Preface |
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xiii | |
About the authors |
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xv | |
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1 Important Biological Features |
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1 | (24) |
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1 | (1) |
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2 | (1) |
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3 | (2) |
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Anatomic and physiologic features |
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5 | (4) |
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9 | (1) |
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Basic Biologic Parameters |
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9 | (1) |
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9 | (2) |
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11 | (1) |
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12 | (1) |
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13 | (2) |
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15 | (2) |
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Behavior, well-being, and enrichment |
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17 | (1) |
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17 | (2) |
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19 | (1) |
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20 | (1) |
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21 | (4) |
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25 | (44) |
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25 | (1) |
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25 | (3) |
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28 | (2) |
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30 | (3) |
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33 | (3) |
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Personal protective equipment (PPE) |
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36 | (1) |
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Special considerations for immunodeficient mice |
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37 | (1) |
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38 | (1) |
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38 | (1) |
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39 | (1) |
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39 | (1) |
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40 | (1) |
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Sanitation and pest control |
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41 | (1) |
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41 | (1) |
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41 | (2) |
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43 | (1) |
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Research equipment cleaning |
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43 | (1) |
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43 | (1) |
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44 | (1) |
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44 | (3) |
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47 | (1) |
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47 | (1) |
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48 | (1) |
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49 | (3) |
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52 | (1) |
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53 | (1) |
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54 | (1) |
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Identification and record keeping |
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55 | (1) |
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55 | (2) |
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57 | (1) |
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58 | (1) |
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58 | (2) |
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60 | (1) |
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60 | (9) |
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69 | (10) |
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Regulatory agencies and compliance |
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69 | (2) |
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Institutional Animal Care and Use Committee (IACUC) |
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71 | (1) |
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71 | (1) |
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Responsibilities of the IACUC |
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72 | (1) |
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Occupational health and zoonotic diseases |
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72 | (3) |
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75 | (1) |
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76 | (3) |
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79 | (62) |
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Basic veterinary supplies |
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79 | (1) |
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Physical examination of the mouse |
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80 | (2) |
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Common spontaneous and noninfectious diseases |
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82 | (2) |
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Common Conditions Involving the Alimentary System |
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84 | (1) |
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Non-neoplastic conditions |
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84 | (1) |
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85 | (1) |
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Common Conditions Involving the Cardiovascular System |
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85 | (1) |
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Non-neoplastic conditions |
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85 | (2) |
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87 | (1) |
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Common Conditions Involving the Endocrine System |
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87 | (1) |
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Non-neoplastic conditions |
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87 | (1) |
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87 | (1) |
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Hematopoietic and Immune System |
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88 | (1) |
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Non-neoplastic conditions |
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88 | (1) |
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Hematopoietic and immune system tumors |
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89 | (1) |
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Common Conditions Involving the Integumentary System |
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89 | (1) |
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Non-neoplastic conditions |
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89 | (2) |
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Tumors of skin and adnexae |
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91 | (2) |
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Common Conditions Involving the Musculoskeletal System |
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93 | (1) |
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Non-neoplastic conditions |
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93 | (1) |
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94 | (1) |
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Common Conditions Involving the Nervous System |
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94 | (1) |
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Non-neoplastic conditions |
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94 | (2) |
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96 | (1) |
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Common Conditions Involving the Respiratory System |
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97 | (1) |
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Non-neoplastic conditions |
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97 | (1) |
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97 | (1) |
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Common Conditions Involving the Urogenital System |
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97 | (1) |
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Non-neoplastic conditions |
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97 | (1) |
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98 | (1) |
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Common Systemic or Multisystem Conditions |
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98 | (1) |
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98 | (1) |
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99 | (1) |
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Conditions related to nutritional status |
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99 | (1) |
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100 | (1) |
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Common Infectious Diseases |
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100 | (2) |
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102 | (1) |
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Viral Agents and Diseases |
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103 | (1) |
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104 | (1) |
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104 | (1) |
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Mouse hepatitis virus (MHV) |
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105 | (1) |
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Theiler's mouse encephalomyelitis virus (TMEV) |
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106 | (1) |
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Mouse rotavirus (MRV, EDIM) |
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106 | (1) |
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107 | (1) |
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Mouse adenoviruses (MAV 1 and 2) |
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107 | (1) |
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Lymphocytic choriomeningitis virus (LCMV) |
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108 | (1) |
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Lactate dehydrogenase-elevating virus (LDV, LDEV) |
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108 | (1) |
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108 | (1) |
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108 | (1) |
