Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.
With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.
- Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population
- Addresses the effect of time and age on human stem cells
- Includes chapters from contributors exploring the biology of stem cell aging around the globe
Recenzijas
"Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging." --Anticancer Research
1. Theories of stem cell aging
2. Progress in human embryonic stem cell research and aging
3. Stem cell aging and wound healing
4. Stem cells and multiomics approaches in senescence: From benchside to
bedside
5. Signaling pathways influencing stem cell self-renewal and differentiation
6. Immunity, stem cells, and aging
7. Aging of hematopoietic stem cells: Insight into mechanisms and
consequences
8. Ocular stem cells and again
9. Skeletal muscle cell aging and stem cells
10. Aging and stability of cardiomyocytes
11. Signaling pathways influencing stem cell self-renewal and differentiation
Special emphasis on cardiomyocytes
12. Angiogenesis in aging hearts - Cardiac stem cell therapy
13. Gut stem cells: Interplay with immune system, microbiota, and aging
14. Cellular senescence and aging in bone
15. Aging-induced stem cell dysfunction: Molecular mechanisms and potential
therapeutic avenues
16. Therapeutic approaches for the treatment of aging-induced stem cell
dysfunction
17. Role of biological markers in stem cell aging and its implications in
therapeutic processes
18. Alternative stromal cell-based therapies for aging and regeneration
19. Stem cell-based therapeutic strategy in delaying prion disease
20. Traditional medicine for aging-related disorders: Implications for drug
discovery
Prof. Surajit Pathak, PhD, is currently working as a professor at Chettinad Academy of Research and Education (CARE), Chennai, India (from 2015 to date). He is currently serving as a principal research scientist (2022 JuneDec 2022) at Linkoping University, Linkoping, Sweden. He received his PhD degree from India in 2007 and completed his postdoctoral training (200715) from the University of Alabama, United States, the University of Padova, Italy, and the University of Linkoping, Sweden. His current research focuses on Biomarker discoveries for early detection of colorectal cancer. He has published more than 100 research articles in peer-reviewed international journals of repute with 2233 citations and 27 H-index. Dr. Pathak has edited Elsevier book Stem Cells and Aging in 2021. He is the member of various professional research bodies of India, including the Indian Association of Cancer Research and the Indian Science Congress. Dr. Antara Banerjee, PhD, is presently working as an associate professor at CARE, Chennai from 2016 to date. After completing her PhD in 2008 from India, Dr. Banerjee pursued her postdoctoral work at the University of Padova, Italy and Linkoping University, Sweden (200915). She has published over 95 peer-reviewed research articles in international and national journals with citation index-1408 and H-index 19. The Banerjees lab at Chettinad Hospital and Research Institute is now focused on understanding the role of mesenchymal stem cells niche in tissue regeneration and exploring signaling pathways in governing stem cell fate. She is the editor of Elsevier book Stem Cells and Aging in 2021. She is the member of various professional research bodies, including the Indian Association of Cancer Research and the Indian Science Congress.
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