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E-grāmata: Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 2: Diagnosis, Therapeutic Targets, and Molecular Mechanisms

Edited by Ramakrishna Vadde (Assistant Professor, Department of Biotechnology and Bioinformatics, Yogi Vemana University, India), Edited by Ganji Purnachandra Nagaraju (Assistant Professor, School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL, USA)

Formāts: EPUB+DRM
Izdošanas datums: 02-Apr-2022
Izdevniecība: Academic Press Inc
Valoda: eng
ISBN-13: 9780323993654

Citas grāmatas par šo tēmu:

Oncology

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Formāts: EPUB+DRM
Izdošanas datums: 02-Apr-2022
Izdevniecība: Academic Press Inc
Valoda: eng
ISBN-13: 9780323993654

Citas grāmatas par šo tēmu:

Oncology

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Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies.

This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

Provides detailed information on traditional and novel diagnostic tools for hepatocellular carcinoma
Discusses promising targeted therapies, both available and in development, explaining the best option to use for specific cases
Brings recent findings in immunotherapies, immune checkpoint inhibitors and nanotechnology-based therapeutic approaches for treatment of HCC

List of contributors

About the editors

xix

Preface

xxi

1 Hepatocellular carcinoma diagnosis

(6)

Gayathri Chalikonda

Sekani Allen

Ramakhshna Vadde

Ganji Pumachandra Nagaraju

Abstract

(1)

Keywords

(1)

Abbreviations

(1)

Introduction

(2)

Conflict of interest

(1)

Funding

(1)

References

(3)

2 Computational analysis of prognosis-related genes in liver cancer

(14)

Vigneshwar Suriya Prakash Sinnarasan

Dahrii Paul

Mathavan Muthaiyan

Dinakara Rao Ampasala

Amouda Venkatesan

Abstract

(1)

Keywords

(1)

Abbreviations

(1)

Introduction

(1)

Materials and methods

(1)

Data collection

(1)

Identification of differentially expressed genes

(1)

Functional enrichment analysis of differentially expressed genes

(1)

Network and module analysis

(1)

Survival analysis

(1)

Results

(1)

Identification of differentially expressed genes

(1)

Functional analysis

(1)

Protein---protein interaction network and hub genes

(1)

Survival analysis

(2)

Discussion

(2)

Conclusion

(1)

References

(2)

Further reading

(2)

3 Computational approaches to identify biomarkers, enzymes, and pathways of hepatocellular carcinoma

(14)

Amajala Krishna Chaitanya

Gudivad Indu Priya

Rama Rao Malla

Abstract

(1)

Keywords

(1)

Introduction

(1)

Computational methods/approaches used for identification of biomarkers/pathways/enzymes in hepatocellular carcinoma

(1)

Dataset selection from microarray data

(1)

Differentially expressed gene identification

(3)

Pathway enrichment analysis (gene ontology and Kyoto encyclopedia of genes and genomes)

(1)

Differentially expressed genes weighted correlation network analysis

(1)

Network analysis by protein-protein interaction

(1)

Hub genes validation

(1)

Hub gene survival analysis

(1)

Potential biomarkers identified through integrated hub-protein-protein interaction bioinformatics analysis

(1)

Significant genes and pathways identified through bioinformatics analysis

(1)

Enzymes identified through bioinformatics analysis

(1)

Conclusion

(1)

Acknowledgment

(1)

Conflict of interest

(1)

Funding

(1)

Abbreviations

(1)

References

(5)

4 Ribonucleic acid sequence analysis in deciphering hepatocellular carcinoma

(10)

Sravanthi Mannem

Muralidhar Yegireddy

Narayanan Krishnaswamy

Bala Prabhakar Girish

Prakash Nadoor

Abstract

(1)

Keywords

(1)

Abbreviations

(2)

Introduction

(1)

RNA-sequencing technologies and applications in cancer

(1)

Transcriptomics in hepatocellular carcinoma

(2)

RNAseq analysis of the tumor microenvironment in hepatocellular carcinoma

(1)

Noncoding RNAs as biomarkers in hepatocellular carcinoma

(1)

Conclusion and future perspectives

(1)

Conflict of interest

(1)

References

(2)

