| Contributors |
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ix | |
| Preface |
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xi | |
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1 Chromatin regulation and dynamics in stem cells |
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1 | (72) |
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1 Chromatin compaction, structure, and function |
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3 | (5) |
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2 Chromatin dynamics regulate gene expression |
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8 | (1) |
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3 ATP-dependent nucleosome remodeling complexes establish and maintain chromatin state |
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9 | (9) |
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4 Histone modifications provide an additional layer of gene regulation |
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18 | (7) |
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5 Histone chaperones and histone variants regulate chromatin structure |
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25 | (4) |
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29 | (2) |
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31 | (1) |
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32 | (4) |
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9 Chromatin structure is dynamic and highly regulated |
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36 | (1) |
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10 Stem cell chromatin is dynamic and tuned to regulate cell fate |
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36 | (1) |
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11 ES cells carefully regulate their chromatin via specialized transcription factors |
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37 | (2) |
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12 Embryonic stem cell chromatin is poised for action |
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39 | (1) |
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13 Histone modifications are specifically regulated in stem cells to maintain pluripotency and facilitate differentiation |
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39 | (3) |
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14 Chromatin state is precisely regulated by nucleosome remodeling factors in ES cells |
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42 | (9) |
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15 Long-range chromatin interactions are critical for regulation of luripotency |
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51 | (3) |
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16 ES cells regulate chromatin by common processes to preserve pluripotency |
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54 | (19) |
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55 | (1) |
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55 | (18) |
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2 Role of IncRNAs in stem cell maintenance and differentiation |
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73 | (40) |
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74 | (1) |
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2 Origin of noncoding RNAs |
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75 | (1) |
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3 Core regulatory circuit in ESCs |
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76 | (2) |
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4 LncRNAs: New determinants of ES cell fate |
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78 | (1) |
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5 Long noncoding RNAs (IncRNAs) and their biological function |
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78 | (2) |
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6 Discovery of IncRNAs: From sequences to function |
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80 | (1) |
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7 Long noncoding RNAs and epigenetic regulation |
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80 | (1) |
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8 Dissecting functional IncRNAs from transcriptional noise |
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81 | (1) |
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9 LncRNAs in ESC pluripotency and somatic cell reprogramming |
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81 | (6) |
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10 LncRNAs play a role in the differentiation of pluripotent stem cells |
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87 | (1) |
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11 LncRNAs regulating the epigenome |
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88 | (1) |
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12 The role of IncRNAs in dosage composition |
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89 | (1) |
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13 LncRNAs implicated in imprinting developmentally associated genes |
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90 | (1) |
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14 LncRNAs regulating signaling pathways in ESCs |
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91 | (1) |
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15 LncRNAs regulating organ development |
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92 | (1) |
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16 LncRNAs affecting neural development |
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93 | (1) |
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17 LncRNAs regulating organogenesis |
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94 | (1) |
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18 Cellular localization and maturation of IncRNAs |
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95 | (1) |
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19 LncRNAs regulating the stability and functions of other RNAs |
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95 | (1) |
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20 LncRNAs functioning in protein modification pathways |
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96 | (1) |
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21 Mechanisms of lncRNA:DNA/RNA interaction |
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96 | (2) |
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22 Allosteric regulation of proteins by IncRNAs |
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98 | (1) |
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23 Single cell analysis of IncRNA functions |
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99 | (1) |
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24 LncRNAs in disease progression |
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100 | (1) |
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25 LncRNA knockouts often show lack of phenotype: The importance of context and redundancy |
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101 | (1) |
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102 | (9) |
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102 | (9) |
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111 | (2) |
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3 Regulation of pluripotency and reprogramming by RNA binding proteins |
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113 | (26) |
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1 Pluripotency and reprogramming |
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114 | (1) |
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115 | (9) |
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3 RNA helicases and DEAD-box helicase family |
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124 | (6) |
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130 | (9) |
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130 | (1) |
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130 | (9) |
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4 Generating primed pluripotent epiblast stem cells: A methodology chapter |
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139 | (36) |
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140 | (1) |
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141 | (8) |
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149 | (17) |
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166 | (1) |
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166 | (5) |
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171 | (4) |
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173 | (1) |
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173 | (2) |
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5 Differentiation of human pluripotent stem cells toward pharyngeal endoderm derivatives: Current status and potential |
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175 | (34) |
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176 | (2) |
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2 Overview of the pharyngeal apparatus formation within the gut tube |
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178 | (2) |
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3 Pharyngeal endoderm development and lineage specification within the pharyngeal pouches |
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180 | (2) |
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4 Pharynx derivative pluripotent stem cell differentiation protocols: Current status |
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182 | (13) |
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5 Applications of hPSCs for studying pharyngeal endoderm development and disease |
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195 | (1) |
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6 Future directions for hPSC differentiation approaches toward pharyngeal derivatives |
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196 | (3) |
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199 | (10) |
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199 | (1) |
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199 | (10) |
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6 Epigenetic metabolites license stem cell states |
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209 | |
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210 | (1) |
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210 | (2) |
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3 Metabolism of quiescent stem cells |
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212 | (5) |
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4 Metabolism of active stem cells |
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217 | (5) |
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5 HIF, the master regulator of metabolism |
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222 | (2) |
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6 Epigenetic signatures and epigenetic metabolites |
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224 | (5) |
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229 | |
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230 | (1) |
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230 | (10) |
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240 | |
