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Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery [Hardback]

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  • Formāts: Hardback, 456 pages, height x width x depth: 231x145x25 mm, weight: 816 g
  • Izdošanas datums: 26-Feb-2019
  • Izdevniecība: Wiley-Blackwell
  • ISBN-10: 1119436672
  • ISBN-13: 9781119436676
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Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug DiscoveryPalielināt
  • Formāts: Hardback, 456 pages, height x width x depth: 231x145x25 mm, weight: 816 g
  • Izdošanas datums: 26-Feb-2019
  • Izdevniecība: Wiley-Blackwell
  • ISBN-10: 1119436672
  • ISBN-13: 9781119436676
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781119436676.html
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Introduces readers to the growing applications of nutraceuticals and other natural product derivatives

This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population.

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more.

  • Offers an alternative, natural approach to the prevention of chronic diseases
  • Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies
  • Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention
  • Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Editor Biographies xv
List of Contributors xvii
Foreword xxi
Preface xxv
About the Book xxix
Expert Commentary xxxi
1 Natural Food Sources for the Control of Glycemia and the Prevention of Diabetic Complications 1(24)
Carlo Pesc
Carla Iacobini
Stefano Menini
1.1 Introduction: Obesity, Metabolic Syndrome, and Type 2 Diabetes Epidemics: The Role of Nutrition
1(2)
1.2 Phytochemicals of Nutraceutical Importance and Functional Foods of Plant Origin
3(5)
1.2.1 Dietary Oils
3(1)
1.2.2 Vegetables and Fruits
4(4)
1.3 Nutraceuticals and Functional Foods of Animal Origin
8(1)
1.3.1 The Case of Carnosine
8(1)
1.4 Nutraceuticals of Both Plant and Animal Origin
9(3)
1.5 Probiotics, Prebiotics, and Symbiotics
12(3)
1.6 Conclusion
15(2)
References
17(8)
2 Anti-Aging Effects of Sulfur-Containing Amino Acids and Nutraceuticals 25(14)
Geetika Garg
Abhishek Kumar Singh
Sandeep Singh
Syed Ibrahim Rizvi
2.1 Aging and Nutrition
25(1)
2.2 Natural Antioxidants
26(2)
2.2.1 Sulfur-Containing Amino Acids and Their Role as Antioxidants
26(1)
2.2.2 Anti-Aging Effects of L-Cysteine
27(1)
2.3 N-Acetyl-L-Cysteine
28(2)
2.3.1 Neuroprotective Effects of N-Acetyl-L-Cysteine
29(1)
2.3.2 N-Acetyl-L-Cysteine in Combination with Other Antioxidants
29(1)
2.4 Methionine
30(1)
2.4.1 Methionine Restriction
30(1)
2.5 Sulfur-Containing Nutraceuticals and Foods Rich in Sulfur-Containing Amino Acids
31(2)
2.5.1 Whey Protein
32(1)
2.5.2 Anti-Aging Effects of Whey Protein
32(1)
2.6 Conclusion
33(1)
Acknowledgments
33(1)
Conflict of Interest
33(1)
References
33(6)
3 Garcinia Fruits: Their Potential to Combat Metabolic Syndrome 39(42)