5 Hepatocarcinogenesis and the role of next-generation sequencing in liver cancer

(14)

Ngalah Bidii Stephen

Dhatri Madduru

Pranathi Pappu

Urvashi Vijay

Prashanth Suravajhala

Obul Reddy Bandapalli

Abstract

(1)

Keywords

(1)

Abbreviations

(1)

Introduction

(1)

Mechanisms of viral hepatocellular pathogenicity

(2)

Nonviral risk factors associated with liver cancer formation

(1)

Stages of liver cancer and risk factors involved

(1)

Genetic profiling of hepatocellular carcinoma using next-generation sequencing

(2)

Deep Sequencing and whole-exome sequencing in unveiling the heterogeneity of hepatocellular carcinoma

(1)

Genome arrays in liver cancer screening

(1)

Prospects of next-generation sequencing findings leading to precision medicine/therapy

(1)

References

(4)

6 Liver cancer: the tumor microenvironment and associated pathways

(24)

Ankit Banik

Karishma Shaw

Aejaz Ahmad Dar

Sujatha Peela

Pavan Kumar Kancharla

Abstract

(1)

Keywords

(1)

Abbreviation

(1)

Introduction

(1)

Major risk factors for developing liver cancer

(1)

Influence of the tumor microenvironment

(1)

Cellular components

(3)

Noncellular components

(1)

Molecular mechanisms

(1)

Loss of senescence control

(1)

Loss of cell cycle control

(1)

Dysregulation of apoptosis

(1)

Liver inflammation and hepatocarcinogenesis

(1)

Associated pathways

(1)

p53 Pathway

(1)

pRB pathway

(1)

NF-k3 pathway

(1)

Hippo/yes-associated protein pathway

(1)

Epithelial-to-mesenchymal transition-driving signaling pathways

(1)

Wnt/catenin pathway

(1)

Mitogen-activated protein kinase pathway

(1)

Janus kinases/signal transducers and activators of transcription pathway

(2)

PI3/AKT/mTOR pathway

(1)

Ubiquitin-proteasome pathway

(1)

Conclusion

(1)

References

(10)

7 Metabolic pathway-based target therapy to hepatocellular carcinoma: a computational approach

(22)

Gayatri Gouda

Manoj Kumar Gupta

Ravindra Donde

Lambodar Behera

Ramakrishna Vadde

Abstract

(1)

Keywords

(1)

Abbreviations

(1)

Introduction

(1)

Pathways to cause liver cancer

(1)

Notch signaling

(1)

Hippo signaling pathway

(1)

Raf/ERK pathway

(1)

Wnt signaling pathway

(1)

Computational approach

(1)

Microarray-based therapy

(1)

Identification of key genes

(1)

Protein-protein interaction

(1)

microRNA-based therapy

(1)

miRNA inhibition

(1)

Copy number variations study

(1)

Target therapy in liver cancer

(1)

Glucose metabolism---based target therapy

(1)

Amino acid metabolism---based target therapy

(1)

Glutamine metabolism

(1)

Proline metabolism

(1)

Branched-chain amino acid metabolism

(1)

Mathematical modeling

(1)

Ensemble modeling

(1)

Machine learning model

(1)

Genome-scale metabolic modeling

(1)

Epigenetic regulation

(1)

Conclusion

(1)

Conflict of interest

(1)

References

(9)

8 Targeting ion channels in hepatic cancer

105

(28)

Murugavel Ponnusamy

Senthilkumar Rajagopal

Abstract

105

(1)

Keywords

105

(1)

Abbreviations

105

(2)

Introduction

107

(1)

Ion channels

108

(2)

Ion channels in cancer pathophysiology

110

(1)

Ion channels in liver cancer

111

(1)

Ca2+'permeable channels in liver cancer

112

(4)

Targeting Ca2+ channels for liver cancer therapy

116

(2)

K+ channels in liver cancer

118

(2)

Targeting K channels for liver cancer therapy

120

(1)

Cl~ channels in liver cancer

121

(1)

Targeting Cl~ channels for liver cancer therapy

122

(1)

Na+ channels in liver cancer

123

(1)

Targeting Na+ channels for liver cancer therapy

124

(1)

Diagnostic and prognostic value of ion channels and their subunits in hepatic cancer

