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E-grāmata: Drugs Easily Explained

  • Formāts: EPUB+DRM
  • Izdošanas datums: 10-Dec-2022
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783031121883
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  • Formāts: EPUB+DRM
  • Izdošanas datums: 10-Dec-2022
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783031121883

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Billions of people worldwide take medicines every day to treat important diseases. In many cases, however, neither the doctor nor the pharmacist has the time to explain to the patient why a particular drug should be taken, how the drug works and what side effects to expect. Of course, the patient can find "everything" about a particular drug on the Internet. But how reliable and understandable is this information? In addition, most Internet sources do not point out the interrelationships between different diseases and drug interactions. Written by an experienced and well-known textbook author, this book provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.


1 What Should I Know About Drugs?
1(36)
1.1 Some Important Terms
1(5)
Drugs Are Useful; Poisons Are Harmful
2(2)
An Overview of Different Dosage Forms
4(1)
What Is a Placebo Effect?
5(1)
What Is a Nocebo Effect?
5(1)
Do Drugs Work the Same for Everyone?
6(1)
1.2 Drug Names
6(7)
Are Drug Names Just Medical Jargon?
7(2)
Names of Old Drugs
9(1)
Problems Associated with Use of Brand-Names
9(1)
The Difference Between a Brand-Name Drug and a Generic Drug
10(1)
Problems Associated with Use of Generics
11(1)
Problems Associated with Traditional Drug Class Names
12(1)
1.3 How Do Drugs Get to Market?
13(7)
How Did Drug Development Work in the Past?
13(1)
Caution When Buying Drugs Abroad
14(1)
How Does Drug Development Work?
15(2)
Real-World Testing of Drugs
17(1)
Off-Label Use of Drugs
18(1)
Drug Repurposing
18(1)
Getting Information on Drugs
19(1)
1.4 How Do Drugs Work in Your Body?
20(6)
What Is the Basis of Drug Effects?
21(1)
Receptors as Target No. 1
22(1)
Enzymes as Target No. 2
23(1)
Pumps as Target No. 3
23(1)
Channels as Target No. 4
23(1)
The Cell Nucleus as Target No. 5
24(1)
Is It Good or Bad if a Drug Has Only One Target?
24(1)
Is It Good or Bad if a Drug Has Many Targets?
25(1)
How Do Adverse Drug Reactions Occur?
25(1)
1.5 How Do Drugs Travel Through the Body?
26(11)
The Path of a Drug Through the Body
28(1)
Other Forms of Drug Administration
29(1)
Therapeutic Drug Monitoring
30(1)
Risks of Taking Many Drugs (Polypharmacy)
30(2)
Interaction of Foods with Drugs
32(2)
Reduce Drug Doses in Kidney Failure
34(1)
Treating Infants and Young Children
35(2)
2 Painkillers (Analgesics)
37(22)
2.1 Overview and Nonopioid Analgesics
37(11)
How Pain Arises and How It Is Assessed
38(1)
Different Painkillers
38(5)
Nonsteroidal Anti-inflammatory Drugs: Risks for the Stomach, Blood Pressure, and Kidney
43(1)
Problematic Coxibs
44(1)
Use of Acetylsalicylic Acid for Pain Is Outdated
45(1)
Paracetamol: Toxic for the Liver
45(1)
Metamizole: Effective but Not Available Everywhere
46(2)
2.2 Opioid Analgesics
48(11)
How Do Opioid Analgesics Work?
48(4)
Use of Opioid Analgesics
52(1)
Many Effects of Opioid Analgesics
52(2)
Addiction to Opioid Analgesics
54(1)
Tramadol: Popular and Overrated
55(1)
Buprenorphine: Less Effective Than Morphine
56(1)
Morphine: The Gold Standard
56(1)
Fentanyl: Versatile but Risky
56(3)
3 Drugs for Gastrointestinal Disorders
59(22)
3.1 Gastroesophageal Reflux Disease
59(9)
How Does Gastroesophageal Reflux Disease Develop?
60(1)
Proton Pumps in the Stomach Are the Most Important
Target for Treatment of Gastroesophageal Reflux Disease
61(1)
What Are the Causes of Gastroesophageal Reflux Disease?
