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Understanding Pathophysiology - Binder Ready 6th ed. [Loose-leaf]

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(Professor College of Nursing University of Utah Salt Lake City UT), (Professor Emeritus College of Nursing University of Utah Salt Lake City UT)
  • Formāts: Loose-leaf, weight: 2270 g, Illustrations
  • Izdošanas datums: 22-Jan-2016
  • Izdevniecība: Mosby
  • ISBN-10: 0323639496
  • ISBN-13: 9780323639491
Citas grāmatas par šo tēmu:
  • Formāts: Loose-leaf, weight: 2270 g, Illustrations
  • Izdošanas datums: 22-Jan-2016
  • Izdevniecība: Mosby
  • ISBN-10: 0323639496
  • ISBN-13: 9780323639491
Citas grāmatas par šo tēmu:
Binder-Ready Edition: This loose-leaf copy of the full text is a convenient, accessible, and customizable alternative to the bound book. With this binder-ready edition, you can personalize the text to match your unique study needs! Master the important pathophysiology concepts you need to know with the most engaging and reader-friendly text available. Filled with vibrant illustrations and complemented by online resources that bring pathophysiology concepts to life, Understanding Pathophysiology, 6th Edition continues its tradition of delivering the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan, giving you the fundamental knowledge needed to move forward in your nursing education and career. New additions include a new chapter on epigenetics, new content on rare diseases, a separate chapter for male and female reproductive alterations, streamlined features, simplified language, and fully updated information throughout. Introduction to Pathophysiology in the front matter section provides intro to the subject of pathophysiology and explains why it is important.Consistent presentation helps readers better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease.More than 1,000 high-quality illustrations vividly depict clinical manifestations and cellular mechanisms underlying diseases.Lifespan coverage details age-specific conditions affecting pediatric, adult, and aging patients in depth.Algorithms throughout the text clarify disease progression.Risk Factor boxes alert readers to important safety considerations associated with specific diseases.Health Alert boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more.Quick Check boxes test readers retention of important chapter concepts.Geriatric Considerations boxes and Pediatric Considerations boxes highlight key considerations for these demographics in relevant chapters.Did You Understand? sections provide a fast and efficient review of chapter content.Chapter outlines help readers find specific information with ease.Chapter introductions explain why chapter content is important and how it fits into a broader health care context.Key terms are bolded throughout the text for fast, easy reference.Glossary of selected terms familiarizes readers with the most difficult or important terminology.Additional online resources on Evolve companion website offers access to animations, review questions, key terms matching exercises, and more.NEW! Chapter on Epigenetics gives readers knowledge and insight into key processes that influence normal and abnormal cell growth and development.NEW! Streamlined tables and flowcharts make information easier to access.NEW! Updated content throughout reflects the latest clinical findings and research across the full spectrum of pathophysiology.NEW! Additional content on rare diseases gives readers a more comprehensive understanding of conditions that affect the human body.NEW! Division of Alterations of the Reproductive Systems chapter will now cover male and female reproductive systems in separate chapters.NEW! 25 additional illustrations bring key concepts to life.
Part One Basic Concepts of Pathophysiology
Unit 1 The Cell
1 Cellular Biology
1(37)
Kathryn L. McCance
Prokaryotes and Eukaryotes
1(1)
Cellular Functions
1(1)
Structure and Function of Cellular Components
2(1)
Nucleus
2(1)
Cytoplasmic Organelles
2(1)
Plasma Membranes
2(1)
Cellular Receptors
9(1)
Cell-to-Cell Adhesions