125

(1)

Summary and future perspectives

126

(1)

Conflict of interest

127

(1)

References

127

(6)

9 Tyrosine kinases: their role in hepatocellular carcinoma

133

(16)

Suchita Dattatray Shinde

Bichismita Sahu

Ambika Chamoli

Amit Mandoli

Kiran Kalia

Santosh Kumar Behera

Abstract

133

(1)

Keywords

133

(1)

Abbreviations

134

(1)

Introduction

134

(1)

Treatment of hepatocellular carcinoma

135

(1)

Curative therapies

136

(1)

Noncurative therapy

137

(1)

Involvement of tyrosine kinases in liver cancer

138

(1)

Classification of tyrosine kinases

138

(1)

Small molecules as tyrosine kinase inhibitors that target receptor tyrosine kinase

139

(1)

Vascular endothelial growth factor receptor

139

(1)

Platelet-derived growth factor receptor

140

(1)

Fibroblast growth factor receptor

141

(1)

Epidermal growth factor receptor

142

(1)

Other tyrosine kinase inhibitors

142

(1)

Small molecules as tyrosine kinase inhibitors that target nonreceptor tyrosine kinase

143

(1)

Conclusion and future perspectives

143

(2)

References

145

(4)

10 Role of transcription factors in hepatocellular carcinoma

149

(16)

Suchita Dattatray Shinde

Neeraj Kulkarni

Bichismita Sahu

Kiran Kalia

Santosh Kumar Behera

Abstract

149

(1)

Keywords

149

(1)

Abbreviations

149

(1)

Introduction to transcription factors

150

(1)

Hepatocellular carcinoma and transcription factor

151

(1)

v-myc Avian myelocytomatosis viral oncogene homolog transcription factor

152

(1)

v-myb Myeloblastosis viral oncogene homolog (avian)-like 2 transcription factor

153

(1)

Beta-catenin transcription factor

153

(1)

Activator protein-1 transcription factor

153

(1)

p53 Transcription factor

154

(1)

Hypoxia-inducible factor 1 transcription factor

154

(1)

E2F transcription factors

154

(1)

Homeobox protein transcription factor

154

(1)

Drugs targeting hepatocellular carcinoma and their mode of action

155

(1)

Sorafenib

155

(1)

Regorafenib

156

(1)

Nivolumab

157

(1)

Cabozanitnib

157

(1)

Lenvatinib

157

(1)

Pembrolizumab

157

(1)

Atezolizumab

158

(1)

Bevacizumab

158

(1)

Ramucirumab

158

(1)

YC-1

158

(1)

EF24

158

(1)

Hypoxia-inducible factor 1 inhibitors

159

(1)

INCB057643 and BMS-986158

159

(1)

Troglitazone

159

(1)

Conclusion and future perspectives

159

(1)

References

159

(6)

11 Modulatory act of diverse transcriptional factors in liver carcinoma

165

(20)

Rashmi Nagesh

Rajeshwari H. Patil

M. Naveen Kumar

K.M. Kiran Kumar

Shivaleela Biradar

Babu R. Lamani

Abstract

165

(1)

Keywords

165

(1)

Abbreviations

166

(1)

Introduction

166

(2)

Transcriptional regulation of activator protein 1 in hepatic cell carcinoma

168

(1)

Regulatory act of hypoxia-inducible factor 1 in hepatocellular carcinoma

169

(2)

Implications of E2F transcription factors in human primary liver carcinoma

171

(1)

Zinc finger homeobox 3 in hepatocellular carcinoma progression

172

(2)

Inference of forkhead box Ml in hepatocellular carcinoma

174

(1)

Influence of nuclear factor kappa-B transcription factor in hepatocellular carcinoma

175

(2)

Conclusions and future perspectives

177

(1)

Conflict of interest

177

(1)

References

177

(7)

Further reading

184

(1)

12 Association of specificity protein 1 with hepatocellular carcinoma

185

(10)

Nwamaka Iloani

Areeba Hafeez

Serena Bao

Victoria Dulemba

Christoffer Lambring

Umesh T. Sankpal

Riyaz Basha

Abstract

185

(1)

Keywords

185

(1)

Abbreviations

185

(1)

Introduction

186

(1)

