This book provides a comprehensive overview of aging and its mechanisms through the prism of telomere length and its link to lifestyle parameters and environmental pollutants, diseases where telomere length attrition is prominent, and therapeutic approaches to slow down or prevent the process of telomere length reduction. It also provides an extensive comparison of the methodology for telomere length determination and characterization. The book will help researchers in any discipline to obtain an in-depth and broad knowledge of the most recent advances in telomere research written by specialists in the field. It is also addressed to the readers interested in gaining an insight into the processes of aging and those factors that affect graceful aging, enabling them to extract even useful tips in improving their everyday habits.
This book provides a comprehensive overview of aging and its mechanisms through the prism of telomere length and its link to lifestyle parameters and environmental pollutants, diseases where telomere length attrition is prominent, and therapeutic approaches to slow down or prevent the process of telomere length reduction.
PART I AGING
1 Aging
PART II TELOMERE LENGTH
2 Telomere Length as a Marker of Biological Age
3 Computational Tools for Telomere Length Measurement
PART III LIFESTYLE
4 The Impact of the First 1000 Days of Human Life on Telomere Length
5 Diet as a Strategy to Lengthen Life Expectancy
6 The First Steps toward Balanced Eating
7 Fasting and Telomeres
8 The Impact of Exercise on Telomere Length
9 Telomere Shortening: A Link between Substances of Abuse and Accelerated
Senescence
10 Telomere Length as Potential Metal Exposure Biomarker: State of the Art
and Perspectives
PART IV DISEASES
11 Telomeres Association with Diseases
12 Telomere Length and Metabolomics in Autoimmune Diseases
13 Osteoarthritis
14 Microbiome
15 Intestinal Microbiota and Human Telomere Length: A Dynamic Crosstalk
between Two Worlds
16 Cardiovascular Diseases and Telomeres
17 Decelerating Cardiovascular Aging: Diet, Exercise, and Medication
18 Male and Female Infertility
19 Telomere Length and Human Carcinogenesis: Liable or Random Finding?
20 Telomere Length Biology in Blood Disorders and Childhood Cancer
21 Skin Aging
PART V THERAPEUTIC APPROACHES
22 Telomeres, Telomerase, and Shelterin Complex: Promising Drug Targets for
Longevity, Age-Related Diseases, and Cancer
23 Therapeutic Targeting of Telomerase
Aristidis Tsatsakis is the director of the Department of Toxicology and Forensic Sciences at the Medical School of the University of Crete and the University Hospital of Heraklion, Greece. He is the founder and chief scientific leader of the University of Crete spinoff company ToxPlus S.A. and the startup LifePlus. Prof. Tsatsakis motivation logo Toxicology addresses societys real-life risks for sustainable health and wellbeing is indicated on the EUROTOX 2025 website.
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