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E-grāmata: Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications

Edited by (Pioneer Scientist, Department of Pharmaceutical Sciences, India), Edited by (Assistant Professor, Amity institute of Pharmacy, Amity University, ), Edited by (Associate Professor, Department of Pharmaceutical Sciences, Sagar (Madhya Pradesh) 470003, India)
  • Formāts: EPUB+DRM
  • Izdošanas datums: 12-Nov-2022
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780323913997
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Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic ApplicationsPalielināt
  • Formāts: EPUB+DRM
  • Izdošanas datums: 12-Nov-2022
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780323913997
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Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.
  • Provides comprehensive overview of the potential role of polymeric systems in drug delivery
  • Explores the design, synthesis, and application of different smart material-based delivery systems
  • Includes fundamental and clinical applications
Contributors xix
Chapter 1 Introduction to smart polymers and their application
1(46)
Aiswarya Chaudhuri
Kamalpreet Kaur Sandha
Ashish Kumar Agrawal
Prem N. Gupta
1 Introduction
1(2)
1.1 History
2(1)
1.2 Concept and design
2(1)
1.3 Why smart polymers?
3(1)
2 Types of smart polymers
3(20)
2.1 Stimulus-responsive polymers
5(11)
2.2 Bioresponsive polymers
16(2)
2.3 Shape memory polymers
18(2)
2.4 Self-healing polymers
20(2)
2.5 Hydrogels
22(1)
3 Application of smart polymers
23(11)
3.1 Tissue engineering
30(1)
3.2 Drug delivery system
31(1)
3.3 Biomedical devices
32(1)
3.4 Biosensors or actuators
33(1)
4 Conclusions
34(13)
Acknowledgments
35(1)
References
35(12)
Chapter 2 Thermoresponsive polymers: Phase behavior, drug delivery, and biomedical applications
47(18)
Amit Verma
Pritish Kumar Panda
Sharad Mangal
Souravh Bais
1 Introduction
47(1)
2 Thermoresponsive polymers
48(3)
2.1 Phase transition behaviors of thermoresponsive polymers
49(2)
3 Applications of thermoresponsive polymers in biomedical and drug delivery
51(8)
3.1 Thermoresponsive polymeric micelles
51(2)
3.2 Thermoresponsive nanoparticles
53(2)
3.3 Thermoresponsive liposomes
55(2)
3.4 Thermoresponsive hydrogels
57(2)
4 Conclusion and future prospects
59(6)
References
60(4)
Further reading
64(1)
Chapter 3 pH-sensitive polymeric nanocarriers for enhanced intracellular drug delivery
65(44)
Deepti Pandita
Vakar
Neelam Poonia
Gaurav Chaudhary
Gaurav Kumar Jain
Viney Lather
Roop K. Khar
1 Introduction
65(2)
2 pH-dependent cellular microenvironments
67(1)
3 Different strategies for the development of pH-sensitive polymeric nanocarriers
67(6)
3.1 pH-responsive linkages
67(1)
3.2 pH-sensitive nanomaterials
68(5)
4 Mechanism of drug release from pH-sensitive nanocarriers
73(1)
5 pH-responsive nanocarriers for drug delivery and targeting
73(19)
5.1 Small molecule drug delivery
73(14)
5.2 Gene delivery
87(1)
5.3 Dual drug delivery
88(3)
5.4 Combination with photothermal/photodynamic therapy
91(1)
6 pH-responsive nanocarriers for disease diagnosis
92(6)
7 Challenges in the design of pH-sensitive nanocarriers
98(1)
8 Future perspectives
99(1)
9 Concluding remarks
100(9)
References
100(9)
