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Statistical DNA Forensics: Theory, Methods and Computation [Hardback]

(University of Hong Kong, China), (South East University, China)
  • Formāts: Hardback, 264 pages, height x width x depth: 252x173x20 mm, weight: 603 g
  • Sērija : Statistics in Practice
  • Izdošanas datums: 25-Jan-2008
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 0470066369
  • ISBN-13: 9780470066362
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  • Cena: 123,57 €
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  • Bibliotēkām
  • Formāts: Hardback, 264 pages, height x width x depth: 252x173x20 mm, weight: 603 g
  • Sērija : Statistics in Practice
  • Izdošanas datums: 25-Jan-2008
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 0470066369
  • ISBN-13: 9780470066362
Citas grāmatas par šo tēmu:
Advances in the understanding of DNA as evidence, as well as new technologies and techniques, have made statistical methods essential to the collection, analysis and interpretation of forensic data. Fung and Hu (both statistics and actuarial science, U. of Hong Kong) provide a practical guide to the analysis of DNA evidence, focusing on essential statistical methodology and computational techniques. They also provide readers with basic information on population genetics and statistics so specialists in either field can become conversant with the other. They cover parentage testing (including motherless cases) and testing for kinship (including situations in which three people are involved), interpreting mixtures of materials, interpreting mixtures in the presence of relatives, and working with lineage markers, haplotypic genetic markers for mixture, Bayesian networks, peak information, mass disasters and database searchers. They provide exercises and solutions. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

Statistical methodology plays a key role in ensuring that DNA evidence is collected, interpreted, analyzed and presented correctly. With the recent advances in computer technology, this methodology is more complex than ever before. There are a growing number of books in the area but none are devoted to the computational analysis of evidence. This book presents the methodology of statistical DNA forensics with an emphasis on the use of computational techniques to analyze and interpret forensic evidence.
Preface. List of figures.

List of tables.

