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Laboratory Mouse 3rd edition [Hardback]

(University of Kentucky), (FAS, Harvard Univ.), (Colorado Univ., Boulder)
  • Formāts: Hardback, 244 pages, height x width: 229x152 mm, weight: 503 g, 16 Tables, black and white; 3 Line drawings, black and white; 35 Halftones, color; 9 Halftones, black and white; 35 Illustrations, color; 12 Illustrations, black and white
  • Sērija : Laboratory Animal Pocket Reference
  • Izdošanas datums: 08-Feb-2023
  • Izdevniecība: CRC Press
  • ISBN-10: 1032416858
  • ISBN-13: 9781032416854
  • Hardback
  • Cena: 197,77 €
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  • Pievienot vēlmju sarakstam
  • Formāts: Hardback, 244 pages, height x width: 229x152 mm, weight: 503 g, 16 Tables, black and white; 3 Line drawings, black and white; 35 Halftones, color; 9 Halftones, black and white; 35 Illustrations, color; 12 Illustrations, black and white
  • Sērija : Laboratory Animal Pocket Reference
  • Izdošanas datums: 08-Feb-2023
  • Izdevniecība: CRC Press
  • ISBN-10: 1032416858
  • ISBN-13: 9781032416854
With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. Revised to reflect advances since the second edition, The Laboratory Mouse continues to be the most accessible reference on the biology and care of the mouse in research settings.

This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers on the humane care and use of the mouse. The new edition adds information on novel technologies such as CRISPR-Cas and on housing systems and management practices; it covers new concepts such as pain assessment by facial expression and the importance of nest-building as an assessment tool of well-being. There are now expanded sections on anesthesia and analgesia, and on behavior and enrichment.

