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E-grāmata: TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

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TCTP/tpt1 - Remodeling Signaling from Stem Cell to DiseasePalielināt
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This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis.

In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.

1 Introduction: How We Encountered TCTP and Our Purpose in Studying It
1(8)
Adam Telerman
Robert Amson
1.1 The Initial Years: The Tumor Reversion Project
2(1)
1.2 Learning to Work with High-Throughput Technology and the First Molecular Data
3(1)
1.3 The Year 2000: Giving a Decisive Turn into the Understanding of the Tumor Reversion Program
3(1)
1.4 The P53-TCTP Reciprocal Negative Feedback Loop and the Clinical Significance
4(1)
1.5 Conclusion and Perspectives
5(4)
References
6(3)
2 Structural Insights into TCTP and Its Interactions with Ligands and Proteins
9(38)
Nadine Assrir
Florian Malard
Ewen Lescop
2.1 Introduction
9(1)
2.2 Sequence and Structure of TCTP
10(11)
2.2.1 Description of the Structure of TCTP
10(2)
2.2.2 Structural Homologues of TCTP
12(5)
2.2.3 Functional Elements Within TCTP Sequence
17(4)
2.3 Binding Properties and Structural Aspects of TCTP in Complex with Ions, Small Molecules, Carbohydrates, Peptides, and Nucleic Acids
21(8)
2.3.1 Calcium Binding
21(2)
2.3.2 Antihistaminic Drugs and the Related Sertraline/Thioridazine
23(3)
2.3.3 Peptides
26(1)
2.3.4 Heme, Artemisinine, and Analogs
26(1)
2.3.5 Nucleic Acids
27(1)
2.3.6 Bombyx mori TCTP as a Binding Platform for Saccharides
28(1)
2.4 Structural Aspects of TCTP in Complex with Proteins
29(9)
2.4.1 TCTP Directly Interacts with Dozens of Proteins
29(6)
2.4.2 Structural Information on Native Complexes
35(3)
2.4.3 TCTP Tends to Self-associate
38(1)
2.5 Conclusions
38(9)
References
40(7)
3 Structure-Function Relationship of TCTP
47(22)
Beatriz Xoconostle-Cazares
Roberto Ruiz-Medrano
3.1 Introduction
48(1)
3.2 Conserved Functions of TCTP Across Kingdoms
49(1)
3.3 Taxon-Specific Functions of TCTP
50(10)
3.3.1 Fungi
51(1)
3.3.2 Plants
52(3)
3.3.3 Blood-Borne and Other Vertebrate Parasites
55(5)
3.4 Non-cell Autonomous Functions of TCTP
60(3)
3.5 Perspectives
63(6)
References
64(5)
4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation
69(58)
Ulrich-Axel Bommer
4.1 Introduction
70(5)
4.1.1 The `Translationally Controlled Tumour Protein TCTP': Names and History
71(1)
4.1.2 Gene Structure and mRNA
72(2)
4.1.3 Molecular Structure, Conservation and Interactions
74(1)
4.2 Biological Functions of TCTP
75(16)
4.2.1 Maintaining Cell Homoeostasis and Survival
75(6)
4.2.2 Involvement in the Cell Cycle and in Early Development
81(4)
4.2.3 TCTP in Cell Growth Regulation, Protein Synthesis and Degradation
85(3)
4.2.4 Extracellular Functions of TCTP
88(3)
4.3 Involvement of TCTP in Disease Processes
91(14)
4.3.1 TCTP in Human Cancer
91(7)
4.3.2 Participation in Immunological Reactions
98(2)
4.3.3 TCTP in Lower Animals and Parasitic Infections
100(3)
4.3.4 TCTP in Other (Patho)physiological Processes
103(2)
4.4 Regulation of Cellular TCTP Levels
105(7)
4.4.1 Cell Physiologic Conditions That Result in Regulation of TCTP Levels
105(1)
4.4.2 Mechanisms Involved in Regulation of Cellular TCTP Levels
105(7)
4.5 Synopsis
112(15)
References
114(13)
5 Current Understanding of the TCTP Interactome
127(10)
Siting Li
Feng Ge
5.1 Introduction
127(1)
5.2 Global Interactome Profiling Methods
128(1)
5.3 The Current Knowledge of the TCTP Interactome
129(4)
5.3.1 Chaperone Proteins
130(1)
5.3.2 Nucleic Acid-Binding Proteins
130(1)
5.3.3 Cytoskeletal Proteins
130(2)
5.3.4 Other Functions
132(1)
5.4 Concluding Remarks
133(4)
References
133(4)
6 Role and Fate of TCTP in Protein Degradative Pathways
137(12)
Michel Vidal
6.1 Introduction
138(1)
6.2 TCTP as Protein Stabilizer
138(3)
6.2.1 TCTP Masks the Ubiquitination Sites of Its Partners
139(1)
6.2.2 TCTP Binding Leads to E3 Ligase Degradation
140(1)
6.2.3 Mmi1/ScTCTP Modulates Proteasome Activity
140(1)
6.3 TCTP as Degradation Inducer
141(1)
6.4 TCTP Degradation
142(2)
6.5 Conclusion
144(5)
References
146(3)
7 Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development
149(24)
Leo Betsch
Julie Savarin
Mohammed Bendahmane
Judit Szecsi
7.1 Introduction
149(1)
7.2 Features of Plant TCTP Genes
150(4)
7.3 TCTP Is Essential for Plant Development
154(4)
7.4 Role of TCTP in Plant Signaling
158(8)
7.4.1 Is TCTP a Component of the TOR Pathway?