10(1)
Extracellular Matrix
10(1)
Specialized Cell Junctions
11(1)
Cellular Communication and Signal Transduction
12(2)
Cellular Metabolism
14(1)
Role of Adenosine Triphosphate
16(1)
Food and Production of Cellular Energy
16(1)
Oxidative Phosphorylation
16(1)
Membrane Transport: Cellular Intake and Output
17(1)
Electrolytes as Solutes
18(1)
Transport by Vesicle Formation
21(1)
Movement of Electrical Impulses: Membrane Potentials
24(1)
Cellular Reproduction: The Cell Cycle
25(1)
Phases of Mitosis and Cytokinesis
26(1)
Rates of Cellular Division
26(1)
Growth Factors
26(1)
Tissues
27(1)
Tissue Formation
27(1)
Types of Tissues
27(11)
2 Genes and Genetic Diseases
38(24)
Lynn B. Jorde
DNA, RNA, and Proteins: Heredity at the Molecular Level
38(1)
Definitions
38(1)
From Genes to Proteins
39(3)
Chromosomes
42(1)
Chromosome Aberrations and Associated Diseases
42(7)
Elements of Formal Genetics
49(1)
Phenotype and Genotype
49(1)
Dominance and Recessiveness
49(1)
Transmission of Genetic Diseases
49(1)
Autosomal Dominant Inheritance
50(1)
Autosomal Recessive Inheritance
52(1)
X-Linked Inheritance
54(2)
Linkage Analysis and Gene Mapping
56(1)
Classic Pedigree Analysis
56(1)
Complete Human Gene Map: Prospects and Benefits
57(1)
Multifactorial Inheritance
57(5)
3 Epigenetics and Disease
62(11)
Diane P. Genereux
Lynn B. Jorde
Epigenetic Mechanisms
62(1)
DNA Methylation
62(1)
Histone Modifications
63(1)
RNA-Based Mechanisms
64(1)
Epigenetics and Human Development
64(1)
Genomic Imprinting
64(1)
Prader-Willi and Angelman Syndromes
65(1)
Beckwith-Wiedemann Syndrome
65(1)
Russell-Silver Syndrome
66(1)
Long-Term and Multigenerational Persistence of Epigenetic States Induced by Stochastic and Environmental Factors
66(1)
Epigenetics and Nutrition
66(1)
Epigenetics and Maternal Care
66(1)
Epigenetics and Mental Illness
67(1)
Twin Studies Provide Insights on Epigenetic Modification
68(1)
Molecular Approaches to Understand Epigenetic Disease
68(1)
Epigenetics and Cancer
68(1)
DNA Methylation and Cancer
68(1)
miRNAs and Cancer
69(1)
Epigenetic Screening for Cancer
69(1)
Emerging Strategies for the Treatment of Epigenetic Disease
69(1)
Future Directions
70(3)
4 Altered Cellular and Tissue Biology
73(41)
Kathryn L. McCance
Todd Cameron Grey
Cellular Adaptation
74(1)
Atrophy
74(1)
Hypertrophy
75(1)
Hyperplasia
76(1)
Dysplasia: Not a True Adaptive Change
77(1)
Metaplasia
77(1)
Cellular Injury
77(1)
General Mechanisms of Cell Injury
78(1)
Hypoxic Injury
78(1)
Free Radicals and Reactive Oxygen Species-Oxidative Stress
81(1)
Chemical or Toxic Injury
84(1)
Unintentional and Intentional Injuries
93(1)
Infectious Injury
96(1)
Immunologic and Inflammatory Injury
96(1)
Manifestations of Cellular Injury: Accumulations
96(1)
Water
97(1)
Lipids and Carbohydrates
98(1)
Glycogen
98(1)
Proteins
98(1)
Pigments
99(1)
Calcium
100(1)
Urate
101(1)
Systemic Manifestations
101(1)
Cellular Death
101(1)
Necrosis
102(1)
Apoptosis
104(1)
Autophagy
105(2)
Aging and Altered Cellular and Tissue Biology
107(1)
Normal Life Span, Life Expectancy, and Quality-Adjusted Life Year
108(1)
Degenerative Extracellular Changes
108(1)
Cellular Aging
108(1)
Tissue and Systemic Aging
109(1)
Frailty
109(1)
Somatic Death
109(5)
5 Fluids and Electrolytes, Acids and Bases
114(20)
Sue E. Huether
Distribution of Body Fluids and Electrolytes
114(1)
Water Movement Between Plasma and Interstitial Fluid
115(1)
Water Movement Between ICF and ECF
115(1)
Alterations in Water Movement
115(1)
Edema
115(1)
Sodium, Chloride, and Water Balance
116(3)
Alterations in Sodium, Chloride, and Water Balance
119(1)
Isotonic Alterations
119(1)
Hypertonic Alterations
119(1)
Hypotonic Alterations
121(1)
Alterations in Potassium and Other Electrolytes
122(1)
Potassium
122(1)
Other Electrolytes-Calcium, Phosphate, and Magnesium
125(1)
Acid-Base Balance
125(1)
Hydrogen Ion and pH
125(1)
Buffer Systems
125(1)
Acid-Base Imbalances
127(4)
Pediatric Considerations: Distribution Of Body Fluids
131(1)
Geriatric Considerations: Distribution of Body Fluids
131(3)
Unit 2 Mechanisms of Self-Defense
6 Innate Immunity: Inflammation and Wound Healing
134(24)
Neal S. Rote
