Preface |
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xi | |
About the Author |
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xiii | |
Important Notice |
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xv | |
Chapter 1 Introduction |
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1 | (54) |
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1 | (1) |
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2 | (3) |
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5 | (27) |
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5 | (1) |
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1.3.2 Eukaryotes and Prokaryotes |
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5 | (1) |
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5 | (7) |
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1.3.3.1 Multicellular eukaryotes |
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5 | (2) |
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7 | (5) |
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12 | (1) |
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12 | (1) |
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12 | (11) |
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12 | (10) |
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22 | (1) |
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23 | (5) |
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28 | (1) |
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29 | (3) |
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1.4 General Considerations |
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32 | (22) |
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1.4.1 Microbial Resistance |
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32 | (1) |
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1.4.2 Evaluation of Efficacy |
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32 | (12) |
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1.4.2.1 Suspension testing |
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34 | (3) |
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37 | (3) |
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1.4.2.3 Biological, chemical, and other indicators |
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40 | (3) |
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1.4.2.4 Parametric control |
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43 | (1) |
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1.4.2.5 Microscopy and other techniques |
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44 | (1) |
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1.4.3 Disinfection versus Sterilization |
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44 | (2) |
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1.4.4 Choosing a Process or Product |
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46 | (1) |
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1.4.5 Guidelines and Standards |
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46 | (1) |
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1.4.6 Formulation Effects |
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47 | (2) |
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49 | (1) |
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1.4.8 The Importance of Cleaning |
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50 | (2) |
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52 | (2) |
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54 | (1) |
Chapter 2 Physical Disinfection |
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55 | (24) |
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55 | (1) |
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55 | (7) |
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62 | (1) |
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62 | (8) |
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70 | (7) |
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77 | (2) |
Chapter 3 Chemical Disinfection |
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79 | (70) |
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79 | (1) |
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3.2 Acids and Acid Derivatives |
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79 | (4) |
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83 | (2) |
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85 | (5) |
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90 | (2) |
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92 | (1) |
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93 | (3) |
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96 | (3) |
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99 | (1) |
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3.10 Essential Oils and Plant Extracts |
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100 | (2) |
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3.11 Halogens and Halogen-Releasing Agents |
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102 | (9) |
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111 | (4) |
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3.13 Peroxygens and Other Forms of Oxygen |
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115 | (15) |
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130 | (3) |
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3.15 Antiseptic Phenolics |
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133 | (7) |
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3.16 QACs and Other Surfactants |
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140 | (4) |
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3.17 Miscellaneous Biocides or Applications |
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144 | (4) |
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144 | (1) |
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3.17.2 Biocides Integrated into Surfaces |
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144 | (2) |
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3.17.3 Antimicrobial Enzymes, Proteins, or Peptides |
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146 | (2) |
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148 | (1) |
Chapter 4 Antiseptics And Antisepsis |
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149 | (16) |
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149 | (1) |
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4.2 Some Definitions Specific to Antisepsis |
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149 | (1) |
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4.3 The Structure of Skin |
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150 | (1) |
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151 | (1) |
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4.5 Antiseptic Applications |
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151 | (7) |
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4.5.1 Routine Skin Hygiene |
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152 | (2) |
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4.5.2 Pretreatment of Skin Prior to Surgical Intervention |
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154 | (1) |
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4.5.3 Treatment of Skin or Wound Infections |
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155 | (2) |
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4.5.4 Treatment of Oral and Other Mucous Membranes |
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157 | (1) |
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4.5.5 Material-Integrated Applications |
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158 | (1) |
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4.6 Biocides Used as Antiseptics |
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158 | (5) |
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4.6.1 General Considerations |
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158 | (2) |
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4.6.2 Major Types of Biocides in Antiseptic Skin Washes and Rinses |
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160 | (3) |
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4.6.3 Other Antiseptic Biocides |
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163 | (1) |
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163 | (2) |
Chapter 5 Physical Sterilization |
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165 | (26) |
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165 | (1) |
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165 | (10) |
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5.2.1 An Introduction to Steam Sterilization |
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165 | (4) |
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5.2.2 Factors That Affect Steam Sterilization |
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169 | (6) |
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5.3 Dry-Heat Sterilization |
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175 | (2) |
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5.4 Radiation Sterilization |
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177 | (7) |
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184 | (1) |
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184 | (4) |
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184 | (2) |
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186 | (1) |
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5.6.3 Supercritical Fluids |
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187 | (1) |
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5.6.4 Pulsed Electric Fields |
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188 | (1) |
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188 | (3) |
Chapter 6 Chemical Sterilization |
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191 | (26) |
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191 | (1) |
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191 | (6) |
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197 | (3) |
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6.4 High-Temperature Formaldehyde-Alcohol |
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200 | (1) |
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201 | (5) |
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6.6 Other Oxidizing-Agent-Based Processes |
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206 | (9) |
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206 | (1) |
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207 | (5) |
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212 | (1) |
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213 | (1) |
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214 | (1) |
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215 | (2) |
Chapter 7 Mechanisms Of Action |
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217 | (36) |
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217 | (1) |
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218 | (3) |
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7.2.1 Antibacterials (Antibiotics) |
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218 | (1) |
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219 | (1) |
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220 | (1) |
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7.2.4 Antiparasitic Drugs |
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221 | (1) |
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7.3 Macromolecular Structure |
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221 | (5) |
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7.4 General Mechanisms of Action |
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226 | (25) |
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226 | (2) |
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228 | (3) |
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7.4.3 Cross-Linking, or Coagulating, Agents |
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231 | (7) |
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238 | (6) |
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7.4.5 Other Structure-Disrupting Agents |
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244 | (7) |
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251 | (2) |
Chapter 8 Mechanisms Of Microbial Resistance |
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253 | (82) |
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253 | (1) |
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8.2 Biocide-Microorganism Interaction |
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253 | (2) |
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8.3 Intrinsic Bacterial Resistance Mechanisms |
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255 | (34) |
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8.3.1 General Stationary-Phase Phenomena |
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255 | (1) |
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8.3.2 Motility and Chemotaxis |
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256 | (1) |
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257 | (4) |
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261 | (4) |
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8.3.5 Enzymatic and Chemical Protection |
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265 | (1) |
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8.3.6 Intrinsic Resistance to Heavy Metals |
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265 | (3) |
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8.3.7 Capsule and Slime Layer Formation and S-Layers |
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268 | (1) |
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8.3.8 Biofilm Development |
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269 | (5) |
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8.3.9 Bacteria with Extreme Intrinsic Resistance |
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274 | (2) |
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276 | (3) |
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279 | (8) |
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8.3.12 Revival Mechanisms |
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287 | (2) |
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8.4 Intrinsic Resistance of Mycobacteria |
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289 | (2) |
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8.5 Intrinsic Resistance of Other Gram-Positive Bacteria |
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291 | (1) |
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8.6 Intrinsic Resistance of Gram-Negative Bacteria |
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292 | (3) |
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8.7 Acquired Bacterial Resistance Mechanisms |
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295 | (19) |
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295 | (2) |
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8.7.2 Mutational Resistance |
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297 | (9) |
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8.7.3 Plasmids and Transmissible Elements |
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306 | (8) |
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8.8 Mechanisms of Viral Resistance |
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314 | (4) |
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8.9 Mechanisms of Prion Resistance |
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318 | (2) |
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8.10 Mechanisms of Fungal Resistance |
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320 | (9) |
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8.11 Mechanisms of Resistance in Other Eukaryotic Microorganisms |
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329 | (4) |
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333 | (2) |
Index |
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335 | |