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Part I Structure, Function and Regulation |
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The Human Pulmonary Circulation |
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1 The Human Pulmonary Circulation: Historical Introduction |
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3 | (10) |
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Structure and Function of the Pulmonary Circulation |
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2 Microcirculation of the Lung: Functional and Anatomic Aspects |
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13 | (12) |
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3 Pulmonary Vascular Development |
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25 | (36) |
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4 Pulmonary Vascular Function |
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61 | (12) |
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5 Pulmonary Vascular Mechanics |
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73 | (18) |
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6 Modeling of the Pulmonary Vasculature |
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91 | (14) |
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7 Metabolic and Clearance Function at the Pulmonary Microvascular Endothelial Surface in Pulmonary Hypertension |
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105 | (12) |
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Pulmonary Vasomotor Tone, Vascular Reactivity, and Vascular Permeability |
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8 The Influence of the Major Vasoactive Mediators Relevant to the Pathogenesis of Pulmonary Hypertension |
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117 | (18) |
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9 The Normal Fetal and Neonatal Pulmonary Circulation |
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135 | (12) |
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10 Excitation-Contraction Coupling and Regulation of Pulmonary Vascular Contractility |
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147 | (20) |
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11 Endothelial Regulation of Pulmonary Vascular Tone |
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167 | (30) |
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12 Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers |
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197 | (26) |
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13 Ion Channels and Transporters in the Pulmonary Vasculature: A Focus on Smooth Muscle |
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223 | (22) |
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14 Receptor-Mediated Signal Transduction and Cell Signaling |
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245 | (16) |
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15 Role of Calcium as a Second Messenger in Signaling: A Focus on Endothelium |
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261 | (12) |
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16 Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells |
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273 | (14) |
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Geerten P. van Nieuw Amerongen |
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Oxygen Sensing and Reactive Oxygen Specials in the Lung |
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17 The Chemistry of Biological Gases |
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287 | (14) |
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18 Role of Oxygen-Derived Species in the Regulation of Pulmonary Vascular Tone |
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301 | (12) |
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19 Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O2 Sensing |
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313 | (10) |
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Cell Proliferation and Apoptosis |
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20 Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation |
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323 | (12) |
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21 Role of Ca2+ in Vascular Smooth Muscle Gene Expression and Proliferation |
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335 | (12) |
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22 Biochemistry and Cellular Mechanisms of Apoptosis in Vascular Smooth Muscle and Endothelial Cells |
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347 | (10) |
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Coagulation, Thrombosis, and Fibrinolysis |
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23 The Coagulation Cascade and Its Regulation |
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357 | (14) |
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24 Platelets in Pulmonary Vascular Physiology and Pathology |
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371 | (14) |
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25 Lysis and Organization of Pulmonary Thromboemboli |
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385 | (14) |
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Interactions of Pulmonary Vascular Cells with Circulating Blood Cells |
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26 Interactions of Leukocytes and Coagulation Factors with the Vessel Wall |
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399 | (12) |
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27 Interaction of the Plasminogen System with the Vessel Wall |
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411 | (14) |
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28 Endothelial Apoptosis and Repair in Pulmonary Arterial Hypertension |
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425 | (14) |
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The Systemic Circulation in the Lung |
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29 Bronchial Arterial Circulation in the Human |
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439 | (14) |
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Part II Methodological Approaches for Research |
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In vivo and Genetic Animal Models |
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30 Animal Models of Pulmonary Hypertension |
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453 | (6) |
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31 Transgenic and Gene-Targeted Mouse Models for Pulmonary Hypertension |
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459 | (12) |
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32 Animal Models of Increased Lung Vascular Permeability |
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471 | (14) |
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Morphological, Functional, and Regulatory Approaches |
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33 Isolation and Culture of Pulmonary Vascular Smooth Muscle and Endothelial Cells |
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485 | (10) |
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34 Conventional Patch Clamp Techniques and High-Throughput Patch Clamp Recordings on a Chip for Measuring Ion Channel Activity |
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495 | (16) |
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35 Measurement of Pulmonary Vascular Structure and Pulmonary Blood Distribution by Multidetector-Row Computed Tomography and Magnetic Resonance Imaging Techniques |
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511 | (14) |
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Molecular Biological Techniques |
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36 Quantification of DNA, RNA, and Protein Expression |
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525 | (14) |
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37 Gene Cloning, Transfection, and Mutagenesis |
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539 | (18) |
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38 Approaches for Manipulation of Gene Expression |
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557 | (10) |
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Genomic, Proteomic and Bioinformatical Approaches |
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39 Bioinformatics, Genomics, and Functional Genomics: Overview |