62(1)
What Options Do You Have for Self-Treatment?
62(3)
H2 Receptor Blockers
65(1)
Self-Medication with Proton Pump Inhibitors
65(1)
How Your Doctor Treats Gastroesophageal Reflux Disease
65(2)
What Are the Risks of Taking a Proton Pump Inhibitor for Many Years?
67(1)
When Is Metoclopramide Used?
67(1)
3.2 Peptic Ulcer Disease
68(5)
How Does Peptic Ulcer Disease Develop, and How Is It Treated?
69(1)
How Does Nonsteroidal Anti-inflammatory Drug Treatment Cause Peptic Ulcer Disease?
70(2)
What to Do if You Take Cortisone, Acetylsalicylic Acid, or Clopidogrel
72(1)
3.3 Constipation and Diarrhea
73(8)
How Does Constipation Occur?
74(1)
Why You Should Not Take Laxatives Regularly
74(3)
Which Drugs Can Cause Constipation?
77(1)
Which Laxative Should You Take?
78(1)
What Causes Diarrhea?
79(1)
How to Treat Diarrhea
80(1)
4 Drugs for Respiratory Diseases
81(20)
4.1 Allergies and Asthma
82(13)
How Do Allergies and Asthma Develop?
82(2)
From Harmless to Life Threatening
84(1)
General Therapy
84(5)
Drugs for Wheals, Conjunctivitis, and Rhinitis
89(1)
Asthma Therapy
90(1)
Short-Acting and Long-Acting Beta Receptor Agonists
91(1)
Cortisone
92(1)
More Options
92(1)
Aspirin-Induced Asthma
93(1)
Anaphylactic Shock
93(1)
Treatment of Anaphylactic Shock
94(1)
4.2 Chronic Obstructive Pulmonary Disease
95(6)
How Does Chronic Obstructive Pulmonary Disease Develop?
95(2)
Short-Acting Beta Agonists and Long-Acting Muscarinic Antagonists
97(1)
Long-Acting Beta Agonists and Phosphodiesterase Inhibitors
98(1)
Oxygen and Lung Transplantation
99(1)
Caution with Cortisone
99(2)
5 Drugs for Cardiovascular Diseases
101(28)
5.1 High Blood Pressure
102(9)
What Is High Blood Pressure?
102(2)
How Do I Know I Have High Blood Pressure?
104(1)
What Are the Consequences of Untreated High Blood Pressure?
104(1)
What Are the Risk Factors for Developing High Blood Pressure?
104(1)
Which Drugs Are Used for High Blood Pressure?
105(2)
Drug Class A
107(1)
Drug Class B
108(1)
Drug Class C
109(1)
Drug Class D
109(1)
How Is High Blood Pressure Treated During Pregnancy?
110(1)
Hypertensive Emergencies
110(1)
5.2 Heart Attacks and Strokes
111(11)
How Do Heart Attacks and Strokes Occur?
112(1)
Drugs as Risk Factors
113(1)
How Are Heart Attacks and Strokes Treated?
113(4)
Primary and Secondary Prevention
117(1)
Cholesterol-Lowering Drugs
118(1)
When Statins Aren't Enough
119(1)
Platelet Aggregation Inhibitors
119(1)
Vitamin K Antagonists
120(1)
Alternatives to Vitamin K Antagonists
121(1)
Amiodarone
122(1)
5.3 Chronic Heart Failure
122(7)
Chronic Heart Failure
123(1)
Underlying Diseases
124(1)
Problematic Drugs
125(1)
Heart Protection
126(1)
Eliminate Causes and Exercise as Best You Can
126(1)
Drugs for Heart Failure
126(3)
6 Drags for Metabolic Disorders
129(26)
6.1 Diabetes
130(10)
How Does Diabetes Develop?
130(2)
How Is Type 1
Diabetes Treated?
132(3)
Which Adverse Drug Reaction Can Occur with Insulin Treatment?
135(1)
What Do I Need to Consider When Dosing Insulin?
136(1)
How Is Type 2 Diabetes Treated?
136(1)
Metformin, the Gold Standard
137(1)
Gliptins and Incretin Mimetics
138(1)
Gliflozins
138(1)
Other Drugs
139(1)
6.2 Thyroid Diseases
140(8)
What Is the Task of the Thyroid Gland?