Oliver D. John
Lindsay Brown
Sunil K. Panchal
3.1 Introduction
39(1)
3.2 Overview of Compounds in Garcinia Species
40(23)
3.2.1 Garcinia mangostana
44(6)
3.2.1.1 Chemical Properties
45(1)
3.2.1.2 Biological Activities of G. mangostana
45(4)
3.2.1.3 Toxicity
49(1)
3.2.2 Garcinia cambogia
50(3)
3.2.2.1 Chemical Properties
50(1)
3.2.2.2 Biological Activities
51(2)
3.2.2.3 Toxicity
53(1)
3.2.2.4 Future Research
53(1)
3.2.3 Garcinia humilis
53(2)
3.2.3.1 Chemical Properties
53(1)
3.2.3.2 Biological Activities
54(1)
3.2.4 Garcinia dulcis
55(28)
3.2.4.1 Chemical Properties
55(1)
3.2.4.2 Biological Properties
55(1)
3.2.4.3 Potential Research
56(7)
3.3 Limitations
63(1)
3.4 Conclusion
64(1)
References
64(17)
4 Pro-Angiogenic and Anti-Angiogenic Effects of Small Molecules from Natural Products 81(30)
Jingyi Ma
Xuelin Zhou
4.1 Biological Mechanisms of Angiogenesis
81(1)
4.2 Pharmacological Models for Angiogenesis Study
82(1)
4.3 Pro-Angiogenic Effects of Small Molecules from Natural Products
83(3)
4.3.1 Natural Products as Sources for Screening Pro-Angiogenic Stimulators
83(1)
4.3.2 Flavonoids
84(1)
4.3.3 Saponins
84(1)
4.3.4 Salvianolic Acids
85(1)
4.3.5 Other Small Molecules
85(1)
4.3.5.1 Ferulic Acid
85(1)
4.3.5.2 Aloe vera-Derived Compounds
85(1)
4.3.6 Summary
86(1)
4.4 Anti-Angiogenic Effects of Small Molecules from Natural Products
86(13)
4.4.1 Natural Products as Sources for Screening Angiogenic Inhibitors
87(1)
4.4.2 Flavonoids
87(2)
4.4.3 Diterpenoids
89(1)
4.4.4 Polyphenol
90(2)
4.4.5 Saponins
92(1)
4.4.6 Alkaloids
93(1)
4.4.7 Chalcone
93(1)
4.4.8 Anthraquinone
93(1)
4.4.9 Carotenoids
94(1)
4.4.10 Other Small Molecules
94(5)
4.4.10.1 Cucurbitacin B
94(1)
4.4.10.2 Honokiol
95(1)
4.4.10.3 Shikonin
95(1)
4.4.10.4 Hyperforin
95(1)
4.4.10.5 Glyceollins
95(4)
4.4.10.6 Sulforaphane
99(1)
4.4.11 Summary
99(1)
4.5 Conclusion
99(1)
Acknowledgment
99(1)
Conflict of Interest
99(1)
References
100(11)
5 Nutraceuticals and Natural Product Derivatives in the Premises of Disease Prevention 111(26)
Mohammad Fahad Ullah
Showket Hussain Bhat
Faisel M. Abu-Duhier
5.1 Introduction: How Significant Is the Role of Natural Molecules in Disease Prevention?
111(2)
5.2 Natural Products in Cancer Chemoprevention
113(4)
5.3 Natural Products in the Management of Diabetes
117(5)
5.4 Natural Products as Therapeutic Agents against Gout Disease
122(2)
5.5 Herbal Derivatives in Prevention of Alzheimer's Disease
124(3)
5.6 Conclusion
127(1)
Acknowledgments
127(1)
References
127(10)
6 Honey- and Propolis-Mediated Regulation of Protein Networks in Cancer Cells 137(8)
Ammad Ahmad Farooqi
Mirna Azalea Romero
Aliye Aras
Muhammad Zahid Qureshi
Lara Hanna Wakim
6.1 Introduction
137(1)
6.2 Honey-Mediated Targeting of Signal Transducer and Activator of Transcription (STAT) Proteins
138(1)
6.3 Reactive Oxygen Species (ROS) Production in Cancer Cells
138(1)
6.4 Apoptosis
139(1)
6.5 Regulation of DNA Damage
