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Skin Delivery Systems: Transdermals, Dermatologicals, and Cosmetic Actives [Hardback]

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  • Formāts: Hardback, 408 pages, height x width x depth: 261x186x26 mm, weight: 890 g
  • Izdošanas datums: 26-Jun-2006
  • Izdevniecība: Iowa State University Press
  • ISBN-10: 0813808480
  • ISBN-13: 9780813808482
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  • Formāts: Hardback, 408 pages, height x width x depth: 261x186x26 mm, weight: 890 g
  • Izdošanas datums: 26-Jun-2006
  • Izdevniecība: Iowa State University Press
  • ISBN-10: 0813808480
  • ISBN-13: 9780813808482
Citas grāmatas par šo tēmu:
Rising industry profits and consumer interest in natural anti-aging products are driving the interest in new drug delivery technologies. A consultant to the pharmaceutical and cosmetics industries thus introduces 22 chapters by US academic and industry experts. After addressing dermatological principles and limitations to the development of transdermal products, authors discuss the topical agents (topical actives such as retinoic acid) being developed to overcome the skin barrier and prevent transdermal drug-induced adverse skin reactions. They review product design challenges and advances, delivery systems for administering a wide range of drugs, and experimental and patient studies on new botanical approaches to improving aging skin. The volume does not include before-and-after shots of patients treated with cosmeceuticals. Annotation ©2006 Book News, Inc., Portland, OR (booknews.com)

Current interest in drug delivery technologies is exceedingly high. Similarly, a recent upsurge in consumer awareness of the potential antiaging and antiwrinkling benefits of natural products and botanicals has spurred a revolution in the cosmetic industry for better skin care delivery technologies, both to preserve inherent activity as well as to enhance their benefits through novel formulation and delivery methods.



With these considerations in mind, Skin Delivery Systems: Transdermals, Dermatologicals and Cosmetic Actives brings together the emerging fields of cosmetic actives with new advances in skin delivery technologies and provides a methodical and systematic explanation of technologies used to transport pharmaceuticals and cosmetic actives through the skin's barriers. After reviewing the basic principles of dermatology and skin penetration, the reference describes and explains the most current methods of transdermal transport. Coverage includes new materials, such as amphiphilic polymers; new formulation methods, such as miniemulsions; and variations on technologies such as sonophoresis and iontophoresis. The authors also show the connections between skin penetration and a variety of active substances, including specialized pharmaceuticals and natural and botanical ingredients used in cosmetics. The book presents critical empirical data and design information intended to assist researchers, product developers, and testers in the pharmaceutical and cosmetics industries.
Contributors vii
Preface ix
Part I: General Skin Considerations
Fundamental Concepts in Skin Reactivity
3(22)
John J. Wille
Agis F. Kydonieus
Strategies for Improving the Skin Barrier by Cosmetic Skin Care Treatments
25(18)
Gopinathan K. Menon
Michelle Duggan
Abrogation of Skin Reactions: Methods and Agents
43(26)
John J. Wille
Agis F. Kydonieus
Clinical Perspectives on the Efficacy of Cosmetic Actives (Cosmeceuticals)
69(8)
Emi Dika
Howard I. Maibach
Part II: Novel Topical Actives
Phytocosmeceuticals: Cutaneous Actives
77(20)
John J. Wille
Hydroxy Acids Delivery System
97(20)
Shyam Gupta
Cosmetic Benefits from Modulation of Cellular Energy Metabolism in Aging Skin
117(12)
Lieve Declercq
Donald Collins
Reyhaneh Foyouzi-Yousseffi
David Gan
Thomas Mammone
Edward Pelle
Kenneth Marenus
Harvey Gedeon
Daniel Maes
Part III: Trends in Skin Therapy
Current Trends in Dermatologicals and Delivery Systems
129(8)
Braham Shroot
Duncan Aust
Current Topical Treatment of Skin Diseases
137(14)
Richard S. Kalish
Corneotherapy: New Topical Treatment of the Stratum Corneum
151(22)
John J. Wille
Part IV: Skin Delivery Systems
Skin Care Delivery Systems: An Overview
173(14)
Vispi D. Kanga
Emulsions: Factors and Issues for Skin Care
187(24)
Stig E. Friberg
Zhuning Ma
PnarmaDur Bioadhesive Delivery System
211(12)
Kishore R. Shah
Thixogel: A Starch Matrix Encapsulation Technology for Topical Drug and Cosmetic Delivery
223(24)
John J. Wille
Nanoparticles for Cosmetics and Personal Care Formulations
247(12)
Ponisseril Somasundaran
Soma Chakraborty
Puspendu Deo
Namita Deo
Tamara Somasundaran
Part V: Transdermal Drug Delivery Technologies
Transdermal Delivery Device Development: A Patent Review
259(18)
Agis Kydonieus
John J. Wille
Chemical Enhancers
277(20)
Rashmi A. Thakur
Yifan Song
Bozena B. Michniak
Accelerated Development of Topicai and Transdermal Delivery Systems
297(12)
R. Dominic King-Smith
John M. Newsam
Microncedles for Drug and Vaccine Delivery: When Will the Dream Become a Reality?
309(18)
John A. Mikszta
M. Ishaq Haider
Ronald J. Pettis
Pulsatile Delivery of Drugs and Topical Actives
327(32)
Steven A. Giannos
Microfluidics for Drug Transdermal Delivery
359(16)
Joseph Zhili Huang
Future Considerations for Advanced Delivery Systems
375(10)
Linda D. Rhein
Index 385


John J. Wille, Ph.D is president of Bioderm Technologies, Inc., a consulting firm in the pharmaceutical and cosmetic industries. Dr. Wille obtained his doctorate in genetics from Indiana University and served as a professor of cell biology at the University of Cincinnati, Louisiana State University and Mayo Medical School, before joining Bristol Myers Squibb as Director of Skin Research. Dr. Wille has published more than 200 research papers and has 15 U.S. patents in the field of skin biology.