1. Introduction.

1.1 Statistics, forensic science and the law.

1.2 The use of statistics in forensic DNA.

1.3 Genetic basis of DNA profiling and typing technology.

1.3.1 Genetic basis.

1.3.2 Typing technology.

1.4 About the book.

2. Probability and statistics.

2.1 Probability.

2.2 Dependent events and conditional probability.

2.3 Law of total probability.

2.4 Bayes Theorem.

2.5 Binomial probability distribution.

2.6 Multinomial distribution.

2.7 Poisson distribution.

2.8 Normal distribution.

2.9 Likelihood ratio.

2.10 Statistical inference.

2.10.1 Test of hypothesis.

2.10.2 Estimation and testing.

2.11 Problems.

3. Population genetics.

3.1 Hardy-Weinberg equilibrium.

3.2 Test for Hardy-Weinberg equilibrium.

3.2.1 Observed and expected heterozygosities.

3.2.2 Chi-square test.

3.2.3 Fishers exact test.

3.2.4 Computer software.

3.3 Other statistics for analysis of a population database.

3.3.1 Linkage equilibrium.

3.3.2 Power of discrimination.

3.4 DNA profiling.

3.5 Subpopulation models.

3.6 Relatives.

3.7 Problems.

4. Parentage testing.

4.1 Standard trio.

4.1.1 Paternity index.

4.1.2 An example.

4.1.3 Posterior odds and probability of paternity.

4.2 Paternity computer software.

4.2.1 Steps in running the software.

4.2.2 The software to deal with an incest case.

4.3 A relative of the alleged father is the true father.

4.4 Alleged father unavailable but his relative is.

4.5 Motherless case.

4.5.1 Paternity index.

4.5.2 Computer software and example.

4.6 Motherless case: relatives involved.

4.6.1 A relative of the alleged father is the true father.

4.6.2 Alleged father unavailable but his relative is.

4.6.3 Computer software and example.

4.7 Determination of both parents.

4.8 Probability of excluding a random man from paternity.

4.9 Power of exclusion.

4.9.1 A random man case.

4.9.2 A relative case.

4.9.3 An elder brother case: mother available.

4.10 Other issues.

4.10.1 Reverse parentage.

4.10.2 Mutation.

4.11 Problems.

5. Testing for kinship.

5.1 Kinship testing of any two persons: HWE.

5.2 Computer software.

5.3 Kinship testing of two persons: subdivided populations.

5.3.1 Joint genotype probability.

5.3.2 Relatives involved.

5.4 Examples with software.

5.5 Three persons situation: HWE.

5.6 Computer software and example.

5.7 Three persons situation: subdivided populations.

5.7.1 Standard trio.

5.7.2 A relative of the alleged father is the true father.

5.7.3 Alleged father unavailable but his relative is.

5.7.4 Example.

5.7.5 General method and computer software.

5.8 Complex kinship determinations: method and software.

5.8.1 EasyPA_In_1_Minute software and the method.

5.8.2 EasyPAnt_In_1_Minute.

5.8.3 EasyIN_In_1_Minute.

5.8.4 EasyMISS_In_1_Minute.

5.8.5 Other considerations: probability of paternity and mutation.

5.9 Problems.

6. Interpreting mixtures.

6.1 An illustrative example.

6.2 Some common cases and a case example.

6.2.1 One victim, one suspect and one unknown.

6.2.2 One suspect and two unknowns.

6.2.3 Two suspects and two unknowns.

6.2.4 Case example.

6.2.5 Exclusion probability.

6.3 A general approach.

6.4 Population in Hardy-Weinberg equilibrium.

6.5 Population with multiple ethnic groups.

6.6 Subdivided population.

6.6.1 Single ethnic group: simple cases.

6.6.2 Single ethnic group: general situations.

6.6.3 Multiple ethnic groups.

6.7 Computer software and example.

6.8 NRC II Recommendation 4.1.

6.8.1 Single ethnic group.

6.8.2 Multiple ethnic groups.

6.9 Proofs.

6.9.1 The proof of Equation (6.6).

6.9.2 The proof of Equation (6.8).

6.9.3 The proof of Equation (6.9).

6.9.4 The proofs of Equations (6.11) and (6.12).

6.9.5 The proofs of Equations (6.14) and (6.15).

6.10 Problems.

7. Interpreting mixtures in the presence of relatives.

7.1 One pair of relatives: HWE.

7.1.1 Motivating example.

7.1.2 A probability formula.

7.1.3 Tested suspect with an unknown relative.

7.1.4 Unknown suspect with a tested relative.

7.1.5 Two related persons were unknown contributors.

7.1.6 An application.

7.2 Two pairs of relatives: HWE.

7.2.1 Two unknowns related respectively to two typed persons.

7.2.2 One unknown is related to a typed person and two other.

unknowns are related.

7.2.3 Two pairs of related unknowns.

7.2.4 Examples.

7.2.5 Extension.

7.3 Related people from the same subdivided population.

7.3.1 Introductory example.

7.3.2 A simple case with one victim, one suspect and one relative.

7.3.3 General formulas.

7.3.4 An example analyzed by the software.

7.4 Proofs.

7.4.1 Preliminary.

7.4.2 The proof of Equation (7.5).

7.4.3 The proof of Equation (7.7).

7.4.4 The proof of Equation (7.9).

7.4.5 The proof of Equation (7.11).

7.4.6 The proof of Equation (7.13).

7.4.7 The proofs of Equations (7.18) and (7.20).

7.5 Problems.

8. Other issues.

8.1 Lineage markers.

8.2 Haplotypic genetic markers for mixture.

8.3 Bayesian network.

8.4 Peak information.

8.5 Mass disaster.

8.6 Database search.

Solutions to Problems.

Appendix A: The standard normal distribution.

Appendix B: Upper 1% and 5% points of w2 distributions.

Bibliography.

Index.
Wing Kam Fung Department of Statistics and Actuarial Science, University of Hong Kong With 20 years of lecturing and research experience, Professor Fung has been invited many times to give talks at workshops and international conferences. He has written over 130 papers in statistics, DNA profiling and forensic science, and is currently an Associate Editor for 4 statistical journals. Yue-Qing Hu Department of Mathematics, Southeast University An Associate Professor, Yue-Qing Hu has published over 30 refereed papers, a number of these with Wing Kam Fung.