An ideal quick reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in a research setting, this book will be particularly valuable to those new to working with mice who need to start research programs using these animals.
Preface xiii
About the authors xv
1 Important Biological Features
1(24)
Introduction
1(1)
Stocks and strains
2(1)
Nomenclature
3(2)
Anatomic and physiologic features
5(4)
Normative values
9(1)
Basic Biologic Parameters
9(1)
Clinical Chemistry
9(2)
Urinalysis
11(1)
Hematology
12(1)
Immunodeficient mice
13(2)
Wild mice
15(2)
Behavior, well-being, and enrichment
17(1)
Behavior
17(2)
Well-being
19(1)
Enrichment
20(1)
References
21(4)
2 Husbandry
25(44)
Housing
25(1)
Caging
25(3)
Housing Systems
28(2)
Bedding
30(3)
Barriers and containment
33(3)
Personal protective equipment (PPE)
36(1)
Special considerations for immunodeficient mice
37(1)
Environment
38(1)
Temperature and Humidity
38(1)
Ventilation
39(1)
Illumination
39(1)
Noise and Vibration
40(1)
Sanitation and pest control
41(1)
Sanitation
41(1)
Cage cleaning
41(2)
Room cleaning
43(1)
Research equipment cleaning
43(1)
Quality control
43(1)
Pest Control
44(1)
Nutrition
44(3)
Water
47(1)
Breeding
47(1)
Basic Genetics
48(1)
Breeding Schemes
49(3)
Pheromone Influences
52(1)
Timed Pregnancy
53(1)
Genetic Monitoring
54(1)
Identification and record keeping
55(1)
Identification
55(2)
Records
57(1)
Transportation
58(1)
Between Institutions
58(2)
Within the Institution
60(1)
References
60(9)
3 management
69(10)
Regulatory agencies and compliance
69(2)
Institutional Animal Care and Use Committee (IACUC)
71(1)
IACUC Composition
71(1)
Responsibilities of the IACUC
72(1)
Occupational health and zoonotic diseases
72(3)
Compassion fatigue
75(1)
References
76(3)
4 Clinical Medicine
79(62)
Basic veterinary supplies
79(1)
Physical examination of the mouse
80(2)
Common spontaneous and noninfectious diseases
82(2)
Common Conditions Involving the Alimentary System
84(1)
Non-neoplastic conditions
84(1)
Alimentary tumors
85(1)
Common Conditions Involving the Cardiovascular System
85(1)
Non-neoplastic conditions
85(2)
Cardiovascular tumors
87(1)
Common Conditions Involving the Endocrine System
87(1)
Non-neoplastic conditions
87(1)
Endocrine tumors
87(1)
Hematopoietic and Immune System
88(1)
Non-neoplastic conditions
88(1)
Hematopoietic and immune system tumors
89(1)
Common Conditions Involving the Integumentary System
89(1)
Non-neoplastic conditions
89(2)
Tumors of skin and adnexae
91(2)
Common Conditions Involving the Musculoskeletal System
93(1)
Non-neoplastic conditions
93(1)
Musculoskeletal tumors
94(1)
Common Conditions Involving the Nervous System
94(1)
Non-neoplastic conditions
94(2)
Nervous system tumors
96(1)
Common Conditions Involving the Respiratory System
97(1)
Non-neoplastic conditions
97(1)
Respiratory tumors
97(1)
Common Conditions Involving the Urogenital System
97(1)
Non-neoplastic conditions
97(1)
Urogenital tumors
98(1)
Common Systemic or Multisystem Conditions
98(1)
Amyloidosis
98(1)
Hyalinosis
99(1)
Conditions related to nutritional status
99(1)
Stress-related changes
100(1)
Common Infectious Diseases
100(2)
Diagnostic Methods
102(1)
Viral Agents and Diseases
103(1)
Murine noroviruses (MNV)
104(1)
Parvoviruses
104(1)
Mouse hepatitis virus (MHV)
105(1)
Theiler's mouse encephalomyelitis virus (TMEV)
106(1)
Mouse rotavirus (MRV, EDIM)
106(1)
Murine astrovirus
107(1)
Mouse adenoviruses (MAV 1 and 2)
107(1)
Lymphocytic choriomeningitis virus (LCMV)
108(1)
Lactate dehydrogenase-elevating virus (LDV, LDEV)
108(1)
Hantaviruses (Han)
108(1)
Herpesviruses
108(1)
Ectromelia virus (mousepox)
108(1)
Papovaviruses
109(1)
Paramyxoviruses
110(1)
Reovirus 3 (REO3)
110(1)
Bacterial Agents and Diseases
110(1)
Bordetella species
110(1)
Filobacterium rodentium (formerly cilia-associated respiratory bacillus, CAR bacillus, CARB)
111(1)
Citrobacter rodentium
111(1)
Clostridium piliforme
112(1)
Corynebacterium bovis
112(1)
Helicobacter
112(1)
Mycoplasma
113(1)
Rodentibacter pneumotropicus and R. heylii (formerly Pasteurella pneumotropica type Jawetz or Heyl)
113(1)
Pseudomonas aeruginosa
114(1)
Staphylococcus
114(1)
Fungal Agents and Diseases
115(1)
Pneumocystis murina
115(1)
Intestinal protozoa
115(2)
Parasitic Agents and Diseases
117(1)
Arthropods
117(2)
Helminths
119(3)
Treatment and supportive care of sick mice
122(1)
Drug Dosages
122(1)
General Treatment of Open Skin Lesions
122(1)
General Treatment of Weak Mice
122(1)
Provision of supplemental fluids
123(1)
Provision of food
123(1)
Provision of supplemental heat
124(1)
Treatment of Dystocia
124(1)
Clinical endpoints
125(4)
Treating disease on a colony basis
129(1)
Prevention of Spread
129(2)
Approaches to Elimination
131(1)
Depopulation
131(1)
Test and cull
131(1)
Burnout
132(1)
Medical treatment
132(1)
Facility Decontamination
133(1)
References
133(8)
5 Preventive Medicine
141(16)
Receiving
141(1)
Reviewing Health Reports
141(3)
Options for Newly Imported Mice
144(1)
Transport directly to barrier
144(1)
Quarantine
144(2)
Rederivation
146(2)
Cryopreservation
148(1)
Testing of biological materials
148(1)
Risks for Humans and Animals
148(2)
Health surveillance and monitoring
150(1)
Principles
150(1)
Selection of Test Subjects
151(2)
Diagnostic Testing
153(1)
Disease prevention through sanitation
153(1)
References
154(3)
6 Experimental Methodology
157(52)
Restraint
157(1)
Cage Transfer
157(1)
Restraint for Manipulation
158(1)
Restraint Devices
159(1)
Sampling methods
159(1)
Blood
159(6)
Urine
165(2)
Feces
167(1)
Samples for DNA Analysis
167(1)
Vaginal Swabs
168(1)
Compound administration
169(1)
Oral (PO)
169(1)
Intramuscular (IM)
170(1)
Intraperitoneal (IP)
171(1)
Subcutaneous (SC)
172(1)
Intradermal (ID)
172(1)
Intravenous (IV)
172(1)
Retro-orbital (RO)
173(1)
Implantable Cannulas and Pumps
174(1)
Anesthesia and analgesia
175(1)
Anesthesia
175(1)
Methods and drugs
176(6)
Periprocedural Care
182(3)
Analgesia
185(3)
Euthanasia
188(1)
Laws, Regulations, and Guidelines
189(1)
Management Considerations
189(1)
Scientific Considerations
190(1)
Experimental Endpoints
190(1)
Euthanasia Methods
191(2)
Necropsy
193(1)
Equipment and Materials
193(2)
Necropsy Procedure
195(1)
External examination
196(1)
Dissection and specimen collection
196(3)
Trimming tissues for histology
199(1)
Histopathology
200(1)
Reporting and archiving data and specimens
200(1)
References
200(9)
7 Resources and additional information
209(12)
Organizations
209(1)
American Association for Laboratory Animal Science (AALAS), www.aalas.org
209(1)
Laboratory Animal Management Association (LAMA), www.lama-online.org
210(1)
American Society of Laboratory Animal Practitioners (ASLAP), www.aslap.org
210(1)
American College of Laboratory Animal Medicine (ACLAM), www.aclam.org
210(1)
Laboratory Animal Welfare Training Exchange (LAWTE), www.lawte.org
211(1)
Institute for Laboratory Animal Research (ILAR), www.nationalacademies.org/ilar/institute-for Taboratory-animal-research
211(1)
AAALAC International, www.aaalac.org
211(1)
Foundation for Biomedical Research (FBR), fbresearch.org
212(1)
National Association for Biomedical Research (NABR), www.nabr.org
212(1)
Publications
212(1)
Books
212(2)
Guideline Documents
214(1)
Periodicals
214(1)
Electronic resources
215(2)
Appendix
217(1)
Suggested cassette numbering system and some trimming suggestions
217(4)
Index 221
Mark A. Suckow is Associate Vice President for Research, Attending Veterinarian, and Professor of Biomedical Engineering at the University of Kentucky, in Lexington, KY. Dr. Suckow earned the degree of Doctor of Veterinary Medicine from the University of Wisconsin in 1987 and completed a post-doctoral residency program in laboratory animal medicine at the University of Michigan in 1990. He is a Diplomate of the American College of Laboratory Animal Medicine. Dr. Suckow has published over 100 scientific papers and chapters in books. He is a Past President of the American Association for Laboratory Animal Science, Past President of the American Society of Laboratory Animal Practitioners, and serves on the Council on Accreditation of AAALAC, International.