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567 | (14) |
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40 Genomic Applications to Study Pulmonary Hypertension |
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581 | (10) |
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41 Proteomics and Functional Proteomics |
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591 | (22) |
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42 Maintenance, Propagation, and Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells |
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613 | (8) |
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43 Identification of Adult Stem and Progenitor Cells in the Pulmonary Vasculature |
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621 | (16) |
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44 Differentiation of Embryonic Stem Cells to Vascular Cell Lineages |
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637 | (14) |
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Clinical Research Approaches |
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45 Statistics and Clinical Data Analysis: A Reference Guide |
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651 | (24) |
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Part III Pathology and Pathobiology |
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Hypoxia and Hyperoxia in the Development of Pulmonary Hypertension |
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46 Hypoxic Pulmonary Vasoconstriction |
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675 | (8) |
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47 Pathogenic Roles of Ca2+ and Ion Channels in Hypoxia-Mediated Pulmonary Hypertension |
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683 | (12) |
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48 Roles of Endothelium-Derived Vasoactive and Mitogenic Factors in the Development of Chronic-Hypoxia-Mediated Pulmonary Hypertension |
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695 | (18) |
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49 Oxygen-Sensitive Transcription Factors and Hypoxia-Mediated Pulmonary Hypertension |
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713 | (12) |
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50 Developmental Regulation of Pulmonary Vascular Oxygen Sensing |
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725 | (8) |
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51 Pulmonary Vascular Remodeling by High Oxygen |
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733 | (26) |
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Pulmonary Vasoconstriction and Vascular Remodeling in Pulmonary Hypertension |
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52 Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms |
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759 | (20) |
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53 Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure |
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779 | (8) |
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54 Shear Stress, Cell Signaling, and Pulmonary Vascular Remodeling |
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787 | (14) |
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55 Pulmonary Hypertension and the Extracellular Matrix |
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801 | (10) |
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56 Role of Progenitor Cells in Pulmonary Vascular Remodeling |
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811 | (14) |
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57 Receptor Signaling in Pulmonary Arterial Hypertension |
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825 | (12) |
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Patricia A. Thistlethwaite |
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Endothelium and Thrombosis in the Development of Pulmonary Hypertension |
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58 Role of Endothelium in the Development of Pulmonary Hypertension |
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837 | (14) |
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59 Coagulation and the Vessel Wall in Pulmonary Embolism |
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851 | (10) |
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Pulmonary Edema and Acute Lung Injury |
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60 Alveolar Epithelial Fluid Transport in Lung Injury |
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861 | (10) |
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61 High-Altitude Pulmonary Edema |
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871 | (18) |
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62 Statins and Acute Lung Injury |
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889 | (10) |
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63 Genomics of Acute Lung Injury and Vascular Barrier Dysfunction |
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899 | (14) |
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64 Ventilator-Induced Mechanical Stress and Lung Vascular Dysfunction |
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913 | (24) |
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Part IV Pulmonary Vascular Diseases |
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Nomenclature, Classification and Epidemiology of Pulmonary Hypertension |
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65 Classification of Pulmonary Hypertension: History and Perspectives |
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937 | (6) |
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66 Epidemiology of Pulmonary Arterial Hypertension |
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943 | (20) |
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67 Air Pollution and the Pulmonary Vasculature |
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963 | (16) |
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Pulmonary Arterial Hypertension |
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68 Idiopathic Pulmonary Arterial Hypertension |
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979 | (18) |
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69 Genetics of Familial and Idiopathic Pulmonary Arterial Hypertension |
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997 | (14) |
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70 Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases |
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1011 | (12) |
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71 Pathology and Management of Portopulmonary Hypertension |
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1023 | (10) |
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72 Pathobiology and Treatment of Pulmonary Hypertension in HIV Disease |
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1033 | (10) |
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73 Pulmonary Arterial Hypertension Secondary to Anorexigensand Other Drugs and Toxins |
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1043 | (18) |
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74 Pulmonary Arterial Hypertension Related to Gaucher's Disease, Sarcoidosis, and Other Disorders |
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1061 | (22) |
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Pulmonary Arterial Hypertension in Pediatric Patients |
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75 Pediatric Pulmonary Hypertension: An Integrated View from Pediatric Subspecialists |
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1083 | (26) |
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76 Persistent Pulmonary Hypertension of the Newborn: Mechanisms and Treatment |
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1109 | (10) |
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77 The Pulmonary Circulation in Congenital Heart Disease |
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1119 | (20) |
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78 Pulmonary Hypertension Secondary to Congenital Systemic-to-Pulmonary (Left-to-Right) Shunts |
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1139 | (14) |
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79 Surgical Evaluation of Congenital-Heart-Disease-Associated Pulmonary Hypertension |