Chapter 4 Photoresponsive nanocarriers for the delivery of bioactives
109(20)
Rameshroo Kenwat
Vijay Singh
Shivani Rai Paliwal
Rishi Paliwal
1 Introduction
109(2)
2 Photoresponsiveness: Light as source for triggering drug release
111(3)
2.1 Photoresponsive biomaterials
112(1)
2.2 Response of chemical structure to the light sources
112(2)
3 Development of photosensitive nanocarriers
114(1)
4 Mechanisms of photoresponsive nanoparticles for drug release
114(3)
4.1 Drug release by NIR light
116(1)
4.2 Photothermal responsive
116(1)
5 Photoresponsive drug delivery nanocarriers
117(6)
5.1 Gold nanoparticles
117(1)
5.2 Polymeric nanobioconjugates
117(3)
5.3 Polymeric nanoparticles
120(1)
5.4 Polymeric micelle
120(1)
5.5 Liposomes
121(1)
5.6 Polymersomes
121(1)
5.7 Mesoporous silica nanoparticles
122(1)
5.8 Hydrogels
122(1)
5.9 Nanogels
122(1)
6 Conclusions and future prospects
123(6)
Acknowledgment
123(1)
References
123(6)
Chapter 5 Magnetically responsive polymeric gels and elastomeric system(s) for drug delivery
129(22)
Priya Shrivastava
Nikhar Vishwakarma
Laxmikant Gautam
Suresh P. Vyas
1 Introduction
129(2)
2 Polymer gels and elastomers
131(1)
3 Magnetic modulation of polymer gels and elastomers
132(5)
4 Transport phenomenon in magnetic drug delivery
137(1)
4.1 Convective transport in magnetic drug delivery
137(1)
5 For disease therapy
138(6)
5.1 Delivery of chemotherapeutic drugs to liver tumors
138(1)
5.2 Magnetic targeting of radioactivity
139(1)
5.3 Treatment of tumors with magnetically induced hyperthermia
140(2)
5.4 Magnetically enhanced gene therapy
142(1)
5.5 Magnetically responsive systems for the diagnosis of diseases
143(1)
6 Concluding remarks and future prognosis
144(7)
References
145(6)
Chapter 6 Bioadhesive and phase change polymers for drug delivery
151(36)
Nidhi Mishra
Raquibun Nisha
Neelu Singh
Priyanka Maurya
Priya Singh
Alka
Ravi Raj Pal
Samipta Singh
Shubhini A. Saraf
1 Introduction
151(2)
2 Bioadhesive polymers in drug delivery
153(1)
3 Advantages of bioadhesive polymers in drug delivery
154(1)
4 Theories of bioadhesion
155(2)
4.1 The electrostatic theory
155(1)
4.2 The wettability theory
155(1)
4.3 The diffusion interpenetration theory
156(1)
4.4 The adsorption theory
156(1)
4.5 The fracture theory
157(1)
4.6 Mechanical theory
157(1)
5 Requirements for an ideal bioadhesive polymer
157(1)
6 Factors affecting the bioadhesive polymers
157(4)
6.1 Polymer-related factors
159(1)
6.2 Environmental factors
160(1)
6.3 Physiological factors
161(1)
7 Classification of bioadhesive polymers
161(2)
7.1 Classification based on polymer origin
161(1)
7.2 Classification based on solubility
162(1)
7.3 Classification based on polymer charge
162(1)
8 Commonly employed bioadhesive polymers in drug delivery
163(1)
8.1 Chitosan
163(1)
8.2 Starch
163(1)
8.3 Alginates
163(1)
8.4 Hyaluronic acid
163(1)
8.5 Carbopol
163(1)
8.6 Sodium carboxymethyl cellulose
164(1)
8.7 Polyethylene glycol
164(1)
8.8 Polyacrylates
164(1)
9 Phase change polymers
164(8)
9.1 pH-responsive polymers
166(1)
9.2 Temperature/thermoresponsive polymers
166(1)
9.3 Light-responsive polymers
167(1)
9.4 Metabolite-responsive polymers
168(1)
9.5 Electric current-responsive polymers
169(1)
9.6 Ultrasound-responsive polymers
169(1)
9.7 Magnetic-responsive polymers
170(1)
9.8 Osmotic-responsive polymers
170(1)