Human Defense Mechanisms
134(1)
Innate Immunity
134(1)
First Line of Defense: Physical and Biochemical Barriers and the Human Microbiome
135(1)
Second Line of Defense: Inflammation
137(1)
Plasma Protein Systems and Inflammation
138(1)
Cellular Components of Inflammation
141(6)
Acute and Chronic Inflammation
147(1)
Local Manifestations of Acute Inflammation
149(1)
Systemic Manifestations of Acute Inflammation
149(1)
Chronic Inflammation
149(2)
Wound Healing
151(1)
Phase I: Inflammation
152(1)
Phase II: Proliferation and New Tissue Formation
152(1)
Phase III: Remodeling and Maturation
153(1)
Dysfunctional Wound Healing
153(1)
Pediatric Considerations: Age-Related Factors Affecting Innate Immunity in the Newborn Child
154(1)
Geriatric Considerations: Age-Related Factors Affecting Innate Immunity in the Elderly
154(4)
7 Adaptive Immunity
158(18)
Neal S. Rote
Third Line of Defense: Adaptive Immunity
158(2)
Antigens and Immunogens
160(1)
Antibodies
161(1)
Classes of Immunoglobulins
161(1)
Antigen-Antibody Binding
162(1)
Function of Antibodies
162(4)
Immune Response: Collaboration of B Cells and T Cells
166(1)
Generation of Clonal Diversity
166(1)
Clonal Selection
167(5)
Cell-Mediated Immunity
172(1)
T-Lymphocyte Function
172(1)
Pediatric Considerations: Age-Related Factors Affecting Mechanisms of Self-Defense in the Newborn Child
173(1)
Geriatric Considerations: Age-Related Factors Affecting Mechanisms of Self-Defense in the Elderly
173(3)
8 Infection and Defects in Mechanisms of Defense
176(38)
Neal S. Rote
Infection
176(1)
Microorganisms and Humans: A Dynamic Relationship
176(1)
Countermeasures Against Infectious Microorganisms
187(2)
Deficiencies in Immunity
189(1)
Initial Clinical Presentation
189(1)
Primary (Congenital) Immune Deficiencies
190(1)
Secondary (Acquired) Immune Deficiencies
192(1)
Evaluation and Care of Those with Immune Deficiency
193(1)
Replacement Therapies for Immune Deficiencies
193(1)
Acquired Immunodeficiency Syndrome (AIDS)
194(5)
Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity
199(1)
Mechanisms of Hypersensitivity
199(1)
Antigenic Targets of Hypersensitivity Reactions
206(8)
9 Stress and Disease
214(19)
Margaret F. Clayton
Kathryn L. McCance
Lorey K. Takahashi
Historical Background and General Concepts
214(1)
Stress Overview: Allostasis, Multiple Mediators, and Systems
217(1)
The Stress Response
218(1)
Regulation of the Hypothalamic-Pituitary-Adrenal System
218(1)
Neuroendocrine Regulation: Autonomic Nervous System
221(1)
Histamine and Other Hormones
223(1)
Role of the Immune System
225(1)
Stress, Personality, Coping, and Illness
225(1)
Coping
226(2)
Geriatric Considerations: Aging & the Stress-Age Syndrome
228(5)
Unit 3 Cellular Proliferation: Cancer
10 Biology of Cancer
233(33)
Neal S. Rote
David M. Virshup
Cancer Terminology and Characteristics
233(1)
Tumor Classification and Nomenclature
233(3)
The Biology of Cancer Cells
236(1)
Sustained Proliferative Signaling
238(1)
Evading Growth Suppressors
241(1)
Genomic Instability
242(1)
Enabling Replication Immortality
245(1)
Inducing Angiogenesis
245(1)
Reprograming Energy Metabolism
246(1)
Resisting Apoptotic Cell Death
247(1)
Tumor-Promoting Inflammation
248(1)
Evading Immune Destruction
250(1)
Activating Invasion and Metastasis
251(3)
Clinical Manifestations of Cancer
254(1)
Paraneoplastic Syndromes
254(1)
Pain
255(1)
Fatigue
255(1)
Cachexia
255(1)
Anemia
256(1)
Leukopenia and Thrombocytopenia
256(1)
Infection
257(1)
Gastrointestinal Tract
257(1)
Hair and Skin
258(1)
Diagnosis, Characterization, and Treatment of Cancer
258(1)
Diagnosis and Staging
258(1)
Classification of Tumors-Classic Histology and Modern Genetics
259(1)
Treatment
260(6)
11 Cancer Epidemiology
266(35)
Kathryn L. McCance
Genetics, Epigenetics, and Tissue
266(1)
Incidence and Mortality Trends
272(1)
In Utero and Early Life Conditions
272(2)
Environmental-Lifestyle Factors
274(1)
Tobacco Use
274(1)
Diet
276(1)
Nutrition, Obesity, Alcohol Consumption, and Physical Activity: Impacts on Cancer
276(1)
Ionizing Radiation
283(1)
Ultraviolet Radiation
287(1)
Electromagnetic Radiation
289(1)
Infection, Sexual and Reproductive Behavior