Sara Hashway is the Director of the Office of Animal Resources, Attending Veterinarian, and Assistant Research Professor of Psychology and Neuroscience at the University of Colorado, Boulder in Boulder, CO. Dr. Hashway earned her veterinary degree from the University of Georgia in 2010 and completed a post-doctoral fellowship in Laboratory Animal Medicine at the University of Michigan in 2013. She is a Diplomate of the American College of Laboratory Animal Medicine and serves as an ad hoc consultant for AAALAC, International. She has published multiple scientific papers and co-authored the chapter "The Translational Potential of Rats" for the third edition of the ACLAM Series book The Laboratory Rat.

Kathleen R. Pritchett-Corning is the Attending Veterinarian and Director, Office of Animal Resources, at the Harvard University Faculty of Arts and Sciences and an Affiliate Assistant Professor in the Department of Comparative Medicine at the University of Washington. Dr. Pritchett-Corning received her B.S. and her D.V.M. from Washington State University and her post-doctoral training from the University of Washington. She became a Diplomate of the American College of Laboratory Animal Medicine in 2002 and has held positions at the University of Washington, the Jackson Laboratory, and Charles River. In 2015, she received the AALAS Pravin Bhatt Scientific Excellence Award. Dr. Pritchett-Corning has worked primarily with mice for 30 years and has authored more than 80 peer-reviewed publications.