9.9 Dual-/multiresponsive polymers
171(1)
10 Application of bioadhesive and phase change polymers in drug delivery
172(6)
10.1 Buccal drug delivery
172(1)
10.2 Ocular drug delivery
172(1)
10.3 Nasal drug delivery
173(1)
10.4 Gastrointestinal drug delivery
174(1)
10.5 Vaginal drug delivery
174(1)
10.6 Rectal drug delivery
175(3)
11 Conclusions
178(9)
References
178(9)
Chapter 7 Block copolymer micelles as long-circulating drug vehicles
187(34)
Aravind Sai Patha
Tanvi Patil
Pawan Kumar Pandey
Kaushik Kuche
Rohan Ghadi
Sanyog Jain
1 Introduction
187(1)
2 Design criteria of block copolymers for self-assembly of polymeric micelles
188(8)
2.1 Molecular weight
189(1)
2.2 Critical micelle concentration
190(1)
2.3 Hydrophilic (corona-forming) blocks
191(2)
2.4 Hydrophobic (core forming) blocks
193(2)
2.5 Crystallinity of the core-forming blocks
195(1)
3 Micelle preparation method
196(1)
3.1 Dialysis method
196(1)
3.2 Thin film hydration method
196(1)
3.3 Oil-in-water emulsion method
197(1)
3.4 Solid dispersion method
197(1)
4 General considerations and characteristics of micelles
197(6)
4.1 Drug partition coefficient
197(2)
4.2 Core-drug compatibility
199(2)
4.3 Drug/polymer ratio
201(1)
4.4 Micellar dimensions
201(2)
5 Synthesis of amphiphilic block copolymers possessing PEG chain for stealth effect
203(2)
6 Fate of polymeric systems upon systemic delivery
205(2)
6.1 Role of physical barriers
206(1)
6.2 Role of biological barriers
206(1)
7 Avoiding rapid clearance from systemic circulation
207(2)
7.1 Manipulating physical properties
208(1)
7.2 Manipulating chemical properties
208(1)
8 Future trends
209(2)
9 Conclusions
211(10)
References
212(9)
Chapter 8 Polymer-drug conjugates: Origins, progress to date, and future directions
221(28)
Ankita Dadwal
Ashish Garg
Bhupinder Kumar
R.K. Narang
Neeraj Mishra
1 Introduction
221(1)
2 Advantages of polymer-drug conjugates
222(3)
3 Origins of polymer-drug conjugates
225(2)
4 Types of polymer-drug conjugates for drug targeting
227(3)
4.1 End group system
227(1)
4.2 Pendant group system
227(3)
5 Targeted vs nontargeted conjugates
230(1)
6 Approaches for designing the polymer-drug conjugates
231(2)
7 Gap between the current studies and clinical application for polymeric-drug conjugates
233(1)
8 Approaches for the enhancing the transportation of polymer-drug conjugates
233(1)
9 Clinical status of polymer-drug conjugates
234(1)
10 Future prospects of polymer-drug conjugates
234(15)
References
240(9)
Chapter 9 Molecularly imprinted polymers for drug delivery and biomedical applications
249(40)
Vineet Kumar Rai
Kumar Nishchay
Ghanshyam Das Gupta
1 Introduction
249(1)
2 Concept behind the molecularly imprinted polymers
250(2)
3 Designing MIPs for drug delivery
252(4)
3.1 MIP designing
254(1)
3.2 Production limitations
254(1)
3.3 Template expulsion
255(1)
4 MlP-based drug delivery systems
256(3)
5 Stimuli-responsive molecularly imprinted polymers
259(7)
6 MIPs for drug delivery and biomedical applications
266(9)
6.1 Targeted drug release
267(1)
6.2 Cell recognition
267(1)
6.3 Gastrointestinal disorders
268(1)
6.4 Ophthalmic disorders
269(1)
6.5 Chemotherapy
270(1)
6.6 Gene therapy
271(1)
6.7 Biomedical application
272(1)
6.8 Molecular imaging and disease diagnosis
273(2)
7 Conclusions
275(14)
References
277(12)
