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E-grāmata: Studies on Experimental Toxicology and Pharmacology

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This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology.

Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders.

With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.

Part I Toxicological Mechanisms and Evaluation of Oxidative Stress
1 A Historical Perspective on Oxidative Stress and Intracellular Redox Control
3(18)
Ethiene Castellucci Estevam
Muhammad Jawad Nasim
Lisa Faulstich
Marina Hakenesch
Torsten Burkholz
Claus Jacob
2 An Overview of Free Radicals as Causes and Consequences of Toxicity
21(8)
James P. Kehrer
Lars-Oliver Klotz
Stephen M. Roberts
3 Oxidants, Radicals, Free Radicals, and Other Bad Stuff in Mechanisms of Toxicity
29(14)
Charles Vincent Smith
4 Lipid Oxidation
43(38)
Norsyahida Mohd Fauzi
Corinne M. Spickett
5 Protein Oxidation in Toxicology
81(22)
Sandra Reeg
Tilman Grune
6 Oxidative Stress and DNA Damage Association with Carcinogenesis: A Truth or a Myth?
103(28)
Vasiliki I. Hatzi
Danae A. Laskaratou
Ifigeneia V. Mavragani
Gabriel E. Pantelias
Georgia I. Terzoudi
Alexandras G. Georgakilas
7 Glutathione and Thiols
131(18)
Lou Ann S. Brown
Dean P. Jones
8 Reactive Oxygen Species as Initiators and Mediators of Cellular Signaling Processes
149(24)
Lars-Oliver Klotz
9 Role of Oxidative Stress in the Process of Carcinogenesis
173(28)
Susannah Havermann
Christian Buchter
Karoline Koch
Wim Watjen
Part II Agents That Produce Toxicity: Mechanisms and Therapeutic Interventions
10 Isolation of Murine Adult Bone Marrow and Fetal Liver Cells for Mechanistic Assessment of Hematotoxicity Caused by Organic Solvents
201(12)
Nicola A. Philbrook
Louise M. Winn
11 Oxidative Stress and Ethanol Toxicity
213(20)
Juliane I. Beier
Gavin E. Arteel
12 Pharmaceutical Agents
233(18)
Abdullah Al Maruf
Peter J. O'Brien
13 Insecticides and Herbicides
251(16)
Georgia K. Hinkley
Stephen M. Roberts
14 Health Effects of Indoor Air Pollution Due to Cooking with Biomass Fuel
267(36)
Dona Sinha
Manas Ranjan Ray
15 Outdoor Air Pollutants
303(20)
Francesca Aiello
Fedora Grande
Claudia Sticozzi
Giuseppe Valacchi
16 Oxidative Stress and the Inorganic Carcinogens
323(12)
Erik J. Tokar
Wei Qu
Rachel J. Person
Olive N. Ngalame
Michael P. Waalkes
17 UV-induced Signaling: Role of Reactive Oxygen Species
335(12)
Lars-Oliver Klotz
18 Oxidative Stress and Nanomaterial-Cellular Interactions
347(22)
Vamsi Kodali
Brian D. Thrall
19 Chemical Warfare Agents
369(14)
Uri Wormser
Yoram Finkelstein
Elena Proscura
Berta Brodsky
Michael Aschner
Part III Special Topics
20 On the Biochemistry of Antioxidants: Current Aspects
383(14)
Lars-Oliver Klotz
21 Prevention of Age-Related Diseases: Effects of Antioxidant Supplements
397(16)
Wilhelm Stahl
22 The Neural Progenitor Cell (NPC) Niche in the Adult Brain Provides a Target for Neurotoxicity: A Putative Adverse Outcome Pathway for ROS-Induced NPC Dysfunction with Higher Sensitivity During Aging
413(14)
Ellen Fritsche
23 Oxygen Toxicity: From Cough to Convulsion
427(22)
Marlon A. Medford
Claude A. Piantadosi
24 Oxidative Stress in Reproductive Toxicology
449(18)
Yu-Guang Zhao
Lu Cai
25 Toxicogenomics-Based Assessment of Xenobiotic-Induced Oxidative Stress
467(14)
Christine M. Karbowski
Melissa M. Martin
Paul Nioi
26 Oxidative Stress Responses in Aquatic and Marine Fishes
481(14)
Michael J. Carvan
Richard T. Di Giulio
Index 495
Stephen M. Roberts, Ph.D. is Director of the Center for Environmental & Human Toxicology at the University of Florida, and is a Professor with joint appointments in the College of Veterinary Medicine, College of Medicine, and the College of Public Health and Health Professions.  He received his Ph.D. from the University of Utah College of Medicine, and has developed an active research career focusing on mechanisms of toxicity of drugs and chemicals with funding from the National Institutes of Health, the U.S. Environmental Protection Agency, the Department of Defense, and private industry.  He has served on a federal scientific advisory committees dealing with matters related to toxicology for the U.S. Department of Health and Human Services, the Food and Drug Administration, and the U.S. Environmental Protection Agency.





James P. Kehrer Ph.D received a B.S. in pharmacy from Purdue University and a Ph.D. in pharmacology/toxicology from the University of Iowa College of Medicine.  He did postdoctoral work at Oak Ridge National Laboratory and served on the faculty at the University of Texas at Austin for 25 years. He is currently Dean of the Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta.  Dr. Kehrer has served on numerous NIH grant review panels, as a member of the US-EPA Science Advisory Board Exposure and Human Health Committee, and on the US-FDA Nonprescription Drug Advisory Committee.He served as Editor-in-Chief of Toxicology Letters for 21 years. He is a Fellow of the American Association for the Advancement of Science.





Lars-Oliver Klotz, Ph.D. is a Professor of Nutrigenomics at Friedrich Schiller University in Jena, Germany. His research interests include the biochemistry of oxidative stress and stress-induced signal transduction. Following his Diploma degree in biochemistry (University of Tübingen), he received a Ph.D. in biochemistry from

the University of Düsseldorf (1998). He was a postdoctoral fellow at the National Institute on Aging in Baltimore, USA, and returned to Düsseldorf to establish a laboratory at the Dept. of Biochemistry and Molecular Biology and, later, the Leibniz Research Institute for Environmental Medicine. In 2010, he moved to the University of Alberta, Edmonton, Canada, where he was an Associate Professor and Canada Research Chair at the Faculty of Pharmacy and Pharmaceutical Sciences. In September 2013, Dr. Klotz assumed his current position as chair of the Department of Nutrigenomics at the University of Jena.