| Series Introduction |
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iii | |
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| Preface |
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vii | |
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Oxidative Stress in Ceil Biology and Biochemistry |
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1 The Importance of Oxidant-Antioxidant Balance |
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1 | (8) |
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2 The Effect of Oxidative Stress on Cells by Oxygen Radicals and Its Inhibition by Antioxidants |
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9 | (6) |
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3 Cytotoxicity of Radiation-Derived Reactive Oxygen Species |
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15 | (14) |
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Oxidative Stress and Cellular Signaling |
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4 Regulation of the Bacterial Response to Hydrogen Peroxide |
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29 | (6) |
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5 Activation of Lymphocyte Signal Pathways by Oxidative Stress: Role of Tyrosine Kinases and Phosphatases |
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35 | (10) |
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6 Oxidant-mediated Modulation of Phospholipases in Endothelial Cells: Possible Implication in Vascular Disorders |
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45 | (18) |
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7 NFkB Transcription Factor Activation: Importance of the Redox Regulation |
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63 | (12) |
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8 Redox Regulation of the NFkB Signaling Pathway and Disease Control |
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75 | (8) |
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9 Mechanism of Activation of NFkB by Hydrogen Peroxide |
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83 | (6) |
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10 Self-regulation of the NFKB/lKBa System, and Its Positive and Negative Control by the Cellular Redox Status |
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89 | (8) |
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Fernando Arenzana-Seisdedos |
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11 The Role of Hydrogen Peroxide in Signal Transduction and the Involvement of Iron |
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97 | (16) |
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12 Redox Regulation of Heat Shock Protein Expression and Protective Effects Against Oxidative Stress |
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113 | (14) |
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Muriel R. Jacquier-Sarlin |
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13 Low-Density Lipoproteins Modulate Nitric Oxide and Heme Oxygenase Signal Transduction Pathways in Vascular Endothelium and Smooth Muscle |
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127 | (12) |
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14 Nitric Oxide-stimulated Tyrosine Phosphorylation-dependent Signaling Pathways in Cultured Cells |
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139 | (8) |
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15 Regulation of Cell Activation by Receptors for IgG |
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147 | (16) |
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16 Signal Transduction Pathways Activated by Mitogenic Neuropeptides |
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163 | (16) |
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Oxidative Stress and Apoptosis |
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17 Glutathione Metabolism During Apoptosis |
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179 | (12) |
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Diets J. van den Dobbelsteen |
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18 Endogenously Generated Superoxide and Hydrogen Peroxide in the Redox Modulation of Cell Proliferation, Apoptosis, and Virus Replication |
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191 | (8) |
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19 Deoxy-D-Ribose-Induced GSH Depletion and Induction of Apoptosis in Human Quiescent Peripheral Blood Mononuclear Cells: Effects of N-Acetyl Cysteine and L-Buthionine-(S,R)-sulfoximine |
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199 | (6) |
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20 Nitric Oxide and Hydrogen Peroxide Production during Apoptosis of Human Neutrophils |
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205 | (8) |
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21 The Mitochondrion as a Sensor/Effector of Oxidative Stress During Apoptosis |
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213 | (10) |
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Oxidative Stress and Antioxidants |
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22 Antioxidants and the Regulation of Reactive Iron |
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223 | (6) |
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23 Redox Regulation by the Thioredoxin and Glutaredoxin Systems |
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229 | (18) |
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24 Thioredoxin/Adult T Cell Leukemia-Derived Factor as the Key Redox Regulator of Signaling |
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247 | (4) |
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25 Therapeutic Potential of the Antioxidant and Redox Properties of a-Lipoic Acid |
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251 | (18) |
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26 Glutathione Compartmentation and Oxidative Stress |
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269 | (16) |
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27 Flavonoid Functions In Vivo: Are They Predominantly Antioxidant? |
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285 | (20) |
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28 Immunoregulatory Properties of Superoxide Dismutase |
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305 | (8) |
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29 Pharmacological Inhibition of Endothelial Cytoskeleton Alterations Induced by Hydrogen Peroxide and TNF-α |
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313 | (10) |
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30 Perinatal Development of Superoxide Dismutase and Other Antioxidant Enzyme Activities in Rat-brain Mitochondria |
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323 | (10) |
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31 Coexistence of a "Reactive Oxygen Cycle" with "Q Cycle" and "H+-Cycle" in the Respiratory Chain: A Hypothesis for the Generation, Partitioning, Targeting, and Functioning of Superoxide in Mitochondria |
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333 | (18) |
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Oxidative Stress and Cancer |
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32 Endogenous Oxidative DNA Damage and Spontaneous Mutagenesis: Role of 8-Oxoguanine |
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351 | (8) |
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33 The Elevated Serum Level of Thioredoxin in Patients with Malignant Disease and Chronic Inflammatory Diseases |
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359 | (10) |
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34 The Role of Free Radicals in Antitumor Effects of Various Cancer Treatments |
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369 | (4) |
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Oxidative Stress and AIDS |
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35 The Role of Cysteine and Glutathione in the Pathogenesis of HIV Infection: Effects of Treatment with N-Acetylcysteine |
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373 | (6) |
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36 Low Glutathione Levels in CD4 T Cells Predict Poor Survival in AIDS; Af-Acetylcysteine May Improve Survival |
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379 | (10) |
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37 Modulation of HIV-1 Long Terminal Repeat by Arachidonic Acid |
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389 | (10) |
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38 Protein Degradation in Lymphocytes as an Indicator of Oxidative Stress in HIV Infection |
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399 | (10) |
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39 Oxidative Stress and AIDS: One-year Supplementation of HIV-positive Patients with Selenium or (3-Carotene |
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409 | (20) |
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40 Glutathione Oxidation and Mitochondrial DNA Damage in AIDS: Effect of Zidovudine |
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429 | (8) |
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Jose Garci'a-de-la-Asuncion |
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41 Effect of L-Carnitine Treatment In Vivo on Apoptosis and Ceramide Generation by Peripheral Blood Lymphocytes from AIDS Patients |
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437 | (10) |
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42 Nutriceutical Modulation of Glutathione with a Humanized Native Milk Serum Protein Isolate, Immunocal™: Application in AIDS and Cancer |
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447 | (16) |
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43 Successful Antioxidant Therapy Including Superoxide Dismutase Associated with Antiretroviral Therapy in an HIV-infected Patient with Hepatitis B-related Cirrhosis |
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463 | (6) |
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44 Parkinson's Disease, Apoptosis, and Oxidative Stress |
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469 | (16) |
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45 Protein Oxidation and Glycation in Neurodegenerative Diseases |
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485 | (12) |
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46 Glycation as Oxidative Stress and Redox Regulation: Implications for Aging, Diabetes, and Familial Amyotrophic Lateral Sclerosis |
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497 | (6) |
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47 Oxidative Stress in Ischemia - Reperfusion: Reilly's Irritation Syndrome Revisited |
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503 | (4) |
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48 Evaluation of the Antiperoxidase Defense System of the Lens Utilizing GSH Peroxidase Transgenics and Knockouts |
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507 | (10) |
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49 The Rheumatoid Joint: Redox-Paradox? |
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517 | (20) |
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50 Chronic Oxidative Stress in Rheumatoid Arthritis: Implications for T Cell Function |
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537 | (10) |
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Ellen A. M. van der Voort |
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| Index |
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547 | |