290(1)
Other Viruses and Microorganisms
292(1)
Air Pollution
292(1)
Chemical and Occupational Hazards as Carcinogens
293(8)
12 Cancer in Children and Adolescents
301(6)
Lauri A. Linder
Nancy E. Kline
Incidence, Etiology, and Types of Childhood Cancer
301(1)
Etiology
302(1)
Genetic and Genomic Factors
303(1)
Environmental Factors
303(2)
Prognosis
305(2)
Part Two Body Systems and Diseases
Unit 4 The Neurologic System
13 Structure and Function of the Neurologic System
307(29)
Lynne M. Kerr
Sue E. Huether
Richard A. Sugerman
Overview and Organization of the Nervous System
307
Cells of the Nervous System
301(1)
The Neuron
307(1)
Neuroglia and Schwann Cells
308(1)
Nerve Injury and Regeneration
309(1)
The Nerve Impulse
309(1)
Synapses
311(1)
Neurotransmitters
311(1)
The Central Nervous System
311(1)
The Brain
311(1)
The Spinal Cord
318(1)
Motor Pathways
320(1)
Sensory Pathways
320(1)
Protective Structures of the Central Nervous System
321(1)
Blood Supply of the Central Nervous System
323(2)
The Peripheral Nervous System
325(1)
The Autonomic Nervous System
326(1)
Anatomy of the Sympathetic Nervous System
327(1)
Anatomy of the Parasympathetic Nervous System
329(1)
Neurotransmitters and Neuroreceptors
329(1)
Functions of the Autonomic Nervous System
329(3)
Geriatric Considerations: Aging & the Nervous System
332(4)
14 Pain, Temperature, Sleep, and Sensory Function
336(23)
George W. Rodway
Sue E. Huether
Jan Belden
Pain
336(1)
Neuroanatomy of Pain
336(1)
Pain Modulation
338(1)
Clinical Descriptions of Pain
339(3)
Temperature Regulation
342(1)
Control of Body Temperature
342(1)
Temperature Regulation in Infants and Elderly Persons
342(1)
Pathogenesis of Fever
342(1)
Benefits of Fever
343(1)
Disorders of Temperature Regulation
344(1)
Sleep
344(1)
Sleep Disorders
345(1)
The Special Senses
346(1)
Vision
346(1)
Hearing
350(1)
Olfaction and Taste
353(1)
Somatosensory Function
353(1)
Touch
353(1)
Proprioception
353(1)
Geriatric Considerations: Aging & Changes in Hearing
354(1)
Geriatric Considerations: Aging & Changes in Olfaction and Taste
354(5)
15 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
359(31)
Barbara J. Boss
Sue E. Huether
Alterations in Cognitive Systems
359(1)
Alterations in Arousal
359(1)
Alterations in Awareness
365(1)
Data Processing Deficits
367(1)
Seizure Disorders
372(1)
Types of Seizure
373(1)
Alterations in Cerebral Hemodynamics
373(1)
Increased Intracranial Pressure
374(1)
Cerebral Edema
375(1)
Hydrocephalus
376(1)
Alterations in Neuromotor Function
376(1)
Alterations in Muscle Tone
376(1)
Alterations in Muscle Movement
377(1)
Upper and Lower Motor Neuron Syndromes
381(1)
Motor Neuron Diseases
384(1)
Amyotrophic Lateral Sclerosis
384(1)
Alterations in Complex Motor Performance
385(1)
Disorders of Posture (Stance)
385(1)
Disorders of Gait
385(1)
Disorders of Expression
386(1)
Extrapyramidal Motor Syndromes
386(4)
16 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction
390(32)
Barbara J. Boss
Sue E. Huether
Central Nervous System Disorders
390(1)
Traumatic Brain and Spinal Cord Injury
390(1)
Degenerative Disorders of the Spine
400(1)
Cerebrovascular Disorders
402(1)
Headache
406(1)
Infection and Inflammation of the Central Nervous System
408(1)
Demyelinating Disorders
411(1)
Peripheral Nervous System and Neuromuscular Junction Disorders
412(1)
Peripheral Nervous System Disorders
412(1)
Neuromuscular Junction Disorders
412(2)
Tumors of the Central Nervous System
414(1)
Brain Tumors
414(1)
Spinal Cord Tumors
417(5)
17 Alterations of Neurologic Function in Children
422(17)
Lynne M. Kerr
Sue E. Huether
Vinodh Narayanan
Development of the Nervous System in Children
422(1)
Structural Malformations
423(1)
Defects of Neural Tube Closure
423(1)
Craniosynostosis
426(1)
Malformations of Brain Development
427(2)
Alterations in Function: Encephalopathies
429(1)
Static Encephalopathies
429(1)
Inherited Metabolic Disorders of the Central Nervous System
429(1)
Acute Encephalopathies
430(1)
Infections of the Central Nervous System
431(1)
Cerebrovascular Disease in Children
431(1)
Perinatal Stroke
431(1)
Childhood Stroke
431(1)
