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E-grāmata: Liver Pathology

  • Formāts: 560 pages
  • Sērija : Consultant Pathology Series
  • Izdošanas datums: 28-Mar-2011
  • Izdevniecība: Demos Medical Publishing
  • Valoda: eng
  • ISBN-13: 9781935281474
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  • Formāts: 560 pages
  • Sērija : Consultant Pathology Series
  • Izdošanas datums: 28-Mar-2011
  • Izdevniecība: Demos Medical Publishing
  • Valoda: eng
  • ISBN-13: 9781935281474
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This unique book provides detailed insight into a wealth of expert experience in liver pathology, with an in-depth review of the expert's analysis and diagnostic process supported by high-quality colour photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. The diagnostic problems and cases selected show the wide range of specimens seen in liver pathology and address the difficult issues in diagnosis encountered in these lesions. Chapters and cases are authored by many of the leading experts and educators in liver pathology today.

Liver Pathology will be essential reading for every Pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for Pathology Residents and Fellows.

All Consultant Pathology titles provide:

Actual consultation cases and expert analysis Expert analysis provides a detailed discussion of the reasoning behind the diagnosis of each case Comprehensive coverage of challenging diagnoses The cases are richly illustrated with high-quality photomicrographs

Recenzijas

**** 5 Star Review ***** ""This is a uniquely presented book that provides average pathologists a window into the analysis and diagnostic process that leading liver experts use when working up challenging liver cases. The illustrations and discussions support the final diagnosis and criteria by which one evaluates the cases. As a pathologist who sees liver biopsies, I read this book with the same enthusiasm I read a novel and I wholeheartedly recommend it to anyone with an interest in liver pathology.""-Doody's Reviews

