Series Foreword |
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xv | |
Preface |
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xvii | |
Acknowledgments |
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xix | |
Contributors |
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xxi | |
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1 | (14) |
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1.1 Acute Hepatitis With Inflammation-Dominant Pattern |
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7 | (2) |
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1.2 Acute Hepatitis With Bridging Necrosis |
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9 | (2) |
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11 | (2) |
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1.4 Nonspecific Reactive Hepatitis |
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13 | (2) |
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15 | (6) |
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2.1 Acute Liver Failure With Necrosis-Dominant Injury Pattern |
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18 | (3) |
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3 Autoimmune Hepatitis/Overlap Syndromes |
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21 | (18) |
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3.1 Autoimmune Hepatitis With Bile Duct Injury Versus Primary Biliary Cirrhosis |
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26 | (4) |
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3.2 Autoimmune Hepatitis-Primary Biliary Cirrhosis Overlap Syndrome |
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30 | (2) |
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3.3 Autoimmune Hepatitis-Primary Sclerosing Cholangitis Overlap Syndrome |
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32 | (2) |
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3.4 Chronic Hepatitis C With Autoantibodies Versus Autoimmune Hepatitis |
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34 | (2) |
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3.5 Syncytial Giant Cell Hepatitis |
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36 | (3) |
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39 | (28) |
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4.1 Steatosis With Inflammation Versus Steatohepatitis |
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41 | (2) |
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4.2 Steatohepatitis With Minimal Ballooning |
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43 | (2) |
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4.3 Steatohepatitis Without Activity |
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45 | (2) |
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4.4 Nonalcoholic Steatohepatitis With Moderate/Marked Portal Inflammation |
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47 | (5) |
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4.5 Steatohepatitis With Elevated Serum Iron Indices and Siderosis |
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52 | (2) |
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4.6 Alcoholic Steatohepatitis |
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54 | (2) |
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56 | (1) |
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4.8 Microvesicular Steatosis |
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57 | (1) |
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4.9 Pediatric Fatty Liver Disease |
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5 | (58) |
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4.10 Chemotherapy-Associated Steatohepatitis Due to Irinotecan |
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61 | (3) |
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4.11 Subacute Steatohepatitis |
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64 | (3) |
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5 Hepatic Granulomas and Granulomatous Hepatitis |
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67 | (22) |
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5.1 Necrotizing Epithelioid Granulomas |
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70 | (3) |
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73 | (4) |
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5.3 Fibrin Ring Granulomas |
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77 | (2) |
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79 | (3) |
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82 | (3) |
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5.6 Chronic Granulomatous Disease |
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85 | (4) |
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89 | (28) |
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6.1 Drug-Induced Pure Cholestasis |
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96 | (3) |
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6.2 Bile Ductular Cholestasis Associated With Sepsis |
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99 | (3) |
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6.3 Crohn Disease With Primary Sclerosing Cholangitis |
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102 | (2) |
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6.4 Chronic Large Bile Duct Obstruction of Uncertain Cause |
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104 | (3) |
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6.5 Primary Sclerosing Cholangitis, Exclude Cholangiocarcinoma |
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107 | (3) |
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6.6 Immunoglobin G4-Associated Cholangitis Versus Primary Sclerosing Cholangitis |
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110 | (3) |
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113 | (4) |
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7 Bile Duct Damage and Ductopenia |
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117 | (14) |
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7.1 Primary Biliary Cirrhosis With Nonspecific Changes and Positive Antimitochondrial Antibody |
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120 | (3) |
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7.2 Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis |
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123 | (2) |
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7.3 Primary Biliary Cirrhosis With Ductopenia |
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125 | (3) |
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7.4 Primary Biliary Cirrhosis With Cirrhosis |
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128 | (3) |
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8 Ductal Plate Malformations and Cystic Diseases of the Liver |
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131 | (22) |
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8.1 Congenital Hepatic Fibrosis Versus Cirrhosis |