140(3)
How Do I Know I Have Hyperthyroidism?
143(1)
How Is Hyperthyroidism Treated?
144(1)
How Do I Know I Have Hypothyroidism?
145(1)
How Is Hypothyroidism Treated?
146(1)
Misuse of Thyroid Hormones
147(1)
Stay Away from "Natural" Thyroid Hormones
147(1)
6.3 Osteoporosis
148(7)
How Does Osteoporosis Develop?
148(3)
Diseases and Drugs That Can Lead to Osteoporosis
151(1)
What Is the Basic Treatment for Osteoporosis?
152(1)
Bisphosphonates
152(1)
Selective Estrogen Receptor Modulators
153(1)
Denosumab
154(1)
7 Drags for Her and Him
155(14)
7.1 Hormone Replacement Therapy
155(6)
The Female Sex Hormones Estrogen and Progesterone
156(2)
What Happens to Hormones During Menopause?
158(1)
How to Treat Menopausal Symptoms
159(1)
Consider Selective Estrogen Receptor Modulators, Statins, and Antihypertensives
160(1)
7.2 Erectile Dysfunction
161(8)
What Makes a Penis Erect?
162(1)
How Does Erectile Dysfunction Occur?
163(1)
Treatment of Erectile Dysfunction with Sildenafil
164(2)
Sexual Activity in Patients with Angina Pectoris
166(1)
Caution with Methylphenidate and Antipsychotics
166(3)
8 Drugs for Neurological Disorders
169(16)
8.1 Parkinson's Disease
169(6)
Parkinson's Disease, a Neurodegenerative Disorder
170(1)
How Does Parkinson's Disease Develop?
170(3)
Parkinson's Syndrome Caused by Antipsychotics
173(1)
How Is Parkinson's Disease Treated?
173(1)
Risks of Too Much Dopamine
174(1)
Options When Levodopa Fails
174(1)
Inhibition of Acetylcholine
174(1)
8.2 Epilepsies
175(10)
How Do Epilepsies Develop, and How Are They Treated?
176(4)
Mechanisms of Action of Antiepileptic Drugs
180(1)
Rules for Treatment with Antiepileptic Drugs
181(1)
Use of Antiepileptic Drugs in Other Neurological and
Mental Disorders
181(1)
Carbamazepine, Lamotrigine, Phenytoin, and Valproic Acid
182(1)
Pregabalin
183(1)
Benzodiazepines
183(1)
Z-Drugs
184(1)
9 Drugs for Mental Disorders
185(32)
9.1 Attention Deficit-Hyperactivity Disorder
185(5)
How Does Attention Deficit-Hyperactivity Disorder Develop?
186(1)
How Can Attention Deficit-Hyperactivity Disorder Be Treated?
186(3)
Methylphenidate Abuse
189(1)
9.2 Depression
190(11)
How Do I Know If I or Someone Else Is Suffering from Depression?
191(1)
How Does Depression Develop?
191(4)
Who Diagnoses and Treats Depression?
195(1)
How Is Depression Treated?
195(1)
Ketamine
195(1)
Antidepressants Have Many Uses
196(1)
Are Antidepressants Ineffective?
196(1)
Do Antidepressants Cause Addiction?
196(1)
How to Choose an Antidepressant
197(1)
How to Start Treatment for Depression
197(1)
How Is Depression Treated When Selective Serotonin Reuptake Inhibitors Do Not Work?
198(1)
What Can Be Done If This Therapy Doesn't Help Either?
198(1)
What to Do If Nonselective Monoamine Reuptake Inhibitors Do Not Help
199(1)
Avoid Chocolate, Cheese, and Red Wine if You Take Monoamine Oxidase Inhibitors
199(1)
Other Drugs for Severe Depression
200(1)
Ten Reasons for Taking an Antidepressant for Depression
200(1)
Herbal Remedies for Depression
201(1)
9.3 Bipolar Disorder
201(5)
How Does Bipolar Disorder Develop?