Series Foreword xv
Preface xvii
Acknowledgments xix
Contributors xxi
1 Acute Hepatitis
1(14)
Sanjay Kakar
1.1 Acute Hepatitis With Inflammation-Dominant Pattern
7(2)
1.2 Acute Hepatitis With Bridging Necrosis
9(2)
1.3 Resolving Hepatitis
11(2)
1.4 Nonspecific Reactive Hepatitis
13(2)
2 Acute Liver Failure
15(6)
Ruge Shree Ramachandran
Sanjay Kakar
2.1 Acute Liver Failure With Necrosis-Dominant Injury Pattern
18(3)
Sanjay Kakar
3 Autoimmune Hepatitis/Overlap Syndromes
21(18)
Kay Washington
3.1 Autoimmune Hepatitis With Bile Duct Injury Versus Primary Biliary Cirrhosis
26(4)
3.2 Autoimmune Hepatitis-Primary Biliary Cirrhosis Overlap Syndrome
30(2)
3.3 Autoimmune Hepatitis-Primary Sclerosing Cholangitis Overlap Syndrome
32(2)
3.4 Chronic Hepatitis C With Autoantibodies Versus Autoimmune Hepatitis
34(2)
3.5 Syncytial Giant Cell Hepatitis
36(3)
4 Fatty Liver Disease
39(28)
Matthew M. Yeh
Elizabeth M. Brunt
4.1 Steatosis With Inflammation Versus Steatohepatitis
41(2)
4.2 Steatohepatitis With Minimal Ballooning
43(2)
4.3 Steatohepatitis Without Activity
45(2)
4.4 Nonalcoholic Steatohepatitis With Moderate/Marked Portal Inflammation
47(5)
4.5 Steatohepatitis With Elevated Serum Iron Indices and Siderosis
52(2)
4.6 Alcoholic Steatohepatitis
54(2)
4.7 Drugs and NAFLD
56(1)
4.8 Microvesicular Steatosis
57(1)
4.9 Pediatric Fatty Liver Disease
5(58)
Cynthia Behling
4.10 Chemotherapy-Associated Steatohepatitis Due to Irinotecan
61(3)
Vikram Deshpande
Gregory Y. Lauwers
4.11 Subacute Steatohepatitis
64(3)
Linda D. Ferrell
5 Hepatic Granulomas and Granulomatous Hepatitis
67(22)
Laura W. Lamps
5.1 Necrotizing Epithelioid Granulomas
70(3)
5.2 Sarcoidosis
73(4)
5.3 Fibrin Ring Granulomas
77(2)
5.4 Schistosomiasis
79(3)
5.5 Cat Scratch Disease
82(3)
5.6 Chronic Granulomatous Disease
85(4)
David E. Kleiner
6 Cholestasis
89(28)
Jay H. Lefkowitch
6.1 Drug-Induced Pure Cholestasis
96(3)
6.2 Bile Ductular Cholestasis Associated With Sepsis
99(3)
6.3 Crohn Disease With Primary Sclerosing Cholangitis
102(2)
6.4 Chronic Large Bile Duct Obstruction of Uncertain Cause
104(3)
6.5 Primary Sclerosing Cholangitis, Exclude Cholangiocarcinoma
107(3)
6.6 Immunoglobin G4-Associated Cholangitis Versus Primary Sclerosing Cholangitis
110(3)
Vikram Deshpande
6.7 Hepatolithiasis
113(4)
Polly W. Y. Lam
Wilson M. S. Tsui
7 Bile Duct Damage and Ductopenia
117(14)
Kay Washington
7.1 Primary Biliary Cirrhosis With Nonspecific Changes and Positive Antimitochondrial Antibody
120(3)
7.2 Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis
123(2)
7.3 Primary Biliary Cirrhosis With Ductopenia
125(3)
7.4 Primary Biliary Cirrhosis With Cirrhosis
128(3)
8 Ductal Plate Malformations and Cystic Diseases of the Liver
131(22)
Barton Kenney
Dhanpat Jain
8.1 Congenital Hepatic Fibrosis Versus Cirrhosis
143(2)
8.2 Caroli Disease/Syndrome Versus Other Cystic Disease
145(2)
8.3 Adult Polycystic Liver Disease Versus Caroli Disease
147(2)
8.4 Choledochal Cyst
149(2)
8.5 Solitary Hepatic Cyst Versus Hydatid Cyst
151(2)
9 Hereditary Hyperbilirubinemias
153(6)
Sarangarajan Ranganathan
9.1 Dubin-Johnson Syndrome
157(2)
10 Neonatal Cholestatic Liver Disease
159(16)
Grace E. Kim
Linda D. Ferrell
10.1 Biliary Atresia
164(3)
10.2 Neonatal Hepatitis With Hypopituitarism
167(3)
10.3 Paucity of Intrahepatic Bile Ducts
170(2)
10.4 Neonatal Hepatitis Due to Alpha-1-Antitrypsin Deficiency
172(3)
11 Sinusoidal Dilatation and Congestion
175(12)
Sanjay Kakar
11.1 Budd-Chiari Syndrome Versus Biliary Disease
177(3)
11.2 Sinusoidal Obstruction
180(2)
11.3 Veno-Occlusive Disease (Sinusoidal Obstruction Syndrome)
182(2)
11.4 Amyloidosis
184(3)
12 Peliosis Hepatis
187(4)
Sandra Fischer
Maha Guindi
12.1 Alcoholic Lipopeliosis
188(1)
12.2 Lipopeliosis in Transplanted Donor Livers
189(2)
13 Portal Hypertension Without Cirrhosis