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1153 | (16) |
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Pulmonary Venous Hypertension |
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80 Pulmonary Veno-occlusive Disease |
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1169 | (14) |
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81 Left Ventricular Diastolic Heart Function and Pulmonary Hypertension |
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1183 | (6) |
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Pulmonary Hypertension Associated with Hypoxia and Hypoxemia |
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82 Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Diseases |
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1189 | (8) |
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83 Pulmonary Hypertension Associated with Interstitial Lung Disease |
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1197 | (14) |
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84 High-Altitude Pulmonary Hypertension |
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1211 | (12) |
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85 Pulmonary Hypertension and Congenital Heart Defects at High Altitude |
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1223 | (8) |
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Alexandra Heath de Freudenthal |
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Franz-Peter Freudenthal Tichauer |
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Carmen R. Condori Taboada |
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Pulmonary Hypertension due to Chronic Thrombotic and/or Embolic Disease |
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86 Pulmonary Embolism and Deep Vein Thrombosis |
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1231 | (8) |
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87 Pulmonary Hypertension Due to Pulmonary Embolism and Thromboembolic Obstruction of Proximal and Distal Pulmonary Arteries |
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1239 | (14) |
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88 Risk Factors for Chronic Thromboembolic Pulmonary Hypertension |
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1253 | (8) |
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89 Evaluation of Small-Vessel Arteriopathy in Chronic Thromboembolic Pulmonary Hypertension |
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1261 | (8) |
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90 Hemolytic-Anemia-Associated Pulmonary Hypertension: Sickle-Cell-Disease-and Thalassemia-Associated Pulmonary Hypertension |
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1269 | (14) |
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Pulmonary Hypertension due to Disorders Directly Affecting the Pulmonary Vasculature |
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91 Pulmonary Hypertension Due to Schistosomiasis |
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1283 | (14) |
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92 Pulmonary Hypertension Due to Capillary Hemangiomatosis |
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1297 | (8) |
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Right Heart Dysfunction and Pulmonary Hypertension |
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93 Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease |
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1305 | (8) |
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94 Right Ventricular Dysfunction in Pulmonary Hypertension |
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1313 | (20) |
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Other Disorders of the Pulmonary Circulation |
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95 Large Vessel Pulmonary Arteritis |
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1333 | (10) |
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96 Tumors of the Pulmonary Vascular Bed |
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1343 | (12) |
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1355 | (22) |
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98 Pregnancy and Contraception in Patients with Pulmonary Arterial Hypertension |
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1377 | (10) |
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Part V Diagnosis and Treatment |
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Diagnostic Approaches for Pulmonary Vascular Diseases |
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99 Cardiac Catheterization in the Patient with Pulmonary Hypertension |
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1387 | (16) |
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100 Imaging of Pulmonary Vascular Diseases |
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1403 | (10) |
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101 Histological and Pathological Diagnosis of Pulmonary Hypertension: Pathological Classification of Pulmonary Vascular Lesions |
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1413 | (12) |
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102 Echocardiography in Pulmonary Vascular Disease |
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1425 | (22) |
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Therapeutic Interventions for Pulmonary Vascular Diseases |
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103 Calcium Channel Blockers in the Treatment of Pulmonary Arterial Hypertension |
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1447 | (4) |
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104 Prostacyclin and Prostaglandins |
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1451 | (14) |
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105 Endothelin Receptor Antagonists for the Treatment of Pulmonary Arterial Hypertension |
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1465 | (12) |
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106 Phosphodiesterase Inhibitors in the Treatment of Pulmonary Hypertension |
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1477 | (10) |
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107 Nitric Oxide for Children |
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1487 | (14) |
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108 The Serotonin System as a Therapeutic Target in Pulmonary Hypertension |
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1501 | (8) |
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109 Combination Therapy for Pulmonary Arterial Hypertension |
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1509 | (12) |
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110 Thrombolytic and Anticoagulant Therapy for Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension |
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1521 | (10) |
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111 Nursing Care of Patients with Pulmonary Arterial Hypertension |
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1531 | (28) |
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Interventional and Surgical Approaches to Treatment of Pulmonary Vascular Diseases |
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1559 | (8) |
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113 Evaluation of Patients with Chronic Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy |
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1567 | (8) |
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114 Pulmonary Endarterectomy |
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1575 | (16) |
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115 Evaluation of Patients with Pulmonary Hypertension for Lung Transplantation |
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1591 | (6) |
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116 Lung Transplantation for Pulmonary Hypertension |
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1597 | (4) |
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117 Living-Donor Lobar Lung Transplantation for Pulmonary Arterial Hypertension |
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1601 | (10) |
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118 Results of Lung Transplantation |
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1611 | (14) |
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| Index |
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1625 | |
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