The specificity protein transcription factor

186

(1)

CD147 protein and specificity protein 1

187

(1)

Cystathionine f-lyase

187

(1)

Ras guanine nucleotide-releasing protein 1

188

(1)

RING1 and YY1 binding protein

189

(1)

Noncoding RNA genes regulated by specificity protein 1 that promotes hepatocellular carcinoma

189

(1)

miR-130b-3p

189

(1)

Metastasis-associated lung adenocarcinoma transcript 1

190

(1)

Conclusions and future directions

191

(1)

Acknowledgment

192

(1)

References

192

(3)

13 Promising biomarkers for liver cancer

195

(14)

Ravikiran Tekupalli

Santosh Anand

Sowbhagya Ramachandregowda

Anupama Sindhghatta Kariyappa

Abstract

195

(1)

Keywords

195

(1)

Abbreviations

195

(1)

Introduction

196

(1)

Biomarkers

197

(1)

Serum biomarkers

198

(3)

Growth factors

201

(1)

Long noncoding RNAs

202

(1)

MicroRNAs

203

(1)

Conclusion

204

(1)

Acknowledgment

204

(1)

References

204

(5)

14 Molecular signaling and its role in drug resistance in hepatocellular carcinomas

209

(18)

Fayyaz Rasool

Binayak Kumar

Deepu Sharma

Sri Krishna Jayadev Magani

Abstract

209

(1)

Keywords

209

(1)

Abbreviations

209

(1)

Introduction

210

(1)

Signaling pathways and their significance in drug resistance

211

(1)

PI3K/AKT/mTOR pathway

212

(1)

Mitogen-activated protein kinase pathway

213

(2)

Wnt/beta-catenin pathway

215

(1)

JAK/STAT pathway

216

(1)

Cancer stem cells

217

(1)

Cancer stem cell markers in hepatocellular carcinoma

217

(1)

The cancer stem cell microenvironment

218

(1)

Cancer stem cell---regulating transcription factors

218

(1)

MicroRNAs as cancer stem cell regulators in liver cancer

219

(1)

Stem cell regulatory pathways

219

(1)

Conclusion

220

(1)

Conflict of interest

220

(1)

References

220

(7)

15 Multidrug resistance, a major obstacle in hepatocellular carcinoma treatment: challenges and future perspectives

227

(28)

Tarun Sahu

Arundhati Mehta

Henu Kumar Verma

L.V.K.S. Bhaskar

Abstract

227

(1)

Keywords

227

(1)

Abbreviations

228

(1)

Introduction

229

(1)

Current therapy for hepatocellular carcinoma

230

(1)

Chemotherapy

230

(1)

Immunotherapy

230

(1)

Radiotherapy

231

(1)

Surgical therapy

231

(1)

Molecular drug targets

232

(1)

Antiangiogenic factors

232

(1)

Sorafenib

232

(1)

Bevacizumab

233

(1)

Sunitinib

234

(1)

Pazopanib

234

(1)

Brivanib

234

(1)

Axitinib

235

(1)

Linifanib

235

(1)

Foretinib

235

(1)

Dovitinib

235

(1)

Anti-epidermal growth factor receptor inhibitors

235

(1)

Ramucirumab

235

(1)

Erlotinib

236

(1)

Lapatinib

236

(1)

Mammalian target of rapamycin pathway inhibitor

236

(1)

Rapamycin

237

(1)

Everolimus

237

(1)

Pathway associated with multidrug resistance

237

(4)

DNA repair pathway

241

(1)

Apoptotic pathway

242

(1)

Autophagy

243

(1)

Cancer stem cells

243

(1)

Tumor microenvironment

244

(1)

Therapeutic aspects (overcoming multidrug resistance)

244

(1)

Conclusion and future perspectives

245

(1)

References

246

(9)

16 Proliferative signaling pathways in hepatocellular carcinoma

255

(18)

Pradeep Madhamanchi

Kishore Madhamanchi

Sujatha Peela

Panchareddy Madhava Rao

Pallaval Veera Bramhachari

Prakash Babu Panithi

Abstract

255

(1)

Keywords

255

(1)

Abbreviations

255

(2)

Introduction

257

(1)