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143 | (2) |
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8.2 Caroli Disease/Syndrome Versus Other Cystic Disease |
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145 | (2) |
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8.3 Adult Polycystic Liver Disease Versus Caroli Disease |
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147 | (2) |
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149 | (2) |
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8.5 Solitary Hepatic Cyst Versus Hydatid Cyst |
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151 | (2) |
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9 Hereditary Hyperbilirubinemias |
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153 | (6) |
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9.1 Dubin-Johnson Syndrome |
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157 | (2) |
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10 Neonatal Cholestatic Liver Disease |
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159 | (16) |
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164 | (3) |
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10.2 Neonatal Hepatitis With Hypopituitarism |
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167 | (3) |
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10.3 Paucity of Intrahepatic Bile Ducts |
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170 | (2) |
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10.4 Neonatal Hepatitis Due to Alpha-1-Antitrypsin Deficiency |
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172 | (3) |
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11 Sinusoidal Dilatation and Congestion |
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175 | (12) |
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11.1 Budd-Chiari Syndrome Versus Biliary Disease |
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177 | (3) |
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11.2 Sinusoidal Obstruction |
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180 | (2) |
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11.3 Veno-Occlusive Disease (Sinusoidal Obstruction Syndrome) |
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182 | (2) |
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184 | (3) |
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187 | (4) |
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12.1 Alcoholic Lipopeliosis |
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188 | (1) |
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12.2 Lipopeliosis in Transplanted Donor Livers |
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189 | (2) |
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13 Portal Hypertension Without Cirrhosis |
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191 | (12) |
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13.1 Hepatoportal Sclerosis |
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191 | (2) |
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13.2 Portal Vein Thrombosis |
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193 | (2) |
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13.3 Budd-Chiari Syndrome |
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195 | (4) |
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13.4 Regressed Cirrhosis Case |
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199 | (4) |
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14 Clinical and Morphological Spectrum of Liver Diseases in Pregnancy |
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203 | (10) |
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14.1 Recurrent Cholestasis of Pregnancy |
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205 | (2) |
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14.2 Acute Fatty Liver of Pregnancy |
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207 | (3) |
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14.3 Toxemia/HELLP Syndrome |
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210 | (3) |
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15 Drug-Induced Liver Injury |
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213 | (30) |
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15.1 Acetaminophen-Induced Fulminant Liver Failure |
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217 | (3) |
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15.2 Statin-Associated Acute Hepatotoxicity |
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220 | (3) |
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15.3 Drug-Induced Autoimmune Hepatitis |
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223 | (3) |
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15.4 Drug-Induced Cholestatic Hepatitis |
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226 | (3) |
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15.5 Drug-Induced Ductopenia |
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229 | (3) |
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15.6 Methotrexate-Induced Chronic Liver Disease |
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232 | (3) |
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15.7 Liver Injury Due to Total Parenteral Nutrition |
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235 | (2) |
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15.8 Amiodarone-Induced Phospholipidosis |
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237 | (3) |
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15.9 Drug-Induced Microvesicular Steatosis |
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240 | (3) |
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243 | (8) |
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16.1 Alpha-1-Antitrypsin Deficiency |
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245 | (4) |
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16.2 Alpha-1-Antichymotrypsin Deficiency |
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249 | (2) |
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17 Glycogenic Abnormalities on Liver Biopsy |
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251 | (14) |
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17.1 Glycogenic Hepatopathy |
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255 | (2) |
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17.2 Glycogen in the Liver: Abnormal Versus Normal |
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257 | (1) |
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17.3 Glycogenic Hepatopathy, Cause Uncertain |
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258 | (2) |
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17.4 Glycogenic Hepatopathy, Type II Diabetes |
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260 | (1) |
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17.5 Glycogen Pseudo-Ground-Glass |
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261 | (2) |
