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Prologue |
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xiv | |
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1 | (164) |
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1 Biocompatibility, sterilization, and materials selection for implant design |
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3 | (23) |
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1.1 Historical perspective and overview |
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3 | (1) |
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4 | (1) |
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1.3 Successful device performance and implant design |
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4 | (3) |
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7 | (1) |
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8 | (1) |
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9 | (1) |
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1.7 Structural requirements |
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10 | (3) |
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1.8 Classifying biomaterials |
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13 | (3) |
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1.9 Structure-property relationships |
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16 | (1) |
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1.10 Attributes and limitations of synthetic biomaterials |
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17 | (3) |
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1.11 Case study: deterioration of orthopedic-grade UHMWPE due to ionizing radiation |
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20 | (2) |
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22 | (1) |
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1.13 Problems for consideration |
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23 | (1) |
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23 | (3) |
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2 Metals for medical implants |
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26 | (44) |
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2.1 Historical perspective and overview |
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26 | (1) |
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27 | (1) |
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2.3 Bonding and crystal structure |
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28 | (4) |
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32 | (2) |
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2.5 Crystallographic planes and directions |
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34 | (2) |
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2.6 Theoretical shear strength |
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36 | (2) |
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2.7 Imperfections in metals and alloys |
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38 | (4) |
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42 | (11) |
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53 | (7) |
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2.10 Metals in medical implants |
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60 | (4) |
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2.11 Case study: corrosion in modular orthopedic implants |
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64 | (3) |
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67 | (1) |
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2.13 Problems for consideration |
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67 | (1) |
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68 | (2) |
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70 | (22) |
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3.1 Historical perspective and overview |
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70 | (1) |
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71 | (1) |
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3.3 Bonding and crystal structure |
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71 | (4) |
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3.4 Mechanical behavior of ceramics |
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75 | (7) |
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3.5 Processing of ceramics |
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82 | (3) |
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3.6 Ceramics in medical implants |
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85 | (2) |
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3.7 Case study: the use of coral as a bone substitute |
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87 | (2) |
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89 | (1) |
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3.9 Problems for consideration |
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89 | (1) |
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90 | (2) |
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92 | (37) |
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4.1 Historical perspective and overview |
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92 | (2) |
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94 | (1) |
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4.3 Bonding and crystal structure |
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95 | (11) |
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4.4 Molecular weight distribution in polymers |
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106 | (3) |
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4.5 Mechanical behavior of polymers |
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109 | (3) |
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112 | (1) |
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4.7 Polymers in medical implants |
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113 | (11) |
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4.8 Case study: resorbable sutures and suture anchors |
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124 | (1) |
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125 | (1) |
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4.10 Problems for consideration |
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126 | (1) |
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127 | (2) |
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5 Mechanical behavior of structural tissues |
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129 | (36) |
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5.1 Historical perspective and overview |
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129 | (2) |
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131 | (1) |
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5.3 Building blocks of tissues |
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131 | (5) |
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136 | (20) |
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5.5 Case study: creating a scaffold for tissue engineering |
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156 | (2) |
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158 | (1) |
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5.7 Problems for consideration |
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158 | (1) |
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159 | (4) |
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163 | (2) |
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165 | (230) |
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167 | (41) |
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167 | (2) |
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169 | (1) |
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169 | (24) |
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6.4 Bending stresses and beam theory |
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193 | (7) |
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200 | (3) |
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6.6 Case study: modifying material and cross-section to reduce bone absorption |
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203 | (2) |
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205 | (1) |
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6.8 Problems for consideration |
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206 | (1) |
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207 | (1) |
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207 | (1) |
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208 | (33) |
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208 | (1) |
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209 | (1) |
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7.3 Introduction to viscoelasticity |
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209 | (5) |
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7.4 Linear viscoelastic networks |
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214 | (13) |
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7.5 Frequency domain analysis |
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227 | (6) |
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7.6 Time-temperature equivalence |
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233 | (2) |
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7.7 Nonlinear viscoelasticity |
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235 | (2) |
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7.8 Case study: creep behavior of UHMWPE used in total joint replacements |
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237 | (1) |
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238 | (1) |
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7.10 Problems for consideration |
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238 | (1) |
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239 | (2) |
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241 | (42) |
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241 | (3) |
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244 | (1) |
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244 | (1) |
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8.4 Maximum shear stress (Tresca yield criterion) |
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245 | (4) |
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8.5 Maximum distortional energy (von Mises yield criterion) |
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249 | (6) |
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8.6 Predicting yield in multiaxial loading conditions |
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255 | (6) |
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8.7 Modified yield criteria |
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261 | (4) |
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8.8 Maximum normal stress failure theory |
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265 | (1) |
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8.9 Notches and stress concentrations |
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266 | (3) |
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8.10 Failure mechanisms in structural biomaterials |
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269 | (7) |
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8.11 Case study: stress distribution in a total joint replacement |
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276 | (3) |
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279 | (1) |