Epilepsy and Seizure Disorders in Children
432(1)
Childhood Tumors
432(1)
Brain Tumors
432(1)
Embryonal Tumors
435(4)
Unit 5 The Endocrine System
18 Mechanisms of Hormonal Regulation
439(21)
Valentina L. Brashers
Sue E. Huether
Mechanisms of Hormonal Regulation
439(1)
Regulation of Hormone Release
439(1)
Hormone Transport
440(1)
Mechanisms of Hormone Action
440(3)
Structure and Function of the Endocrine Glands
443(1)
Hypothalamic-Pituitary System
443(1)
Pineal Gland
448(1)
Thyroid and Parathyroid Glands
448(1)
Endocrine Pancreas
451(1)
Adrenal Glands
453(4)
Geriatric Considerations: Aging & Its Effects on Specific Endocrine Glands
457(3)
19 Alterations of Hormonal Regulation
460(30)
Valentina L. Brashers
Robert E. Jones
Sue E. Huether
Mechanisms of Hormonal Alterations
460(1)
Alterations of the Hypothalamic-Pituitary System
461(1)
Diseases of the Posterior Pituitary
461(1)
Diseases of the Anterior Pituitary
463(3)
Alterations of Thyroid Function
466(1)
Thyrotoxicosis/Hypothyroidism
466(1)
Hypothyroidism
468(1)
Thyroid Carcinoma
469(1)
Alterations of Parathyroid Function
470(1)
Hyperparathyroidism
470(1)
Hypoparathyroidism
470(1)
Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
471(1)
Types of Diabetes Mellitus
472(1)
Acute Complications of Diabetes Mellitus
477(1)
Chronic Complications of Diabetes Mellitus
478(4)
Alterations of Adrenal Function
482(1)
Disorders of the Adrenal Cortex
482(1)
Disorders of the Adrenal Medulla
485(5)
Unit 6 The Hematologic System
20 Structure and Function of the Hematologic System
490(23)
Neal S. Rote
Kathryn L. McCance
Components of the Hematologic System
490(1)
Composition of Blood
490(1)
Lymphoid Organs
494(1)
The Mononuclear Phagocyte System
497(1)
Development of Blood Cells
497(1)
Hematopoiesis
497(1)
Development of Erythrocytes
500(1)
Development of Leukocytes
503(1)
Development of Platelets
504(1)
Mechanisms of Hemostasis
504(1)
Function of Platelets and Blood Vessels
504(1)
Function of Clotting Factors
507(1)
Retraction and Lysis of Blood Clots
507(1)
Pediatrics & Hematologic Value Changes
508(3)
Aging & Hematologic Value Changes
511(2)
21 Alterations of Hematologic Function
513(41)
Anna Schwartz
Kathryn L. McCance
Neal S. Rote
Alterations of Erythrocyte Function
513(1)
Classification of Anemias
513(1)
Macrocytic-Normochromic Anemias
515(1)
Microcytic-Hypochromic Anemias
517(1)
Normocytic-Normochromic Anemias
519(1)
Myeloproliferative Red Cell Disorders
519(1)
Polycythemia Vera
521(1)
Iron Overload
522(1)
Alterations of Leukocyte Function
523(1)
Quantitative Alterations of Leukocytes
523(8)
Alterations of Lymphoid Function
531(1)
Lymphadenopathy
531(1)
Malignant Lymphomas
532(6)
Alterations of Splenic Function
538(2)
Hemorrhagic Disorders and Alterations of Platelets and Coagulation
540(1)
Disorders of Platelets
541(1)
Alterations of Platelet Function
544(1)
Disorders of Coagulation
544(10)
22 Alterations of Hematologic Function in Children
554(15)
Joan Shea
Nancy E. Kline
Anna E. Roche
Kathryn L. McCance
Disorders of Erythrocytes
554(1)
Acquired Disorders
554(1)
Inherited Disorders
557(6)
Disorders of Coagulation and Platelets
563(1)
Inherited Hemorrhagic Disease
563(1)
Antibody-Mediated Hemorrhagic Disease
563(1)
Neoplastic Disorders
564(1)
Leukemia
564(1)
Lymphomas
565(1)
Hodgkin Lymphoma
566(3)
Unit 7 The Cardiovascular and Lymphatic Systems
23 Structure and Function of the Cardiovascular and Lymphatic Systems
569(29)
Susanna G. Cunningham
Valentina L. Brashers
Kathryn L. McCance
The Circulatory System
569(1)
The Heart
569(1)
Structures That Direct Circulation Through the Heart
570(1)
Structures That Support Cardiac Metabolism: The Coronary Vessels
573(1)
Structures That Control Heart Action
576(1)
Factors Affecting Cardiac Output
581(2)
The Systemic Circulation
583(1)
Structure of Blood Vessels
584(1)
Factors Affecting Blood Flow
587(1)
Regulation of Blood Pressure
589(1)
Regulation of the Coronary Circulation
592(1)
The Lymphatic System
592(6)
24 Alterations of Cardiovascular Function
598(57)
Valentina L. Brashers
Diseases of the Veins
598(1)
Varicose Veins and Chronic Venous Insufficiency
598(1)
Thrombus Formation in Veins
