| Preface |
|
v | |
|
|
|
|
|
|
| Contributors |
|
xiii | |
|
PART I OVERVIEW: EPIDEMIOLOGY, PATHOLOGY, IMAGING, STAGING, AND PROGNOSIS |
|
|
|
1 Environmental and Inherited Risk Factors in Sarcomas |
|
|
1 | (10) |
|
|
|
|
|
2 Introduction to Pathology |
|
|
11 | (4) |
|
|
|
|
|
3 Pathology of Soft-Tissue Tumors |
|
|
15 | (26) |
|
|
|
|
|
|
|
|
|
|
|
|
|
4 Pathology of Bone Sarcoma |
|
|
41 | (14) |
|
|
|
|
|
5 Bone and Soft-Tissue Tumors: Contemporary Imaging |
|
|
55 | (4) |
|
|
|
|
|
6 PET Imaging of Mesenchymal Tumors |
|
|
59 | (12) |
|
|
|
|
|
7 Traditional Size-Based Response Evaluation Criteria in Solid Tumors and New Evidence-Based Response Evaluation Criteria (Choi Criteria) in Sarcoma |
|
|
71 | (4) |
|
|
|
|
|
75 | (4) |
|
|
|
|
|
9 Soft Tissue Sarcoma Staging and Nomograms |
|
|
79 | (8) |
|
|
|
|
|
PART II SARCOMA TREATMENT MODALITIES |
|
|
|
10 Sarcoma Surgery: Purpose and Role Relationships to Other Modalities |
|
|
87 | (2) |
|
|
|
|
|
11 Margins and Sarcoma Resections---What Is Marginal? |
|
|
89 | (4) |
|
|
|
12 Surgery of the Abdominal Wall and Trunk Sarcoma |
|
|
93 | (4) |
|
|
|
|
|
|
|
13 Surgical Management of Upper Extremity Bone Sarcomas |
|
|
97 | (4) |
|
|
|
|
|
14 Surgical Management of Lower Extremity Bone Sarcomas |
|
|
101 | (12) |
|
|
|
|
|
|
|
15 Surgical Management of Spinal Sarcoma |
|
|
113 | (10) |
|
|
|
|
|
|
|
16 Surgical Treatment of Pelvic Bone Sarcomas |
|
|
123 | (10) |
|
|
|
|
|
|
|
|
|
|
|
17 Isolated Limb Perfusion with Melphalan and TNF-a in the Treatment of Extremity Sarcoma |
|
|
133 | (6) |
|
|
|
|
|
18 Surgical Treatment of Sarcomatous Lung Metastases |
|
|
139 | (4) |
|
|
|
|
|
|
|
19 Composite Tissue Reconstruction after Sarcoma Resection |
|
|
143 | (10) |
|
|
|
|
|
20 External Beam/Intensity Modulated Radiotherapy |
|
|
153 | (12) |
|
|
|
|
|
|
|
|
|
|
|
21 Intraoperative Irradiation |
|
|
165 | (12) |
|
|
|
|
|
22 Soft-Tissue Sarcoma Brachytherapy |
|
|
177 | (6) |
|
|
|
23 Particle Beam Therapy for Sarcoma |
|
|
183 | (12) |
|
|
|
|
|
|
|
24 Hyperthermia in Sarcoma Treatment |
|
|
195 | (6) |
|
|
|
|
|
25 Chemotherapy for Soft-Tissue Sarcomas: Contemporary Approaches |
|
|
201 | (6) |
|
|
|
|
|
26 Personalized Molecular Therapeutics for Sarcomas |
|
|
207 | (6) |
|
|
|
|
|
|
|
|
|
27 Sarcomas of the Breast |
|
|
213 | (6) |
|
|
|
|
|
28 Sarcomas of the Head and Neck |
|
|
219 | (6) |
|
|
|
|
|
|
|
PART III MULTIDISCIPLINARY CARE |
|
|
|
29 Genitourinary Sarcomas |
|
|
225 | (8) |
|
|
|
|
|
|
|
30 Multidisciplinary Management of Retroperitoneal Sarcoma and Relapse |
|
|
233 | (6) |
|
|
|
31 Sarcoma of the Heart and Great Vessels |
|
|
239 | (8) |
|
|
|
|
|
|
|
|
|
|
|
247 | (4) |
|
|
|
PART IV SPECIFIC HISTOLOGIES |
|
|
|
33 Desmoid Tumors: A Treatment Algorithm According to Biological Behavior? |
|
|
