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Synopsis of Pathophysiology in Nuclear Medicine 2014 ed. [Hardback]

  • Formāts: Hardback, 357 pages, height x width: 254x178 mm, weight: 928 g, 88 Illustrations, color; 100 Illustrations, black and white; XVII, 357 p. 188 illus., 88 illus. in color., 1 Hardback
  • Izdošanas datums: 06-Jun-2014
  • Izdevniecība: Springer International Publishing AG
  • ISBN-10: 331903457X
  • ISBN-13: 9783319034577
Citas grāmatas par šo tēmu:
Synopsis of Pathophysiology in Nuclear Medicine 2014 ed.Palielināt
  • Formāts: Hardback, 357 pages, height x width: 254x178 mm, weight: 928 g, 88 Illustrations, color; 100 Illustrations, black and white; XVII, 357 p. 188 illus., 88 illus. in color., 1 Hardback
  • Izdošanas datums: 06-Jun-2014
  • Izdevniecība: Springer International Publishing AG
  • ISBN-10: 331903457X
  • ISBN-13: 9783319034577
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9783319034577.html
Keywords:
This book offers a synopsis of the pathophysiologic basis of nuclear medicine and molecular imaging. It concisely relates anatomic, physiologic and pathologic aspects to the scintigraphy of each organ system.

This Synopsis of Nuclear Medicine Pathophysiology arose from the recognition that there is a need for a compact, readable account of this complex and important subject. The book concisely describes relevant anatomic and physiologic considerations for each organ system and the pathophysiologic features of different relevant diseases and relates them to the scintigraphy of each system. It thereby provides an informative synopsis of the pathophysiologic basis of nuclear medicine and molecular imaging. The volume will serve as a quick reference that will help the reader to understand different diagnostic scintigraphic patterns and to select appropriate treatment modalities based on functional imaging. It will prove useful to undergraduates and postgraduates as well as to practitioners in clinical and research fields.

Recenzijas

This book is organized into 15 chapters for a total of 357 pages. Most of the chapters include extremely educational high-quality figures and/or tables. this book serves as a quick reference that may help readers understand different scintigraphic patterns and select appropriate treatment modalities, on the basis of an understanding of pathophysiology. a more compact and easily readable text on this complex and important subject. (Nicola Frega and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 42, 2015)

1 Pathophysiology: General Principles
1(8)
1.1 Introduction
1(1)
1.2 Pathology
1(1)
1.3 Definition of Disease
2(1)
1.3.1 Homeostasis
2(1)
1.3.2 The Genome
2(1)
1.4 Physiology
2(1)
1.5 Pathophysiology
2(1)
1.6 Basic Major Principles of Pathophysiology
3(6)
1.6.1 Cell Injury
3(1)
1.6.2 Cell and Tissue Response to Injury
4(4)
References
8(1)
2 The Cell and Tissue Biology
9(18)
2.1 Introduction
9(1)
2.2 Cell Structure and Function
9(4)
2.2.1 Plasma Membrane
11(1)
2.2.2 Cytoplasm and Its Organelles
11(1)
2.2.3 Cytoskeleton
12(1)
2.2.4 Nucleus
12(1)
2.3 The Genetic Material and Gene Expression
13(2)
2.3.1 The Genetic Material: DNA
13(1)
2.3.2 Gene Expression and Protein Synthesis
14(1)
2.3.3 Genetic Code
15(1)
2.3.4 DNA Translation: Protein Synthesis
15(1)
2.4 Cell Reproduction
15(2)
2.4.1 The Cell Cycle
15(1)