139(1)
6.6 Combinatorial Strategies: It Takes Two to Tango
139(2)
6.7 Bioactive Propolis Chemicals as Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) Sensitizers
141(1)
6.8 Bioactive Chemicals of Propolis Target Different Proteins of Cell-Signaling Pathways
142(1)
6.9 Conclusion
142(1)
References
142(3)
7 Antiproliferative Effects and Mechanism of Action of Phytosterols Derived from Bioactive Plant Extracts 145(22)
Gabriel Lopez-Garcia
Amparo Alegria
Reyes Barbera
Antonio Cilia
7.1 Introduction
145(1)
7.2 Mechanisms of the Anticancer Actions of Phytosterols
146(1)
7.3 Anticancer Effects of Phytosterols
147(14)
7.3.1 Plant Extracts Containing Phytosterols
148(7)
7.3.2 Isolated Phytosterols from Plant Extracts
155(6)
7.4 Conclusions
161(1)
Acknowledgments
162(1)
References
162(5)
8 Yerba Mate (Ilex paraguariensis A. St. Hil.): A Promising Adjuvant in the Treatment of Diabetes, Obesity, and Metabolic Syndrome 167(16)
Vanesa Gesser Correa
Rubia Carvalho Gomes Correa
Tatiane Francielli Vieira
Eloa Angelica Koehnlein
Adelar Bracht
Rosane Marina Peralta
8.1 Introduction
167(2)
8.2 Nutritional Composition of Ilex paraguariensis
169(1)
8.3 Composition in Bioactive Compounds
170(1)
8.4 Yerba Mate: Research Trends and Main Findings over 20 Years
171(1)
8.5 Biological Activities of Yerba Mate Related to Diabetes, Obesity, and Metabolic Syndrome
172(5)
8.5.1 In Vitro Studies
172(2)
8.5.2 Animal Studies
174(2)
8.5.3 Clinical Trials
176(1)
8.6 Summarizing Conclusion and Perspectives
177(1)
References
178(5)
9 Role of Natural Antioxidants from Selected Plants Belonging to the Scrophulariaceae and Buddlejaceae Families in the Prevention and Treatment of Neurodegenerative Diseases 183(54)
Cigdem Kahraman
Zeliha S. Akdemir
I. Irem Tatli
9.1 Introduction
183(5)
9.2 Natural Antioxidants from Verbascum Species (Mullein) for Their Therapeutic Activities against Neurodegenerative Diseases
188(12)
9.3 Natural Antioxidants from Scrophularia Species (Figwort) for Their Therapeutic Activities against Neurodegenerative Diseases
200(9)
9.4 Natural Antioxidants from Buddleja Species (Butterfly Bush) for Their Therapeutic Activities against Neurodegenerative Diseases
209(12)
9.5 Secondary Metabolites and Their Therapeutic Activities against Neurodegenerative Diseases
221(4)
9.6 Conclusions
225(1)
Acknowledgments
226(1)
References
226(11)
10 Recent Trends in Drug Discovery against Alzheimer's Disease: Use of Natural Products and Nutraceuticals from Botanicals 237(42)
Sudatta Malty
Samapika Nandy
Anuradha Mukherjee
Abhifit Dey
10.1 Introduction
237(1)
10.2 Symptoms
237(1)
10.3 Etiopathogenesis
238(1)
10.4 Conventional Therapy
239(1)
10.5 Complementary and Alternative Therapies (CATS) for AD
239(1)
10.6 Research Methodology
240(1)
10.7 Neuroprotective Biomolecules: Possible Roles against AD Pathogenesis
241(22)
10.7.1 1-o-acetyllycorine
241(4)
10.7.2 α-iso-cubebenol
245(1)
10.7.3 α-onocerin
