Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe , The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more.
Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.
- Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies
- Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches
- Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
1. Cellular Senescence in Aging: Molecular Basis, Implications and
Therapeutic Interventions Jemima Princilly, Bhavana Veerabhadrappa,
Nagashree N. Rao and Madhu Dyavaiah
2. Mitochondria in cell senescence: A Friend or Foe?
Qian Chen, Lindon Young, Robert Barsotti
3. The role of mitochondria and mitophagy in cell senescence
Tayyab Ali, Fatma Hussain, Haroon Ur Rashid Kayani, Muhammad Naeem, and
Fozia Anjum
4. Mitochondria-associated cellular senescence mechanisms: Biochemical and
pharmacological perspectives
Mehmet Can Atayik and Ufuk Ēakatay
5. Changing ROS, NAD and AMP: A path to longevity via mitochondrial
therapeutics
Oleh Lushchak, Dmytro Gospodaryov, Olha Strilbytska, and Maria Bayliak
6. Mitochondria-derived peptides in healthy ageing and therapy of
age-related diseases
Siarhei A. Dabravolski
7. Senolytic and senomorphic interventions to defy senescence-associated
mitochondrial dysfunction
Jan O. Nehlin
8. Melatonin as mitochondria-targeted drug
Sibel Suzen, Luciano Saso
9. Coenzyme Q-related compounds to maintain healthy mitochondria during
aging
Guillermo López-Lluch
10. Targeting mitochondrial dysfunction to salvage cellular senescence for
managing neurodegeneration
Komal Sharma, Joyobrata Sarkar, Anchal Trisal, Rishika Ghosh, Anubhuti
Dixit, Abhishek Kumar Singh
11. Targeting the microbiota-mitochondria crosstalk in neurodegeneration
with senotherapeutics
Jan Homolak
12. Therapeutic targeting of mitochondriaproteostasis axis by antioxidant
polysaccharides in neurodegeneration
Qiangqiang Wang, Muhammad Zeeshan Adil, Xiaoliang Xie, Shihao Zhao, Ju
Zhang, and Zebo Huang
13. Phytotherapeutic targeting of the mitochondria in neurodegenerative
disorders
Priyanka Sarkar, Ashish Kumar, Partha Sarathi Behera, and Kavitha
Thirumurugan
Ufuk Ēakatay (May 09, 1965 ) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpaa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Ēakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Ēakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University. Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Ēakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.
