What happens with our genome and epigenome in the first fundamental days of our development? How can this be analysed? What do we need to know when faced with patients' questions about their own infertility, or how to prevent the birth of affected children? For the first time, this book brings together both scientists' and clinicians' viewpoints on human reproductive genetics, making for a more comprehensive discussion of interest to ART professionals and developmental biologists. With worldwide leaders in this burgeoning field guiding the reader through from the basics to the most exciting recent discoveries, this book presents the wider picture of how reproductive medicine and biology links with genetics. The editors also address the new challenges raised in how to treat and counsel patients at fertility and genetic clinics, as well as eliciting vivid bioethical debates. This book brings together genetics, reproductive biology and medicine for practitioners and geneticists.
Papildus informācija
This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.
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vii | |
| Preface |
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ix | |
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1 Basic genetics and cytogenetics: a brief reminder |
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1 | (14) |
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2 How to analyze a single blastomere? Application of whole genome technologies: microarrays and next generation sequencing |
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15 | (18) |
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3 Meiosis: how to get a good start in life |
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33 | (19) |
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4 Chromosomes in early human embryo development: incidence of chromosomal abnormalities, underlying mechanisms and consequences for development |
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52 | (16) |
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5 DNA is not the whole story: transgenerational epigenesis and imprinting |
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68 | (15) |
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6 Genes are not the whole story: retrotransposons as new determinants of male fertility |
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83 | (14) |
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7 Chromosomal causes of infertility: the story continues |
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97 | (16) |
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113 | (14) |
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9 Genetic counseling and gamete donation in assisted reproductive treatment |
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127 | (19) |
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10 Genetic testing for infertile patients |
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146 | (11) |
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11 Preimplantation genetic diagnosis |
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157 | (15) |
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12 Epigenetics and assisted reproductive technology |
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172 | (12) |
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Aafke P. A. van Montfoort |
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13 Ethical considerations in human reproductive genetics |
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184 | (15) |
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| Index |
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199 | |
Karen Sermon is Professor, Research Group Reproduction and Genetics, Vrije Universiteit Brussel, Brussels, Belgium. Stéphane Viville is Professor in the Institute de Génétique et de Biologie Moléculaire, University of Strasbourg, Strasbourg, France.
