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E-grāmata: Therapeutic Applications of Dopamine D3 Receptor Function: New Insight After 30 Years Of Research

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Therapeutic Applications of Dopamine D3 Receptor Function: New Insight After 30 Years Of ResearchPalielināt
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The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor.

The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.

Preface.- A Historic Review of the D3 Dopamine System from D3 Cloning to
Clinical Trials in Schizophrenia and Drug Addiction.- Location, Location,
Location: The Expression of D3 Dopamine Receptors in the Nervous System.-
Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3
and D1 Receptor-Receptor Interaction and Striatal Function.- Involvement
of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity
of the Emotional Brain Circuits: Possible Role in Depression.- Dopamine D3
Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention
Target.- Dopamine D3 Receptors: A Potential Target to Treat Motivational
Deficits in Parkinsons Disease.- Therapeutic Challenges of Cognitive
Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3
Receptor.- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders.- The
Role of D3 Dopamine-Receptors in Nicotine Dependence:  A Synthesis of the
Pre-Clinical and ClinicalLiterature.- The Dopamine D3 receptor in Food
Addiction.- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of
D3 Receptor Ligands in Schizophrenia.- D3 receptors and Restless Legs
Syndrome.- D3 receptors and PET imaging.
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