245(11)
10.7.4 Acteoside
256(1)
10.7.5 Apigenin
256(1)
10.7.6 β-Asarone
256(1)
10.7.7 Baicalein and Baicalin
256(1)
10.7.8 Bellidin, Bellidifolin, Bellidin 8-O-β-Glucopyranoside and Bellidifolin 8-O-β-Glucopyranoside
256(1)
10.7.9 Catalpol
257(1)
10.7.10 Cryptotanshinone
257(1)
10.7.11 Curcuminoids
257(1)
10.7.12 Cynatroside B
258(1)
10.7.13 Galantamine
258(1)
10.7.14 Genistein
258(1)
10.7.15 Huperzine A
258(1)
10.7.16 Icariin
259(1)
10.7.17 Isorhynchophylline
259(1)
10.7.18 Luteolin
259(1)
10.7.19 Melatonin
259(1)
10.7.20 Naringenin
260(1)
10.7.21 Piceatannol
260(1)
10.7.22 p-coumaric Acid
260(1)
10.7.23 Piperine
260(1)
10.7.24 Quercetin
261(1)
10.7.25 Salidroside
261(1)
10.7.26 Silibinin
261(1)
10.7.27 Stepharanine, Cyclanoline, and N-Methyl Stepholidine
262(1)
10.7.28 Tripchlorolide (T4)
262(1)
10.7.29 Triptexanthoside C
262(1)
10.7.30 Ursolic Acid
262(1)
10.7.31 Xanthoceraside
262(1)
10.7.32 Xylocoside G
263(1)
10.7.33 Zeatin
263(1)
10.7.34 z-Ligustilide
263(1)
10.8 Conclusion
263(1)
Abbreviations
264(2)
References
266(13)
11 Therapeutic Potential of Metalloherbal Nanoceuticals: Current Status and Future Perspectives 279(26)
Shazia Usmani
Muhammad Arif
Syed Misbah Hasan
11.1 Historical Background of Indian Herbal Medicine
279(1)
11.2 Concept of Herbalism
280(1)
11.3 Positive Correlation between Phytopharmacology and Phytochemistry: Need of the Hour
280(1)
11.4 Validation of Herbal Therapeutics: An Indispensable Boon for Ayurveda
281(5)
11.4.1 Reverse Pharmacology-Based Validation of Herbal Drugs [ 14]
281(1)
11.4.2 Amplifying Approaches for Validation of Traditional Medicine
282(1)
11.4.3 Scientific Integration of Traditional Herbals in Clinical Practice
282(1)
11.4.3.1 Evidence-Based Benefits of Herbs
282(1)
11.4.4 Bhasmas: The Metal-Based Ayurvedic Medicine
283(1)
11.4.4.1 Preparation of Bhasmas
283(1)
11.4.5 Steps Involved in the Preparation of Bhasmas
284(2)
11.4.5.1 Characterization of Bhasma
285(1)
11.5 Metals Commonly Employed for Preparation of Bhasmas
286(4)
11.5.1 Swarna (Gold)
286(1)
11.5.2 Parada (Mercury)
287(3)
11.5.2.1 Tamra (Copper)
287(1)
11.5.2.2 Lauha (Iron)
288(1)
11.5.2.3 Rajata (Silver)
288(1)
11.5.2.4 Yashada (Zinc)
289(1)
11.5.2.5 Naga (Lead)
289(1)
11.5.2.6 Vanga (Tin)
290(1)
11.6 Toxicity Aspect: An Issue of Concern in the Use of Herbomineral Formulations
290(8)
11.6.1 Conflictive Opposition by Western Medicine Philosophy
291(1)
11.6.2 Conclusive Statements Supported by Varied Research Works
292(6)
11.6.3 Future Prospects in Light of Knowledge within Ayurvedic Texts and Its Application as Nanomedicine
298(1)
References
298(7)
12 Green Tea Polyphenols: A Putative Mechanism for Cytotoxic Action against Cancer Cells 305(28)
Mohd Farhan
Uzma Shamim
S.M. Hadi
12.1 Dietary Constituents and Their Role in Prevention of Cancer
305(1)
12.2 Cancer Chemoprevention by Dietary Polyphenols
306(2)
12.3 Polyphenolic Compounds and Their Chemical Classification
