| Contributors |
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xi | |
| Preface |
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xv | |
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1 Vasotocin and the origins of the vasopressin/oxytocin receptor gene family |
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1 | (28) |
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2 | (4) |
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2 Emergence of the second ligand and derivation of the oxytocin receptor |
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6 | (10) |
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3 Evolution of the V2A receptor and cAMP signaling |
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16 | (3) |
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4 Promoter region regulatory elements and evolution of expression |
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19 | (2) |
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5 Conclusions and future directions |
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21 | (2) |
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23 | (1) |
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24 | (5) |
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2 Oxytocin/vasopressin-like neuropeptide signaling in insects |
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29 | (26) |
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30 | (2) |
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2 OT/VP-like signaling in beetles |
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32 | (3) |
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3 OT/VP-like signaling in locusts |
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35 | (4) |
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4 OT/VP-like signaling in ants |
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39 | (3) |
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5 Mining of ligand and receptor genes in other insects |
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42 | (3) |
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6 Possible applications of insect inotocin ligands in pharmacology |
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45 | (3) |
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48 | (1) |
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48 | (7) |
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3 Amyloid-like aggregation of provasopressin |
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55 | (24) |
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Cristina Prescianotto Baschong |
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1 Biosynthesis and secretion of vasopressin |
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56 | (4) |
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2 Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) caused by amyloid-like provasopressin aggregation in the ER |
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60 | (4) |
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3 Granule sorting by functional amyloid aggregation in the TGN |
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64 | (1) |
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4 Sequence elements mediating ER aggregation and granule sorting |
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65 | (5) |
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5 Provasopressin is a physiological substrate of ERAD |
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70 | (4) |
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74 | (1) |
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74 | (5) |
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4 V2 vasopressin receptor mutations |
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79 | (22) |
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1 Short introduction: V2 receptor and its physiological role in the kidney |
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80 | (1) |
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2 X-linked congenital nephrogenic diabetes insipidus (NDI) |
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80 | (2) |
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3 Loss-of-function mutations of V2R that cause NDI |
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82 | (10) |
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4 Gain-of-function mutations causing nephrogenic syndrome of inappropriate antidiuresis (NSIAD) |
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92 | (2) |
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94 | (1) |
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94 | (7) |
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5 Vasopressin inactivation: Role of insulin-regulated aminopeptidase |
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101 | (28) |
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Estifanos N. Habtemichael |
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1 Introduction: Antidiuretic activity is regulated enzymatically by vasopressin inactivation |
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102 | (2) |
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2 Discovery and function of placental leucine aminopeptidase |
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104 | (2) |
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3 Discovery and characterization of insulin regulated aminopeptidase (IRAP) |
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106 | (7) |
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4 TUG mediates coordinated regulation of water and glucose homeostasis |
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113 | (2) |
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5 Implications of vasopressin degradation: Copeptin and the metabolic syndrome |
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115 | (3) |
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118 | (1) |
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119 | (1) |
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119 | (10) |
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6 Molecular aspects of aquaporins |
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129 | (54) |
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1 Discovery of the first aquaporin |
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130 | (1) |
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2 Classification and isoforms of mammalian aquaporins |
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131 | (6) |
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3 Structural characterization of mammalian aquaporins |
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137 | (2) |
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4 Protein modification of AQP2 |
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139 | (11) |
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5 Molecular machinery of AQP2 trafficking |
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150 | (6) |
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6 AQP2 protein abundance by vasopressin and others |
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156 | (3) |
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7 Pathophysiology of vasopressin-regulated AQP2 |
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159 | (4) |
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163 | (1) |
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163 | (20) |
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7 The vasotocinergic system and its role in the regulation of stress in birds |
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183 | (34) |
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184 | (1) |
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2 Anatomy of the avian HPA axis, with emphasis on arginine vasotocin (AVT) |
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185 | (9) |
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3 Roles of AVT and CRH in regulating blood concentration of corticosterone in birds |
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194 | (5) |
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4 Receptors associated with stress within the anterior pituitary and vasotocin antagonists specific for the avian Via and V1bRs |
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199 | (8) |
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5 Conclusions and future directions |
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207 | (1) |
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207 | (1) |
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208 | (8) |
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216 | (1) |
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8 Vasopressin actions in the kidney renin angiotensin system and its role in hypertension and renal disease |
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217 | (22) |
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218 | (1) |
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2 Vasopressin and its receptors in the kidney |
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219 | (2) |
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3 Structural characterization of vasopressin receptors |
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221 | (5) |
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4 Vasopressin actions in the kidney renin angiotensin system |
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226 | (1) |
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5 Vasopressin in hypertension |
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227 | (1) |
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6 Vasopressin and kidney disease |
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228 | (4) |
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7 Conclusions and future directions |
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232 | (1) |
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233 | (6) |
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9 Vasopressin receptor subtypes and renal sodium transport |
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239 | (20) |
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1 Phenomenology of vasopressin-induced natriuresis |
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240 | (1) |
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240 | (1) |
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3 Vasopressin and receptors in the kidney |
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241 | (5) |
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246 | (3) |
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5 Natriuretic effect of vasopressin |
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249 | (3) |
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252 | (1) |
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252 | (1) |
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253 | (6) |
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10 Development and therapeutic potential of vasopressin synthetic analog [ V4Q5]dDAVP as a novel anticancer agent |
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259 | (32) |
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260 | (4) |
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2 Design of novel AVP synthetic analogs as anticancer agents |
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264 | (5) |
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3 [ V4Q5]dDAVP as a second generation AVP analog with enhanced biological activity |
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269 | (11) |
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4 Conclusions and future perspectives |
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280 | (2) |
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282 | (1) |
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282 | (9) |
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11 Vasopressin and vasopressin receptors in brain edema |
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291 | |
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1 Vasopressin and vasopressin receptors |
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292 | (3) |
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295 | (1) |
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3 Water diffusion and vasopressin in brain edema |
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296 | (2) |
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4 Injury-induced brain edema and vasopressin |
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298 | (2) |
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5 Subarachnoid hemorrhage (SAH)-induced brain edema and vasopressin |
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300 | (1) |
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6 Kidneys, brain edema and vasopressin |
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301 | (1) |
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7 Inflammation in brain edema and vasopressin |
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302 | (1) |
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8 Liver disease-caused brain edema and vasopressin |
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303 | (1) |
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303 | (1) |
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304 | (1) |
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304 | |
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