2.4.2 Mitosis and Cytokinesis
15(1)
2.4.3 Rates of Cell Division
16(1)
2.4.4 Chromosomes and Diseases
16(1)
2.5 Cell Transformation and Differentiation
17(1)
2.6 Normal and Malignant Growth
17(4)
2.6.1 Normal Growth
17(3)
2.6.2 Neoplastic Growth
20(1)
2.7 Cellular Metabolism
21(1)
2.7.1 Role of ATP
21(1)
2.7.2 Production of ATP
21(1)
2.8 Transport Through the Cell Membrane
21(3)
2.8.1 Transport of Water and Solutes
21(2)
2.8.2 Transport by Vesicle Formation
23(1)
2.8.3 Transport by Transmission of Electrical Impulses
24(1)
2.9 Cell Death
24(3)
2.9.1 Imaging Cell Death
24(1)
References
25(2)
3 Basis of Radiopharmaceutical Localization
27(14)
3.1 Radiopharmaceuticals
27(1)
3.2 Mechanism(s) of Radiopharmaceutical Localization
27(14)
3.2.1 Isotope Dilution
29(1)
3.2.2 Capillary Blockade
29(1)
3.2.3 Physicochemical Adsorption
29(1)
3.2.4 Cellular Migration and Sequestration
29(1)
3.2.5 Membrane Transport
30(3)
3.2.6 Metabolic Substrates and Precursors
33(1)
3.2.7 Radiopharmaceuticals for Tissue Hypoxia Imaging
34(1)
3.2.8 Cell Proliferation Radiopharmaceuticals
35(1)
3.2.9 Specific Receptor Binding
35(3)
3.2.10 Imaging Gene Expression Mechanism
38(1)
References
38(3)
4 Inflammation
41(18)
4.1 Definition
41(1)
4.2 Classification of Inflammation
42(1)
4.3 General Pathophysiological Changes of Inflammation
42(4)
4.3.1 Local Pathophysiological Changes of Inflammation
42(3)
4.3.2 Systemic Pathophysiological Changes of Inflammation
45(1)
4.3.3 Pathophysiological Changes of Healing
45(1)
4.4 Pathophysiology of Major Soft Tissue Inflammation
46(3)
4.4.1 Abdominal Inflammation
46(1)
4.4.2 Chest Inflammation
47(1)
4.4.3 Renal Inflammation
48(1)
4.5 Pathophysiology of Major Skeletal Inflammations
49(1)
4.6 Radiopharmaceuticals for Inflammation Imaging
49(2)
4.7 Infection Imaging
51(8)
4.7.1 Imaging of Soft Tissue Infections
51(4)
4.7.2 Imaging of Skeletal Infection
55(1)
References
56(3)
5 Musculoskeletal System
59(46)
5.1 Anatomical and Physiological Considerations
59(4)
5.1.1 Bone Structure
59(1)
5.1.2 Blood Supply
60(1)
5.1.3 Bone Remodeling
60(1)
5.1.4 Bone Marrow
61(1)
5.1.5 Response of Bone to Injury
62(1)
5.2 Bone Diseases
63(25)
5.2.1 Nonneoplastic Bone Diseases
63(7)
5.2.2 Avascular Necrosis (Osteonecrosis)
70(4)
5.2.3 Complex Regional Pain Syndrome-1 (CRPS-1)
74(2)
5.2.4 Fibrous Dysplasia
76(1)
5.2.5 Trauma
76(3)
5.2.6 Growth-Plate Injury
79(1)
5.2.7 Metabolic Bone Diseases
79(7)
5.2.8 Arthropathy
86(2)
5.3 Neoplastic Bone Disease
88(17)
5.3.1 Primary Bone Tumors
88(5)
5.3.2 Metastatic Bone Disease
93(8)
References
101(4)
6 Genitourinary System
105(20)
6.1 Anatomical and Physiological Considerations
105(2)
6.1.1 Major Structures
105(1)
6.1.2 The Nephron
106(1)
6.1.3 Renal Vasculature
107(1)
6.1.4 Juxtaglomerular Apparatus
107(1)
6.2 Renal Radiopharmaceuticals
107(1)
6.3 Renal Scintigraphy
107(1)
6.3.1 Principles of Interpretation
108(1)
6.4 Major Diseases
108(17)
6.4.1 Renovascular Hypertension (RVH)
108(2)
6.4.2 Urine Outflow Obstruction
110(1)
6.4.3 Urinary Tract Infection
111(4)
6.4.4 Renal Transplantation Complications
115(2)
6.4.5 Vesicoureteral Reflux
117(2)
6.4.6 Testicular Torsion
119(3)
References
122(3)
7 Endocrine System
125(32)
7.1 Thyroid Gland
125(9)
7.1.1 Anatomical and Physiological Considerations
125(3)
7.1.2 Thyroid Radiopharmaceuticals
128(1)
7.1.3 Major Thyroid Disorders
129(5)
7.1.4 Thyroid Dysfunction During Pregnancy