251 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
34 Dermatofibrosarcoma Protuberans |
|
|
259 | (6) |
|
|
|
Christopher K. Bichakjian |
|
|
|
|
|
|
265 | (2) |
|
|
|
36 Gastrointestinal Stroma Tumor: Contemporary Understanding and Management |
|
|
267 | (12) |
|
|
|
|
|
|
|
|
|
|
|
279 | (8) |
|
|
|
|
|
38 Medical Management and Treatment of Recurrent Gastrointestinal Stromal Tumor |
|
|
287 | (10) |
|
|
|
|
|
|
|
39 Surgical Management of Gastrointestinal Stromal Tumor (GIST) Vinod P. Balachandran |
|
|
297 | (6) |
|
|
|
40 Malignant Peripheral Nerve Sheath Tumor |
|
|
303 | (6) |
|
|
|
|
|
|
|
|
|
|
|
41 Osteosarcoma: A Multidisciplinary Approach |
|
|
309 | (20) |
|
|
|
|
|
|
|
|
|
|
|
42 Ewing Sarcoma Family of Tumors |
|
|
329 | (6) |
|
|
|
|
|
335 | (6) |
|
|
|
|
|
341 | (6) |
|
|
|
|
|
|
|
347 | (4) |
|
|
|
|
|
351 | (8) |
|
|
|
|
|
|
|
359 | (4) |
|
|
|
48 Undifferentiated Pleomorphic Sarcoma or Malignant Fibrous Histiocytoma |
|
|
363 | (4) |
|
|
|
|
|
|
|
367 | (4) |
|
|
|
|
|
|
|
371 | (6) |
|
|
|
|
|
|
|
51 Solitary Fibrous Tumor in the Twenty-First Century: A Clinical and Pathologic Update |
|
|
377 | (6) |
|
|
|
|
|
|
|
|
|
383 | (6) |
|
|
|
|
|
|
|
|
|
53 Alveolar Soft Part Sarcoma |
|
|
389 | (6) |
|
|
|
|
|
|
|
395 | (6) |
|
|
|
|
|
401 | (6) |
|
|
|
|
|
|
|
|
56 Treatment-Induced Soft Tissue and Bone Sarcomas |
|
|
407 | (6) |
|
|
|
|
|
57 Locally Recurrent Extremity Soft Tissue Sarcoma |
|
|
413 | (6) |
|
|
|
PART VI ADDITIONAL CONSIDERATIONS |
|
|
|
58 Chemotherapy for Palliation |
|
|
419 | (8) |
|
|
|
|
|
59 Palliative Care for Advanced Sarcoma Patients |
|
|
427 | (8) |
|
|
|
60 Palliation for Soft Tissue Sarcomas |
|
|
435 | (8) |
|
|
|
|
|
|
|
61 Cost-Effective Patient Surveillance after Sarcoma Treatment |
|
|
443 | (6) |
|
|
|
|
|
|
|
449 | (6) |
|
|
|
|
|
63 Long-Term Consequences of Systemic Therapies in Sarcoma |
|
|
455 | (4) |
|
|
|
|
|
64 Long-term Complications Associated with Radiation Therapy in Soft Tissue Sarcoma Management |
|
|
459 | (6) |
|
|
|
|
|
65 Outcome Measures in Musculoskeletal Oncology |
|
|
465 | (4) |
|
|
|
66 Patient Advocacy in Sarcoma |
|
|
469 | (2) |
|
|
|
|
|
67 The Role of the Internet in Sarcoma Care |
|
|
471 | (4) |
|
|
|
|
|
PART VII LABORATORY RESEARCH |
|
|
|
68 Sarcoma Cancer Stem Cells |
|
|
475 | (4) |
|
|
|
|
|
|
|
69 Genetically Engineered Mouse Models of Sarcoma |
|
|
479 | (8) |
|
|
|
70 Molecular Profiling of Sarcomas |
|
|
487 | (10) |
|
|
|
|
|
|
|
|
|
71 Recent Advances in the Characterization of Mesenchymal Tumors: From Sarcoma Genomics to Targeted Therapies |
|
|
497 | (10) |
|
|
|
|
|
|
|
|
|
72 Telomere Maintenance Mechanisms |
|
|
507 | (8) |
|
|
|
|
|
|
|
|
|
73 Tumor Microenvironment Cross-talk: A Process Critical for Sarcoma Progression and Metastasis |
|
|
515 | |
|
|
|
|
|
|
| Index |
|
1 | |