Chapter 10 Dendritic polymer macromolecular carriers for drug delivery
289(40)
Himani Singh
Sofiya Tarannum
Rakesh Kumar Sahoo
Vinay Kumar
Umesh Gupta
1 Introduction
290(2)
2 Properties of dendritic polymer macromolecular carriers
292(1)
3 Synthesis of dendrimers
293(2)
3.1 Divergent approach
293(1)
3.2 Convergent approach
293(1)
3.3 Other approaches
294(1)
4 Toxicity of dendritic polymer macromolecules
295(2)
4.1 Cytotoxicity
295(1)
4.2 Hematological toxicity
296(1)
4.3 Immunogenicity
296(1)
4.4 In vivo toxicity
296(1)
5 Types of dendritic polymer macromolecular carriers
297(8)
5.1 Functionality-based dendrimers
297(2)
5.2 Biodegradable dendrimers
299(1)
5.3 Stimuli-responsive dendrimers
300(5)
6 Drug delivery strategies
305(3)
6.1 Encapsulation
305(2)
6.2 Conjugation
307(1)
6.3 Electrostatic interaction
307(1)
7 Applications of dendritic macromolecules
308(8)
7.1 Dendrimers in the delivery of anticancer agents
309(2)
7.2 Dendrimers in gene delivery
311(2)
7.3 Dendrimers in the delivery of antimicrobial agents
313(2)
7.4 Dendrimers in neurodegenerative diseases
315(1)
7.5 Miscellaneous drug delivery applications
316(1)
8 Conclusions
316(13)
References
317(12)
Chapter 11 Advances in hydrogel-based controlled drug-delivery systems
329(22)
M. Ramchandani
G. Rath
A.K. Goyal
1 Introduction
329(1)
2 Hydrogels
330(1)
3 Structure of hydrogels
331(1)
4 Classification of hydrogels
332(1)
5 Preparation of hydrogels
333(3)
6 Characterization of hydrogels
336(6)
6.1 Physicochemical characterization
336(4)
6.2 Morphological and structural characterization
340(1)
6.3 Thermal characterization
341(1)
7 Therapeutic application of hydrogels
342(4)
7.1 Hydrogels for the vision system
342(1)
7.2 Hydrogels for the small intestine
343(1)
7.3 Hydrogels for the skin
343(1)
7.4 Hydrogels for the colon
343(1)
7.5 Hydrogels for the respiratory system
344(1)
7.6 Hydrogels for drug-delivery to brain
344(1)
7.7 Advanced use of hydrogels for tissue engineering and tissue imaging
345(1)
8 Current research and future prospects
346(5)
References
346(5)
Chapter 12 Stimuli-responsive protein fibers for advanced applications
351(50)
Ayushi Jain
Thomson Santosh Alex
Damanpreet K. Lang
Swati Gupta
1 Introduction
351(1)
2 Synthesis
352(4)
3 Various responsive systems
356(10)
3.1 pH-responsive systems
356(1)
3.2 Thermo-responsive systems
357(4)
3.3 Enzyme-responsive systems
361(1)
3.4 Light-responsive systems
362(1)
3.5 Ultrasound-responsive systems
363(3)
4 Preclinical studies
366(11)
4.1 RATEA-16 nanofibrillar hydrogel in the treatment of hyperglycemia
366(1)
4.2 IGF-1 functionalized peptide nanofibers for treatment of myocardial infarction
366(1)
4.3 PVNFKFLSH-hemopressin peptide for the treatment of atherosclerosis
367(1)
4.4 RATEA-16 polypeptide employed for wound healing
368(1)
4.5 RADA 16-I and RADA 16-mix in neuron repair and regeneration
369(1)
4.6 FDPC polypeptide for enhanced drug delivery in tumor therapy
370(1)
4.7 NF/PDGF-BB in myocardial protection
371(1)
4.8 PEG-Pep-TPE (FFKY) in synergistic chemotherapy
372(1)
4.9 Using BP-KLVFF-SWTLYTPSGQSK (BFS) to prevent tumor metastasis
373(1)
4.10 (Fbp-GDFDFDYD (E, S, or K)-ss-ERGD) as immune adjuvant in anticancer therapy
374(3)
5 Clinical trial studies
377(4)
5.1 Silk/elastin/collagen-based polymers
377(2)
5.2 Polymeric micellar systems in clinical trials
379(2)
