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E-grāmata: Movement Disorders in Childhood

, (Frederick A. Horner, MD Distinguished Professor in Pediatric Neurology, Univer), (Professor Emeritus, Johns Hopkins University School of Medicine, Department of Neurology, and the Kennedy Krieger Institute, Baltimore, MD, United States),
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  • Izdošanas datums: 27-Oct-2015
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780124115804
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  • Formāts: EPUB+DRM
  • Izdošanas datums: 27-Oct-2015
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780124115804

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Movement Disorders in Childhood, Second Edition provides the most up-to-date information on movement disorders, a relatively new area of specialization within child neurology.For many years, movement abnormalities affecting the pediatric population received little attention in adult-oriented textbooks. Over the past several decades, child neurologists have assumed a greater role in the care of children with these disorders and the investigation of their underlying etiologies and mechanisms. This new edition builds upon the newfound interest on the topic and the success of the first edition, adding materials and a more-disease oriented approach, along with coverage of genetic causes and the metabolic and immunological origination of movement disorders in childhood.Provides the only current tutorial/reference specifically focused on childhood movement disordersInvestigates the underlying etiologies and mechanisms of these disordersCompletely revised and updated with new materials and a more disease-oriented approachNew coverage of genetics and movement disorders, immunology and movement disorders, and an introduction to the latest quantitative analysis

