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Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties [Hardback]

Edited by (Royal Society Industry Fellow, University of Cambridge, UK; Principal Consultant, Lucideon, UK)
  • Formāts: Hardback, 476 pages, height x width: 229x152 mm, weight: 900 g
  • Sērija : Woodhead Publishing Series in Biomaterials
  • Izdošanas datums: 04-Oct-2016
  • Izdevniecība: Woodhead Publishing Ltd
  • ISBN-10: 0081003722
  • ISBN-13: 9780081003725
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Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and PropertiesPalielināt
  • Formāts: Hardback, 476 pages, height x width: 229x152 mm, weight: 900 g
  • Sērija : Woodhead Publishing Series in Biomaterials
  • Izdošanas datums: 04-Oct-2016
  • Izdevniecība: Woodhead Publishing Ltd
  • ISBN-10: 0081003722
  • ISBN-13: 9780081003725
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780081003725.html
Keywords:

Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development.

Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers.

  • Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine
  • Contains comprehensive coverage of material properties, including unique insights into modeling degradation
  • Written by an eclectic mix of international authors with experience in academia and industry

Papildus informācija

This book provides authoritative and valuable content on the fundamentals and principles of biodegradeable polymer science in medicine
List of contributors
xi
Woodhead Publishing Series in Biomaterials xiii
1 Biodegradable medical polymers: fundamental sciences
1(34)
X. Zhang
X. Peng
S.W. Zhang
1.1 Introduction
1(10)
1.2 Biodegradable polymer chain structures
11(5)
1.3 Physical properties of biodegradable polymers
16(3)
1.4 Biodegradable polymers in solid state
19(3)
1.5 Biodegradable polymers in solutions
22(1)
1.6 Biodegradable polymer hybrids
23(1)
1.7 Materials selection and design control for medical applications
23(7)
1.8 Summary -- key points learnt in the chapter
30(5)
References
30(5)
Part One Biodegradable and bioresorbable synthetic medical polymers
35(220)
2 Synthetic biodegradable medical polyesters
37(42)
S. Li
2.1 Introduction
37(1)
2.2 Synthesis methods and structure-properties
38(2)
2.3 Physico-chemical properties
40(1)
2.4 Degradation of poly(lactic acid) and poly(glycolic acid) polymers
41(25)
2.5 Case studies for biomedical and pharmaceutical applications
66(4)
2.6 Future trends
70(9)
References
70(9)
3 Synthetic biodegradable medical polyesters: poly-ε-caprolactone
79(28)
G. Cama
D.E. Mogosanu
A. Houben
P. Dubruel
3.1 Introduction
79(2)
3.2 Chemical structure and methods for producing poly-ε-caprolactone
81(3)
3.3 Processing techniques of poly-ε-caprolactone
84(4)
3.4 Mechanical properties and degradation of poly-ε-caprolactone-based biomaterials
88(6)
3.5 Surface functionalisation of poly-ε-caprolactone and poly-ε-caprolactone biological properties
94(2)
3.6 Case studies of medical applications
96(1)
3.7 Commercialisation and future trends of poly-ε-caprolactone-based biomaterials
97(1)
3.8 Summary -- key points learnt in the chapter
98(9)
Acknowledgement
99(1)
References
99(8)
4 Synthetic biodegradable medical polyesters: poly(trimethylene carbonate)
107(46)
P. Dobrzynski
J. Kasperczyk
S. Li
4.1 Introduction
107(2)
4.2 Synthesis and structure--properties
109(10)
4.3 Degradation of poly(trimethylene carbonate) and copolymers
119(16)
4.4 Biomedical and pharmaceutical applications
135(5)
4.5 Conclusion and perspectives
140(13)
References
140(13)
5 Synthetic biodegradable medical polymer: poly anhydrides
153(36)
R. Ghadi
E. Muntimadugu
A.J. Domb
W. Khan
X. Zhang
5.1 Introduction
153(2)
5.2 Historical perspective
155(1)
5.3 Classification of polyanhydrides and chemical structures
155(7)
5.4 Methods of synthesis
162(6)
5.5 Processing techniques
168(3)
5.6 Degradation mechanism
171(3)
5.7 Biocompatibility
174(1)
5.8 Medical applications of polyanhydrides
175(5)
5.9 Future trends
180(1)
5.10 Summary
180(9)
List of abbreviations
181(1)
References
181(8)
6 Synthetic biodegradable medical polyurethanes
189(28)
V. Chiono
S. Sartori
S. Calzone
M. Boffito
C. Tonda-Turo
C. Mattu
P. Gentile
G. Ciardelli
6.1 Introduction
189(1)
6.2 Synthesis methods of polyurethanes
190(5)
6.3 Degradable and biocompatibile polyurethanes: selection of block constituents
195(3)
6.4 Main general applications of degradable polyurethanes in regenerative medicine and drug release
198(12)
6.5 Future trends
210(1)
6.6 Summary -- key points learnt in the chapter
211(6)
Acknowledgements
212(1)
References