191(12)
Sandra Fischer
Maha Guindi
13.1 Hepatoportal Sclerosis
191(2)
13.2 Portal Vein Thrombosis
193(2)
13.3 Budd-Chiari Syndrome
195(4)
13.4 Regressed Cirrhosis Case
199(4)
14 Clinical and Morphological Spectrum of Liver Diseases in Pregnancy
203(10)
Andrew Kenneth Burroughs
Amar Paul Dhillon
14.1 Recurrent Cholestasis of Pregnancy
205(2)
14.2 Acute Fatty Liver of Pregnancy
207(3)
14.3 Toxemia/HELLP Syndrome
210(3)
15 Drug-Induced Liver Injury
213(30)
David E. Kleiner
15.1 Acetaminophen-Induced Fulminant Liver Failure
217(3)
15.2 Statin-Associated Acute Hepatotoxicity
220(3)
15.3 Drug-Induced Autoimmune Hepatitis
223(3)
15.4 Drug-Induced Cholestatic Hepatitis
226(3)
15.5 Drug-Induced Ductopenia
229(3)
15.6 Methotrexate-Induced Chronic Liver Disease
232(3)
15.7 Liver Injury Due to Total Parenteral Nutrition
235(2)
15.8 Amiodarone-Induced Phospholipidosis
237(3)
15.9 Drug-Induced Microvesicular Steatosis
240(3)
16 Cytoplasmic Globules
243(8)
Elaine S. Chan
Matthew M. Yeh
16.1 Alpha-1-Antitrypsin Deficiency
245(4)
16.2 Alpha-1-Antichymotrypsin Deficiency
249(2)
17 Glycogenic Abnormalities on Liver Biopsy
251(14)
Michael Torbenson
17.1 Glycogenic Hepatopathy
255(2)
17.2 Glycogen in the Liver: Abnormal Versus Normal
257(1)
17.3 Glycogenic Hepatopathy, Cause Uncertain
258(2)
17.4 Glycogenic Hepatopathy, Type II Diabetes
260(1)
17.5 Glycogen Pseudo-Ground-Glass
261(2)
17.6 Smooth Endoplasmic Reticulum Proliferation
263(2)
18 Macrophage Infiltrate
265(10)
Ryan M. Gill
Sanjay Kakar
Linda D. Ferrell
18.1 Gaucher Disease
271(2)
18.2 Niemann-Pick Disease
273(2)
19 Approach to Liver Biopsy With Minimal or Nonspecific Histologic Findings
275(6)
Dhanpat Jain
Sanjay Kakar
19.1 Mild Hepatic Steatosis Versus Ito Cell Lipidosis
278(3)
Katharine van Patten
Sanjay Kakar
Dhanpat Jain
20 Interpreting Iron in Liver Specimens
281(18)
Michael Torbenson
20.1 Genetic Hemochromatosis
284(5)
20.2 Grading Iron
289(2)
20.3 Hepatic Iron Index
291(2)
20.4 Marked Hepatic Iron but No Genetic Mutation
293(1)
20.5 Iron in the Setting of Chronic Hepatitis C
294(2)
20.6 Neonatal Hemochromatosis
296(3)
Linda D. Ferrell
21 Wilson Disease
299(8)
Linda D. Ferrell
21.1 Fulminant Form of Wilson Disease
301(3)
21.2 Chronic Hepatitis Due to Wilson Disease
304(1)
21.3 Cirrhosis With Chronic Hepatitis Consistent With Wilson Disease
305(2)
22 Liver Transplant Pathology
307(36)
Oyedele Adeyi
22.1 Acute Cellular Rejection
309(2)
22.2 Recurrent Hepatitis C
311(2)
22.3 Acute Cellular Rejection Versus Recurrent Hepatitis C
313(2)
22.4 Late Cellular Rejection Versus Autoimmune Hepatitis Versus Recurrent Hepatitis C
315(4)
22.5 Fibrosing Cholestatic Hepatitis C Versus Biliary Obstruction Versus Adverse Reaction to Medication
319(4)
22.6 Mechanical Biliary Obstruction Versus Chronic Rejection
323(3)
22.7 Chronic Rejection Versus Recurrent Primary Sclerosing Cholangitis Versus Non-PSC Stricture
326(4)
22.8 Zone 3 (Centrilobular) Necrosis
330(7)
22.9 Cytomegalovirus Hepatitis
337(3)
22.10 Graft Versus Host Disease
340(3)
23 Benign Hepatocellular Lesions
343(18)
Valerie Paradis
23.1 Atypical Focal Nodular Hyperplasias on Imaging
347(2)
23.2 Focal Nodular Hyperplasia Versus Inflammatory/Telangiectatic Hepatocellular Adenoma
349(2)
23.3 Hepatocellular Adenoma Subtyping: Inflammatory/Telangiectatic Versus Steatotic Adenoma
351(3)
23.4 Hepatocellular Adenoma Subtyping: Associated Liver Nodules
354(2)
23.5 Hepatocellular Adenoma Subtyping: Inflammatory/Telangiectatic Adenoma
356(3)
23.6 Hepatocellular Adenoma Subtyping: Adenoma With Atypical Features
359(2)
24 Biliary Neoplasms
361(26)
Kisha Mitchell
Dhanpat Jain
24.1 Bile Duct Adenoma Versus Biliary Hamartoma
365(5)
24.2 Intrahepatic Cholangiocarcinoma Versus Hepatocellular Carcinoma
370(3)
