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E-grāmata: Switchable and Responsive Surfaces and Materials for Biomedical Applications

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Edited by (Principal Scientist, Semprus BioSciences, USA)
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Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics.

Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

  • A comprehensive overiew of switchable and responsive materials and surfaces
  • Includes in depth analysis of thermo-responsive polymers, photonic sensitve materials and peptide-based surfaces
  • Detailed exploration of biological ineractions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices

Papildus informācija

A comprehensive scientific overview of the issues and methods involved with effective surface engineering of biomaterials to enhance their compatibility with the human body
List of contributors
ix
Woodhead Publishing Series in Biomaterials xi
Introduction xv
Part One Switchable and responsive materials and surfaces
1(164)
1 Thermo-responsive polymers: structure and design of smart materials
3(42)
A.K. Teotia
H. Sami
A. Kumar
1.1 Introduction
3(1)
1.2 Thermo-responsive polymers and their characteristics
4(2)
1.3 Types of thermo-responsive polymers
6(14)
1.4 Physical forms of switchable materials and their applications
20(10)
1.5 Summary
30(15)
References
31(14)
2 Environmentally responsive polyelectrolytes and zwitterionic polymers
45(20)
M.T. Bernards
2.1 Introduction
45(1)
2.2 Monomer subunits and polymerization approaches
46(3)
2.3 General solution properties
49(3)
2.4 Stimuli-induced changes and their applications
52(6)
2.5 Future trends
58(1)
2.6 Sources of further information
58(7)
References
59(6)
3 Peptide-based switchable and responsive surfaces
65(28)
M. Zelzer
3.1 Introduction
65(3)
3.2 Preparation of peptide surfaces
68(4)
3.3 Responsive peptide surfaces
72(5)
3.4 Peptides attached to responsive surfaces
77(4)
3.5 Protein surfaces
81(2)
3.6 Physical properties and characterisation
83(5)
3.7 Emerging applications
88(1)
3.8 Future trends
89(4)
References
90(3)
4 Photonic sensitive switchable materials
93(26)
L. Jiang
L. Wen
4.1 Introduction
93(1)
4.2 Photonic sensitive switchable materials
94(5)
4.3 Potential applications
99(12)
4.4 Conclusions and future trends
111(8)
References
112(7)
5 Responsive polymer brushes for biomedical applications
119(28)
N. Akkilic
W.M. de Vos
5.1 Introduction
119(4)
5.2 Brush architecture
123(1)
5.3 Types of responsive polymer brushes
124(7)
5.4 Biomedical applications
131(7)
5.5 Summary and future trends
138(9)
References
141(6)
6 Preparation and analysis of switchable copolymers for biomedical application
147(18)
M. Nitschke
S. Gramm
6.1 Introduction
147(1)
6.2 Switchable copolymer coatings
147(6)
6.3 Advanced analytical techniques
153(8)
6.4 Future trends
161(1)
6.5 Sources of further information
161(4)
References
161(4)
Part Two Biological interactions and biomedical applications of switchable surfaces
165(134)
7 Interaction of switchable biomaterials surfaces with proteins
167(22)
Q. Yu
H. Chen
7.1 Introduction
167(1)
7.2 Protein adsorption on surfaces
168(1)
7.3 Protein adsorption on thermo-responsive surfaces
169(5)
7.4 Protein adsorption on pH and/or ionic strength-responsive surfaces
174(4)
7.5 Protein adsorption on other responsive surfaces
178(2)
7.6 Synergistic effect of surface chemistry and nanostructures on protein adsorption
180(1)
7.7 Aspects for future research
181(8)
Acknowledgments
182(1)
References
183(6)
8 Interaction of responsive/switchable surfaces with cells
189(14)
B.L. Banik
J.L. Brown
8.1 Introduction
189(1)
8.2 Controlling stem cell behavior
190(1)
8.3 Interfacial properties
191(3)
8.4 Physical behavior
194(4)
8.5 Future trends
198(5)
References
199(2)
Further reading
201(2)
9 Temperature-responsive polymers for cell culture and tissue engineering applications
203(32)
Y. Akiyama
T. Okano
9.1 Introduction
203(1)
9.2 Methods for preparing temperature-responsive cell culture surfaces (TRCSs) and their characteristics
204(16)
9.3 Cell sheet-based regenerative medicine
220(3)
9.4 Future application of temperature-responsive cell culture surface to support and promote regenerative medicine field
223(12)
References
225(10)
10 Stimuli-sensitive polymers for drug delivery and diagnostic systems interacting with biosurfaces
235(24)
T. Yoshida
10.1 Introduction
235(1)
10.2 Polymers sensitive to body's internal stimuli
236(9)
10.3 Polymers sensitive to the body's external stimuli
245(6)
10.4 Future trends
251(8)
References
252(7)
11 Application of responsive polymers in implantable medical devices and biosensors
259(40)
J. Li
M. Stachowski
Z. Zhang
11.1 Introduction
259(1)
11.2 Biocompatibility of medical devices and responsive polymers
260(2)
11.3 Cardiovascular devices
262(7)
11.4 Drug delivery/infection control coatings and devices
269(2)
11.5 Surgical devices
271(3)
11.6 Dental and orthopedic devices
274(2)
11.7 Ophthalmic devices
276(2)
11.8 Respiratory devices
278(1)
11.9 Gastrointestinal devices
279(1)
11.10 Urogenital devices/urinary devices
279(1)
11.11 Insulin delivery devices for diabetes management
280(1)
11.12 Biosensors
281(6)
11.13 Summary
287(12)
References
288(11)
Index 299
Semprus BioSciences, Cambridge, MA, USA
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