212(5)
7 Synthetic biodegradable medical polymers: polymer blends
217(38)
X. Zhang
X. Peng
S.W. Zhang
7.1 Introduction
217(1)
7.2 Thermodynamics and nanophase diagram of biodegradable polymer blends
217(11)
7.3 Biodegradable polymer blends
228(18)
7.4 Case studies of medical applications
246(4)
7.5 Future trends
250(1)
7.6 Summary -- key points learnt in the chapter
251(4)
References
251(4)
Part Two Biodegradable and bioresorbable natural medical polymers
255(122)
8 Natural bacterial biodegradable medical polymers: polyhydroxyalkanoates
257(22)
P. Basnett
S. Ravi
I. Roy
8.1 Introduction
257(2)
8.2 Types of polyhydroxyalkanoates and their properties
259(5)
8.3 Degradation of polyhydroxyalkanoates
264(2)
8.4 Applications of polyhydroxyalkanoates
266(5)
8.5 Future trends
271(1)
8.6 Summary -- key points learnt in the chapter
272(7)
References
272(7)
9 Natural biodegradable medical polymers: cellulose
279(16)
Sherif M.A.S. Keshk
M. Gouda
9.1 Introduction
279(1)
9.2 Types and chemical structure of cellulose
279(2)
9.3 Degradation mechanisms
281(4)
9.4 Processing techniques
285(1)
9.5 Case studies: cellulose application in medical applications
286(3)
9.6 Future trends
289(1)
9.7 Summary -- key points learnt in the chapter
289(6)
References
290(5)
10 Natural bacterial biodegradable medical polymers: bacterial cellulose
295(26)
Sherif M.A.S. Keshk
Attala F. El-Kott
10.1 Introduction
295(1)
10.2 Types and chemical structure of bacterial cellulose
296(3)
10.3 Processing techniques
299(5)
10.4 Case studies of medical applications
304(6)
10.5 Future trends
310(1)
10.6 Summary -- key points learnt in the chapter
311(10)
References
311(5)
Further reading
316(5)
11 Natural biodegradable medical polymers: therapeutic peptides and proteins
321(30)
Z. Fang
Wusgal
H. Cheng
L. Liang
11.1 Introduction
321(1)
11.2 Structure and bioactive properties of food proteins/peptides
321(8)
11.3 Instability of proteins/peptides
329(1)
11.4 Oral delivery of proteins/peptides
329(9)
11.5 Medical applications of nisin, a food preservation additive
338(1)
11.6 Future trends
339(1)
11.7 Summary -- key points learnt in the chapter
340(11)
References
340(11)
12 Natural biodegradable medical polymers: silk
351(26)
M. Woltje
M. Bobel
12.1 Introduction
351(1)
12.2 Types and chemical structure of silk
352(3)
12.3 Processing techniques of silk
355(3)
12.4 Mechanical properties
358(2)
12.5 Degradation mechanisms
360(2)
12.6 Medical applications
362(3)
12.7 Future trends
365(1)
12.8 Summary -- key points learnt in the chapter
366(11)
References
367(10)
Part Three Properties of biodegradable medical polymers
377(72)
13 Biocompatibility of biodegradable medical polymers
379(36)
D. Ozdil
I. Wimpenny
H.M. Aydin
Y. Yang
13.1 Introduction: definitions of biocompatibility
379(1)
13.2 Chemical compatibility
380(4)
13.3 Mechanical compatibility
384(3)
13.4 Interactions between degradable polymers and biological systems
387(5)
13.5 Design principles to ensure biocompatibility for medical applications
392(9)
13.6 Summary -- key points learnt in the chapter
401(14)
References
402(13)
14 Degradation characterisation of biodegradable polymers
415(12)
S. Bennett
X. Zhang
14.1 Introduction
415(1)
14.2 In vitro characterisation of degradation studies
415(2)
14.3 Effect of isotope on degradation rate
417(1)
14.4 New imaging technology for degradation studies
417(4)
14.5 Mechanical characterisation
421(3)
14.6 Summary -- key points learnt in the chapter
424(3)
References
424(3)
15 Modelling degradation of biodegradable polymers
427(22)
X. Han
X. Zhang
15.1 Introduction
427(1)
15.2 Diffusion kinetics -- Fick's law and water diffusion modelling
427(5)
15.3 Computer modelling of polymer degradation
432(13)
15.4 Computer modelling of the mechanical property change during biodegradation
445(2)
15.5 Summary -- key points learnt in the chapter
447(2)
References
447(2)
Index 449
Dr. Zhang has the benefit of academic and industrial experience in the medical industry, having worked in academia for 17 years before moving to applied research for industry in 1999. For the last 15 years, he has been involved in fundamental, applied research (mainly for industry) in polymers and his fundamental understanding of polymer science has helped him to develop successful medical products. Dr. Zhangs work has covered most aspects of medical materials and medical devices from R&D stages to manufacturing. In addition to working as Principal Consultant for Lucideon, Dr. Zhang is currently organizing and supervising research in degradable polymers and their hybrid composites for medical applications at the University of Cambridge.