Significant targeting pathways in hepatocellular carcinoma

257

(1)

Epidermal growth factor receptor and epidermal growth factor receptor 2 signaling

257

(1)

Hepatocyte growth factor---mesenchymal epithelial transition signaling

258

(1)

Hippo signaling

258

(1)

Insulin glucose signaling

259

(1)

JAK/STAT signaling

260

(1)

MAP kinase signaling

260

(1)

mTOR signaling

261

(1)

Nodal signaling

261

(1)

Notch signaling

262

(1)

Nuclear receptor signaling

262

(1)

Phosphoinositide 3-kinase---protein kinase B signaling

263

(1)

Ras homolog A signaling

263

(1)

Transforming growth factor-beta signaling

263

(1)

Vascular endothelial growth factor signaling

264

(1)

Wnt/beta-catenin signaling

264

(1)

Conclusions and future perspectives

265

(1)

Conflict of interest

265

(1)

References

265

(6)

Further reading

271

(2)

17 Targeting angiogenesis in hepatocellular carcinoma

273

(8)

Neha Merchant

Afroz Alam

Sujatha Peela

Ganji Purnachandra Nagaraju

Abstract

273

(1)

Keywords

273

(1)

Abbreviations

273

(1)

Introduction

274

(2)

Antiangiogenic treatment for hepatocellular carcinoma

276

(1)

Imaging investigations for angiogenesis

276

(2)

Conclusion

278

(1)

Conflict of interest

278

(1)

Funding

278

(1)

References

278

(3)

18 Conventional and novel biomarkers for the diagnosis and prognosis of liver cancer

281

(26)

Pranathi Pappu

Urvashi Vijay

Dhatri Madduru

Ngalah Bidii Stephen

Prashanth Suravajhala

Obul Reddy Bandapalli

Abstract

281

(1)

Keywords

281

(1)

Abbreviations

282

(1)

Introduction

283

(2)

Various biomarkers known for hepatocellular carcinoma

285

(3)

Alpha-fetoprotein and lectin-bound alpha fetoprotein 3

288

(1)

Alpha-fetoprotein

288

(1)

Prothrombin induced by vitamin K absence II or des-~f-carboxy prothrombin

289

(1)

The GALAD model

290

(1)

Glypican 3, osteopontin, and novel biomarkers

290

(1)

Alypican 3

291

(1)

Osteopontin

291

(1)

Cystatin B

291

(1)

Golgi protein 73

292

(1)

Midikines

293

(1)

Alpha-L-fucosidase

293

(1)

Cytokeratin 19

293

(1)

Circulating tumor cells

294

(1)

Squamous cell carcinoma antigen

294

(1)

Heat shock protein

294

(2)

Transcribed ultraconserved region element 338

296

(1)

MicroRNAs

296

(1)

Transforming growth factor beta

297

(1)

Tumor-specific growth factor

297

(1)

Epidermal growth factor receptor

297

(1)

Hepatocyte growth factor

297

(1)

Diagnostic imaging

298

(1)

Ultrasound

298

(1)

CT scan and MRI scan

298

(1)

Next-generation sequencing analysis in hepatocellular carcinoma

299

(1)

Gut microbe markers

299

(1)

Conclusions

300

(1)

References

301

(5)

Further reading

306

(1)

19 Updates on the staging and treatment of hepatocellular carcinoma

307

(14)

Hariharasudan Mani

Saeed Ali

Sarfraz Ahmad

Abstract

307

(1)

Keywords

307

(1)

Abbreviations

307

(1)

Introduction

308

(1)

Staging

308

(1)

Treatment

308

(2)

Barcelona Clinic Liver Cancer stage 0

310

(1)

Barcelona Clinic Liver Cancer stage A (early stage)

311

(1)

Tumor ablation

312

(1)

Barcelona Clinic Liver Cancer stage B (intermediate stage)

312

(1)

Transarterial chemoembolization

312

(1)

Barcelona Clinic Liver Cancer stage C (advanced stage)

313

(1)

Barcelona Clinic Liver Cancer stage D (terminal stage)

314

(1)

Prognostic factors

314

(1)

Summary

314

(2)

Acknowledgment

316

(1)

References

316

(5)

20 ROS-mediated pathways: potential role in hepatocellular carcinoma biology and therapy

321

(16)

