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E-grāmata: Transcriptomics and Gene Regulation

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  • Formāts: PDF+DRM
  • Sērija : Translational Bioinformatics 9
  • Izdošanas datums: 17-Nov-2015
  • Izdevniecība: Springer
  • Valoda: eng
  • ISBN-13: 9789401774505
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Transcriptomics and Gene RegulationPalielināt
  • Formāts: PDF+DRM
  • Sērija : Translational Bioinformatics 9
  • Izdošanas datums: 17-Nov-2015
  • Izdevniecība: Springer
  • Valoda: eng
  • ISBN-13: 9789401774505
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This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing  analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, protein and gene expression data integration, and the influence of genetic variation such as single nucleotide polymorphisms on gene expression in complex human diseases etc. The book is useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, and physicians etc.   Dr. Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Centre, Houston, USA.?
1 Introductory and Historical Remarks
1(28)
Introduction
2(1)
A Short History of Respiratory Gases
3(4)
Of Energy and Work
7(3)
Oxidative and Anaerobic Metabolism
10(4)
The Respiratory System
14(3)
Maximal Oxygen Consumption
17(1)
The Oxygen Equilibrium Curve
18(2)
Exercise Transients
20(1)
The Perspective of This Book
21(3)
References
24(5)
2 Aerobic Metabolism and the Steady-State Concept
29(36)
Introduction
30(2)
The Steady-State Concept
32(1)
Quantitative Relationships at Steady State
33(4)
The Effects of Ventilation---Perfusion Heterogeneity
37(6)
Diffusion--Perfusion Interaction in Alveolar--Capillary Gas Transfer
43(2)
Breathing Pure Oxygen and the Correction for Nitrogen
45(1)
The Mechanical Efficiency of Exercise
46(3)
Energy Cost of Locomotion
49(5)
The Cardiovascular Responses to Exercise
54(1)
The Q-VO2 Diagram
55(4)
Conclusions
59(1)
References
60(5)
3 Exercise Transients
65(32)
Introduction
66(1)
The Energetics of the Oxygen Deficit During Light Exercise
67(4)
The Energetics of the Oxygen Deficit During Intense Exercise
71(2)
Mechanisms Underlying the Oxygen Deficit
73(2)
The Double-exponential Model of VO2 Kinetics
75(1)
Kinetics of Cardiac Output and Oxygen Delivery at Exercise Onset
76(3)
The VO2 Kinetics in Hypoxia
79(1)
The Slow Component
80(5)
The Effect of Priming Exercise
85(1)
Ramp and Sinusoidal Exercise
86(1)
The Problem of Gas Flow Analysis on a Breath-by-Breath Basis
87(2)
Conclusions
89(1)
References
90(7)
4 Maximal Oxygen Consumption
97(40)
Introduction
98(1)
The Unifactorial Vision of VO2max Limitation
99(2)
The Oxygen Cascade at Maximal Exercise
101(2)
An Analysis of di Prampero's Model
103(4)
Experimental Testing of di Prampero's Model
107(1)
An Analysis of Wagner's Model
108(1)
Experimental Testing of Wagner's Model
109(2)
A Critical Comparison of the Two Models
111(4)
Of Maximal Oxygen Consumption in Hypoxia
115(4)
Of Maximal Oxygen Consumption at the End of Bed Rest
119(4)
Of the Central Governor Hypothesis
123(2)
Of Measuring VO2max
125(3)
Conclusions
128(1)
References
128(9)
5 Critical Power
137(20)
Introduction
138(2)
The Physiological Meaning of the Energy Store Component
140(2)
Descriptive Physiology of Critical Power and Energy Store Component
142(1)
Energetic Consequences of the Hyperbolic Critical Power Model
143(2)
The Critical Power Model in Intermittent Exercise
145(1)
The Relationship Between VO2max, Critical Power and Maximal Aerobic Power
146(4)
Simultaneous Determination of Critical Power and Maximal Aerobic Power
150(1)
The Three-Parameter Model of Critical Power
151(2)
Conclusions
153(1)
References
154(3)
6 Supramaximal Exercise
157
Introduction
158(1)
The Meaning of Blood Lactate in Supramaximal Exercise
158(2)
On the Distribution of Lactate
160(2)
The Energetics of Supramaximal Exercise
162(2)
The Maximal Lactic Power
164(1)
The Maximal Lactic Capacity
165(1)
The P/La Ratio
166(2)
Energetics of All-Out Efforts of Extremely Short Duration
168(1)
The Measurement of Maximal Anaerobic Alactic Power
169(4)
Maximal Instantaneous Alactic Power and Aerobic Exercise
173(1)
Maximal Mean Alactic Power and Aerobic Exercise
174(2)
Anaerobic Alactic Capacity
176(1)
Conclusions
176(1)
References
177
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