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E-grāmata: Single Nucleotide Polymorphisms: Methods and Protocols

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  • Formāts: EPUB+DRM
  • Sērija : Methods in Molecular Biology 578
  • Izdošanas datums: 19-Sep-2009
  • Izdevniecība: Humana Press Inc.
  • Valoda: eng
  • ISBN-13: 9781603274111
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Single Nucleotide Polymorphisms: Methods and ProtocolsPalielināt
  • Formāts: EPUB+DRM
  • Sērija : Methods in Molecular Biology 578
  • Izdošanas datums: 19-Sep-2009
  • Izdevniecība: Humana Press Inc.
  • Valoda: eng
  • ISBN-13: 9781603274111
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In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. InSingle Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successfulMethods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols,Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.



In this updated second edition, researchers explore the latest advances in this area, highlighting the progress made in SNP genotyping, recent developments in high-throughput genotyping, and our new understanding of the impact of SNPs on gene function.

Recenzijas

From the reviews of the second edition:

This second edition brings 11 new chapters . Its target audience continues to be researchers and laboratory personnel. One helpful feature the book includes is a set of notes at the end of each chapter to be very useful for readers choosing to utilize a technique for the first time. Overall, this book is a good addition to any laboratory setting actively working on complex human traits or interested in personalized medicine and drug treatments. (Alexandre R. Vieira, Birth Defects Research (Part A): Clinical and Molecular Teratology, Vol. 88 (12), 2010)

to Single Nucleotide Polymorphisms.- SNPs: Impact on Gene Function and
Phenotype.- Silent (Synonymous) SNPs: Should We Care About Them?.-
Bioinformatic Analysis of SNPs.- SNP Databases.- Mining SNPs from DNA
Sequence Data; Computational Approaches to SNP Discovery and Analysis.- SNP
Identification and Detection Strategies: Whole Genome Sequencing and
Re-Sequencing.- Next-Generation Sequencing Methods: Impact of Sequencing
Accuracy on SNP Discovery.- Scanning Probe and Nanopore DNA Sequencing: Core
Techniques and Possibilities.- Pyrosequencing for SNP Genotyping.-
Prescreening (Melting Based) Methods for SNP Discovery and Analysis.- Single
Nucleotide Polymorphism Screening with Denaturing Gradient Gel
Electrophoresis.- Temporal Temperature Gradient Electrophoresis for Detection
of Single Nucleotide Polymorphisms.- Prescreening (Conformation Based)
Methods for SNP Discovery and Analysis.- Zn(II)Cyclen Polyacrylamide Gel
Electrophoresis for SNP Detection.- Phosphate-Affinity Polyacrylamide Gel
Electrophoresis for SNP Genotyping.- Estimation of SNP Allele Frequencies by
SSCP Analysis of Pooled DNA.- Phenylethynylpyrene Excimer Forming
Hybridization Probes for Fluorescence SNP Detection.- The Chemical Cleavage
of Mismatch for the Detection of Mutations in Long DNA Fragments.- Mismatch
Oxidation Assay: Detection of DNA Mutations Using a Standard UV/Vis
Microplate Reader.- Towards High-Throughput Methods of SNP Genotyping.-
High-Throughput Methods for SNP Genotyping.- High-Throughput SNP Genotyping:
Combining Tag SNPs and Molecular Beacons.- SNP Genotyping by the 5?-Nuclease
Reaction: Advances in High-Throughput Genotyping with Nonmodel Organisms.-
The TaqMan Method for SNP Genotyping.- Qualitative and Quantitative
Genotyping Using Single Base Primer Extension Coupledwith Matrix-Assisted
Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MassARRAY®).-
SNP Detection Using Trityl Mass Tags.- Putting the Invader® Assay to Work:
Laboratory Application and Data Management.- SNP Genotyping Using Multiplex
Single Base Primer Extension Assays.- High-Throughput SNP Detection Based on
PCR Amplification on Magnetic Nanoparticles Using Dual-Color Hybridization.-
Other Methods.- Restriction Enzyme Analysis of PCR Products.- Allele-Specific
PCR in SNP Genotyping.- Modified Multiple Primer Extension Method.- Detection
of SNP by the Isothermal Smart Amplification Method.
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