Rama Rao Malla

Rakshmitha Marni

Anandita Chakraborty

Abstract

321

(1)

Keywords

321

(1)

Abbreviations

321

(1)

Introduction

322

(1)

Reactive oxygen species biology

323

(1)

Reactive oxygen species mediates liver carcinogenesis

324

(1)

Reactive oxygen species-mediated cellular pathways

325

(2)

Reactive oxygen species in hepatocellular carcinoma therapy

327

(1)

Anticancer natural compounds

327

(3)

Conclusion

330

(1)

Acknowledgment

331

(1)

Conflict of interest

331

(1)

Funding

331

(1)

References

331

(6)

21 Dysregulated cell-signaling pathways in hepatocellular carcinoma: causes and therapeutic options

337

(20)

Vinit Singh Baghel

Sapnita Shinde

Vineeta Dixit

Naveen Kumar Vishvakarma

Atul Kumar Tiwari

Soumitra Tiwari

Dhananjay Shukla

Abstract

337

(1)

Keywords

337

(1)

Abbreviations

338

(1)

Introduction

338

(1)

Signaling factors and pathways implicated in hepatocellular carcinoma

339

(1)

Vascular endothelial growth factor receptor signaling

339

(1)

Epidermal growth factor receptor, insulin-like growth factor, and hepatocyte growth factor signaling

340

(1)

Ras/MAPK signaling pathway and hepatocellular carcinoma

340

(2)

Notch-signaling pathway

342

(2)

Signal transducer and activator of transcription signaling pathway

344

(1)

WNT/beta-catenin pathways

345

(1)

PI3K/AKT/mTOR signaling

345

(1)

Therapeutic options in hepatocellular carcinoma

346

(1)

Therapies targeting vascular endothelial growth factor and their receptors

346

(1)

Ras/MAPK inhibitors

346

(1)

Notch-signaling inhibitors

347

(1)

STAT-signaling inhibitors

347

(1)

Future prospects

348

(1)

Conclusion

348

(1)

References

349

(8)

22 LKB11/STK11-mediated signal transduction in hepatocellular carcinoma

357

(8)

Gorantla Sri Charitha

Nyshadham S.N. Chaitanya

Aramati Bindu Madhava Reddy

Abstract

357

(1)

Keywords

357

(1)

Abbreviations

357

(1)

Introduction

358

(1)

Liver kinase B1 as a regulator of hepatocellular carcinoma progression

359

(1)

Mechanism of liver kinase B1 signaling in hepatocellular carcinoma

359

(3)

Adenosine monophosphate---activated protein kinase as the downstream signaling mediator of liver kinase B1

362

(2)

Therapeutic strategies

364

(1)

Conclusion

365

(1)

Acknowledgments

365

(1)

References

365

(4)

Index

369

Dr. Nagaraju obtained his MSc and his PhD, both in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. He received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagarajus research focuses on translational projects related to gastrointestinal malignancies. He has published over 100 research papers in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. Dr. Nagaraju is author and editor of several published books in Elsevier and Springer Nature. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), The Science Advisory Board, The RNA Society, The American Association for Clinical Chemistry (AACC) and the American Association of Cancer Research (AACR). Dr Vadde Ramakrishna is Assistant Professor at the Department of Biotechnology & Bioinformatics, Yogi Vemana University, India. He obtained his MSc and PhD, both in Biochemistry, from Sri Krishnadevaraya University, Anantapur, India, and subsequently received a DBT CREST Award to pursue advanced training in cancer research at Pennsylvania State University and Colorado State University, USA. He is currently using in vitro, in vivo and in silico models to explore the role of dietary bioactive compounds in both the development and prevention of cancer through a polypharmacology approach. He has published over 90 research papers in prominent international journals and has presented more than 40 papers at national and international conferences. He serves as an editorial board member for several international journals, and is an Associate Fellow of Andhra Pradesh Academy of Sciences.

Biežāk uzdotie jautājumi par e-grāmatām

Permanent link: https://www.kriso.lv/db/97803239936546e.html

Keywords:

Liver - Cancer

E-grāmata: Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 2: Diagnosis, Therapeutic Targets, and Molecular Mechanisms

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