599(1)
Superior Vena Cava Syndrome
599(1)
Diseases of the Arteries
600(1)
Hypertension
600(1)
Orthostatic (Postural) Hypotension
604(1)
Aneurysm
604(1)
Thrombus Formation
606(1)
Embolism
606(1)
Peripheral Vascular Disease
606(1)
Atherosclerosis
607(1)
Peripheral Artery Disease
610(1)
Coronary Artery Disease, Myocardial Ischemia, and Acute Coronary Syndromes
610(12)
Disorders of the Heart Wall
622(1)
Disorders of the Pericardium
622(1)
Disorders of the Myocardium: The Cardiomyopathies
624(1)
Disorders of the Endocardium
625(1)
Cardiac Complications in Acquired Immunodeficiency Syndrome (AIDS)
632(1)
Manifestations of Heart Disease
632(1)
Heart Failure
632(1)
Dysrhythmias
637(1)
Shock
637(1)
Impairment of Cellular Metabolism
637(1)
Clinical Manifestations of Shock
640(1)
Treatment for Shock
641(1)
Types of Shock
641(1)
Multiple Organ Dysfunction Syndrome
646(9)
25 Alterations of Cardiovascular Function in Children
655(16)
Nancy Pike
Nancy L. McDaniel
Congenital Heart Disease
655(1)
Obstructive Defects
656(1)
Defects with Increased Pulmonary Blood Flow
659(1)
Defects with Decreased Pulmonary Blood Flow
661(1)
Mixing Defects
663(1)
Heart Failure
665(1)
Acquired Cardiovascular Disorders
666(1)
Kawasaki Disease
666(1)
Systemic Hypertension
667(4)
Unit 8 The Pulmonary System
26 Structure and Function of the Pulmonary System
671(16)
Valentina L. Brashers
Structures of the Pulmonary System
671(1)
Conducting Airways
671(1)
Gas-Exchange Airways
672(1)
Pulmonary and Bronchial Circulation
673(1)
Control of the Pulmonary Circulation
674(1)
Chest Wall and Pleura
675(1)
Function of the Pulmonary System
676(1)
Ventilation
676(1)
Neurochemical Control of Ventilation
676(1)
Mechanics of Breathing
678(1)
Gas Transport
680(4)
Geriatric Considerations: Aging & the Pulmonary System
684(3)
27 Alterations of Pulmonary Function
687(28)
Valentina L. Brashers
Sue E. Huether
Clinical Manifestations of Pulmonary Alterations
687(1)
Signs and Symptoms of Pulmonary Disease
687(1)
Conditions Caused by Pulmonary Disease or Injury
689(1)
Disorders of the Chest Wall and Pleura
691(1)
Pleural Abnormalities
691(2)
Pulmonary Disorders
693(1)
Restrictive Lung Diseases
693(1)
Obstructive Lung Diseases
698(1)
Respiratory Tract Infections
703(1)
Pulmonary Vascular Disease
706(1)
Malignancies of the Respiratory Tract
709(6)
28 Alterations of Pulmonary Function in Children
715(15)
Valentina L. Brashers
Sue E. Huether
Disorders of the Upper Airways
715(1)
Infections of the Upper Airways
715(1)
Aspiration of Foreign Bodies
717(1)
Obstructive Sleep Apnea
717(1)
Disorders of the Lower Airways
718(1)
Respiratory Distress Syndrome of the Newborn
718(1)
Bronchopulmonary Dysplasia
720(1)
Respiratory Tract Infections
721(1)
Aspiration Pneumonitis
723(1)
Bronchiolitis Obliterans
723(1)
Asthma
723(1)
Acute Lung Injury/Acute Respiratory Distress Syndrome
725(1)
Cystic Fibrosis
725(1)
Sudden Infant Death Syndrome (SIDS)
726(4)
Unit 9 The Renal and Urologic Systems
29 Structure and Function of the Renal and Urologic Systems
730(17)
Sue E. Huether
Structures of the Renal System
730(1)
Structures of the Kidney
730(1)
Urinary Structures
734(1)
Renal Blood Flow
735(1)
Autoregulation of Intrarenal Blood Flow
735(1)
Neural Regulation of Renal Blood Flow
736(1)
Hormones and Other Factors Regulating Renal Blood Flow
736(1)
Kidney Function
736(1)
Nephron Function
736(1)
Hormones and Nephron Function
741(1)
Renal Hormones
741(1)
Tests of Renal Function
741(1)
Renal Clearance
741(1)
Plasma Creatinine Concentration
743(1)
Blood Urea Nitrogen
743(1)
Pediatric Considerations: Pediatrics & Renal Function
743(1)
Geriatric Considerations: Aging & Renal Function
743(4)
30 Alterations of Renal and Urinary Tract Function
747(23)
Sue E. Huether
Urinary Tract Obstruction
747(1)
Upper Urinary Tract Obstruction
747(1)
Lower Urinary Tract Obstruction
749(1)
Tumors
751(2)
Urinary Tract Infection
753(1)
Causes of Urinary Tract Infection
753(1)
Types of Urinary Tract Infection
753(2)
Glomerular Disorders
755(1)
Glomerulonephritis
755(1)
Nephrotic and Nephritic Syndromes
759(1)
Acute Kidney Injury
760(1)
Classification of Kidney Dysfunction