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17.6 Smooth Endoplasmic Reticulum Proliferation |
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263 | (2) |
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265 | (10) |
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271 | (2) |
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18.2 Niemann-Pick Disease |
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273 | (2) |
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19 Approach to Liver Biopsy With Minimal or Nonspecific Histologic Findings |
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275 | (6) |
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19.1 Mild Hepatic Steatosis Versus Ito Cell Lipidosis |
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278 | (3) |
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20 Interpreting Iron in Liver Specimens |
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281 | (18) |
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20.1 Genetic Hemochromatosis |
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284 | (5) |
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289 | (2) |
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291 | (2) |
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20.4 Marked Hepatic Iron but No Genetic Mutation |
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293 | (1) |
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20.5 Iron in the Setting of Chronic Hepatitis C |
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294 | (2) |
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20.6 Neonatal Hemochromatosis |
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296 | (3) |
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299 | (8) |
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21.1 Fulminant Form of Wilson Disease |
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301 | (3) |
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21.2 Chronic Hepatitis Due to Wilson Disease |
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304 | (1) |
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21.3 Cirrhosis With Chronic Hepatitis Consistent With Wilson Disease |
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305 | (2) |
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22 Liver Transplant Pathology |
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307 | (36) |
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22.1 Acute Cellular Rejection |
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309 | (2) |
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22.2 Recurrent Hepatitis C |
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311 | (2) |
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22.3 Acute Cellular Rejection Versus Recurrent Hepatitis C |
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313 | (2) |
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22.4 Late Cellular Rejection Versus Autoimmune Hepatitis Versus Recurrent Hepatitis C |
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315 | (4) |
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22.5 Fibrosing Cholestatic Hepatitis C Versus Biliary Obstruction Versus Adverse Reaction to Medication |
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319 | (4) |
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22.6 Mechanical Biliary Obstruction Versus Chronic Rejection |
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323 | (3) |
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22.7 Chronic Rejection Versus Recurrent Primary Sclerosing Cholangitis Versus Non-PSC Stricture |
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326 | (4) |
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22.8 Zone 3 (Centrilobular) Necrosis |
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330 | (7) |
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22.9 Cytomegalovirus Hepatitis |
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337 | (3) |
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22.10 Graft Versus Host Disease |
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340 | (3) |
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23 Benign Hepatocellular Lesions |
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343 | (18) |
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23.1 Atypical Focal Nodular Hyperplasias on Imaging |
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347 | (2) |
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23.2 Focal Nodular Hyperplasia Versus Inflammatory/Telangiectatic Hepatocellular Adenoma |
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349 | (2) |
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23.3 Hepatocellular Adenoma Subtyping: Inflammatory/Telangiectatic Versus Steatotic Adenoma |
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351 | (3) |
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23.4 Hepatocellular Adenoma Subtyping: Associated Liver Nodules |
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354 | (2) |
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23.5 Hepatocellular Adenoma Subtyping: Inflammatory/Telangiectatic Adenoma |
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356 | (3) |
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23.6 Hepatocellular Adenoma Subtyping: Adenoma With Atypical Features |
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359 | (2) |
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361 | (26) |
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24.1 Bile Duct Adenoma Versus Biliary Hamartoma |
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365 | (5) |
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24.2 Intrahepatic Cholangiocarcinoma Versus Hepatocellular Carcinoma |
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370 | (3) |
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24.3 Cholangiocarcinoma in Association With Von Meyenburg Complexes |
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373 | (2) |
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24.4 Diagnosis of Hilar/Extrahepatic Cholangiocarcinoma |
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375 | (3) |
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24.5 Bile Duct Cystadenoma/Carcinoma Versus Foregut Cyst |
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378 | (3) |
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24.6 Biliary Adenofibroma |
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381 | (2) |
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24.7 Biliary Papillomatosis/Intraductal Cholangiocarcinoma |
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383 | (4) |
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25 Hepatocellular Carcinoma |
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387 | (20) |
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25.1 Well-Differentiated Hepatocellular Carcinoma |
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394 | (4) |
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25.2 Poorly Differentiated Hepatocellular Carcinoma |