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Ectromelia virus (mousepox) |
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108 | (1) |
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109 | (1) |
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110 | (1) |
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110 | (1) |
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Bacterial Agents and Diseases |
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110 | (1) |
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110 | (1) |
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Filobacterium rodentium (formerly cilia-associated respiratory bacillus, CAR bacillus, CARB) |
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111 | (1) |
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111 | (1) |
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112 | (1) |
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112 | (1) |
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112 | (1) |
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113 | (1) |
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Rodentibacter pneumotropicus and R. heylii (formerly Pasteurella pneumotropica type Jawetz or Heyl) |
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113 | (1) |
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114 | (1) |
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114 | (1) |
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Fungal Agents and Diseases |
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115 | (1) |
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115 | (1) |
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115 | (2) |
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Parasitic Agents and Diseases |
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117 | (1) |
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117 | (2) |
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119 | (3) |
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Treatment and supportive care of sick mice |
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122 | (1) |
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122 | (1) |
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General Treatment of Open Skin Lesions |
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122 | (1) |
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General Treatment of Weak Mice |
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122 | (1) |
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Provision of supplemental fluids |
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123 | (1) |
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123 | (1) |
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Provision of supplemental heat |
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124 | (1) |
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124 | (1) |
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125 | (4) |
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Treating disease on a colony basis |
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129 | (1) |
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129 | (2) |
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Approaches to Elimination |
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131 | (1) |
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131 | (1) |
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131 | (1) |
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132 | (1) |
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132 | (1) |
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133 | (1) |
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133 | (8) |
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141 | (16) |
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141 | (1) |
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141 | (3) |
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Options for Newly Imported Mice |
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144 | (1) |
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Transport directly to barrier |
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144 | (1) |
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144 | (2) |
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146 | (2) |
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148 | (1) |
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Testing of biological materials |
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148 | (1) |
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Risks for Humans and Animals |
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148 | (2) |
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Health surveillance and monitoring |
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150 | (1) |
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150 | (1) |
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Selection of Test Subjects |
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151 | (2) |
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153 | (1) |
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Disease prevention through sanitation |
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153 | (1) |
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154 | (3) |
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6 Experimental Methodology |
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157 | (52) |
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157 | (1) |
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157 | (1) |
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Restraint for Manipulation |
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158 | (1) |
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159 | (1) |
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159 | (1) |
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159 | (6) |
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165 | (2) |
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167 | (1) |
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167 | (1) |
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168 | (1) |
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169 | (1) |
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169 | (1) |
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170 | (1) |
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171 | (1) |
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172 | (1) |
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172 | (1) |
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172 | (1) |
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173 | (1) |
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Implantable Cannulas and Pumps |
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174 | (1) |
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175 | (1) |
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175 | (1) |
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176 | (6) |
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182 | (3) |
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185 | (3) |
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188 | (1) |
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Laws, Regulations, and Guidelines |
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189 | (1) |
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Management Considerations |
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189 | (1) |
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Scientific Considerations |
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190 | (1) |
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190 | (1) |
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191 | (2) |
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193 | (1) |
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193 | (2) |
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195 | (1) |
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196 | (1) |
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Dissection and specimen collection |
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196 | (3) |
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Trimming tissues for histology |
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199 | (1) |
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200 | (1) |
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Reporting and archiving data and specimens |
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200 | (1) |
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200 | (9) |
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7 Resources and additional information |
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209 | (12) |
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209 | (1) |
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American Association for Laboratory Animal Science (AALAS), www.aalas.org |
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209 | (1) |
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Laboratory Animal Management Association (LAMA), www.lama-online.org |
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210 | (1) |
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American Society of Laboratory Animal Practitioners (ASLAP), www.aslap.org |
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210 | (1) |
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American College of Laboratory Animal Medicine (ACLAM), www.aclam.org |
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210 | (1) |
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Laboratory Animal Welfare Training Exchange (LAWTE), www.lawte.org |
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211 | (1) |
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Institute for Laboratory Animal Research (ILAR), www.nationalacademies.org/ilar/institute-for Taboratory-animal-research |
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211 | (1) |
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AAALAC International, www.aaalac.org |
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211 | (1) |
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Foundation for Biomedical Research (FBR), fbresearch.org |
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212 | (1) |
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National Association for Biomedical Research (NABR), www.nabr.org |
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212 | (1) |
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212 | (1) |
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212 | (2) |
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214 | (1) |
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214 | (1) |
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215 | (2) |
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217 | (1) |
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Suggested cassette numbering system and some trimming suggestions |
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217 | (4) |
Index |
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221 | |