760(1)
Acute Kidney Injury
760(3)
Chronic Kidney Disease
763(1)
Creatinine and Urea Clearance
764(1)
Fluid and Electrolyte Balance
765(1)
Calcium, Phosphate, and Bone
765(1)
Protein, Carbohydrate, and Fat Metabolism
766(1)
Cardiovascular System
766(1)
Pulmonary System
766(1)
Hematologic System
766(1)
Immune System
766(1)
Neurologic System
766(1)
Gastrointestinal System
766(1)
Endocrine and Reproductive Systems
766(1)
Integumentary System
766(4)
31 Alterations of Renal and Urinary Tract Function in Children
770(9)
Patricia Ring
Sue E. Huether
Structural Abnormalities
770(1)
Hypospadias
770(1)
Epispadias and Exstrophy of the Bladder
771(1)
Bladder Outlet Obstruction
771(1)
Ureteropelvic Junction Obstruction
772(1)
Hypoplastic/Dysplastic Kidneys
772(1)
Polycystic Kidney Disease
772(1)
Renal Agenesis
772(1)
Glomerular Disorders
772(1)
Glomerulonephritis
772(1)
Immunoglobulin A Nephropathy
773(1)
Nephrotic Syndrome
773(1)
Hemolytic Uremic Syndrome
773(1)
Nephroblastoma
774(1)
Bladder Disorders
774(1)
Urinary Tract Infections
774(1)
Vesicoureteral Reflex
775(1)
Urinary Incontinence
776(1)
Types of Incontinence
776(3)
Unit 10 The Reproductive Systems
32 Structure and Function of the Reproductive Systems
779(23)
Afsoon Moktar
George W. Rodway
Sue E. Huether
Development of the Reproductive Systems
779(1)
Sexual Differentiation in Utero
779(1)
Puberty and Reproductive Maturation
780(2)
The Female Reproductive System
782(1)
External Genitalia
782(1)
Internal Genitalia
783(1)
Female Sex Hormones
787(1)
Menstrual (Ovarian) Cycle
788(3)
Structure and Function of the Breast
791(1)
Female Breast
791(1)
Male Breast
793(1)
The Male Reproductive System
793(1)
External Genitalia
793(1)
Internal Genitalia
795(1)
Spermatogenesis
796(1)
Male Sex and Reproductive Hormones
796(1)
Aging & Reproductive Function
797(1)
Aging and the Female Reproductive System
797(1)
Aging and the Male Reproductive System
798(4)
33 Alterations of the Female Reproductive System
802(52)
Kathryn L. McCance
Afsoon Moktar
Abnormalities of the Female Reproductive Tract
802(1)
Alterations of Sexual Maturation
803(1)
Delayed or Absent Puberty
804(1)
Precocious Puberty
804(1)
Disorders of the Female Reproductive System
805(1)
Hormonal and Menstrual Alterations
805(1)
Infection and Inflammation
810(1)
Pelvic Organ Prolapse
814(1)
Benign Growths and Proliferative Conditions
815(1)
Cancer
819(1)
Sexual Dysfunction
829(1)
Impaired Fertility
830(1)
Disorders of the Female Breast
830(1)
Galactorrhea
830(1)
Benign Breast Disease and Conditions
831(1)
Breast Cancer
833(21)
34 Alterations of the Male Reproductive System
854(30)
George W. Rodway
Kathryn L. McCance
Alterations of Sexual Maturation
854(1)
Delayed or Absent Puberty
854(1)
Precocious Puberty
854(1)
Disorders of the Male Reproductive System
855(1)
Disorders of the Urethra
855(1)
Disorders of the Penis
855(1)
Disorders of the Scrotum, Testis, and Epididymis
858(1)
Disorders of the Prostate Gland
862(1)
Sexual Dysfunction
873(3)
Disorders of the Male Breast
876(1)
Gynecomastia
876(1)
Carcinoma
877(1)
Sexually Transmitted Diseases
877(7)
Unit 11 The Digestive System
35 Structure and Function of the Digestive System
884(22)
Sue E. Huether
The Gastrointestinal Tract
884(1)
Mouth and Esophagus
884(1)
Stomach
887(1)
Small Intestine
889(1)
Large Intestine
894(1)
Intestinal Microbiome
895(1)
Splanchnic Blood Flow
896(1)
Accessory Organs of Digestion
896(1)
Liver
896(1)
Gallbladder
900(3)
Geriatric Considerations: Aging & the Gastrointestinal System
903(3)
36 Alterations of Digestive Function
906(44)
Sue E. Huether
Disorders of the Gastrointestinal Tract
906(1)
Clinical Manifestations of Gastrointestinal Dysfunction
906(1)
Disorders of Motility
909(1)
Gastritis
914(1)
Peptic Ulcer Disease
915(1)
Malabsorption Syndromes
919(1)
Inflammatory Bowel Disease
920(1)
Diverticular Disease of the Colon
922(1)
Appendicitis
923(1)
Mesenteric Vascular Insufficiency
923(1)
Disorders of Nutrition
924(3)
Disorders of the Accessory Organs of Digestion
927(1)
Common Complications of Liver Disorders
927(1)
Disorders of the Liver
931(1)
Disorders of the Gallbladder
935(1)