158(2)
7.4.2 Role of TCTP in Hormone Signaling
160(2)
7.4.3 Response to Abiotic and Biotic Stresses
162(4)
7.5 Conclusion
166(7)
References
166(7)
8 Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies
173(20)
Kwang-Wook Choi
Sung-Tae Hong
Thao Phuong Le
8.1 Introduction
173(1)
8.2 Identification of Drosophila Tctp Function in Organ Growth
174(1)
8.3 Role of Tctp in TOR Signaling
175(3)
8.4 Regulation of Tctp Function by 14-3-3
178(3)
8.5 Effects of 14-3-3 Isoforms and Tctp on Cyclin E
181(1)
8.6 Tctp Function in DNA Damage Control
181(3)
8.7 Tctp in Chromatin Remodeling and Genome Stability
184(1)
8.8 Concluding Remarks
185(8)
References
187(6)
9 Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms
193(8)
Andrea Senff-Ribeiro
9.1 Introduction
193(1)
9.2 Loxosceles intermedia TCTP
194(2)
9.3 Other TCTPs Found in Animal Venoms
196(2)
9.4 Perspectives
198(3)
References
199(2)
10 Tctp in Neuronal Circuitry Assembly
201(16)
Claudio Gouveia Roque
Christine E. Holt
10.1 Introduction
202(5)
10.1.1 Features of Axon Development
202(1)
10.1.2 Axonal mRNA Localization: One in Thousands
202(3)
10.1.3 Axon Guidance and Cancer: Shared Features
205(2)
10.1.4 Axonal Mitochondria
207(1)
10.2 TCTP in Neuronal Circuitry Assembly
207(5)
10.3 Summary and Future Directions
212(5)
References
213(4)
11 Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation
217(10)
Jacek Z. Kubiak
Malgorzata Kloc
11.1 TCTP and Cell Cycle
218(3)
11.1.1 The Role of TCTP Protein
218(2)
11.1.2 The Role of TCTP mRNA
220(1)
11.2 TCTP and Cytoskeleton
221(2)
11.2.1 TCTP and Microtubules
222(1)
11.2.2 TCTP and Actin
223(1)
11.3 Conclusions
223(4)
References
223(4)
12 The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radiation-Induced DNA Damage
227(28)
Jie Zhang
Grace Shim
Sonia M. de Toledo
Edouard I. Azzam
12.1 Introduction
228(2)
12.2 Primary Effects of Ionizing Radiation
230(2)
12.2.1 Direct and Indirect Effects of Ionizing Radiation
230(2)
12.3 Endogenous and Radiation-Induced DNA Alterations
232(5)
12.3.1 DNA Damage Response Pathways and DNA Damage Repair Mechanisms
233(4)
12.4 TCTP and the Sensing of Genotoxic Stress
237(3)
12.5 TCTP and the Repair of DNA Damage
240(2)
12.6 TCTP and Control of Cell Cycle Progression Under Normal and Stress Conditions
242(2)
12.7 TCTP and Cell Death
244(1)
12.8 Perspective
245(10)
References
247(8)
13 TCTP Has a Crucial Role in the Different Stages of Prostate Cancer Malignant Progression
255(8)
Virginie Baylot
Sara Karaki
Palma Rocchi
13.1 TCTP Is Upregulated in Prostate Cancer
256(1)
13.2 TCTP: A Promising Target in Castration-Resistant Prostate Cancer
256(4)
13.2.1 TCTP Mediates Heat Shock Protein 27 Cytoprotective Function in CRPC
256(1)
13.2.2 TCTP and P53 in CRPC: "Neither Can Live While the Other Survives"
257(2)
13.2.3 Development of a TCTP Antisense Oligonucleotide for Clinical Applications
259(1)
13.3 Discussion
260(3)
References
260(3)
14 Role of TCTP for Cellular Differentiation and Cancer Therapy
263(20)
Ean-Jeong Seo
Nicolas Fischer
Thomas Efferth
14.1 Introduction
265(3)
14.1.1 TCTP in Differentiation Processes
266(2)
14.2 TCTP in Cancer
268(3)
14.2.1 TCTP and Tumor Reversion
268(1)
14.2.2 TCTP as Antiapoptotic Protein
269(1)
14.2.3 Cell Cycle Regulation of TCTP
270(1)
14.2.4 TCTP Reduces Cellular Stress
271(1)
14.3 TCTP for Differentiation Therapy
271(4)
14.3.1 Approaches of Differentiation Therapy in General
271(1)
14.3.2 Retinoids
272(1)
14.3.3 Histone Deacetylase Inhibitors
272(1)
14.3.4 PPARγ Agonists
273(1)
14.3.5 Vitamin D
273(1)
14.3.6 Differentiation Therapy with Antihistaminic Drugs
274(1)
14.4 Conclusions and Perspectives
275(8)
References
276(7)
15 Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment
283(8)
Robert Amson
Christian Auclair
Fabrice Andre
Judith Karp
Adam Telerman
15.1 Introduction
283(1)
15.2 Experimental Approach
284(4)
15.3 Conclusion and Therapeutic Perspectives
288(3)
References
289(2)
16 History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy
291(18)
Susan M. MacDonald
16.1 Introduction/Cloning
292(1)
16.2 Clinical Relevance of HRF/TCTP
293(1)
16.3 HRF/TCTP Extracellular Functions
294(1)
16.4 Other Functions of HRF/TCTP (Mainly Intracellular)
295(1)
16.5 An Inducible HRF/TCTP Transgenic Mouse
296(2)
16.6 The Importance of Ship-1 on HRF/TCTP Signaling
298(2)
16.7 Additional Intracellular Signaling by HRF/TCTP
300(1)
16.8 HRF/TCTP as a Therapeutic Target
301(2)
16.9 Summary
303(6)
References
304(5)
Conclusion 309
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