308(3)
12.4 Dietary Sources of Plant-Derived Polyphenolic Compounds
311(3)
12.5 Metabolism of Polyphenolic Compounds in Humans
314(2)
12.6 Polyphenols and Their Therapeutic Potential
316(5)
12.6.1 Anticancer Properties
316(2)
12.6.2 Prospective Anticancer Mechanisms of Plant-Derived Dietary Polyphenols
318(22)
12.6.2.1 Antioxidant Action
319(1)
12.6.2.2 Pro-Oxidant Action
319(2)
Acknowledgments
321(1)
References
321(12)
13 Nature's Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives 333(42)
Fyaz M.D. Ismail
13.1 Introduction
333(3)
13.2 Synthetic Drugs Allow Mass Prophylaxis of Malarial Infections
336(2)
13.3 The Cooperative World War II Wartime Program
338(2)
13.4 The Post-Chloroquine Era: A Return to Finding Drugs from Nature
340(1)
13.5 Compounds from Plant Sources
340(21)
13.5.1 South America
342(5)
13.5.1.1 Quassinoids
342(2)
13.5.1.2 Amazonia Plants
344(1)
13.5.1.3 Plants Deserving Further Investigation
345(2)
13.5.2 Promising Antimalarials Native to Africa
347(4)
13.5.2.1 Burkina Faso
347(1)
13.5.2.2 Congo
347(2)
13.5.2.3 Ethiopia
349(1)
13.5.2.4 Kenya
350(1)
13.5.2.5 Madagascar
351(1)
13.5.3 North America and Europe
351(2)
13.5.3.1 Helanin
352(1)
13.5.4 India and East Asia
353(6)
13.5.4.1 China
354(5)
13.5.4.2 Japan and Korea
359(1)
13.5.5 Australia
359(2)
13.6 The Future
361(2)
13.7 Conclusion
363(1)
References
363(12)
14 Nutraceutical-Based Pharmacological Intervention in the Management of Liver Diseases 375(20)
Aaliya Shah
Syed Mudassar
14.1 Liver: A Multifunctional Organ
375(2)
14.2 Biomarkers of Hepatic Injury
377(1)
14.3 Nutraceutical Intervention in the Management of Liver Diseases
377(9)
14.3.1 Vitamins
378(2)
14.3.1.1 Vitamin D
378(1)
14.3.1.2 Vitamin C
379(1)
14.3.1.3 Vitamin E
379(1)
14.3.2 Dietary Polyphenols
380(1)
14.3.2.1 Flavonoids
380(1)
14.3.3 Anthocyanins, Isoflavones, and Flavanones
380(1)
14.3.4 Stilbenes
381(1)
14.3.5 Curcuminoids
381(1)
14.3.6 Silymarin
381(1)
14.3.7 Beverages (Coffee and Tea)
381(1)
14.3.8 Polyunsaturated Fatty Acids (PUFAs)
382(1)
14.3.8.1 Short-Chain, Medium-Chain, and Long-Chain Fatty Acids (SCFAs, MCFAs, and LCFAs)
382(1)
14.3.8.2 Polyunsaturated Fatty Acids
382(1)
14.3.9 Probiotics
383(1)
14.3.10 Fruits
384(1)
14.3.10.1 Grape
384(1)
14.3.10.2 Black Currant
384(1)
14.3.10.3 Plum
384(1)
14.3.10.4 Pomegranate
384(1)
14.3.10.5 Gac Fruit
385(1)
14.3.11 Vegetables
385(1)
14.3.11.1 Celery Seeds
385(1)
14.3.11.2 Spices
385(1)
14.3.11.3 Saffron
385(1)
14.3.11.4 Soy
386(1)
14.3.11.5 Cereals
386(1)
14.4 Conclusion
386(1)
References
386(9)
Index 395
About the Editors

Mohammad Fahad Ullah, is an Assistant Professor of Biochemistry in the Department of Medical Laboratory Technology (FAMS) and a Research Scientist at Prince Fahd Research Chair, University of Tabuk, Saudi Arabia.

Aamir Ahmad, is an Assistant Professor of Oncologic Sciences at University of South Alabama's Mitchell Cancer Institute, Mobile, AL, USA.