Disorders of the Pancreas
936(1)
Cancer of the Digestive System
937(1)
Cancer of the Gastrointestinal Tract
937(1)
Cancer of the Accessory Organs of Digestion
941(9)
37 Alterations of Digestive Function in Children
950(18)
Sharon Sables-Baus
Sara J. Fidanza
Disorders of the Gastrointestinal Tract
950(1)
Congenital Impairment of Motility
950(1)
Acquired Impairment of Motility
954(1)
Impairment of Digestion, Absorption, and Nutrition
956(1)
Diarrhea
960(1)
Disorders of the Liver
961(1)
Disorders of Biliary Metabolism and Transport
961(1)
Inflammatory Disorders
962(1)
Portal Hypertension
963(1)
Metabolic Disorders
963(5)
Unit 12 The Musculoskeletal and Integumentary Systems
38 Structure and Function of the Musculoskeletal System
968(23)
Christy L. Crowther-Radulewicz
Kathryn L. McCance
Structure and Function of Bones
968(1)
Elements of Bone Tissue
968(1)
Types of Bone Tissue
972(1)
Characteristics of Bone
973(1)
Maintenance of Bone Integrity
974(1)
Structure and Function of Joints
975(1)
Fibrous Joints
975(1)
Cartilaginous Joints
975(1)
Synovial Joints
977(1)
Structure and Function of Skeletal Muscles
978(1)
Whole Muscle
978(1)
Components of Muscle Function
983(1)
Tendons and Ligaments
986(1)
Aging & the Musculoskeletal System
986(1)
Aging of Bones
986(1)
Aging of Joints
987(1)
Aging of Muscles
987(4)
39 Alterations of Musculoskeletal Function
991(47)
Christy L. Crowther-Radulewicz
Kathryn L. McCance
Musculoskeletal Injuries
991(1)
Skeletal Trauma
991(1)
Support Structures
995(5)
Disorders of Bones
1000(1)
Metabolic Bone Diseases
1000(1)
Infectious Bone Disease: Osteomyelitis
1007(2)
Disorders of Joints
1009(1)
Osteoarthritis
1009(1)
Classic Inflammatory Joint Disease
1012(9)
Disorders of Skeletal Muscle
1021(1)
Secondary Muscular Dysfunction
1021(1)
Fibromyalgia
1022(1)
Chronic Fatigue Syndrome
1023(1)
Muscle Membrane Abnormalities
1023(1)
Metabolic Muscle Diseases
1024(1)
Inflammatory Muscle Diseases: Myositis
1025(1)
Toxic Myopathies
1026(1)
Musculoskeletal Tumors
1027(1)
Bone Tumors
1027(1)
Muscle Tumors
1031(7)
40 Alterations of Musculoskeletal Function in Children
1038(15)
Kristen Lee Carroll
Lynne M. Kerr
Kathryn L. McCance
Congenital Defects
1038(1)
Clubfoot
1038(1)
Developmental Dysplasia of the Hip
1038(1)
Osteogenesis Imperfecta
1039(2)
Bone Infection
1041(1)
Osteomyelitis
1041(1)
Septic Arthritis
1042(1)
Juvenile Idiopathic Arthritis
1043(1)
Osteochondroses
1044(1)
Legg-Calve-Perthes Disease
1044(1)
Osgood-Schlatter Disease
1044(1)
Scoliosis
1045(1)
Muscular Dystrophy
1046(1)
Duchenne Muscular Dystrophy
1046(1)
Becker Muscular Dystrophy
1047(1)
Facioscapulohumeral Muscular Dystrophy
1047(1)
Myotonic Muscular Dystrophy
1047(1)
Musculoskeletal Tumors
1048(1)
Benign Bone Tumors
1048(1)
Malignant Bone Tumors
1048(2)
Nonaccidental Trauma
1050(1)
Fractures in Nonaccidental Trauma
1050(3)
41 Structure, Function, and Disorders of the Integument
1053(31)
Sue Ann McCann
Noreen Heer Nicol
Sue E. Huether
Structure and Function of the Skin
1053(1)
Layers of the Skin
1053(1)
Clinical Manifestations of Skin Dysfunction
1055(5)
Disorders of the Skin
1060(1)
Inflammatory Disorders
1060(1)
Papulosquamous Disorders
1062(1)
Vesiculobullous Diseases
1065(1)
Infections
1066(1)
Vascular Disorders
1068(1)
Benign Tumors
1070(1)
Skin Cancer
1070(1)
Burns
1074(1)
Cold Injury
1078(1)
Disorders of the Hair
1078(1)
Alopecia
1078(1)
Hirsutism
1078(1)
Disorders of the Nail
1078(1)
Paronychia
1078(1)
Onychomycosis
1079(1)
Geriatric Considerations: Aging & Changes in Skin Integrity
1079(5)
42 Alterations of the Integument in Children
1084
Noreen Heer Nicol
Sue E. Huether
Acne Vulgaris
1084(1)
Dermatitis
1085(1)
Atopic Dermatitis
1085(1)
Diaper Dermatitis
1086(1)
Infections of the Skin
1086(1)
Bacterial Infections
1086(1)
Fungal Infections
1087(1)
Viral Infections
1088(3)
Insect Bites and Parasites
1091(1)
Scabies
1091(1)
Pediculosis (Lice Infestation)
1091(1)
Fleas
1091(1)
Bedbugs
1092(1)
Cutaneous Hemangiomas and Vascular Malformations
1092(1)
Cutaneous Hemangiomas
1092(1)
Cutaneous Vascular Malformations
1093(1)
Other Skin Disorders
1093(1)
Miliaria
1093(1)
Erythema Toxicum Neonatorum
1094