Editorial Foreword. Introduction. Bone Grafting Evolution. Materials. Ceramics. Polymers. Composites. Currently available grafts on the market. Growth Factors. BMP-2 and BMP-7. Other growth factors and delivery mechanisms. DBM and grafts. Cells and Biologics. Cell sources for orthopaedic defects. Cell sources for craniofacial defects. Animal Models for regeneration. Infection and antibiotics. Clinical Perspective. Orthopaedic Trauma. Spinal reconstruction. Dental and craniofacial reconstruction. Regulatory and ease-of-use