24.3 Cholangiocarcinoma in Association With Von Meyenburg Complexes
373(2)
24.4 Diagnosis of Hilar/Extrahepatic Cholangiocarcinoma
375(3)
24.5 Bile Duct Cystadenoma/Carcinoma Versus Foregut Cyst
378(3)
24.6 Biliary Adenofibroma
381(2)
Vikram Deshpande
Gregory Y. Lauwers
24.7 Biliary Papillomatosis/Intraductal Cholangiocarcinoma
383(4)
Wilson M.S. Tsui
25 Hepatocellular Carcinoma
387(20)
Prodromos Hytiroglou
25.1 Well-Differentiated Hepatocellular Carcinoma
394(4)
25.2 Poorly Differentiated Hepatocellular Carcinoma
398(5)
25.3 Early Hepatocellular Carcinoma
403(4)
26 Hepatocellular Carcinoma Variants
407(24)
Shriram Jakate
Deborah Giusto
26.1 Pseudoglandular Hepatocellular Carcinoma Versus Cholangiocarcinoma and Metastatic Adenocarcinoma
409(3)
26.2 Hepatocellular Versus Neuroendocrine Carcinoma
412(2)
26.3 Hepatocellular Carcinoma, Clear Cell Variant
414(3)
26.4 Scirrhous Hepatocellular Carcinoma
417(2)
26.5 Combined Hepatocellular-Cholangiocarcinoma
419(2)
26.6 Diffuse Cirrhosis-Like Hepatocellular Carcinoma
421(2)
26.7 Spectrum of Cytoplasmic Contents in Hepatocellular Carcinoma
423(2)
26.8 Poor Differentiation and Vascular Invasion in Hepatocellular Carcinoma
425(2)
26.9 Pedunculated Hepatocellular Carcinoma
427(1)
26.10 Ablated Hepatocellular Carcinoma
428(3)
27 Metastatic Tumors: Illustration of Immunohistochemical Workup
431(10)
Rageshree Ramachandran
Sanjay Kakar
27.1 Hepatocellular Carcinoma Versus Metastatic Adenocarcinoma
436(2)
27.2 Hepatocellular Carcinoma Versus Metastatic Polygonal Cell Tumor
438(3)
28 Hepatoblastoma
441(16)
Sarangarajan Ranganathan
28.1 Biopsy Diagnosis of Hepatoblastoma
447(2)
28.2 Macrotrabecular Hepatoblastoma Versus Hepatocellular Carcinoma
449(3)
28.3 Small Cell Hepatoblastoma Versus Other Small Round Cell Tumors
452(3)
28.4 Teratoid Hepatoblastoma Versus Malignant Teratoma/Yolk Sac Tumor
455(2)
29 Vascular Tumors
457(12)
29.1 Cavernous Hemangioma Variants
457(2)
Linda D. Ferrell
29.2 Epithelioid Hemangioendothelioma
459(3)
Hala R. Makhlouf
Zachary D. Goodman
29.3 Hepatic Angiosarcoma
462(3)
Hala R. Makhlouf
Zachary D. Goodman
29.4 Infantile Hemangioma
465(4)
Michael Torbenson
30 Hematopoietic Tumors of the Liver
469(26)
Patrick A. Treseler
John P. Higgins
30.1 Dense Small B-Cell Infiltrate With Reactive Follicles
476(4)
30.2 Diffuse Large B-Cell Infiltrate
480(2)
30.3 Portal Infiltrate With Reed-Sternberg Cells
482(3)
30.4 Polymorphic Lymphoid Infiltrate in a Transplant Patient
485(2)
30.5 Sinusoidal T-Cell Infiltrate
487(3)
30.6 Portal and Lobular Infiltration by Blasts
490(2)
30.7 Portal and Lobular Infiltration by Mature Granulocytes
492(3)
31 Other Infiltrative Neoplasms of Liver
495(4)
Lawrence Burgart
31.1 Portal-Based Infiltrative Neoplasm Versus Biliary Disease
496(3)
32 Mesenchymal Tumors of the Liver
499(16)
32.1 Mesenchymal Hamartoma
499(3)
Wendy L. Frankel
Xiaoping Zhou
32.2 Embryonal Sarcoma
502(3)
Wendy L. Frankel
Xiaoping Zhou
32.3 Angiomyolipoma
505(3)
Cherise Marie Cortese
Raouf E. Nakhleh
32.4 Angiomyolipoma, Inflammatory Variant
508(2)
Linda D. Ferrell
32.5 Malignant Angiomyolipoma---Malignant Perivascular Epithelioid Cell Tumor
510(5)
William A. Ahrens
Appendices
515(8)
A Adequacy of Needle Biopsy
515(2)
B Grading and Staging
517(4)
C Special Stains in Liver Biopsy Pathology
521(2)
Index 523
Professor and Vice Chair of Clinical Affairs, Director of Surgical Pathology, Department of Pathology, University of California, San Francisco||Associate Professor of Pathology and Vice Chair, University of California San Francisco, and Chief of Pathology, San Francisco VA Medical Center, San Francisco, California|is Professor of Pathology &Laboratory Medicine and Vice Chair for Anatomic Pathology at the Hospital of the University of Pennsylvania. He is also the series editor for the Consultant Pathology Series.