134(1)
7.2 Parathyroid Gland
134(10)
7.2.1 Anatomical and Physiological Considerations
134(2)
7.2.2 Hyperparathyroidism
136(1)
7.2.3 Parathyroid Adenoma
137(2)
7.2.4 Parathyroid Hyperplasia
139(1)
7.2.5 Parathyroid Carcinoma
139(1)
7.2.6 Hyperfunctioning Parathyroid Transplant
139(1)
7.2.7 Consequences of Hyperparathyroidism
140(1)
7.2.8 Preoperative Parathyroid Localization
140(1)
7.2.9 Scintigraphic Localization
141(2)
7.2.10 Atypical Washout of Radiotracer
143(1)
7.2.11 Intraoperative Probe Localization
144(1)
7.3 Adrenal Gland
144(13)
7.3.1 Anatomical and Physiological Considerations
144(1)
7.3.2 Adrenal Cortex
145(2)
7.3.3 Adrenal Medulla
147(5)
7.3.4 Incidental Adrenal Mass
152(1)
References
152(5)
8 Cardiovascular System
157(34)
8.1 The Heart
157(21)
8.1.1 Anatomical Considerations
157(2)
8.1.2 Physiological Considerations
159(1)
8.1.3 Assessment of Left Ventricular Performance
159(1)
8.1.4 Pathophysiology of Cardiac Dysfunction
160(3)
8.1.5 Scintigraphic Evaluation of Cardiac Function
163(5)
8.1.6 Pathophysiology of Coronary Artery Disease
168(1)
8.1.7 Scintigraphic Assessment of Coronary Artery Disease
169(9)
8.2 Lymphatic System
178(13)
8.2.1 Anatomy and Physiology of the Lymphatic System
178(1)
8.2.2 Pathophysiology of Lymphatic Conditions
179(1)
8.2.3 Scintigraphy of Lymphatic System
180(5)
References
185(6)
9 Digestive System
191(32)
9.1 The Esophagus
191(3)
9.1.1 Anatomical and Physiological Considerations
191(1)
9.1.2 Esophageal Motility Disorders
192(2)
9.2 The Stomach
194(2)
9.2.1 Anatomical and Physiological Considerations
194(1)
9.2.2 Disorders of Gastric Emptying
195(1)
9.2.3 Duodenogastric Reflux
196(1)
9.3 The Intestines
196(5)
9.3.1 The Small Intestine
196(3)
9.3.2 The Colon
199(2)
9.4 Salivary Gland
201(1)
9.4.1 Anatomical and Physiological Considerations
201(1)
9.4.2 Pathophysiology of Relevant Conditions
201(1)
9.5 Ascites
201(1)
9.6 Gastrointestinal Scintigraphy
202(6)
9.6.1 Radionuclide Esophageal Transit Time Study
202(1)
9.6.2 Gastroesophageal Reflux Study
202(1)
9.6.3 Gastric Emptying Study
202(1)
9.6.4 Duodenogastric Reflux Study
203(1)
9.6.5 Gastrointestinal Bleeding (GIB) Localization Study
203(1)
9.6.6 Meckel's Diverticulum Study
204(1)
9.6.7 Imaging of Inflammatory Bowel Disease
205(1)
9.6.8 Salivary Gland Imaging
206(1)
9.6.9 Imaging of Appendicitis
206(1)
9.6.10 Nonimaging Procedures
206(2)
9.7 Hepatobiliary System
208(15)
9.7.1 Anatomical and Physiological Considerations
208(1)
9.7.2 Radiopharmaceuticals for Hepatobiliary Imaging
208(2)
9.7.3 Scintigraphy of Liver Diseases
210(8)
References
218(5)
10 Nuclear Oncology
223(30)
10.1 Tumor Pathology
223(4)
10.1.1 Biological Behavior
224(2)
10.1.2 Tumor Grading
226(1)
10.1.3 Tumor Staging
227(1)
10.1.4 Tumor Growth Rate
227(1)
10.2 Tumor Biology
227(7)
10.2.1 Cell Growth and Cell Cycle
227(1)
10.2.2 Tumor Neovascularization (Angiogenesis)
228(1)
10.2.3 Distinguishing Features of Tumor Cells
228(1)
10.2.4 Invasion and Metastasis
229(1)
10.2.5 Carcinogenesis
230(3)
10.2.6 Apoptosis
233(1)
10.2.7 Hereditary Cancer
233(1)
10.3 Tumor Imaging and Pathophysiological Correlation
234(19)
10.3.1 Basis of Uptake of Tumor Radiopharmaceuticals
234(5)
10.3.2 Scintigraphic Imaging
239(10)
References
249(4)
11 Respiratory System
253(20)
11.1 Anatomical and Physiological Considerations
253(3)
11.1.1 Respiratory Airways