6 Applications of self-assembled peptide nanofibers
381(7)
6.1 Regenerative and reparative medicines
381(2)
6.2 Vaccine and immunotherapeutic
383(1)
6.3 Drug delivery systems
383(1)
6.4 Stimuli-responsive drug delivery
383(1)
6.5 4D printing
384(1)
6.6 Tissue engineering
385(1)
6.7 Biosensors and biomaterials
385(1)
6.8 Actuators
385(1)
6.9 Disease-specific study---Diagnosis and treatment
385(3)
7 Marketed preparations
388(1)
7.1 BDPuraMatrix
389(1)
7.2 D-Fibroheal Ag foam
389(1)
8 Conclusion and future prospects
389(12)
References
390(11)
Chapter 13 Smart drug delivery systems and their clinical potential
401(36)
Sunita Dahiya
Rajiv Dahiya
1 Introduction
401(1)
2 Potential stimuli-responsive nanocarriers
402(5)
2.1 Liposomes
403(1)
2.2 Micelles
403(1)
2.3 Polymeric nanoparticles
404(1)
2.4 Nanogels
404(1)
2.5 Dendrimers
405(1)
2.6 Mesoporous silica nanoparticles
406(1)
2.7 Gold nanocarriers
406(1)
2.8 Carbon nanotubes
406(1)
2.9 Iron oxide nanoparticles
407(1)
3 Stimuli-responsive DDSs: Design, rationale, and types
407(17)
3.1 Endogenous/internal stimuli-responsive DDS
409(8)
3.2 Exogenous/external stimuli-responsive SDDs
417(7)
4 Dual/multistimuli-responsive DDSs
424(3)
5 Clinical scenario of stimuli-responsive DDS
427(1)
6 Conclusions
427(10)
Conflict of interests
429(1)
References
429(8)
Chapter 14 Novel biomimetic polymersomes as polymer therapeutics for drug delivery
437(28)
M. Senthil Kumar
L.V. Vigneshwaran
1 Introduction
437(2)
1.1 Self-assembly and fabrication of polymersomes from amphiphilic block copolymers
438(1)
2 Background
439(1)
3 Need and importance
439(1)
4 Variants of polymersomes
440(5)
4.1 Peptide-based polymersomes
440(2)
4.2 Protein-based polymersomes
442(1)
4.3 Multicompartmentalized polymersomes
442(2)
4.4 Synthesis of photoresponsive block copolymers
444(1)
5 Chemistry and preparation of polymersomes
445(3)
5.1 Rehydration
446(1)
5.2 Electroformation
446(1)
5.3 Polymerization-induced self-assembly (PISA)
446(1)
5.4 Direct injection
447(1)
5.5 Emulsion phase transfer
447(1)
5.6 Microfluidics
447(1)
6 Therapeutic applications
448(6)
6.1 Polymersomes as nanoreactors
448(1)
6.2 Polymersomes for medical applications
449(3)
6.3 Vaccine delivery
452(1)
6.4 Nucleic acid delivery
453(1)
7 Beyond polymersomes
454(1)
8 Conclusions
455(10)
References
456(9)
Chapter 15 Bioinspired and biomimetic conjugated drug delivery system(s): A biohybrid concept combining cell(s) and drug delivery carrier(s)
465(20)
Laxmikant Gautam
Shiv Kumar Prajapati
Priya Shrivastava
Suresh P. Vyas
1 Bioinspired systems: An insight
465(1)
2 Methods for active drug delivery of bioconjugates
466(1)
3 Virus-inspired bioactive delivery systems
467(1)
3.1 Virosomes
467(1)
3.2 Virus-mimicking particles
468(1)
4 Mammalian cell-based bioactive delivery systems
468(2)
4.1 Erythrocytes
469(1)
4.2 Immune cells
469(1)
5 Cell-inspired bioactive delivery systems
470(2)
5.1 Exosomes
470(1)
5.2 Cancer cell membrane
471(1)
6 Polymer-based bioactive delivery systems
472(3)
6.1 Chitosan
474(1)
7 Bioactive(s) delivery via biomacromolecular systems
475(10)
7.1 Albumins
475(1)
7.2 Nucleic acid
476(1)
7.3 Lipoprotein
477(1)
Acknowledgment
478(1)
References
478(7)
Chapter 16 Conductive polymers and composite-based systems: A quantum leap in the drug delivery arena and therapeutics
485(38)
