Preface |
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vii | |
Glossary |
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xi | |
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1 | (26) |
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The Scope of Recurrent Events |
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1 | (1) |
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Some Preliminary Examples |
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2 | (7) |
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Mammary Tumors in a Carcinogenicity Study |
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2 | (3) |
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Testing and Debugging a Large Software System |
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5 | (1) |
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Pulmonary Exacerbations in Cystic Fibrosis |
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5 | (2) |
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Automobile Warranty Claims |
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7 | (2) |
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9 | (7) |
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Methods Based on Event Counts |
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11 | (1) |
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Methods Based on Waiting or Gap Times |
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12 | (2) |
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14 | (1) |
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14 | (1) |
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Factors Influencing Model Choice |
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15 | (1) |
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Selection of Individuals and Observation Schemes |
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16 | (4) |
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16 | (2) |
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Defining Periods ``At Risk'' |
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18 | (1) |
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Initial Conditions and Selecting Individuals for Study |
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19 | (1) |
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Intermittent Observation and Interval Censoring |
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20 | (1) |
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20 | (3) |
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Multivariate Event Processes |
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20 | (1) |
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Recurrent Events with Termination |
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20 | (1) |
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21 | (2) |
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Some Other Aspects of Analysis and Design |
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23 | (1) |
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24 | (3) |
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Models and Frameworks for Analysis of Recurrent Events |
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27 | (32) |
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27 | (4) |
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Poisson Processes and Models for Event Counts |
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31 | (8) |
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31 | (3) |
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Covariates in Poisson Processes |
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34 | (1) |
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Random Effects in Poisson Processes |
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35 | (2) |
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Example: Mammary Tumors in Rats |
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37 | (2) |
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Renewal Processes and Models for Gap Times |
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39 | (4) |
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Models for Gap Times Between Events |
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39 | (3) |
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Example: Bowel Motility Cycles |
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42 | (1) |
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General Intensity-Based Models |
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43 | (2) |
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Discrete-Time Models and Time-Varying Covariates |
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45 | (2) |
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Likelihood for Selection and Observation Schemes |
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47 | (4) |
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51 | (1) |
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52 | (7) |
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Methods Based on Counts and Rate Functions |
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59 | (62) |
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59 | (2) |
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Parametric Maximum Likelihood for Poisson Models |
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61 | (4) |
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Score and Information Functions |
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61 | (1) |
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A General Parametric Rate Function |
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62 | (1) |
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63 | (1) |
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64 | (1) |
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Poisson Models with Piecewise-Constant Rates |
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65 | (3) |
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Nonparametric and Semiparametric Poisson Models |
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68 | (8) |
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68 | (2) |
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Semiparametric Regression |
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70 | (3) |
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73 | (2) |
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75 | (1) |
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Poisson Models with Random Effects |
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76 | (6) |
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76 | (2) |
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Models for Zero-Inflated Data |
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78 | (1) |
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79 | (3) |
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Robust Methods for Rate and Mean Functions |
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82 | (6) |
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82 | (1) |
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83 | (1) |
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Robust Semiparametric Methods |
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84 | (2) |
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Robust Methods with Semiparametric Variances |
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86 | (1) |
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Methods Based on Multivariate Failure Time Data |
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86 | (2) |
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Some Useful Tests for Rate Functions |
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88 | (12) |
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88 | (2) |
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Tests for Multiplicative Covariate Effects |
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90 | (2) |
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Generalized Residuals, Martingales, and Assessment of Fit |
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92 | (5) |
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Tests for Extra-Poisson Variation |
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97 | (1) |
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Two-Sample Test Statistics Based on Rates |
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97 | (3) |
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Applications and Illustrations |
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100 | (12) |
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100 | (5) |
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A Trial of Treatment for Herpes Simplex Virus |
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105 | (2) |
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Fitting and Prediction from a Software Debugging Model |
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107 | (3) |
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Comparing Warranty Claim Histories |
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110 | (2) |
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112 | (2) |
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114 | (7) |
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121 | (40) |
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Renewal Processes and Related Methods of Analysis |
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121 | (5) |
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Extensions of Renewal Models |
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126 | (7) |
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Conditional Analysis of Successive Gap Times |
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126 | (2) |
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Models with Random Effects |
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128 | (1) |
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Joint Gap Time Distributions |
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129 | (3) |
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Modulated Renewal Processes |
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132 | (1) |
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133 | (4) |
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133 | (1) |
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Pulmonary Exacerbations and rhDNase Treatment |
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134 | (3) |
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Estimation of Marginal Gap Time Probabilities |
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137 | (9) |
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Nonparametric Estimation of Marginal Gap Time Distributions |
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139 | (4) |
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Estimation for Marginal Regression Models |
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143 | (1) |
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Pulmonary Exacerbations in Cystic Fibrosis |
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143 | (3) |
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Left Truncation of First Gap Times and Initial Conditions |
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146 | (6) |
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Initial Conditions and Renewal Processes |
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147 | (3) |
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Initial Conditions and General Gap Time Analysis |
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150 | (2) |
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152 | (1) |
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153 | (8) |
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General Intensity-Based Models |
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161 | (44) |
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Time Scales and Intensity Modeling |
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161 | (2) |
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Parametric Analysis for Two Useful Models |
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163 | (8) |
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Log-Linear Intensity Models |
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163 | (2) |
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165 | (2) |
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167 | (1) |