253(2)
11.1.2 Pulmonary Vasculature
255(1)
11.1.3 Respiratory Function
256(1)
11.1.4 Distribution of Ventilation and Perfusion
256(1)
11.2 Pulmonary Embolic Disease
256(9)
11.2.1 Pathogenesis and Risk Factors
257(1)
11.2.2 Deep Venous Thrombosis
257(1)
11.2.3 Pulmonary Thromboembolism
258(7)
11.3 Pulmonary Hypertension
265(1)
11.4 Pneumocystis carinii (jiroveci) Pneumonia
266(2)
11.5 Idiopathic Pulmonary Fibrosis
268(1)
11.6 Pulmonary Sarcoidosis
268(1)
11.7 Obstructive Airway Disease
269(1)
11.8 Lung Cancer
270(3)
References
270(3)
12 Central Nervous System
273(18)
12.1 Anatomical and Physiological Considerations
273(2)
12.2 Pathophysiology
275(3)
12.2.1 Cerebrovascular Disease
275(1)
12.2.2 Dementia
275(1)
12.2.3 Epilepsy
276(1)
12.2.4 Brain Tumors
276(1)
12.2.5 Hydrocephalus
277(1)
12.2.6 Cerebrospinal Fluid Leakage
277(1)
12.2.7 Brain Death
277(1)
12.3 Scintigraphic Evaluation of CNS Diseases
278(13)
12.3.1 Radiopharmaceuticals
278(1)
12.3.2 Scintigraphic Imaging Techniques
278(1)
12.3.3 Clinical Applications
279(9)
References
288(3)
13 Nuclear Hematology
291(22)
13.1 Nuclear Hematology
291(1)
13.2 Blood Cells
291(3)
13.3 The Bone Marrow
294(3)
13.4 Erythropoiesis
297(1)
13.5 Iron Metabolism and Erythropoiesis
298(1)
13.6 Ferrokinetics
299(1)
13.7 Life Spans of Red Blood Cells
299(1)
13.8 Assessment of Red Cell Destruction
300(1)
13.9 Megaloblastic Anemia
301(3)
13.9.1 Causes of Vitamin B12 Deficiency
303(1)
13.9.2 Schilling's Test
303(1)
13.9.3 Food Cobalamin (Protein-Bound Vitamin B12) Malabsorption
304(1)
13.10 The Spleen
304(3)
13.10.1 Spleen Imaging
305(2)
13.10.2 Measurement of Splenic Function
307(1)
13.11 Bone Marrow
307(1)
13.12 Blood Platelets
308(5)
13.12.1 Measurement of Platelet Survival
310(1)
References
311(2)
14 Basis of Therapeutic Nuclear Medicine
313(16)
14.1 Radionuclide Therapy
313(1)
14.2 Treatment of Hyperthyroidism
314(3)
14.2.1 Pathophysiology
314(2)
14.2.2 Mechanisms of Therapeutic Effects
316(1)
14.2.3 Factors Affecting the Dose of 131I Used for Therapy
316(1)
14.3 Treatment of Differentiated Thyroid Cancer
317(1)
14.4 Treatment of Pain Secondary to Skeletal Metastases
318(2)
14.4.1 Radiopharmaceuticals
319(1)
14.4.2 Mechanism of Action
319(1)
14.4.3 Choice of Radiopharmaceutical
320(1)
14.4.4 Clinical Use
320(1)
14.5 Treatment of Neuroendocrine Tumors
320(1)
14.6 Radioimmunotherapy
321(1)
14.7 Radionuclide Synovectomy
322(2)
14.7.1 Radiopharmaceuticals for Synovectomy
323(1)
14.7.2 Mechanism of Action
323(1)
14.7.3 Choice of Radiopharmaceutical
323(1)
14.7.4 Clinical Use
323(1)
14.8 Treatment of Primary and Secondary Liver Malignancies
324(1)
14.9 Treatment of Malignant Effusions
325(1)
14.10 Peptide Receptor Radionuclide Therapy
325(1)
14.11 Combined Therapeutic Approach
325(4)
References
326(3)
15 Biological Effects of Ionizing Radiation
329(10)
15.1 Ionizing Radiation
329(1)
15.2 Mechanisms of Radiation Effects
330(2)
15.2.1 Direct Effect
330(1)
15.2.2 Indirect Effect
330(2)
15.3 Factors Affecting Radiation Hazards
332(1)
15.3.1 Factors Related to Ionizing Radiation
332(1)
15.3.2 Factors Related to Biological Target
332(1)
15.4 Radiation-Induced Cell Injury
333(1)
15.5 Various Effects of Radiation
333(4)
15.5.1 Early Radiation Effects
334(1)
15.5.2 Delayed Radiation Effects
335(2)
15.6 Exposure from Medical Procedures
337(2)
References
338(1)
Glossary 339(8)
Index 347