Riyaz Ali Osmani
Ekta Singh
Heena Kazi
Rohit Bhosale
Rudra Vaghela
Vandana Patravale
1 Introduction
485(2)
2 Conductive polymers
487(4)
2.1 Historical perspective
489(1)
2.2 Importance in drug delivery
490(1)
3 Synthesis of conductive polymers (CPs)
491(1)
3.1 Electrochemical synthesis
491(1)
3.2 Chemical synthesis
491(1)
4 Types of CPs
491(3)
4.1 Polypyrrole (PPy)
491(1)
4.2 Polyaniline (PAni)
492(1)
4.3 Polythiophene and derivatives
492(2)
5 CP composites
494(1)
6 Synthesis of CP composites
494(1)
6.1 Melt processing
494(1)
6.2 Mixing
494(1)
6.3 Latex technology
494(1)
6.4 In situ polymerization
495(1)
7 Types of CP composites
495(2)
7.1 Composites based on conjugated CPs
495(1)
7.2 Composites based on nonconjugated CPs
496(1)
8 Applications of CPs and composites
497(13)
8.1 CP architects for drug targeting and drug delivery
497(9)
8.2 For tissue engineering and regenerative medicine
506(1)
8.3 As sensors for biologically important molecules
507(1)
8.4 For neural interfacing
508(2)
9 Conclusions
510(1)
10 Future prospects
511(12)
Acknowledgments
511(1)
Conflicts of Interest
512(1)
References
512(11)
Chapter 17 Nanomedicine: Principles, properties, and regulatory issues
523(44)
Farhan Mazahir
Deepali Bhogale
Amit Kumar Palai
Awesh K. Yadav
1 Introduction
523(4)
2 Dynamic behavior of polymeric nanomedicine
527(4)
3 Preparation methods of polymeric nanomedicines
531(3)
3.1 Polymer precipitation methods
531(1)
3.2 Polymerization-based methods
532(1)
3.3 Amphiphilic macromolecule cross-linking
533(1)
3.4 Ionic gelation
533(1)
3.5 Supercritical fluid
534(1)
3.6 High-pressure homogenization
534(1)
4 Characterization of polymeric nanomedicines
534(7)
4.1 Particle size distribution
534(1)
4.2 Shape
535(1)
4.3 Surface charge
536(1)
4.4 Elasticity
536(1)
4.5 Surface area
537(1)
4.6 Agglomeration
537(1)
4.7 Small angle X-ray diffraction (SAXS) and X-ray diffraction (XRD)
538(1)
4.8 Differential scanning calorimetry (DSC)
538(1)
4.9 Drug entrapment and drug loading
539(1)
4.10 In vitro release studies
540(1)
5 Sterility and pyrogenicity
541(1)
6 Pharmacokinetics and pharmacodynamics
542(1)
7 Nanotoxicity and risk assessment
543(1)
8 Challenges in the manufacturing scale-up and reproducibility
543(1)
9 Regulatory issues
544(8)
9.1 Need for nanomedicine regulations
544(1)
9.2 Regulatory challenges
545(2)
9.3 Regulatory perspective on the development of nanomedicines
547(1)
9.4 Regulatory development of next-gen nanomedicines
548(1)
9.5 Global trends on regulatory of nanomedicines
549(3)
10 Example and list of currently approved polymeric nanomedicines released into the market
552(15)
Consent for publication
555(1)
Acknowledgments
555(1)
References
555(12)
Chapter 18 Polymer-matrix nanocomposites and its potential applications
567(18)
Neha Raina
Radha Rani
Amrita Kumari
Bigul Yogeshver Bhardwaj
Madhu Gupta
1 Introduction
567(1)
2 Processing methods of polymer-matrix nanocomposites
568(10)
2.1 Polymer employed for the fabrication of nanocomposites
570(4)
2.2 Potential applications of polymer nanocomposite in health care
574(4)
3 Conclusions
578(7)
References
578(7)
Index 585