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An Illustration: Air-Conditioning System Failures |
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167 | (4) |
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Semiparametric Markov Analysis |
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171 | (12) |
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Models with Dependence on Prior Counts |
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171 | (2) |
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Markov Nonparametric Estimation |
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173 | (2) |
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175 | (2) |
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Analysis of Outbreaks Due to Herpes Simplex Virus |
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177 | (6) |
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Semiparametric Modulated Renewal Analysis |
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183 | (6) |
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Analysis Based on the Cox Model |
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183 | (2) |
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Illustration: Cerebrospinal Fluid Shunts |
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185 | (4) |
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Some Additional Illustrations |
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189 | (11) |
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Pulmonary Exacerbations in the Study of rhDNase |
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190 | (3) |
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Analysis of Asthma Exacerbations |
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193 | (7) |
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200 | (1) |
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201 | (4) |
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Multitype Recurrent Events |
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205 | (46) |
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205 | (1) |
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206 | (3) |
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Notation and Intensity Functions |
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206 | (1) |
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Remarks on Intensity-Based Models |
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207 | (2) |
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Random Effect Models for Multitype Events |
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209 | (3) |
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Robust Methods for Multitype Events |
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212 | (4) |
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Methods Based on Working Independence Assumptions |
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212 | (2) |
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Robust Methods with Covariance Functions |
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214 | (2) |
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Alternating Two-State Processes |
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216 | (2) |
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Recurrent Events with a Terminal Event |
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218 | (9) |
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Intensity-Based Approaches |
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219 | (1) |
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220 | (2) |
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Robust Methods for Marginal Features |
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222 | (2) |
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Partially Conditional Methods |
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224 | (3) |
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Applications and Illustrations |
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227 | (19) |
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Cerebrospinal Fluid Shunt Failures |
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227 | (5) |
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Exacerbations in Patients with Chronic Bronchitis |
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232 | (4) |
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Skeletal Complications in Metastatic Cancer |
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236 | (5) |
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Relationships Between Skeletal Complications |
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241 | (5) |
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246 | (1) |
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247 | (4) |
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Observation Schemes Giving Incomplete or Selective Data |
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251 | (42) |
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Intermittent Observation During Followup |
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251 | (13) |
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Methods Based on Poisson Processes |
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252 | (2) |
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Robust Estimation of Rate and Mean Functions |
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254 | (2) |
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Illustration: Superficial Tumors of the Bladder |
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256 | (4) |
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Interval-Count Data for Multiple Events |
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260 | (3) |
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Illustration: Joint Damage in Psoriatic Arthritis |
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263 | (1) |
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Dependent Censoring or Inspections |
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264 | (9) |
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Dependent Censoring and Weighted Estimating Functions |
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264 | (4) |
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Rate or Mean Function Estimation with Event-Dependent Censoring |
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268 | (2) |
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270 | (3) |
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Event-Dependent Selection |
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273 | (11) |
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273 | (8) |
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Supplementary Information on Selection |
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281 | (3) |
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284 | (2) |
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286 | (7) |
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293 | (44) |
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Event Processes with Marks |
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293 | (2) |
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Models for Cumulative Costs |
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295 | (7) |
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295 | (2) |
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Estimation for Cost Processes |
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297 | (2) |
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299 | (3) |
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302 | (9) |
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302 | (2) |
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Predictive Probabilities and Calibration |
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304 | (2) |
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Some Examples of Prediction |
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306 | (5) |
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Recurrent Events in Randomized Trials |
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311 | (13) |
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Specification and Testing of Treatment Effects |
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311 | (4) |
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Trial Design for Mixed Poisson Processes |
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315 | (1) |
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Use of Baseline Count Data |
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316 | (4) |
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Interim Monitoring with Recurrent Events |
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320 | (4) |
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324 | (3) |
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327 | (2) |
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Covariate Measurement Error |
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329 | (2) |
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331 | (1) |
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332 | (1) |
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333 | (4) |
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Estimation and Statistical Inference |
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337 | (8) |
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337 | (5) |
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337 | (1) |
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338 | (2) |
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Confidence Regions or Intervals |
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340 | (1) |
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341 | (1) |
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342 | (3) |
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345 | (4) |
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Software for Recurrent Events |
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345 | (1) |
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346 | (1) |
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Simulation and Resampling Methods |
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346 | (3) |
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Code and Remarks for Selected Examples |
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349 | (14) |
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Tumorgenicity Data Analysis of Chapter 3 |
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349 | (6) |
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Poisson Analysis with Weibull Baseline Rate |
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349 | (2) |
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Poisson Analysis with Piecewise-Constant Rates |
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351 | (2) |
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Nonparametric and Semiparametric Poisson Analysis |
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353 | (1) |
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Semiparametric Mixed Poisson Analysis |
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353 | (1) |
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Robust Semiparametric Analysis |
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354 | (1) |
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Code for rhDNase Data Analyses of Chapter 4 |
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355 | (3) |
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Code for Chronic Bronchitis Trial of Chapter 6 |
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358 | (5) |
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363 | (8) |
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363 | (1) |
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364 | (1) |
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Pulmonary Exacerbations and rhDNase |
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365 | (2) |
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367 | (1) |
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Artificial Field Repair Data |
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367 | (4) |
References |
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371 | (20) |
Author Index |
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391 | (6) |
Subject Index |
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397 | |