition of this important guide for designing and planning reliable and evidence based clinical studies.

An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies

Now in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. 

The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.

This revised fourth edition:

  • Offers the only text available to include sample size software for use in designing and planning clinical studies
  • Presents new and extended chapters with many additional and refreshed examples
  • Includes clear explanations of the principles and methodologies involved with relevant practical examples
  • Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results 
  • Contains guidance from an internationally recognised team of medical statistics experts

Written for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and EpidemiologyStudies offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.

Preface vii
1 Basic Design Considerations 1(28)
2 Further Design Considerations 29(12)
3 Binary Outcomes 41(14)
4 Ordered Categorical Outcomes 55(12)
5 Continuous Outcomes 67(16)
6 Rate Outcomes 83(16)
7 Survival Time Outcomes 99(18)
8 Paired Binary, Ordered Categorical and Continuous Outcomes 117(20)
9 Confidence Intervals 137(20)
10 Repeated Outcome Measures 157(12)
11 Non-Inferiority and Equivalence 169(26)
12 Cluster Designs 195(20)
13 Stepped Wedge Designs 215(14)
14 More than Two Groups Designs 229(10)
15 Genomic Targets and Dose-Finding 239(12)
16 Feasibility and Pilot Studies 251(18)
17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 269(14)
18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 283(22)
19 The Correlation Coefficient 305(12)
20 Observer Agreement Studies 317(22)
21 Reference Intervals and Receiver Operating Curves 339(22)
22 Sample Size Software SSS 361(2)
Cumulative References 363(18)
Index 381
David Machin, Leicester Cancer Research Centre, University of Leicester, Leicester and Medical Statistics Group, School of Health and Related Research, University of Sheffield, Sheffield, UK.

Michael J. Campbell, Medical Statistics Group, School of Health and Related Research, University of Sheffield, Sheffield, UK.

Say Beng Tan, SingHealth Duke-NUS Academic Medical Centre, Singapore.

Sze Huey Tan, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.