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398 | (5) |
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25.3 Early Hepatocellular Carcinoma |
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403 | (4) |
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26 Hepatocellular Carcinoma Variants |
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407 | (24) |
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26.1 Pseudoglandular Hepatocellular Carcinoma Versus Cholangiocarcinoma and Metastatic Adenocarcinoma |
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409 | (3) |
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26.2 Hepatocellular Versus Neuroendocrine Carcinoma |
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412 | (2) |
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26.3 Hepatocellular Carcinoma, Clear Cell Variant |
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414 | (3) |
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26.4 Scirrhous Hepatocellular Carcinoma |
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417 | (2) |
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26.5 Combined Hepatocellular-Cholangiocarcinoma |
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419 | (2) |
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26.6 Diffuse Cirrhosis-Like Hepatocellular Carcinoma |
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421 | (2) |
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26.7 Spectrum of Cytoplasmic Contents in Hepatocellular Carcinoma |
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423 | (2) |
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26.8 Poor Differentiation and Vascular Invasion in Hepatocellular Carcinoma |
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425 | (2) |
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26.9 Pedunculated Hepatocellular Carcinoma |
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427 | (1) |
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26.10 Ablated Hepatocellular Carcinoma |
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428 | (3) |
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27 Metastatic Tumors: Illustration of Immunohistochemical Workup |
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431 | (10) |
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27.1 Hepatocellular Carcinoma Versus Metastatic Adenocarcinoma |
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436 | (2) |
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27.2 Hepatocellular Carcinoma Versus Metastatic Polygonal Cell Tumor |
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438 | (3) |
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441 | (16) |
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28.1 Biopsy Diagnosis of Hepatoblastoma |
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447 | (2) |
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28.2 Macrotrabecular Hepatoblastoma Versus Hepatocellular Carcinoma |
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449 | (3) |
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28.3 Small Cell Hepatoblastoma Versus Other Small Round Cell Tumors |
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452 | (3) |
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28.4 Teratoid Hepatoblastoma Versus Malignant Teratoma/Yolk Sac Tumor |
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455 | (2) |
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457 | (12) |
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29.1 Cavernous Hemangioma Variants |
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457 | (2) |
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29.2 Epithelioid Hemangioendothelioma |
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459 | (3) |
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29.3 Hepatic Angiosarcoma |
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462 | (3) |
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29.4 Infantile Hemangioma |
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465 | (4) |
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30 Hematopoietic Tumors of the Liver |
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469 | (26) |
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30.1 Dense Small B-Cell Infiltrate With Reactive Follicles |
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476 | (4) |
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30.2 Diffuse Large B-Cell Infiltrate |
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480 | (2) |
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30.3 Portal Infiltrate With Reed-Sternberg Cells |
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482 | (3) |
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30.4 Polymorphic Lymphoid Infiltrate in a Transplant Patient |
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485 | (2) |
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30.5 Sinusoidal T-Cell Infiltrate |
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487 | (3) |
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30.6 Portal and Lobular Infiltration by Blasts |
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490 | (2) |
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30.7 Portal and Lobular Infiltration by Mature Granulocytes |
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492 | (3) |
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31 Other Infiltrative Neoplasms of Liver |
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495 | (4) |
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31.1 Portal-Based Infiltrative Neoplasm Versus Biliary Disease |
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496 | (3) |
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32 Mesenchymal Tumors of the Liver |
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499 | (16) |
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32.1 Mesenchymal Hamartoma |
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499 | (3) |
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502 | (3) |
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505 | (3) |
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32.4 Angiomyolipoma, Inflammatory Variant |
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508 | (2) |
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32.5 Malignant Angiomyolipoma---Malignant Perivascular Epithelioid Cell Tumor |
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510 | (5) |
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515 | (8) |
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A Adequacy of Needle Biopsy |
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515 | (2) |
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517 | (4) |
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C Special Stains in Liver Biopsy Pathology |
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521 | (2) |
Index |
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523 | |