Recenzijas

2016 BMA Medical Book Awards Highly Commended in Neurology

Papildus informācija

This second edition of the leading tutorial/reference provides the latest advances in this important area of specialization within child neurology
Preface ix
Acknowledgment xi
I Overview
1 Basal Ganglia Anatomy, Biochemistry, and Physiology
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
4(1)
Circuits and Neurotransmitters in the Basal Ganglia
4(3)
Subthalamic Nucleus (STN)
7(1)
Output Nuclei: Globus Pallidus line= (GPi) and Substantia Nigra pars reticulata (SNpr)
7(1)
Globus Pallidus extema (GPe)
8(1)
Inhibiting and Disinhibiting Motor Patterns
8(2)
Implications for Disease: Focal Lesions and Abnormal Movements
10(1)
References
11(3)
2 Cerebellar Anatomy, Biochemistry, Physiology, and Plasticity
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
14(1)
Overview of Cerebellar Structure, Function, and Symptoms
14(1)
Macroscopic to Microscopic Cerebellar Structure
15(6)
Neurotransmitters in the Cerebellum
21(2)
Neuroplasticity in the Cerebellum
23(1)
Cerebellar Stimulation
23(1)
Conclusion
24(1)
References
24(3)
3 Classification of Movement Disorders
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
27(2)
Ataxia (Chapter 14)
29(1)
Athetosis (Chapter 10)
29(2)
Ballismus (Chapter 10)
31(1)
Chorea (Chapter 10)
31(1)
Dystonia (Chapter 11)
32(1)
Myoclonus (Chapter 12)
32(1)
Parkinsonism (Chapter 15)
33(1)
Stereotypies (Chapter 8)
33(1)
Tics (Chapter 7)
34(1)
Tremor (Chapter 13)
34(1)
References
35(3)
4 Diagnostic Evaluation of Children with Movement Disorders
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
38(1)
Preclinic
39(2)
In Clinic
41(7)
The Diagnosis
48(6)
Summary
54(1)
References
55(3)
5 Motor Assessments
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
58(1)
Quantitative Measurement in Movement Disorders
58(1)
Rating Scales for Pediatric Movement Disorders
59(5)
References
64(6)
II Developmental Movement Disorders
6 Transient and Developmental Movement Disorders in Children
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Benign Neonatal Sleep Myoclonus
70(1)
Benign Myoclonus of Early Infancy (Benign Infantile Spasms)
71(1)
Jitteriness
71(1)
Shuddering
72(1)
Paroxysmal Tonic Upgaze of Infancy
72(1)
Spasmus Nutans
73(1)
Head Nodding
73(1)
Benign Paroxysmal Torticollis
74(1)
Benign Idiopathic Dystonia of Infancy
75(1)
Sandifer Syndrome
75(1)
Posturing During Masturbation
75(1)
References
76(6)
III Paroxysmal Movement Disorders
7 Tics and Tourette Syndrome
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
82(1)
Tic Phenomenology
82(1)
Tic Disorders
83(2)
Epidemiology
85(1)
Scales
86(1)
Outcome
86(1)
Associated Behaviors and Psychopathologies in Tic Disorders
86(3)
Etiology
89(1)
Pathophysiology of Tic Disorders
90(4)
Treatment
94(4)
References
98(14)
8 Motor Stereotypies
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
112(1)
Definition
112(1)
Differentiating Stereotypies from Other Disorders
113(2)
Pathophysiology
115(1)
Classification of Motor Stereotypies
116(5)
Therapy
121(1)
Patient and Family Resources
122(1)
References
122(5)
9 Paroxysmal Dyskinesias
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
127(1)
Clinical Characteristics
128(1)
Specific Disorders
129(7)
References
136(8)
IV Hyperkinetic And Hypokinetic Movement Disorders
10 Chorea, Athetosis, and Ballism
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
144(1)
Definitions of Chorea, Athetosis, and Ballism
144(1)
Clinical Characteristics-Phenomenology of Chorea, Athetosis, and Ballism in Children
145(1)
Localization and Pathophysiology
146(1)
Diseases and Disorders
147(18)
Summary of Diagnostic and Therapeutic Approach
165(4)
References
169(9)
11 Dystonia
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
178(1)
Classification of Dystonias
179(5)
Localization and Pathophysiology
184(3)
Etiologies
187(7)
Diagnostic Approach to Dystonia
194(1)
Management and Treatment
195(2)
Patient and Family Resources
197(1)
References
197(9)
12 Myoclonus
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
206(1)
Definition of Myoclonus
206(1)
Clinical Characteristics-Phenomenology of Myoclonus in Children
206(2)
Localization and Pathophysiology
208(6)
Diseases and Disorders
214(16)
Autosomal Dominant, Cortical Myoclonus without Epilepsy
230(1)
Hemifacial Spasm
230(1)
Summary of Diagnostic and Therapeutic Approach
230(1)
References
231(11)
13 Tremor
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
242(1)
Definition of Tremor
242(1)
Clinical Characteristics-Phenomenology of Tremor in Children
243(2)
Localization and Pathophysiology
245(2)
Diseases and Disorders
247(9)
Approach to Diagnosis and Management
256(1)
References
257(7)
14 Ataxia
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
264(1)
Definition of Ataxia
265(1)
Clinical Characteristics-Phenomenology of Ataxia in Children
265(1)
Localization and Pathophysiology
265(1)
Diseases and Disorders
265(27)
Approach to Diagnosis and Management
292(1)
Summary
293(1)
References
293(9)
15 Parkinsonism
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
302(1)
Clinical Features of Parkinsonism
302(1)
Pathophysiology of Parkinsonism
302(3)
Etiologies of Parkinsonism in Children
305(2)
Secondary Parkinsonism
307(5)
Treatment of Parkinsonism
312(1)
References
313(5)
16 Hereditary Spastic Paraplegia
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
318(1)
Definitions of Spasticity and Hypertonia
318(1)
Clinical Characteristics-Phenomenology of Spastic Paraplegia in Children
318(1)
Localization and Pathophysiology
319(1)
Diseases and Disorders
320(8)
Treatment
328(1)
Diagnostic and Management Approach
329(1)
Summary
330(1)
References
330(8)
V Selected Secondary Movement Disorders
17 Inherited Metabolic Disorders with Associated Movement Abnormalities
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Pediatric Neurotransmitter Disorders
338(9)
Metabolic Disorders
347(42)
References
389(21)
18 Movement Disorders in Autoimmune Diseases
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Complication of a Systemic Autoimmune Disorder
410(2)
Post-streptococcal Infections
412(4)
Autoimmune Basal Ganglia Encephalitis
416(1)
Autoimmune Encephalopathies
417(3)
Other Paraneoplastic Syndromes
420(1)
References
421(7)
19 Movements that Occur in Sleep
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Overview of Sleep Physiology
428(3)
Classification of Movements in Sleep
431(1)
Sleep-Related Movement Disorders
431(12)
Hyperkinetic Movement Disorders that Are Present during the Daytime and Persist during Sleep
443(1)
Seizures in and Around the Time of Sleep
443(1)
References
444(10)
20 Cerebral Palsy
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
454(1)
Epidemiology
454(1)
Etiology
455(1)
Differentiating Hypertonia in Children
455(3)
Cerebral Palsy Syndromes
458(4)
Diagnostic Tests
462(3)
Management of Cerebral Palsy
465(4)
References
469(10)
21 Movement Disorders and Neuropsychiatric Conditions
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Attention Deficit Hyperactivity Disorder
479(1)
Obsessive Compulsive Disorder
480(2)