202(1)
Treatment of Bipolar Disorder
202(1)
Lithium
203(1)
Why Patients Should Take Lithium for Bipolar Disorder
204(1)
Adverse Drug Reactions Associated with Lithium
204(1)
Lithium in Pregnancy
205(1)
Caution with Nonsteroidal Anti-inflammatory Drugs and a Low-Sodium Diet
205(1)
Treatment of Bipolar Disorder with Antiepileptic Drugs
205(1)
9.4 Schizophrenia
206(11)
What Is Schizophrenia?
207(1)
Crystal Meth and Cannabis as Triggers of Schizophrenia
208(1)
Antipsychotics
209(1)
Ten Reasons for Taking Antipsychotics in Schizophrenia
209(1)
Antipsychotics for Emergency and Long-Term Therapy
210(1)
Typical and Atypical Antipsychotics
210(2)
"Antagonists at Many Receptors" Explains Therapeutic Effects and Adverse Drug Reactions
212(1)
Problems in Use of Antipsychotics
213(1)
Clozapine
213(1)
Other Uses of Antipsychotics
214(1)
Avoid Antipsychotics in Dementia
215(2)
10 Drugs for Eye Diseases
217(12)
10.1 Glaucoma
217(7)
What Is Glaucoma?
218(1)
How Does Glaucoma Develop?
218(3)
How Is Glaucoma Treated?
221(1)
Prostaglandins
221(1)
Alternatives to Prostaglandins
222(1)
Which Drugs Can Worsen Glaucoma?
223(1)
What to Do in Acute Glaucoma
223(1)
10.2 Wet Macular Degeneration
224(5)
What Is Macular Degeneration?
224(1)
How Does Wet Macular Degeneration Develop?
225(1)
How Is Wet Macular Degeneration Treated?
226(1)
Adverse Drug Reactions Associated with Vascular Endothelial Growth Factor Inhibitors
227(1)
Bevacizumab as an Alternative to Aflibercept and Bevacizumab
227(2)
11 Drugs for Cancer and for Autoimmune and Infectious Diseases
229(24)
11.1 Cancer
229(7)
What Is Cancer?
230(1)
Cancer Development
230(1)
Cancer Diagnostics and Treatment
231(1)
Cytostatics
232(1)
Adverse Drug Reactions due to Cytostatics
233(1)
Cytostatics and Childbearing
233(1)
Targeted Therapeutics
234(1)
Pain Management
235(1)
11.2 Autoimmune Diseases
236(7)
What Are Autoimmune Diseases?
237(1)
Any Organ Can Be Affected
237(1)
T Cells as a Focus of Therapy
238(1)
"Cortisone" and Nonsteroidal Anti-inflammatory Drugs
239(1)
Disease-Modifying Antirheumatic Drugs
239(1)
Coxibs
240(1)
Treatment of Autoimmune Diseases with Cortisone
240(1)
Low-Dose Cytostatics
241(1)
Risks Associated with Low-Dose Methotrexate
242(1)
Treatment of Autoimmune Diseases with Inhibitors of T Cell Function
242(1)
Specific (and Expensive) Approaches
242(1)
11.3 Infectious Diseases
243(10)
How Do Infectious Diseases Develop?
244(1)
Vaccinations
245(1)
No Therapy Without a Proper Diagnosis
245(1)
Antibiotics: A Misleading Term
245(1)
Use Antibiotics Wisely
246(1)
Antibiotic Treatment and Adverse Drug Reactions
246(1)
Beta-Lactam Antibiotics
247(1)
Macrolides
247(1)
Fluoroquinolones
248(1)
Tetracyclines
248(1)
How Are Viral Infectious Diseases Treated?
248(1)
Influenza
249(1)
Herpes Infections
249(1)
Fungal Infections
250(1)
Dermatophyte Infections
250(1)
Yeast Infections
251(1)
Parasite Infections
252(1)
Glossary of Important Pharmacological Terms 253(14)
Further Reading 267
Prof. Dr. Roland Seifert is Full Professor and Institute Director at Medical School Hannover (MHH), Germany. He has been teaching pharmacology for medical students for more than 30 years and since 2010 has regularly received the Best Teacher Award from the medical students, MHH. Roland Seifert is the current Editor-in-chief of the prestigious Springer journal Naunyn-Schmiedeberg's Archives of Pharmacology.