Therapeutics of Natural and Synthetic Compounds in Protease Induced Cancer presents a detailed discussion on the role of therapeutic and synthetic compounds in proteases and how they have been utilized to develop anticancer drugs, covering both their structure and functions. In addition, the book explores the experimental and theoretical aspects of natural and synthetic compound design based on proteases. Sections bridge the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
In 23 chapters, this book gives both insights on the general aspects of the role of natural and synthetic compounds in cancer therapeutics, in cancer development, treatment, and their use in clinical trails. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and for those working to identify targets for drug development.
A. General Aspects
1. Therapeutic aspects of urokinase-plasminogen activator system in cancer
2. The role of acetylcholinesterase in cancer development and possible therapeutic applications by natural and synthetic compounds.
3. Influence of serine proteases on bone morphogenetic proteins: Insights for advancing treatment paradigm in breast cancer
4. Structural insights of proteases in cancer therapy perspectives
B. Role of Synthetic Compounds
5. Role of Boron containing synthetic compounds as serine proteases inhibitors in prostate cancer
6. Exploring Synthetic and Natural Compounds for Cathepsin B-mediated Breast Cancer: Mechanisms and Therapy Responses
C. Role of Natural Compounds
7. Flavonoids containing phytochemicals as protease inhibitors in cancer chemoprevention
8. Dietary proteases and their connection to cancer
9. Natural compounds as potential cancer therapeutics: A focus on curcumin and resveratrol
10. Snake venom proteases as potential cancer therapeutics
11. Autophagy Inhibition with Plant-Derived Alkaloids in Cancer Treatment: From Molecular Mechanisms to Targeted Therapy
12. From Naturally-sourced aspartic and metalloproteases inhibitors to therapeutic aspects of skin cancer
13. Compounds of plant origin as therapeutics for serine protease implicated in colorectal cancer
14. Plant peptides and proteins as protease inhibitors in breast cancer therapy
15. Exploring the Potentials of Genistein, Lycopene, Ellagic acid as Protease Inhibitors in Cancer Therapeutics
16. Modulation of serine proteases in liver cancer by quercetin - a therapeutic perspective
17. Role of natural bioactive small molecules as inhibitors for cysteine proteases in cancer
18. Natural compounds as inhibitors of MMPs
19. A Comprehensive Overview of Epigallocatechin Gallate and Its Role in Human Osteosarcoma inhibition.
20. Exploring the natural repository of serine protease inhibitors for cancer therapeutics
D. Protease inhibitors in Clinical Trials
21. Inhibitors of matrix metalloproteinases in clinical trials
22. Breast cancer therapeutics by protease inhibitors
23. Clinical trials on the efficacy of anticancer protease inhibitors on breast, prostate, lung
Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 40 years teaching and independent research experience in biochemistry, molecular physiology and cell biology. He has published over 110 original research articles, dozens of review articles and book chapters, and also edited fifteen books.
