Established as a definitive reference for the IVF laboratory and clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including Artificial Intelligence, gene editing, disaster management, freeze-all cycles, immunology, and transgender considerations. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts. *Gives both laboratory staff and clinicians a comprehensive resource for problems arising in Reproductive Medicine *Draws on international expertise for practice and guidelines *Presents a new edition of the pre-eminent reference text in laboratory and clinical aspects of Reproductive Medicine
Established as a definitive reference for the IVF laboratory and clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including Artificial Intelligence, gene editing, disaster management, freeze-all cycles, immunology, and transgender considerations.
Volume 1: Laboratory perspectives
Preface
1. Updated guidelines for setting up an assisted reproduction technology
laboratory.
2. Quality control maintaining stability in the laboratory.
3.
KPIs for the IVF laboratory.
4. QC in the Clouds-Digitizing quality control.
5. The assisted reproduction technology laboratory: Current standards.
6.
Evaluation of sperm.
7. Sperm preparation techniques and advanced sperm
selection for intracytoplasmic sperm injection.
8. Sperm chromatin
assessment.
9. Oocyte retrieval and selection.
10. Preparation and evaluation
of oocytes for intracytoplasmic sperm injection.
11. Use of IVM in a clinical
setting: What is its role in ART?.
12. Intracytoplasmic sperm injection:
Technical aspects.
13. Human embryo biopsy procedures.
14. Analysis of
fertilization.
15. Culture Systems for the Human Embryo.
16. Embryo selection
through the analysis of morphology and physiology.
17. Evaluation of embryo
quality: Time-lapse imaging to assess embryo morphokinesis.
18. Artificial
Intelligence (AI).
19. AI in Gamete and Embryo Selection.
20. Demystifying
vitrification.
21. Vitrification of the Human Oocyte.
22. The human embryo:
vitrification.
23. Managing an oocyte bank.
24. Severe male factor
infertility: Genetic consequences and recommendations for genetic testing.
25. Preimplantation genetic testing for aneuploidy to improve clinical
outcomes.
26. Diagnosis of endometrial receptivity, embryoendometrial
dialog, and endometrial microbiome.
27. Artificial Gametes: Oocytes.
28. How
microfluidics and microfabrication will improve diagnosis and treatment in
Human ART.
29. Genome Editing in Human Reproduction.
30. Designing Disaster
Plans for IVF Laboratories.
31. Early human embryo development revealed by
static imaging.
Index
Volume 2: Clinical perspectives
Preface
32. Quality management in reproductive medicine.
33. The use of
digitalisation and precision medicine in the IVF clinic.
34. Lifestyle,
periconception, and fertility.
35. Human Reproduction across the Life Course
and the Total Environment.
36. Indications for in vitro fertilization
treatment.
37. Initial investigation of the infertile couple.
38. Prognostic
testing for ovarian reserve.
39. Drugs used for ovarian stimulation:
Clomiphene citrate, aromatase inhibitors, metformin, gonadotropins,
gonadotropin releasing hormone analogs, and gonadotropins.
40. The role of
follicle-stimulating hormone and luteinizing hormone in ovarian stimulation:
Current concepts.
41. Endocrine characteristics of assisted reproductive
technology cycles.
42. The use of gonadotropin-releasing hormone agonists and
the efficiency of in vitro fertilization.
43. Gonadotropin-releasing hormone
antagonists in ovarian stimulation for in vitro fertilization.
44. GnRH
Agonist Triggering.
45. Segmentation of in vitro fertilization cycles.
46.
Controlled ovarian stimulation for freeze-all cycles.
47. Immunology in ART.
48. Monitoring of stimulated cycles in assisted reproduction.
49. Home
monitoring of ART cycles.
50. Oocyte collection.
51. Luteal phase support in
assisted reproduction techniques.
52. Treatment strategies in assisted
reproduction for the poor-responder patient.
53. The Poseidon stratification
of Low Prognosis Patients in ART: Management strategies and outcomes.
54.
Controlled ovarian stimulation for low responder patients.
55. Adjuvants for
poor responders.
56. Innovative therapies in Diminished Ovarian Reserve (DOR)
and Primary Ovarian Insuffiency (POI) patients.
57. Repeated Implantation
Failure.
58. Ultrasonography in Assisted Reproduction.
59. Sperm recovery
techniques: Clinical aspects and laboratory processing.
60. Embryo Transfer
Technique.
61. Cycle regimes for frozenthawed embryo transfer.
62. The role
of the anesthesiologist in In Vitro Fertilization.
63. Endometriosis and ART.
64. Polycystic ovary syndrome and assisted reproduction.
65. Fertility
preservation strategies.
66. Uterus transplantation in transition from
experimental to clinical procedure.
67. Viral disease and ART.
68. Fertility
options for transgender and nonbinary individuals.
69. Ovarian
Hyperstimulation Syndrome.
70. Bleeding, severe pelvic infection, and ectopic
pregnancy.
71. Egg and embryo donation.
72. Gestational surrogacy.
73.
Patient support in the assisted reproduction technology program.
74. The
relationship between stress and In Vitro Fertilization Outcome.
75. Risk and
safety management in assisted reproduction technology.
Index
David K. Gardner AM, FAA, DPhil is the Scientific Director of Melbourne IVF, and a Distinguished Professor in the School of BioSciences at the University of Melbourne, Australia.
Ariel Weissman MD is a Senior Physician at the IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, and a full Professor of Obstetrics and Gynecology at the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Colin M. Howles PhD, FRSM is based at Aries Consulting SARL, Geneva, Switzerland, and is an Honorary Fellow, University of Edinburgh, UK.
Zeev Shoham MD is a Professor at the Hebrew University, Jerusalem, Israel, a consultant in IVF, and co-founder of IVF-Worldwide.
