Wnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.
- Presents newest findings on the role of Wnt signaling in a variety of tissues and organisms
- Illustrates the diverse actions of Wnt signaling in development and disease
- Highlight tools and technologies to interrogate Wnt signaling in any biological system
1. The logistics of Wnt production and delivery Ines Alvarez-Rodrigo,
David Willnow, and Jean-Paul Vincent
2. Visualizing WNT signaling in
mammalian systems Tanne van der Wal and Ren
3. Wnt signaling and the
regulation of pluripotency Pooja Sonavane and Karl Willert
4. Wnt signaling
in stem cells during development and cell lineage specification Rony Chidiac
and Stephane Angers
5. The role of Wnt signaling in the development of the
epiblast and axial progenitors Ruby E. Schnirman, Samuel J. Kuo, Ryan C.
Kelly, and Terry P. Yamaguchi
6. Role of Wnt signaling and planar cell
polarity in left-right asymmetry Katsura Minegishi, Xiaorei Sai, and Hiroshi
Hamada
7. Non-canonical WNT5A-ROR signaling: New perspectives on an ancient
developmental pathway Sara E. Konopelski Snavely, Srisathya Srinivasan,
Courtney A. Dreyer, Jia Tan, Kermit L. Carraway III, and Hsin-Yi Henry Ho
8.
The role of Wnt signaling in Xenopus neural induction Ian Velloso, Wonhee
Han, Xi He, and Jose G. Abreu
9. Wnt regulation of hematopoietic stem cell
development and disease Kelsey A. Carpenter, Kate E. Thurlow, Sonya E.L.
Craig, and Stephanie Grainger
10. Role of Wnt signaling in the maintenance
and regeneration of the intestinal epithelium Maxime Gasnier, Hui Yi Grace
Lim, and Nick Barker
11. Got WNTS? Insight into bone health from a WNT
perspective Sonya E.L. Craig, Megan N. Michalski, and Bart O. Williams
12.
Wnt signaling in whole-body regeneration Christian P. Petersen
13. From
injury to patterningMAPKs and Wnt signaling in Hydra Anja Tursch and Thomas
W. Holstein
Terry P. Yamaguchi is at NCI-Frederick, MD, USA Karl Willert is at Sanford Consortium for Regenerative Medicine, CA, USA
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