Dr Vyas has over 36 years of teaching and research experience at postgraduate level. He is a pioneer scientist in the field of nano-biotechnology and immunology. He has over 325 research publications to his credit published in journals of high scientific impact and has authored 18 reference books including Pharmaceutical Biotechnology, Liposomal Therapeutics, Novel Controlled Drug Delivery Systems, Targeted Drug Delivery Systems, Theory and Practices in Novel Drug Delivery Systems. He is a commonwealth postdoctoral fellowship awardee and has worked under fellowship at School of Pharmacy University of London (U.K.). He is a recipient of Best Scientist award by Association of Pharmacy Professionals (APP) 2014 and many other honors. He serves on the editorial board of multiple international scientific publications including International Journal of Pharmaceutics (Elsevier). Dr. Agrawal has over 6 years of teaching and research experience at postgraduate level. She served as associate professor at Sagar Institute of Research and Technology Bhopal and Oriental College of Pharmacy Bhopal. She is Gold Medalist in B. Pharm and M. Pharm from Dr. H. S. Gour University and has been awarded with Pharmaceutical Science Alumi Award, Prof. C. S. Chauhan gold medal and Nagarjuna Award from Dr. H. S. Gour University Sagar (MP). She has received various awards in the field of drug delivery for her outstanding innovative research work including M. P Young Scientist Award 2016, Adina Young Scientist Award 2016 in the field of pharmaceutical and medical sciences and many best poster and oral presentation awards. She has more than 40 publications and book chapters in journals of international repute. She is currently working on targeted drug and peptides delivery systems exploiting polymers and nanobiotechnology. Rajeev Sharma is an Assistant Professor at the Amity Institute of Pharmacy, Amity University, Madhya Pradesh, Gwalior, India. He earned his B.Pharm, M.Pharm, and Ph.D. in Pharmaceutical Sciences from Dr. H. S. Gour Central University, Sagar, India. Dr. Sharma has approximately 13 years of experience in both teaching and industry. He has served as a Junior Research Fellow under AICTE, an ICMR-SRF, and a CSIR-RA Fellow during his research career, and has worked as an Assistant Professor in academia and as a Senior Formulation Development Scientist in the R&D industry. Dr. Sharma has edited two international and two national books and has authored over 30 publications and 21 book chapters in international reference books. His work focuses on recent concepts in immunology, nanobiotechnology, novel drug delivery systems, and targeted and controlled drug delivery of bioactives for the treatment of diseases such as cancer and diabetes. He is a life member of the Association of Pharmaceutical Teachers of India (APTI). Dr. Sharma's work has been cited approximately 1,200 times, and he has an h-index of 17. The cumulative impact factor of his published papers is around 120, according to SCOPUS. He is currently working on a research project funded by the Madhya Pradesh Council of Science and Technology (MPCST). Dr. Sharma has received several awards for his research, including the Young Research Scholar award and various awards for best oral and poster presentations at national and international conferences. His current research interest is in nanocarrier-based targeted approaches for the effective delivery of bioactives.
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