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E-grāmata: Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop

  • Formāts: 90 pages
  • Izdošanas datums: 03-Apr-2019
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309488761
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  • Formāts: 90 pages
  • Izdošanas datums: 03-Apr-2019
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309488761
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To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.

Table of Contents



Front Matter 1 Introduction and Background 2 Genetically Modified Nonhuman Primate Models for Neuroscience Research: Rationale and Overview of Potential Opportunities and Challenges 3 State of the Science of Transgenic Nonhuman Primate Models for Nervous System Disorders 4 Translating Research from Nonhuman Primates to Humans 5 Bioethical Considerations for Transgenic Nonhuman Primate Models in Neuroscience Research 6 Understanding the Policy, Infrastructure, and Funding Needed to Advance Neuroscience Research Appendix A: References Appendix B: Workshop Agenda Appendix C: Registered Attendees
1 Introduction and Background
1(6)
Workshop Objectives
3(2)
Organization of the Proceedings
5(2)
2 Genetically Modified Nonhuman Primate Models for Neuroscience Research: Rationale and Overview of Potential Opportunities and Challenges
7(8)
Overcoming the Limitations of Mouse Models with Nonhuman Primate Models
8(1)
Opportunities Provided by Nonhuman Primate Models to Foster Neuroscience Research
9(1)
Challenges of Genetically Modified Nonhuman Primate Models
10(5)
3 State of the Science of Transgenic Nonhuman Primate Models for Nervous System Disorders
15(12)
Genetically Modified Nonhuman Primate Models of Disease
17(6)
Gene Modification as Therapy
23(4)
4 Translating Research from Nonhuman Primates to Humans
27(8)
A Translational Research Roadmap in Autism
28(2)
Assessment Tools for Nonhuman Primates
30(1)
Brain Mapping and Imaging in Genetically Modified Nonhuman Primates
31(4)
5 Bioethical Considerations for Transgenic Nonhuman Primate Models in Neuroscience Research
35(8)
3R Principles and Harm--Benefit
36(5)
Importance of Proactive Communication with the Public
41(2)
6 Understanding the Policy, Infrastructure, and Funding Needed to Advance Neuroscience Research
43(10)
Primate Research Centers
44(3)
Sharing Information and Data
47(1)
Training and Educating the Next Generation of Researchers
48(1)
Organizing Efforts to Meet Infrastructure and Scientific Needs
49(1)
Final Remarks
50(3)
APPENDIXES
A References
53(8)
B Workshop Agenda
61(8)
C Registered Attendees
69