This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generating these species, clinically useful biomarkers for evaluating oxidative stress status in humans, and the pathophysiology, clinical course and management of a variety of pediatric disorders, among others. The book also describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders. It explores emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents.
Written by an international team of experts in both pediatrics and free radical and antioxidant research, Studies on Pediatric Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series.
| Part I General Topics |
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1 Oxygen and Oxidative Stress in the Newborn |
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3 | (12) |
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2 Reactive Oxygen Species and Nitric Oxide in Vascular Function |
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15 | (20) |
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3 Nitrite-Dependent Nitric Oxide Production Pathway: Diversity of NO Production Systems |
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35 | (20) |
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4 Nitric Oxide and Endothelial Dysfunction |
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55 | (16) |
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5 Multifunctional Roles of Nitric Oxide (NO) in Neurons |
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71 | (16) |
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| Part II Basic Science Topics |
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6 Oxidative Stress Biomarkers: Current Status and Future Perspective |
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87 | (28) |
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7 Urinary L-Type Fatty Acid-Binding Protein as a New Renal Biomarker |
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115 | (22) |
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8 Rapid Diagnostic Tests for Oxidative Stress Status |
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137 | (12) |
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9 Analytical Procedures for Nitrative/Nitrosative Stress |
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149 | (10) |
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10 An Animal Model of Citrin Deficiency, the Citrin/Mitochondrial Glycerol 3-Phosphate Dehydrogenase Double-Knockout Mouse |
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159 | (24) |
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11 Antioxidant Supplementation and Therapies |
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183 | (28) |
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12 Edaravone Therapy: From Bench to Bedside |
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211 | (8) |
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13 The Use of Melatonin against Oxidative Stress in Pediatric Disorders |
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219 | (14) |
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14 Thioredoxin Therapy: Challenges in Translational Research |
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233 | (22) |
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| Part III Clinical Topics |
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15 Allergic and Immunological Disorders |
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255 | (16) |
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16 Oxidative Stress in Kawasaki Disease |
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271 | (12) |
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17 Environmental Pollution and Health Consequences |
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283 | (18) |
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18 Oxidative Stress in Inflammatory Bowel Disease |
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301 | (14) |
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19 Genetic Disorders and Oxidative Stress (Especially Chronic Granulomatous Disease) |
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315 | (14) |
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20 Growth, Puberty, and Nutritional Disturbances |
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329 | (20) |
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349 | (22) |
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22 Infectious and Inflammatory Disorders |
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371 | (16) |
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23 Oxidative Stress in Inherited Metabolic Diseases |
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387 | (18) |
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24 Neurological Disorders (Especially Developmental Brain Disorders) |
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405 | (16) |
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25 Oxidative Stress in Kidney Diseases |
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421 | (20) |
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441 | (16) |
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27 Oxidative Stress and Pulmonary Vascular Disorders |
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457 | (24) |
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| Index |
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481 | |
Hirokazu Tsukahara, MD, PhD graduated from the School of Medicine at Kyoto University, in Kyoto, Japan and obtained his PhD in medical science from Fukui Medical School, in Fukui, Japan. He is currently Associate Professor at the Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. Dr. Tsukahara is a clinical scientist, specializing in the field of pediatrics and biological responses. He is the author or coauthor of more than 200 scientific papers and book chapters on general pediatrics, neonatology, endocrinology, metabolic diseases, infectious diseases, and cardiovascular diseases. His experimental research is focused on the chemistry and biology of nitric oxide, free radicals, and other bioactive mediators.
Kazunari Kaneko, MD, PhD graduated from the School of Medicine at Niigata University in Niigata, Japan and obtained his PhD in medical science from Juntendo University, in Tokyo. He is currently Professor and Chairman of the Department of Pediatrics at Kansai Medical University, Osaka, Japan. Dr. Kaneko is a pediatric nephrologist and a leading scientist in clinical studies, specializing in nephrotic syndrome and electrolyte disorders. He has also conducted basic research into the pathophysiological roles of nitric oxide and reactive oxygen species in diverse pediatric kidney diseases. He is currently a member of several regional and international societies including: Japan Pediatric Society (Councilor), Pediatric Nephrology (Executive board member), International Pediatric Nephrology Association, International Society of Nephrology, and American Society of Nephrology. He is on the editorial boards of several well-regarded medical journals, including International Journal of Nephrology, Clinical and Experimental Nephrology, and Journal of Pediatric Biochemistry.
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