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8.13 Problems for consideration |
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280 | (1) |
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281 | (2) |
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283 | (46) |
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283 | (1) |
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284 | (1) |
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9.3 Linear elastic fracture mechanics (LEFM) |
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285 | (14) |
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9.4 Modified methods in LEFM |
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299 | (4) |
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9.5 Elastic-plastic fracture mechanics (EPFM) |
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303 | (15) |
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9.6 Time-dependent fracture mechanics (TDFM) |
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318 | (2) |
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9.7 Intrinsic and extrinsic fracture processes |
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320 | (2) |
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9.8 Fracture mechanisms in structural materials |
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322 | (2) |
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9.9 Case study: fracture of highly crosslinked acetabular liners |
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324 | (1) |
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325 | (1) |
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9.11 Problems for consideration |
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326 | (1) |
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327 | (2) |
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329 | (40) |
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329 | (2) |
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331 | (1) |
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331 | (3) |
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10.4 Total life philosophy |
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334 | (9) |
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10.5 Strain-based loading |
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343 | (3) |
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346 | (2) |
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10.7 Defect-tolerant philosophy |
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348 | (14) |
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10.8 Case study: fatigue fractures in trapezoidal hip stems |
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362 | (2) |
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364 | (1) |
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10.10 Problems for consideration |
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364 | (2) |
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366 | (3) |
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11 Friction, lubrication, and wear |
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369 | (26) |
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369 | (1) |
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370 | (1) |
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11.3 Bulk and surface properties |
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371 | (2) |
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373 | (2) |
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11.5 Surface contact mechanics |
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375 | (2) |
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377 | (4) |
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381 | (5) |
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11.8 Surface contact in biomaterials |
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386 | (1) |
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11.9 Friction and wear test methods |
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387 | (2) |
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389 | (1) |
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11.11 Case study: the use of composites in total joint replacements |
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390 | (1) |
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391 | (1) |
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11.13 Problems for consideration |
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391 | (1) |
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391 | (4) |
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395 | (200) |
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12 Regulatory affairs and testing |
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397 | (19) |
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12.1 Historical perspective and overview |
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397 | (1) |
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398 | (1) |
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12.3 FDA legislative history |
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398 | (3) |
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12.4 Medical device definitions and classifications |
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401 | (3) |
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404 | (4) |
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12.6 Anatomy of a testing standard |
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408 | (1) |
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12.7 Development of testing standards |
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409 | (1) |
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12.8 International regulatory bodies |
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410 | (1) |
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12.9 Case study: examining a 510(k) approval |
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411 | (2) |
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413 | (1) |
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12.11 Problems for consideration |
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413 | (1) |
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414 | (2) |
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416 | (61) |
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13.1 Historical perspective and overview |
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416 | (5) |
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421 | (1) |
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13.3 Total joint replacements |
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421 | (1) |
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13.4 Total hip arthroplasty |
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422 | (13) |
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13.5 Total knee arthroplasty |
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435 | (11) |
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446 | (7) |
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453 | (9) |
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13.8 Engineering challenges and design constraints of orthopedic implants |
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462 | (1) |
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462 | (8) |
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470 | (1) |
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13.11 Looking forward in orthopedic implants |
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470 | (1) |
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13.12 Problems for consideration |
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470 | (1) |
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471 | (6) |
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14 Cardiovascular devices |
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477 | (28) |
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14.1 Historical perspective and overview |
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477 | (1) |
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478 | (1) |
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14.3 Cardiovascular anatomy |
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479 | (4) |
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14.4 Load-bearing devices |
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483 | (13) |
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496 | (4) |
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500 | (1) |
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500 | (1) |
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14.8 Problems for consideration |
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501 | (1) |
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501 | (4) |
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15 Oral and maxillofacial devices |
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505 | (55) |
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505 | (2) |
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507 | (1) |
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15.3 Oral and maxillofacial anatomy |
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507 | (3) |
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510 | (22) |
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15.5 Temporomandibular joint replacements |
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532 | (8) |
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540 | (4) |
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544 | (2) |
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546 | (1) |
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15.9 Problems for consideration |
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546 | (1) |
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547 | (13) |
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16 Soft tissue replacements |
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560 | (35) |
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16.1 Historical perspective and overview |
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560 | (3) |
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563 | (2) |
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565 | (5) |
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570 | (5) |
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575 | (3) |
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578 | (6) |
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584 | (3) |
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587 | (1) |
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588 | (1) |
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589 | (1) |
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16.11 Problems for consideration |
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590 | (1) |
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590 | (5) |
Epilogue |
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595 | (2) |
Appendix A Selected topics from mechanics of materials |
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597 | (3) |
Appendix B Table of material properties of engineering biomaterials and tissues |
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600 | (11) |
Appendix C Teaching methodologies in biomaterials |
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611 | (9) |
Glossary |
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620 | (25) |
Index |
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645 | |