Stem cell science has the potential to impact human reproductive medicine significantly cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.
Papildus informācija
Stem Cells in Reproductive Medicine is essential reading for those keeping abreast of practical developments in this rapidly moving field.
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vii | |
| Preface |
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ix | |
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1 Genetics of germline formation |
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1 | (14) |
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2 Germ-cell differentiation from pluripotent cells |
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15 | (15) |
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30 | (16) |
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4 In vitro production of functional sperm from neonatal mouse testes |
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46 | (6) |
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5 Adult stem-cell population in the human testis |
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52 | (11) |
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Part 3 The embryo/blastomere |
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6 Meiotic recombination in human oocytes |
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63 | (13) |
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7 Gene expression dynamics during human embryonic development |
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76 | (8) |
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8 Embryonic stem cells from blastomeres maintaining embryo viability |
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84 | (9) |
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9 Gamete generation from stem cells to avoid gamete donation and customized hESCs from blastomeres as the cellular insurance for the newborn: Will it ever be ethically acceptable? |
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93 | (9) |
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Part 4 Trophoblast, amniotic fluid, endometrium, and bone marrow |
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10 Amniotic fluid and placental membranes: Unexpected sources of highly multipotent cells |
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102 | (13) |
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11 Adult stem cells in the human endometrium |
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115 | (18) |
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12 In utero hematopoietic cell transplantation |
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133 | (7) |
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13 Bone-marrow stroma: A source of mesenchymal stem cells for cell therapy |
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140 | (12) |
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Part 5 New developments in stem-cell research |
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14 Dedifferentiation, transdifferentiation, and reprogramming |
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152 | (12) |
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15 The metabolic framework of pluripotent stem cells and potential mechanisms of regulation |
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164 | (16) |
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| Index |
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180 | |
Carlos Simon MD PhD is Professor and Scientific Director of Instituto Valenciano de Infertilidad (IVI), Valencia, Spain. Antonio Pellicer MD PhD is Professor and President of Instituto Valenciano de Infertilidad (IVI), Valencia, Spain. Renee Reijo Pera PhD is Professor and Director of Human Embryonic Stem Cell Research and Education, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, USA.
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