"An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The antigen retrieval (AR) technique is used worldwide and has resulted in a revolution in immunohistochemistry (IHC). Featuring contributors who are distinguished experts and researchers in the field, this book discusses several scientific approaches to the standardization of quantifiable IHC. It summarizes the key problems in the four fields of antigen retrieval and provides practical methods and protocols in AR-IHC. Clinical pathologists, molecular cell biologists, basic research scientists, technicians, and graduate students, will benefit from this fully up-to-date work"--Provided by publisher.
"This book is based on the development and application of AR by the editors, one of whom is the inventor of AR, together with members of a world-leading research center of AR"--Provided by publisher.
Provided by publisher.
The most complete, up-to-date reference on antigen retrieval and immunohistochemistry
An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The antigen retrieval (AR) technique is in wide use across the globe, and is a critical technique used in medical diagnosis of disease, particularly clinical targeted cancer treatment.
Antigen Retrieval Immunohistochemistry Based Research and Diagnostics discusses several scientific approaches to the standardization of quantifiable immunohistochemistry (IHC). Based on the development and application of AR by the editors, this volume summarizes recent achievements in AR-IHC and analyzes numerous cutting-edge issues for future research projects.
Featuring contributions from a worldwide group of leading experts and research scientists in the field, this important work:
Summarizes the key problems in the four fields of antigen retrieval
Discusses the advances of AR techniques and their applications
Provides practical methods and protocols in AR-IHC, such as extraction of nucleic acids and proteins for molecular analysis, cell/tissue sample preparation, and standardization and development of various techniques to meet the future needs of clinical and research molecular analysis
Encourages further research in AR and IHC, particularly how AR methods might be employed for improved test performance and the development of greater reliability and reproducibility of IHC
Includes an appendix of related laboratory protocols
Antigen Retrieval Immunohistochemistry Based Research and Diagnostics is intended for clinical pathologists, molecular cell biologists, basic research scientists, technicians, and graduate students who undertake tissue/cell morphologic and molecular analysis and wish to use and extend the power of immunohistochemistry. It is also pertinent for most biotechnology companies majoring in development of IHC products.
Wiley Series in Biomedical Engineering and Multi-Disciplinary Integrated Systems
Kai Chang, Series Editor
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