Autism Spectrum Disorder
482(2)
Conclusion
484(1)
References
485(7)
22 Drug-Induced Movement Disorders in Children
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction and Overview
492(1)
Definition of DIMDs
493(1)
Clinical Characteristics-Phenomenology of DIMDs in Children
493(1)
Drug-Induced Movement Disorders
494(13)
Conclusion
507(1)
References
507(9)
23 Functional (Psychogenic) Movement Disorders
Harvey S. Singer
Jonathan W. Mink
Donald L. Gilbert
Joseph Jankovic
Introduction
516(6)
Conclusion
522(1)
References
523
Appendices
Appendix A: Drug Appendix
527(24)
Appendix B: Search Strategy for Genetic Movement Disorders
551(10)
Appendix C: Video Atlas
561(8)
Index 569
Harvey S. Singer MD is currently Professor Emeritus at the Johns Hopkins University School of Medicine and active faculty member at the Kennedy Krieger Institute. He grew up in the Bronx and Long Island, went to college and medical school in Ohio (Oberlin College and Western Reserve Univ.), did his pediatric training in Chicago and Cleveland, and his pediatric neurology residency at the Johns Hopkins Hospital. After completing his training, Dr Singer remained on the active faculty at Hopkins for 45 years. He was Director of Pediatric Neurology from 1991 2011. He was the first recipient (2013) of the Child Neurology Societys Blue Bird Circle Training Program Director Award and a Hower Award lecturer (2016). His clinical research interests include movement disorders, especially Tourette syndrome, stereotypic movements, and proposed autoimmune disorders. His translational research-oriented laboratory focuses on the neurobiology of stereotypic movements and tics. He has been the recipient of federal and private grants, authored numerous original articles, chapters, and three books. He enjoys biking, travel, visiting his five grandchildren, and work. Jonathan W. Mink, MD PhD is the Frederick A. Horner, MD Distinguished Professor in Pediatric Neurology at the University of Rochester, where is also Professor of Neurology, Neuroscience, and Pediatrics. He is currently Chief of the Child Neurology Division and Vice Chair of the Department of Neurology at the University of Rochester. He graduated from the Medical Scientist Training Program at Washington University and then completed residency training in Child Neurology at St. Louis Childrens Hospital. He completed a fellowship in Movement Disorders at Washington University and remained on the faculty there until moving to his current position at the University of Rochester in 2001. His research interests include basal ganglia mechanisms in movement disorders, experimental therapeutics in pediatric movement disorders, and multiple avenues of investigation in the neuronal ceroid lipofuscinoses (Batten diseases). He is a former member of the NINDS Advisory Council and the FDA Pediatric Advisory Committee. He has served as President of the Child Neurology Society. He has received numerous award in recognition of his contributions including the Derek Denny-Brown Award from the American Neurological Association, the Oliver Sacks Award from the Tourette Association of America, and the Hower Award from the Child Neurology Society. Donald L. Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert trained in pediatrics and pediatric neurology at Johns Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in clinical research design and statistical analysis from the University of Michigan.At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette Syndrome Clinics, which specializes in evaluation and pharmacologic treatment of tics, tremor, chorea, ataxia, dystonia, stereotypies, drug-induced movement disorders, paroxysmal movement disorders, and functional movement disorders https://www.cincinnatichildrens.org/service/m/movement. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette syndrome and pediatric movement disorders. Dr. Gilbert also studies physiological mechanisms of motor control in Tourette Syndrome and Attention Deficit Hyperactivity Disorder in childhood at the Transcranial Magnetic Stimulation Laboratory https://www.cincinnatichildrens.org/research/divisions/n/neurology/labs/gilbe rt-wu at Cincinnati Children's. Joseph Jankovic, M.D. is Professor of Neurology, Distinguished Chair in Movement Disorders, and Founder and Director of the Parkinson's Disease Center and Movement Disorders Clinic (PDCMDC), Department of Neurology, Baylor College of Medicine, Houston, Texas. After completing his Neurology training at Columbia University, New York City, he joined the faculty of Baylor College of Medicine in 1977. Since that time he has led clinical team that focuses on the most compassionate and expert care and research on etiology, pathophysiology, and experimental therapeutics of Parkinsons disease and related neurodegenerative and movement disorders such as tremors, dystonia, Tourette syndrome, Huntington disease, restless legs syndrome, tardive dyskinesia, and paroxysmal dyskinesias. Under the direction of Dr. Jankovic the PDCMDC has been recognized as "Center of Excellence" by the Parkinsons Foundation, the Huntington Disease Society of America, the Tourette Association of America, and the Wilson Disease Association. Past president of the International Parkinson and Movement Disorder Society and of the International Neurotoxin Association, Dr. Jankovic is the recipient of many awards including the American Academy of Neurology (AAN) Movement Disorders Research Award, First National Parkinson Foundation Distinguished Service Award, Huntingtons Disease Society of America Guthrie Family Humanitarian Award, Tourette Syndrome Association Lifetime Achievement Award, Dystonia Medical Research Foundation Distinguished Service Award, Benign Essential Blepharospasm Research Foundation Award, and Lifetime Achievement Award from the International Neurotoxin Association, Dr. Jankovic has been recognized as an Honorary Member of the American Neurological Association, Australian Association of Neurologists, French Neurological Society, and the International Parkinsons Disease and Movement Disorders Society. Dr. Jankovic has published over 1,200 original articles and over 55 books, is included among Highly Cited Researchers”, and has been ranked #1 expert in the world in movement disorders and in botulinum toxins (http://expertscape.com/). He has served as the principal investigator in hundreds of clinical trials and his pioneering research on drugs for parkinsonian disorders and hyperkinetic movement disorders has led to their approval by the Food and Drug Administration. Certified by the American Board of Psychiatry and Neurology, Dr. Jankovic is a fellow of the AAN and current or past member of many scientific and medical advisory boards and has served on the executive scientific advisory boards of the Michael J. Fox Foundation for Parkinsons Research and the National Parkinson Foundation. Dr. Jankovic has mentored numerous fellows and other trainees many of whom have become leaders in the field of neurology and movement disorders. For further information visit www.jankovic.org.